The network for 'response to hormone' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
ESR1 estrogen receptor 1 1.000
PTPN1 protein tyrosine phosphatase, non-receptor type 1 1.000
CREBBP CREB binding protein 1.000
EGFR epidermal growth factor receptor 1.000
AR androgen receptor 1.000
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.999
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.999
CAV1 caveolin 1, caveolae protein, 22kDa 0.998
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.996
GRB2 growth factor receptor-bound protein 2 0.996
NCOA1 nuclear receptor coactivator 1 0.995
GSK3B glycogen synthase kinase 3 beta 0.994
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.985
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.985
EP300 E1A binding protein p300 0.979
INSR insulin receptor 0.975
NCOR2 nuclear receptor corepressor 2 0.973
NCOA6 nuclear receptor coactivator 6 0.972
STAT5A signal transducer and activator of transcription 5A 0.970
PTK2 PTK2 protein tyrosine kinase 2 0.966
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.952
NCOA2 nuclear receptor coactivator 2 0.951
BCAR1 breast cancer anti-estrogen resistance 1 0.949
TP53 tumor protein p53 0.939
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.931
HDAC1 histone deacetylase 1 0.928
HNF4A hepatocyte nuclear factor 4, alpha 0.923
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.920
JAK2 Janus kinase 2 0.912
RXRA retinoid X receptor, alpha 0.905
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.901
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.880
BRCA1 breast cancer 1, early onset 0.876
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.874
RARA retinoic acid receptor, alpha 0.859
GSTM1 glutathione S-transferase mu 1 0.850
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.833
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.832
HDAC3 histone deacetylase 3 0.828
GRB10 growth factor receptor-bound protein 10 0.784
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.784
BCL2 B-cell CLL/lymphoma 2 0.783
SKIL SKI-like oncogene 0.779
SOCS1 suppressor of cytokine signaling 1 0.779
SP1 Sp1 transcription factor 0.766
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.742
IL8 interleukin 8 0.733
RUNX1 runt-related transcription factor 1 0.728
FN1 fibronectin 1 0.724
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.712
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.689
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.685
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.672
IL6 interleukin 6 (interferon, beta 2) 0.670
SKP1 S-phase kinase-associated protein 1 0.666
EPOR erythropoietin receptor 0.657
NCOA3 nuclear receptor coactivator 3 0.654
GSTM2 glutathione S-transferase mu 2 (muscle) 0.654
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.647
RBBP4 retinoblastoma binding protein 4 0.640
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.640
FHL2 four and a half LIM domains 2 0.637
NRP1 neuropilin 1 0.619
STAT1 signal transducer and activator of transcription 1, 91kDa 0.617
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.607
ARRB1 arrestin, beta 1 0.603
DUSP1 dual specificity phosphatase 1 0.594
IL4R interleukin 4 receptor 0.587
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.587
JAG1 jagged 1 0.581
DAXX death-domain associated protein 0.576
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.571
FOXO1 forkhead box O1 0.566
TIMP1 TIMP metallopeptidase inhibitor 1 0.563
EPAS1 endothelial PAS domain protein 1 0.561
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.556
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.555
PLAUR plasminogen activator, urokinase receptor 0.554
TAL1 T-cell acute lymphocytic leukemia 1 0.551
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.545
MAPK3 mitogen-activated protein kinase 3 0.536
NCOR1 nuclear receptor corepressor 1 0.536
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.533
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.521
PTPRB protein tyrosine phosphatase, receptor type, B 0.514
WDR5 WD repeat domain 5 0.514
MAPT microtubule-associated protein tau 0.514
XIAP X-linked inhibitor of apoptosis 0.509
ANXA1 annexin A1 0.502
GABARAPL1 GABA(A) receptor-associated protein like 1 0.492
PPARA peroxisome proliferator-activated receptor alpha 0.492
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.489
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.489
HDAC4 histone deacetylase 4 0.488
TGFB1 transforming growth factor, beta 1 0.486
VEGFA vascular endothelial growth factor A 0.483
TOB1 transducer of ERBB2, 1 0.481
CFLAR CASP8 and FADD-like apoptosis regulator 0.481
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.481
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.911
fabp11a fatty acid binding protein 11a 0.849
egr2b early growth response 2b 0.800
notch1a notch homolog 1a 0.772
prox1 prospero-related homeobox gene 1 0.760
per2 period homolog 2 (Drosophila) 0.727
rbp1a retinol binding protein 1a, cellular 0.525
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.505
sparc secreted acidic cysteine rich glycoprotein 0.503
crabp2a cellular retinoic acid binding protein 2, a 0.466
sox9a SRY-box containing gene 9a 0.450
notch1b notch homolog 1b 0.421
myog myogenin 0.416
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.392
cyp11a1 cytochrome P450, subfamily XIA, polypeptide 1 0.374
gnrh3 gonadotropin-releasing hormone 3 0.373
igf1 insulin-like growth factor 1 0.347
tal1 T-cell acute lymphocytic leukemia 1 0.341
igf2b insulin-like growth factor 2b 0.275
vtg3 vitellogenin 3, phosvitinless 0.269
vasa vasa homolog 0.269
wls wntless homolog (Drosophila) 0.264
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.258
pomca proopiomelanocortin a 0.256
kdrl kinase insert domain receptor like 0.235
mst1 macrophage stimulating 1 (hepatocyte growth factor-like) 0.232
apoeb apolipoprotein Eb 0.228
ca2 carbonic anhydrase II 0.221
angpt2 angiopoietin 2 0.218
cldnh claudin h 0.210
ptger4a prostaglandin E receptor 4 (subtype EP4) a 0.207
pcna proliferating cell nuclear antigen 0.203
adipor2 adiponectin receptor 2 0.202
cry3 cryptochrome 3 0.199
mef2d myocyte enhancer factor 2d 0.195
wnt10a wingless-type MMTV integration site family, member 10a 0.194
sox9b SRY-box containing gene 9b 0.194
rdh10a retinol dehydrogenase 10a 0.194
esr1 estrogen receptor 1 0.186
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.185
inha inhibin, alpha 0.185
sox5 SRY-box containing gene 5 0.183
epas1b endothelial PAS domain protein 1b 0.182
id1 inhibitor of DNA binding 1 0.179
gdnf glial cell derived neurotrophic factor 0.178
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.177
fabp10a fatty acid binding protein 10a, liver basic 0.174
lhcgr luteinizing hormone/choriogonadotropin receptor 0.174
esr2a estrogen receptor 2a 0.171
gnrh2 gonadotropin-releasing hormone 2 0.170
foxc1a forkhead box C1a 0.167
ptgs1 prostaglandin-endoperoxide synthase 1 0.165
fgf3 fibroblast growth factor 3 0.163
plcg1 phospholipase C, gamma 1 0.158
rc3 rabconnectin 3 0.157
otpa orthopedia homolog a 0.155
igf2a insulin-like growth factor 2a 0.152
sema3d semaphorin 3d 0.150
plg plasminogen 0.149
otx5 orthodenticle homolog 5 0.148
efnb2a ephrin B2a 0.146
crygn2 crystallin, gamma N2 0.137
fshb follicle stimulating hormone, beta polypeptide 0.136
ptgs2a prostaglandin-endoperoxide synthase 2a 0.136
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.136
thrab thyroid hormone receptor alpha b 0.131
nr5a2 nuclear receptor subfamily 5, group A, member 2 0.129
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.129
gper G protein-coupled estrogen receptor 1 0.128
sat1a spermidine/spermine N1-acetyltransferase 1a 0.128
socs3a suppressor of cytokine signaling 3a 0.125
avpl arginine vasopressin-like 0.125
rorcb RAR-related orphan receptor C b 0.124
sec24c SEC24 family, member C (S. cerevisiae) 0.124
duox dual oxidase 0.123
notch3 notch homolog 3 0.123
idh1 isocitrate dehydrogenase 1 (NADP+), soluble 0.120
prox2 prospero homeobox 2 0.120
gpia glucose phosphate isomerase a 0.119
tkt transketolase 0.119
myca myelocytomatosis oncogene a 0.117
vcana versican a 0.116
dlx5a distal-less homeobox gene 5a 0.116
wnt5b wingless-type MMTV integration site family, member 5b 0.115
mfn2 mitofusin 2 0.114
serpinc1 serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 0.112
tnnt2a troponin T2a, cardiac 0.108
slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.103
acox1 acyl-Coenzyme A oxidase 1, palmitoyl 0.100
col5a1 procollagen, type V, alpha 1 0.100
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.100
tie1 endothelium-specific receptor tyrosine kinase 1 0.099
si:rp71-39b20.7 si:rp71-39b20.7 0.097
crygm3 crystallin, gamma M3 0.096
tg thyroglobulin 0.095
mstnb myostatin b 0.095
alcama activated leukocyte cell adhesion molecule a 0.094
oxtl oxytocin-like 0.094
cat catalase 0.094
cp ceruloplasmin 0.092
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.648
ci cubitus interruptus 0.496
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.440
ap apterous 0.432
Akt1 CG4006 gene product from transcript CG4006-RA 0.391
Lam Lamin 0.347
hth homothorax 0.304
InR Insulin-like receptor 0.231
Ugt35a UDP-glycosyltransferase 35a 0.214
ftz-f1 ftz transcription factor 1 0.189
Egfr Epidermal growth factor receptor 0.188
if inflated 0.182
spi spitz 0.171
kay kayak 0.149
rap retina aberrant in pattern 0.132
Moe Moesin 0.126
S6k RPS6-p70-protein kinase 0.125
Ilp5 Insulin-like peptide 5 0.125
sgg shaggy 0.124
sev sevenless 0.123
nej nejire 0.112
babo baboon 0.111
Cdc42 CG12530 gene product from transcript CG12530-RA 0.102
dm diminutive 0.094
tsh teashirt 0.093
sina seven in absentia 0.084
cwo clockwork orange 0.083
dac dachshund 0.080
CG7998 CG7998 gene product from transcript CG7998-RA 0.079
osa CG7467 gene product from transcript CG7467-RD 0.079
ey eyeless 0.078
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.075
BRWD3 CG31132 gene product from transcript CG31132-RA 0.074
Tequila CG4821 gene product from transcript CG4821-RE 0.073
drk downstream of receptor kinase 0.072
Mf Myofilin 0.072
mmd mind-meld 0.072
Fhos CG42610 gene product from transcript CG42610-RC 0.070
Mcr Macroglobulin complement-related 0.068
not non-stop 0.067
CG6283 CG6283 gene product from transcript CG6283-RA 0.066
argos CG4531 gene product from transcript CG4531-RA 0.066
Ilp2 Insulin-like peptide 2 0.064
Cyp12a4 CG6042 gene product from transcript CG6042-RA 0.063
kibra kibra ortholog 0.058
foxo forkhead box, sub-group O 0.058
CG13253 CG13253 gene product from transcript CG13253-RB 0.057
slow slowdown 0.055
Stat92E Signal-transducer and activator of transcription protein at 92E 0.055
Cyp9f2 CG11466 gene product from transcript CG11466-RB 0.054
Sos Son of sevenless 0.054
CycG Cyclin G 0.053
LanB2 Laminin B2 0.052
Nrg Neuroglian 0.051
dib disembodied 0.049
CG13310 CG13310 gene product from transcript CG13310-RA 0.049
Elf Ef1alpha-like factor 0.048
Tor Target of rapamycin 0.048
jeb jelly belly 0.048
Thor CG8846 gene product from transcript CG8846-RA 0.047
Cyp12e1 CG14680 gene product from transcript CG14680-RC 0.047
fz2 frizzled 2 0.046
scyl scylla 0.046
put punt 0.046
bowl brother of odd with entrails limited 0.045
norpA no receptor potential A 0.045
Hcf Host cell factor 0.044
chico CG5686 gene product from transcript CG5686-RB 0.044
Nrt Neurotactin 0.043
Mad Mothers against dpp 0.043
fng fringe 0.042
Gyc76C Guanylyl cyclase at 76C 0.042
NPFR1 neuropeptide F receptor 0.042
CycD Cyclin D 0.042
Hop Hsp70/Hsp90 organizing protein homolog 0.042
LamC Lamin C 0.042
rdgA retinal degeneration A 0.042
hep hemipterous 0.042
Smox Smad on X 0.041
Indy I'm not dead yet 0.041
SelD Selenide,water dikinase 0.041
Hsp26 Heat shock protein 26 0.040
G-oalpha47A G protein oalpha 47A 0.040
Fas2 Fasciclin 2 0.040
wts warts 0.040
Ssdp Sequence-specific single-stranded DNA-binding protein 0.039
zetaTry zetaTrypsin 0.039
Ada2b CG9638 gene product from transcript CG9638-RA 0.039
Sox14 Sox box protein 14 0.039
HDAC6 CG6170 gene product from transcript CG6170-RA 0.039
Cyp6d5 CG3050 gene product from transcript CG3050-RA 0.039
boss bride of sevenless 0.038
Gp150 CG5820 gene product from transcript CG5820-RA 0.036
Pkc98E Protein C kinase 98E 0.036
CG14837 CG14837 gene product from transcript CG14837-RC 0.036
sNPF-R short neuropeptide F receptor 0.036
kis kismet 0.036
CG13510 CG13510 gene product from transcript CG13510-RA 0.036
sxc super sex combs 0.036
EcR Ecdysone receptor 0.035
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism