The network for 'erk1 and erk2 cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

erk1 and erk2 cascade

An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
EGFR epidermal growth factor receptor 1.000
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
MAPK14 mitogen-activated protein kinase 14 1.000
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 1.000
MAPK1 mitogen-activated protein kinase 1 1.000
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
FGFR2 fibroblast growth factor receptor 2 1.000
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.999
DUSP1 dual specificity phosphatase 1 0.999
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.999
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.998
MAP2K1 mitogen-activated protein kinase kinase 1 0.997
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.996
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.995
FGFR1 fibroblast growth factor receptor 1 0.995
VEGFA vascular endothelial growth factor A 0.993
SFN stratifin 0.992
IL8 interleukin 8 0.991
FYN FYN oncogene related to SRC, FGR, YES 0.989
CCR5 chemokine (C-C motif) receptor 5 0.986
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.982
TRAF1 TNF receptor-associated factor 1 0.980
FAS Fas (TNF receptor superfamily, member 6) 0.980
TEK TEK tyrosine kinase, endothelial 0.980
MAPK3 mitogen-activated protein kinase 3 0.971
GSK3B glycogen synthase kinase 3 beta 0.965
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.954
FGF1 fibroblast growth factor 1 (acidic) 0.951
SH3KBP1 SH3-domain kinase binding protein 1 0.951
FN1 fibronectin 1 0.951
BCAR1 breast cancer anti-estrogen resistance 1 0.948
IGF1R insulin-like growth factor 1 receptor 0.931
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.903
CCL2 chemokine (C-C motif) ligand 2 0.895
GUCY2C guanylate cyclase 2C (heat stable enterotoxin receptor) 0.894
IL1B interleukin 1, beta 0.894
CAV1 caveolin 1, caveolae protein, 22kDa 0.885
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.879
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.863
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.853
RIPK2 receptor-interacting serine-threonine kinase 2 0.850
BCR breakpoint cluster region 0.845
C1QA complement component 1, q subcomponent, A chain 0.841
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.838
BIRC3 baculoviral IAP repeat containing 3 0.828
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.823
AXL AXL receptor tyrosine kinase 0.783
SOS1 son of sevenless homolog 1 (Drosophila) 0.782
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.779
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.778
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 0.775
IL6 interleukin 6 (interferon, beta 2) 0.765
CCR7 chemokine (C-C motif) receptor 7 0.749
TNF tumor necrosis factor 0.747
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.747
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.742
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.739
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.737
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.735
CCL4 chemokine (C-C motif) ligand 4 0.732
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.700
SPRR2A small proline-rich protein 2A 0.698
MPDZ multiple PDZ domain protein 0.692
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.680
CSNK2B casein kinase 2, beta polypeptide 0.679
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.664
FGA fibrinogen alpha chain 0.664
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.659
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.659
CCL5 chemokine (C-C motif) ligand 5 0.655
CXCL2 chemokine (C-X-C motif) ligand 2 0.654
PLAUR plasminogen activator, urokinase receptor 0.652
ESR1 estrogen receptor 1 0.647
FGB fibrinogen beta chain 0.637
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.626
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.620
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.613
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.609
PECAM1 platelet/endothelial cell adhesion molecule 0.600
NRP1 neuropilin 1 0.600
THBS1 thrombospondin 1 0.589
BRAF v-raf murine sarcoma viral oncogene homolog B1 0.578
SMN1 survival of motor neuron 1, telomeric 0.565
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.565
KLF6 Kruppel-like factor 6 0.542
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.532
LRRC7 leucine rich repeat containing 7 0.531
ICAM1 intercellular adhesion molecule 1 0.529
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.526
CTGF connective tissue growth factor 0.525
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.523
CCL19 chemokine (C-C motif) ligand 19 0.520
SLMAP sarcolemma associated protein 0.520
ZNF496 zinc finger protein 496 0.519
CXCL9 chemokine (C-X-C motif) ligand 9 0.518
GAB1 GRB2-associated binding protein 1 0.518
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.515
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.506
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
efnb2a ephrin B2a 0.615
pdgfaa platelet-derived growth factor alpha a 0.614
nf1a neurofibromin 1a 0.547
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.511
evx1 even-skipped homeobox 1 0.452
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.433
fzd7a frizzled homolog 7a 0.391
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.381
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.360
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.346
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.333
fgf3 fibroblast growth factor 3 0.305
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.290
irx2a iroquois homeobox protein 2, a 0.280
hoxa2b homeo box A2b 0.279
esr1 estrogen receptor 1 0.276
fes feline sarcoma oncogene 0.267
ywhaqa tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a 0.251
wls wntless homolog (Drosophila) 0.243
llgl2 lethal giant larvae homolog 2 (Drosophila) 0.234
celf1 cugbp, Elav-like family member 1 0.220
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.205
rnd3a Rho family GTPase 3a 0.200
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.186
yap1 Yes-associated protein 1 0.186
calm1a calmodulin 1a 0.182
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.179
spry4 sprouty (Drosophila) homolog 4 0.168
lef1 lymphocyte enhancer binding factor 1 0.167
odc1 ornithine decarboxylase 1 0.166
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.166
vegfc vascular endothelial growth factor c 0.153
igf1 insulin-like growth factor 1 0.148
fn1b fibronectin 1b 0.146
pax7b paired box gene 7b 0.144
npnt nephronectin 0.144
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.141
atp6v0d1 ATPase, H+ transporting, V0 subunit D isoform 1 0.139
hdac4 histone deacetylase 4 0.139
dusp5 dual specificity phosphatase 5 0.139
zgc:112982 zgc:112982 0.138
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.136
lama1 laminin, alpha 1 0.136
sox7 SRY-box containing gene 7 0.135
jag1b jagged 1b 0.134
idh1 isocitrate dehydrogenase 1 (NADP+), soluble 0.132
fgfr3 fibroblast growth factor receptor 3 0.130
nrg2a neuregulin 2a 0.128
pigu phosphatidylinositol glycan anchor biosynthesis, class U 0.128
fgfr2 fibroblast growth factor receptor 2 0.127
smad9 MAD homolog 9 (Drosophila) 0.126
arrb2b arrestin, beta 2b 0.126
etv5b ets variant 5b 0.125
ube2v2 ubiquitin-conjugating enzyme E2 variant 2 0.124
fgg fibrinogen, gamma polypeptide 0.122
tfe3b transcription factor binding to IGHM enhancer 3b 0.122
nod1 nucleotide-binding oligomerization domain containing 1 0.114
pea3 ETS-domain transcription factor pea3 0.113
fgb fibrinogen, B beta polypeptide 0.112
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.108
foxo3b forkhead box O3b 0.108
snai1a snail homolog 1a (Drosophila) 0.107
cdh10 cadherin 10, type 2 (T2-cadherin) 0.106
aplp2 amyloid beta (A4) precursor-like protein 2 0.104
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.104
shha sonic hedgehog a 0.103
sdprb serum deprivation response b 0.103
notch2 notch homolog 2 0.101
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.099
polr2j polymerase (RNA) II (DNA directed) polypeptide J 0.098
nod2 nucleotide-binding oligomerization domain containing 2 0.098
tagln3b transgelin 3b 0.097
col11a1a collagen, type XI, alpha 1a 0.096
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.096
snx8 sorting nexin 8 0.096
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.095
wu:fv91b12 wu:fv91b12 0.093
tagln2 transgelin 2 0.093
ptgs1 prostaglandin-endoperoxide synthase 1 0.092
igf2a insulin-like growth factor 2a 0.091
card14 caspase recruitment domain family, member 14 0.091
cmt4b2 Charcot-Marie-Tooth neuropathy 4B2 homolog (human) 0.090
sf3b1 splicing factor 3b, subunit 1 0.090
enc1 ectodermal-neural cortex (with BTB-like domain) 0.090
fzd2 frizzled homolog 2 0.087
wwp2 WW domain containing E3 ubiquitin protein ligase 2 0.087
sc:d812 sc:d812 0.086
lhx2b LIM homeobox 2b 0.086
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.085
zbtb4 zinc finger and BTB domain containing 4 0.085
oprd1a opioid receptor, delta 1a 0.085
podxl podocalyxin-like 0.085
rbm39b RNA binding motif protein 39b 0.084
pax7a paired box gene 7a 0.084
drd2b dopamine receptor D2b 0.083
nf1b neurofibromin 1b 0.083
u2af1 U2(RNU2) small nuclear RNA auxiliary factor 1 0.083
cnr1 cannabinoid receptor 1 0.082
fgfr1b fibroblast growth factor receptor 1b 0.082
ip6k2 inositol hexaphosphate kinase 2 0.082
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Drosophila melanogaster
Name Description Probability Func Analog Organism
phl pole hole 0.739
rl rolled 0.460
Shc SHC-adaptor protein 0.377
drk downstream of receptor kinase 0.356
mbc myoblast city 0.219
shi shibire 0.203
pnt pointed 0.201
csw corkscrew 0.186
Ras85D Ras oncogene at 85D 0.179
gek genghis khan 0.178
mtt mangetout 0.167
E2f2 E2F transcription factor 2 0.163
Sos Son of sevenless 0.158
Taf6 TBP-associated factor 6 0.148
pnut peanut 0.144
CG9797 CG9797 gene product from transcript CG9797-RA 0.140
CG15436 CG15436 gene product from transcript CG15436-RA 0.133
Akt1 CG4006 gene product from transcript CG4006-RA 0.130
sty sprouty 0.126
aop anterior open 0.122
polybromo CG11375 gene product from transcript CG11375-RA 0.110
rho rhomboid 0.108
stumps CG31317 gene product from transcript CG31317-RC 0.102
sev sevenless 0.099
Egfr Epidermal growth factor receptor 0.099
DnaJ-1 DnaJ-like-1 0.096
Ric Ras which interacts with Calmodulin 0.091
Src64B Src oncogene at 64B 0.084
SF1 Splicing factor 1 0.080
CG6015 CG6015 gene product from transcript CG6015-RA 0.079
CG10267 CG10267 gene product from transcript CG10267-RB 0.079
CG7928 CG7928 gene product from transcript CG7928-RA 0.076
dock dreadlocks 0.075
CG1024 CG1024 gene product from transcript CG1024-RB 0.074
tkv thickveins 0.064
Rcd1 Reduction in Cnn dots 1 0.064
lqf liquid facets 0.062
cnk connector enhancer of ksr 0.062
Sry-delta Serendipity delta 0.060
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.057
CG6066 CG6066 gene product from transcript CG6066-RA 0.055
Socs36E Suppressor of cytokine signaling at 36E 0.055
Gap1 GTPase-activating protein 1 0.055
Rac2 CG8556 gene product from transcript CG8556-RA 0.053
Rab5 Rab-protein 5 0.052
dos daughter of sevenless 0.052
Smox Smad on X 0.051
CG6654 CG6654 gene product from transcript CG6654-RA 0.051
eya eyes absent 0.050
CG4854 CG4854 gene product from transcript CG4854-RA 0.050
Jra Jun-related antigen 0.049
l(2)k14710 lethal (2) k14710 0.049
Sema-1a CG18405 gene product from transcript CG18405-RD 0.047
trem trade embargo 0.047
CG10139 CG10139 gene product from transcript CG10139-RA 0.047
foxo forkhead box, sub-group O 0.045
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.045
fl(2)d female lethal d 0.045
S6kII RPS6-protein kinase-II 0.045
hipk homeodomain interacting protein kinase 0.045
trio CG18214 gene product from transcript CG18214-RA 0.045
aux auxillin 0.045
flw flapwing 0.044
Hs6st Heparan sulfate 6-O-sulfotransferase 0.042
CG18764 CG18764 gene product from transcript CG18764-RA 0.042
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.042
Hlc Helicase 0.041
NiPp1 Nuclear inhibitor of Protein phosphatase 1 0.040
mRNA-capping-enzyme CG1810 gene product from transcript CG1810-RA 0.040
CG14641 CG14641 gene product from transcript CG14641-RA 0.039
mael maelstrom 0.039
Mad Mothers against dpp 0.039
Dsor1 Downstream of raf1 0.039
mask multiple ankyrin repeats single KH domain 0.038
CG14711 CG14711 gene product from transcript CG14711-RA 0.038
Apc APC-like 0.038
srp serpent 0.037
repo reversed polarity 0.036
RhoBTB CG5701 gene product from transcript CG5701-RA 0.036
CG12042 CG12042 gene product from transcript CG12042-RA 0.035
crn crooked neck 0.035
Git CG16728 gene product from transcript CG16728-RA 0.035
Fak56D Focal Adhesion Kinase 0.035
pr-set7 CG3307 gene product from transcript CG3307-RC 0.035
gig gigas 0.034
Dad Daughters against dpp 0.034
Pp2B-14D Protein phosphatase 2B at 14D 0.034
CG4424 CG4424 gene product from transcript CG4424-RA 0.033
grau grauzone 0.033
htl heartless 0.033
Gr28b Gustatory receptor 28b 0.033
Ras64B Ras oncogene at 64B 0.033
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.032
spi spitz 0.032
CG14220 CG14220 gene product from transcript CG14220-RA 0.031
CG1965 CG1965 gene product from transcript CG1965-RA 0.031
MBD-like CG8208 gene product from transcript CG8208-RA 0.031
S6k RPS6-p70-protein kinase 0.030
CG17568 CG17568 gene product from transcript CG17568-RA 0.030
Ilp2 Insulin-like peptide 2 0.030
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Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.995
Grb2 growth factor receptor bound protein 2 0.994
Inpp5d inositol polyphosphate-5-phosphatase D 0.988
Pten phosphatase and tensin homolog 0.967
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.954
Kl klotho 0.953
Csf1 colony stimulating factor 1 (macrophage) 0.953
Nf1 neurofibromatosis 1 0.906
Ikzf1 IKAROS family zinc finger 1 0.896
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.887
Btk Bruton agammaglobulinemia tyrosine kinase 0.875
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.874
Cd44 CD44 antigen 0.861
Dok1 docking protein 1 0.835
Col1a1 collagen, type I, alpha 1 0.825
Lyz2 lysozyme 2 0.817
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.779
Plcg1 phospholipase C, gamma 1 0.779
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.778
Cbl Casitas B-lineage lymphoma 0.774
Tgfbr2 transforming growth factor, beta receptor II 0.745
Acvr1 activin A receptor, type 1 0.736
Dok2 docking protein 2 0.726
Trp53 transformation related protein 53 0.686
Fas Fas (TNF receptor superfamily member 6) 0.668
Nos2 nitric oxide synthase 2, inducible 0.645
Tnf tumor necrosis factor 0.618
Cd247 CD247 antigen 0.611
Cd22 CD22 antigen 0.605
Meox2 mesenchyme homeobox 2 0.602
Vegfa vascular endothelial growth factor A 0.592
Ptprc protein tyrosine phosphatase, receptor type, C 0.580
Cav1 caveolin 1, caveolae protein 0.578
Pgr progesterone receptor 0.572
Igh immunoglobulin heavy chain complex 0.558
Ifng interferon gamma 0.554
Prkce protein kinase C, epsilon 0.552
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.552
Fcgr2b Fc receptor, IgG, low affinity IIb 0.550
Ccr1 chemokine (C-C motif) receptor 1 0.547
Ccl2 chemokine (C-C motif) ligand 2 0.522
Ccr2 chemokine (C-C motif) receptor 2 0.518
Src Rous sarcoma oncogene 0.516
Il10 interleukin 10 0.498
Il1r1 interleukin 1 receptor, type I 0.483
Plxnd1 plexin D1 0.471
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.466
Tlr4 toll-like receptor 4 0.465
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.454
Pax3 paired box gene 3 0.446
Csf1r colony stimulating factor 1 receptor 0.445
Arrb2 arrestin, beta 2 0.426
Prf1 perforin 1 (pore forming protein) 0.425
Ltb lymphotoxin B 0.421
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.419
Il2rg interleukin 2 receptor, gamma chain 0.409
Cd40 CD40 antigen 0.408
Mmp9 matrix metallopeptidase 9 0.397
Elf4 E74-like factor 4 (ets domain transcription factor) 0.381
Mas1 MAS1 oncogene 0.380
Il18rap interleukin 18 receptor accessory protein 0.378
Fgf10 fibroblast growth factor 10 0.367
Ret ret proto-oncogene 0.361
Runx2 runt related transcription factor 2 0.359
Itgb3 integrin beta 3 0.353
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.353
Zeb1 zinc finger E-box binding homeobox 1 0.349
Ednra endothelin receptor type A 0.348
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.347
Itgal integrin alpha L 0.344
Tcf21 transcription factor 21 0.335
Cd19 CD19 antigen 0.330
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.322
Nodal nodal 0.320
Eng endoglin 0.313
Pdcd1 programmed cell death 1 0.311
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.302
Cckbr cholecystokinin B receptor 0.298
Egfr epidermal growth factor receptor 0.298
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.288
Shh sonic hedgehog 0.287
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.285
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.283
Raf1 v-raf-leukemia viral oncogene 1 0.282
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.281
Shc1 src homology 2 domain-containing transforming protein C1 0.280
Apoa1 apolipoprotein A-I 0.279
Fgfr2 fibroblast growth factor receptor 2 0.278
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.278
Cx3cr1 chemokine (C-X3-C) receptor 1 0.273
Ccl4 chemokine (C-C motif) ligand 4 0.272
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.270
Tgfb1 transforming growth factor, beta 1 0.267
Mkl2 MKL/myocardin-like 2 0.262
C1qa complement component 1, q subcomponent, alpha polypeptide 0.261
Cd80 CD80 antigen 0.261
Fgf8 fibroblast growth factor 8 0.259
Mapk1 mitogen-activated protein kinase 1 0.257
Drd2 dopamine receptor D2 0.255
H2-DMa histocompatibility 2, class II, locus DMa 0.254
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Rattus norvegicus
Name Description Probability Func Analog Organism
Junb jun B proto-oncogene 0.662
Il1b interleukin 1 beta 0.630
Fos FBJ osteosarcoma oncogene 0.621
Cav1 caveolin 1, caveolae protein 0.531
Cxcl2 chemokine (C-X-C motif) ligand 2 0.421
Ccl4 chemokine (C-C motif) ligand 4 0.374
Tgfbr2 transforming growth factor, beta receptor II 0.337
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.313
Csf1 colony stimulating factor 1 (macrophage) 0.298
Clstn3 calsyntenin 3 0.276
Sirpa signal-regulatory protein alpha 0.255
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.249
Socs3 suppressor of cytokine signaling 3 0.244
Cd4 Cd4 molecule 0.239
Il2rg interleukin 2 receptor, gamma 0.235
Foxa1 forkhead box A1 0.228
Hrh3 histamine receptor H3 0.220
Agtr1a angiotensin II receptor, type 1a 0.178
Mr1 major histocompatibility complex, class I-related 0.178
Vip vasoactive intestinal peptide 0.176
Ptprc protein tyrosine phosphatase, receptor type, C 0.174
Adrb1 adrenergic, beta-1-, receptor 0.166
Phox2a paired-like homeobox 2a 0.162
Ccr2 chemokine (C-C motif) receptor 2 0.161
Trim47 tripartite motif-containing 47 0.161
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.157
Cyss cystatin S 0.156
Ncan neurocan 0.156
Cacng5 calcium channel, voltage-dependent, gamma subunit 5 0.152
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.149
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.147
Nmbr neuromedin B receptor 0.145
LOC100362824 caveolin 2-like 0.144
Psp parotid secretory protein 0.141
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.140
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.137
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.136
Ahsg alpha-2-HS-glycoprotein 0.134
Jak1 Janus kinase 1 0.130
Sdc3 syndecan 3 0.129
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.129
Cdh6 cadherin 6 0.128
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.126
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.124
Hand2 heart and neural crest derivatives expressed 2 0.118
Tgfbr3 transforming growth factor, beta receptor III 0.118
Nras neuroblastoma ras oncogene 0.116
Rgs14 regulator of G-protein signaling 14 0.115
Mbl1 mannose-binding lectin (protein A) 1 0.114
Grm7 glutamate receptor, metabotropic 7 0.113
Ccr3 chemokine (C-C motif) receptor 3 0.113
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.112
Met met proto-oncogene 0.112
Hck hemopoietic cell kinase 0.111
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.111
Olr287 olfactory receptor 287 0.109
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.109
Inpp5d inositol polyphosphate-5-phosphatase D 0.107
Drd3 dopamine receptor D3 0.106
Phkg1 phosphorylase kinase, gamma 1 0.106
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.105
Dbp D site of albumin promoter (albumin D-box) binding protein 0.103
Oprk1 opioid receptor, kappa 1 0.099
Ncr1 natural cytotoxicity triggering receptor 1 0.098
Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 0.098
Cnga1 cyclic nucleotide gated channel alpha 1 0.098
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.095
Klf2 Kruppel-like factor 2 (lung) 0.094
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.094
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.092
Cga glycoprotein hormones, alpha polypeptide 0.092
Pth parathyroid hormone 0.091
Gja1 gap junction protein, alpha 1 0.091
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.089
Bcan brevican 0.088
Gzmk granzyme K 0.088
Klf6 Kruppel-like factor 6 0.087
Ptafr platelet-activating factor receptor 0.086
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.086
Gnrhr gonadotropin releasing hormone receptor 0.086
Il1rl2 interleukin 1 receptor-like 2 0.085
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.084
Fgf16 fibroblast growth factor 16 0.084
Th tyrosine hydroxylase 0.083
N5 DNA binding protein N5 0.082
Itgam integrin, alpha M 0.080
Cd83 CD83 molecule 0.079
Adora1 adenosine A1 receptor 0.078
Fgfr1 Fibroblast growth factor receptor 1 0.078
Kitlg KIT ligand 0.077
Pde3a phosphodiesterase 3A, cGMP inhibited 0.077
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.075
Trhr thyrotropin releasing hormone receptor 0.075
Zg16 zymogen granule protein 16 0.074
Il9r interleukin 9 receptor 0.074
Edn1 endothelin 1 0.073
Cd247 Cd247 molecule 0.073
Proc protein C 0.073
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.072
Il1a interleukin 1 alpha 0.071
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism