The network for 'regulation of response to cytokine stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of response to cytokine stimulus

Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
IRAK1 interleukin-1 receptor-associated kinase 1 0.889
IRAK2 interleukin-1 receptor-associated kinase 2 0.642
LCK lymphocyte-specific protein tyrosine kinase 0.568
IL1R1 interleukin 1 receptor, type I 0.558
C1QA complement component 1, q subcomponent, A chain 0.536
MYD88 myeloid differentiation primary response gene (88) 0.507
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.476
ZNF43 zinc finger protein 43 0.469
TRAF6 TNF receptor-associated factor 6 0.445
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.440
GRB2 growth factor receptor-bound protein 2 0.357
CCR5 chemokine (C-C motif) receptor 5 0.278
PML promyelocytic leukemia 0.258
HCK hemopoietic cell kinase 0.252
DTX3L deltex 3-like (Drosophila) 0.246
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.200
ZNF253 zinc finger protein 253 0.185
ZNF273 zinc finger protein 273 0.180
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.171
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.159
SOCS3 suppressor of cytokine signaling 3 0.153
ZNF675 zinc finger protein 675 0.152
SYK spleen tyrosine kinase 0.152
JAK2 Janus kinase 2 0.151
GHR growth hormone receptor 0.119
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.112
GAS6 growth arrest-specific 6 0.100
TMEM173 transmembrane protein 173 0.098
FAS Fas (TNF receptor superfamily, member 6) 0.093
SPRR2A small proline-rich protein 2A 0.092
CCL4 chemokine (C-C motif) ligand 4 0.091
CXCL9 chemokine (C-X-C motif) ligand 9 0.089
ZNF708 zinc finger protein 708 0.088
SH3KBP1 SH3-domain kinase binding protein 1 0.087
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.081
RNF31 ring finger protein 31 0.081
C1QC complement component 1, q subcomponent, C chain 0.080
RXRA retinoid X receptor, alpha 0.078
C19orf50 chromosome 19 open reading frame 50 0.075
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.073
ZNF91 zinc finger protein 91 0.073
RARA retinoic acid receptor, alpha 0.071
NCOR2 nuclear receptor corepressor 2 0.070
DAXX death-domain associated protein 0.065
UBASH3B ubiquitin associated and SH3 domain containing B 0.060
PLCG1 phospholipase C, gamma 1 0.060
ZNF93 zinc finger protein 93 0.060
ZNF117 zinc finger protein 117 0.059
AXL AXL receptor tyrosine kinase 0.057
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.057
PTPRB protein tyrosine phosphatase, receptor type, B 0.053
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.052
RUNX1 runt-related transcription factor 1 0.051
IRAK4 interleukin-1 receptor-associated kinase 4 0.049
IRF7 interferon regulatory factor 7 0.049
ICAM1 intercellular adhesion molecule 1 0.047
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.046
TLR4 toll-like receptor 4 0.045
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.045
STAT4 signal transducer and activator of transcription 4 0.044
IL1RAP interleukin 1 receptor accessory protein 0.044
APOC1 apolipoprotein C-I 0.044
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.044
ZNF680 zinc finger protein 680 0.044
MAP2K5 mitogen-activated protein kinase kinase 5 0.043
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.043
C1QB complement component 1, q subcomponent, B chain 0.043
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.042
ZNF430 zinc finger protein 430 0.042
IDE insulin-degrading enzyme 0.042
ZNF85 zinc finger protein 85 0.041
CYLD cylindromatosis (turban tumor syndrome) 0.041
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.040
ZNF107 zinc finger protein 107 0.040
NLRC4 NLR family, CARD domain containing 4 0.039
PELI3 pellino homolog 3 (Drosophila) 0.039
CXCL10 chemokine (C-X-C motif) ligand 10 0.038
ZNF254 zinc finger protein 254 0.038
LAT linker for activation of T cells 0.038
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.037
NCK1 NCK adaptor protein 1 0.037
HP haptoglobin 0.036
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.036
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.036
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.036
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.035
CAV2 caveolin 2 0.035
ATN1 atrophin 1 0.035
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.034
SQSTM1 sequestosome 1 0.033
CREBBP CREB binding protein 0.032
CD14 CD14 molecule 0.032
FZD1 frizzled homolog 1 (Drosophila) 0.032
CCL7 chemokine (C-C motif) ligand 7 0.032
CCR7 chemokine (C-C motif) receptor 7 0.031
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.031
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.031
ESR1 estrogen receptor 1 0.031
LIMD1 LIM domains containing 1 0.030
RIPK2 receptor-interacting serine-threonine kinase 2 0.030
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.369
nrp2b neuropilin 2b 0.364
ush1c Usher syndrome 1C (autosomal recessive, severe) 0.307
ift88 intraflagellar transport 88 homolog 0.304
cav1 caveolin 1 0.265
robo2 roundabout homolog 2 0.243
il6r interleukin 6 receptor 0.242
atf3 activating transcription factor 3 0.238
copeb core promoter element binding protein 0.227
stat3 signal transduction and activation of transcription 3 0.222
mmp9 matrix metalloproteinase 9 0.216
cacna1da calcium channel, voltage-dependent, L type, alpha 1D subunit, a 0.204
mapk3 mitogen-activated protein kinase 3 0.146
junb jun B proto-oncogene 0.134
socs3a suppressor of cytokine signaling 3a 0.128
slit3 slit (Drosophila) homolog 3 0.121
ctbp2l C-terminal binding protein 2, like 0.119
grna granulin a 0.119
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.117
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.112
slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 0.107
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.094
hdac4 histone deacetylase 4 0.088
vtg1 vitellogenin 1 0.082
iclp1 invariant chain-like protein 1 0.081
scn1bb sodium channel, voltage-gated, type I, beta b 0.080
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.078
slit2 slit (Drosophila) homolog 2 0.075
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.074
dvl3 dishevelled, dsh homolog 3 (Drosophila) 0.074
tnfsf10l2 tumor necrosis factor (ligand) superfamily, member 10 like 2 0.073
irf11 interferon regulatory factor 11 0.072
c1qc complement component 1, q subcomponent, C chain 0.070
synj1 synaptojanin 1 0.070
dub duboraya 0.070
jak1 Janus kinase 1 0.066
scn1ba sodium channel, voltage-gated, type I, beta a 0.066
si:rp71-39b20.7 si:rp71-39b20.7 0.065
mapk4 mitogen-activated protein kinase 4 0.065
zgc:153997 zgc:153997 0.065
ripk2 receptor-interacting serine-threonine kinase 2 0.064
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.063
lims1 LIM and senescent cell antigen-like domains 1 0.061
mapk15 mitogen-activated protein kinase 15 0.060
gsnb gelsolin b 0.059
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.058
cntn2 contactin 2 0.057
msxa muscle segment homeobox A 0.055
ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.054
LOC566020 Gig2-like protein DreO 0.054
rc3 rabconnectin 3 0.053
stat1b signal transducer and activator of transcription 1b 0.053
ntn2 netrin 2 0.052
col7a1l collagen type VII alpha 1-like 0.051
caspa caspase a 0.051
nrg2a neuregulin 2a 0.050
cx30.3 connexin 30.3 0.050
axin1 axin 1 0.050
zgc:63721 zgc:63721 0.050
fryl furry homolog-like (Drosophila) 0.050
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.049
kdm5c lysine (K)-specific demethylase 5C 0.049
il6st interleukin 6 signal transducer 0.049
pabpc1b poly A binding protein, cytoplasmic 1 b 0.049
pcsk5a proprotein convertase subtilisin/kexin type 5a 0.048
ptena phosphatase and tensin homolog A 0.048
stc1l stanniocalcin 1, like 0.048
appa amyloid beta (A4) precursor protein a 0.047
smg7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.047
igf1rb insulin-like growth factor 1b receptor 0.047
pcdh15a protocadherin 15a 0.047
mcl1a myeloid cell leukemia sequence 1a 0.046
emx3 empty spiracles homeobox 3 0.046
slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 0.046
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.045
s100s S100 calcium binding protein S 0.045
card9 caspase recruitment domain family, member 9 0.043
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.043
alcama activated leukocyte cell adhesion molecule a 0.043
sh3gl1b SH3-domain GRB2-like 1b 0.043
LOC559616 calcium-binding protein 1-like 0.042
card14 caspase recruitment domain family, member 14 0.041
plekhh1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 0.041
cluap1 clusterin associated protein 1 0.041
mapk8b mitogen-activated protein kinase 8b 0.041
ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a 0.040
mapk12 mitogen-activated protein kinase 12 0.040
tnfaip8l2a tumor necrosis factor, alpha-induced protein 8, like 2a 0.040
pdcd2 programmed cell death 2 0.040
kal1b Kallmann syndrome 1b sequence 0.040
si:dkey-76b14.4 si:dkey-76b14.4 0.040
aox3 aldehyde oxidase 3 0.039
ildr1b immunoglobulin-like domain containing receptor 1b 0.039
robo4 roundabout homolog 4 0.038
gmfg glia maturation factor, gamma 0.038
scinlb scinderin like b 0.038
nfe2l2 nuclear factor (erythroid-derived 2)-like 2 0.038
zgc:64051 zgc:64051 0.038
duox dual oxidase 0.037
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.037
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Myd88 myeloid differentiation primary response gene 88 0.855
Tlr4 toll-like receptor 4 0.465
Casp8 caspase 8 0.392
Irak4 interleukin-1 receptor-associated kinase 4 0.319
Il1r1 interleukin 1 receptor, type I 0.295
H2-Aa histocompatibility 2, class II antigen A, alpha 0.295
Stat3 signal transducer and activator of transcription 3 0.263
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.256
Fyn Fyn proto-oncogene 0.246
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.237
Robo1 roundabout homolog 1 (Drosophila) 0.209
Cd44 CD44 antigen 0.205
Traf6 TNF receptor-associated factor 6 0.202
Robo2 roundabout homolog 2 (Drosophila) 0.178
Stat2 signal transducer and activator of transcription 2 0.146
Ccr2 chemokine (C-C motif) receptor 2 0.135
Stat1 signal transducer and activator of transcription 1 0.116
Map3k3 mitogen-activated protein kinase kinase kinase 3 0.111
Socs3 suppressor of cytokine signaling 3 0.107
Nlrp3 NLR family, pyrin domain containing 3 0.103
Sfn stratifin 0.102
Il6 interleukin 6 0.100
Casp1 caspase 1 0.098
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.095
Jak2 Janus kinase 2 0.086
Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) 0.074
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.071
Slit3 slit homolog 3 (Drosophila) 0.070
H2-Eb1 histocompatibility 2, class II antigen E beta 0.069
H2-DMa histocompatibility 2, class II, locus DMa 0.068
Unc93b1 unc-93 homolog B1 (C. elegans) 0.067
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.065
Lyz2 lysozyme 2 0.064
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.064
Mdm2 transformed mouse 3T3 cell double minute 2 0.063
Jak1 Janus kinase 1 0.058
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.058
Cav1 caveolin 1, caveolae protein 0.058
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.052
Gbp5 guanylate binding protein 5 0.050
Aim2 absent in melanoma 2 0.048
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.048
Dock2 dedicator of cyto-kinesis 2 0.046
Ccl2 chemokine (C-C motif) ligand 2 0.046
Sharpin SHANK-associated RH domain interacting protein 0.042
Ikbkb inhibitor of kappaB kinase beta 0.042
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.041
Irak1 interleukin-1 receptor-associated kinase 1 0.040
Fas Fas (TNF receptor superfamily member 6) 0.039
Rnf31 ring finger protein 31 0.038
Tyro3 TYRO3 protein tyrosine kinase 3 0.036
Traf3 TNF receptor-associated factor 3 0.035
Il6st interleukin 6 signal transducer 0.035
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.033
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.031
Il2rb interleukin 2 receptor, beta chain 0.031
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.030
Pag1 phosphoprotein associated with glycosphingolipid microdomains 1 0.030
Csf1 colony stimulating factor 1 (macrophage) 0.029
Mx1 myxovirus (influenza virus) resistance 1 0.029
Apoe apolipoprotein E 0.028
Ifnar1 interferon (alpha and beta) receptor 1 0.028
Il4ra interleukin 4 receptor, alpha 0.028
Rsad2 radical S-adenosyl methionine domain containing 2 0.026
Il1b interleukin 1 beta 0.026
Stat6 signal transducer and activator of transcription 6 0.025
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.025
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.025
Il1rl1 interleukin 1 receptor-like 1 0.024
H2-Q6 histocompatibility 2, Q region locus 6 0.024
Trp63 transformation related protein 63 0.024
Ticam1 toll-like receptor adaptor molecule 1 0.023
Il17ra interleukin 17 receptor A 0.023
Cyld cylindromatosis (turban tumor syndrome) 0.023
Cd247 CD247 antigen 0.023
Adam8 a disintegrin and metallopeptidase domain 8 0.023
Batf basic leucine zipper transcription factor, ATF-like 0.022
Il18r1 interleukin 18 receptor 1 0.022
Cd86 CD86 antigen 0.022
Ifngr1 interferon gamma receptor 1 0.021
Gzmb granzyme B 0.021
Nde1 nuclear distribution gene E homolog 1 (A nidulans) 0.021
Slit2 slit homolog 2 (Drosophila) 0.021
Tgfb1 transforming growth factor, beta 1 0.020
Spp1 secreted phosphoprotein 1 0.020
Parp10 poly (ADP-ribose) polymerase family, member 10 0.020
Icam1 intercellular adhesion molecule 1 0.020
Ptrf polymerase I and transcript release factor 0.020
Mertk c-mer proto-oncogene tyrosine kinase 0.020
Trp53 transformation related protein 53 0.020
Tlr2 toll-like receptor 2 0.019
Lif leukemia inhibitory factor 0.019
Bcl3 B-cell leukemia/lymphoma 3 0.019
Tollip toll interacting protein 0.019
Pparg peroxisome proliferator activated receptor gamma 0.018
Ikbkg inhibitor of kappaB kinase gamma 0.018
Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G 0.018
Eya2 eyes absent 2 homolog (Drosophila) 0.018
1810019J16Rik RIKEN cDNA 1810019J16 gene 0.018
Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) 0.018
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism