The network for 'signal transduction in absence of ligand' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal transduction in absence of ligand

A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor.

Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 0.999
BCL2L1 BCL2-like 1 0.995
PML promyelocytic leukemia 0.950
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.883
BAX BCL2-associated X protein 0.881
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.829
TAL1 T-cell acute lymphocytic leukemia 1 0.792
BID BH3 interacting domain death agonist 0.779
HSPA1A heat shock 70kDa protein 1A 0.695
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.682
BAD BCL2-associated agonist of cell death 0.679
FAS Fas (TNF receptor superfamily, member 6) 0.666
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.611
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.594
HSPA1B heat shock 70kDa protein 1B 0.556
IL8 interleukin 8 0.508
EGFR epidermal growth factor receptor 0.468
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.416
CXCL2 chemokine (C-X-C motif) ligand 2 0.325
CXCL5 chemokine (C-X-C motif) ligand 5 0.312
IL1R1 interleukin 1 receptor, type I 0.273
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.247
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.243
HSPB1 heat shock 27kDa protein 1 0.220
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.213
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.205
MAPK14 mitogen-activated protein kinase 14 0.197
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.196
BCL2A1 BCL2-related protein A1 0.186
PLCG1 phospholipase C, gamma 1 0.182
CCL20 chemokine (C-C motif) ligand 20 0.161
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.153
TRADD TNFRSF1A-associated via death domain 0.153
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.142
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.136
MAP2K5 mitogen-activated protein kinase kinase 5 0.130
CXCL3 chemokine (C-X-C motif) ligand 3 0.106
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.094
IL1B interleukin 1, beta 0.090
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.083
DAXX death-domain associated protein 0.081
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.081
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.080
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.078
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.076
BAG1 BCL2-associated athanogene 0.075
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 0.066
BAK1 BCL2-antagonist/killer 1 0.065
CCL4 chemokine (C-C motif) ligand 4 0.061
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.058
IL1R2 interleukin 1 receptor, type II 0.058
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.057
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.056
APP amyloid beta (A4) precursor protein 0.055
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.054
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.053
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.051
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.051
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.048
CXCL10 chemokine (C-X-C motif) ligand 10 0.046
IL6 interleukin 6 (interferon, beta 2) 0.044
CXCL9 chemokine (C-X-C motif) ligand 9 0.044
RIPK3 receptor-interacting serine-threonine kinase 3 0.044
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.043
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.043
CCL8 chemokine (C-C motif) ligand 8 0.043
HSPH1 heat shock 105kDa/110kDa protein 1 0.042
IL4R interleukin 4 receptor 0.042
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.037
MAPK7 mitogen-activated protein kinase 7 0.037
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.037
JUP junction plakoglobin 0.036
TP53 tumor protein p53 0.036
BCL2L2 BCL2-like 2 0.036
CXCL11 chemokine (C-X-C motif) ligand 11 0.034
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.034
DIABLO diablo, IAP-binding mitochondrial protein 0.033
RIPK2 receptor-interacting serine-threonine kinase 2 0.033
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.032
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.031
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.030
XIAP X-linked inhibitor of apoptosis 0.030
BIRC2 baculoviral IAP repeat containing 2 0.030
GRB7 growth factor receptor-bound protein 7 0.030
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.030
TRAF1 TNF receptor-associated factor 1 0.030
IFI27 interferon, alpha-inducible protein 27 0.029
FGF1 fibroblast growth factor 1 (acidic) 0.029
RNF144B ring finger protein 144B 0.029
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.028
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.028
AXIN1 axin 1 0.028
CCL2 chemokine (C-C motif) ligand 2 0.028
BIRC3 baculoviral IAP repeat containing 3 0.027
INSR insulin receptor 0.027
PI3 peptidase inhibitor 3, skin-derived 0.026
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.025
VDAC1 voltage-dependent anion channel 1 0.024
STK11 serine/threonine kinase 11 0.024
UBD ubiquitin D 0.024
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.481
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.470
bcl2l1 bcl2-like 1 0.461
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.448
nf1a neurofibromin 1a 0.417
ptgs2a prostaglandin-endoperoxide synthase 2a 0.314
twist1b twist1b 0.314
mcl1a myeloid cell leukemia sequence 1a 0.268
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.243
ptgds prostaglandin D2 synthase 0.215
vcana versican a 0.192
ck2b casein kinase 2 beta 0.169
bida BH3 interacting domain death agonist 0.163
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.161
pitx3 paired-like homeodomain transcription factor 3 0.155
acvr2a activin receptor IIa 0.153
tgfb3 transforming growth factor, beta 3 0.151
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.147
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.144
ptgesl prostaglandin E synthase 2-like 0.142
zgc:162126 zgc:162126 0.140
itgb3b integrin beta 3b 0.138
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.133
inha inhibin, alpha 0.133
bcl2 B-cell leukemia/lymphoma 2 0.133
evx1 even-skipped homeobox 1 0.133
six1b sine oculis homeobox homolog 1b 0.130
rag1 recombination activating gene 1 0.129
zbtb4 zinc finger and BTB domain containing 4 0.128
mmp9 matrix metalloproteinase 9 0.123
mcl1b myeloid cell leukemia sequence 1b 0.121
zgc:73210 zgc:73210 0.121
wnt9b wingless-type MMTV integration site family, member 9B 0.116
nrg1 neuregulin 1 0.115
cyp19a1a cytochrome P450, family 19, subfamily A, polypeptide 1a 0.114
egr2b early growth response 2b 0.109
lef1 lymphocyte enhancer binding factor 1 0.106
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.105
hug HuG 0.102
mpx myeloid-specific peroxidase 0.099
lhx2b LIM homeobox 2b 0.096
mfn2 mitofusin 2 0.094
col4a5 collagen, type IV, alpha 5 (Alport syndrome) 0.093
stc1l stanniocalcin 1, like 0.091
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.090
sc:d812 sc:d812 0.086
pnrc2 proline-rich nuclear receptor coactivator 2 0.085
tgfb1a transforming growth factor, beta 1a 0.080
kdrl kinase insert domain receptor like 0.078
dlx5a distal-less homeobox gene 5a 0.077
lhx6 LIM homeobox 6 0.075
olig1 oligodendrocyte lineage transcription factor 1 0.075
bnc2 basonuclin 2 0.074
nrg2a neuregulin 2a 0.073
cmyb transcription factor cmyb 0.071
igf1 insulin-like growth factor 1 0.070
faslg Fas ligand (TNF superfamily, member 6) 0.070
scinla scinderin like a 0.068
cnih cornichon homolog (Drosophila) 0.068
sfrp1b secreted frizzled-related protein 1b 0.067
runx2a runt-related transcription factor 2a 0.066
hmx2 H6 family homeobox 2 0.066
cpla2 cytosolic phospholipase a2 0.066
wnt10a wingless-type MMTV integration site family, member 10a 0.065
uba1 ubiquitin-like modifier activating enzyme 1 0.065
prrx1a paired related homeobox 1a 0.065
bmf1 Bcl2 modifying factor 1 0.065
ptgs1 prostaglandin-endoperoxide synthase 1 0.064
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.063
bc2 putative breast adenocarcinoma marker 0.063
adra2db adrenergic, alpha-2D-, receptor b 0.063
dusp1 dual specificity phosphatase 1 0.063
bik BCL2-interacting killer (apoptosis-inducing) 0.063
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.063
fgf20a fibroblast growth factor 20a 0.063
igf1rb insulin-like growth factor 1b receptor 0.063
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.062
sb:cb166 sb:cb166 0.062
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.062
npas2 neuronal PAS domain protein 2 0.060
lhcgr luteinizing hormone/choriogonadotropin receptor 0.060
hspa12b heat shock protein 12B 0.059
rcc2 regulator of chromosome condensation 2 0.058
kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 0.058
bglap bone gamma-carboxyglutamate (gla) protein 0.057
epas1b endothelial PAS domain protein 1b 0.057
calm3b calmodulin 3b (phosphorylase kinase, delta) 0.056
arf2 ADP-ribosylation factor 2 0.056
csf1ra colony stimulating factor 1 receptor, a 0.054
spry1 sprouty homolog 1 (Drosophila) 0.053
zgc:136878 zgc:136878 0.053
ltk leukocyte tyrosine kinase 0.053
psma6b proteasome (prosome, macropain) subunit, alpha type, 6b 0.053
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.053
casp8 caspase 8, apoptosis-related cysteine peptidase 0.052
slc25a5 solute carrier family 25 alpha, member 5 0.052
fstl1b follistatin-like 1b 0.052
dynlrb1 dynein, light chain, roadblock-type 1 0.052
ppp2r1b protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform 0.051
csnk1db casein kinase 1, delta b 0.050
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 0.997
Col1a1 collagen, type I, alpha 1 0.995
Trp53 transformation related protein 53 0.992
Kit kit oncogene 0.976
Pax2 paired box gene 2 0.962
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.961
Ikzf1 IKAROS family zinc finger 1 0.955
Ret ret proto-oncogene 0.937
Fas Fas (TNF receptor superfamily member 6) 0.935
Pten phosphatase and tensin homolog 0.902
Ifng interferon gamma 0.889
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.863
Pax3 paired box gene 3 0.861
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.847
Lepr leptin receptor 0.840
Bax BCL2-associated X protein 0.838
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.833
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.822
Il10 interleukin 10 0.819
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.819
Shh sonic hedgehog 0.799
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.790
Egfr epidermal growth factor receptor 0.764
Zeb1 zinc finger E-box binding homeobox 1 0.755
Bcl2 B-cell leukemia/lymphoma 2 0.747
Tnf tumor necrosis factor 0.747
Fbn1 fibrillin 1 0.741
Bmp4 bone morphogenetic protein 4 0.704
Rb1 retinoblastoma 1 0.690
Il1b interleukin 1 beta 0.683
Ptprc protein tyrosine phosphatase, receptor type, C 0.665
Snai1 snail homolog 1 (Drosophila) 0.651
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.648
Ccr1 chemokine (C-C motif) receptor 1 0.639
Rxra retinoid X receptor alpha 0.625
Efnb2 ephrin B2 0.611
Fgfr2 fibroblast growth factor receptor 2 0.606
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.601
Col5a2 collagen, type V, alpha 2 0.584
Sox10 SRY-box containing gene 10 0.548
Tgfbr2 transforming growth factor, beta receptor II 0.543
Foxp3 forkhead box P3 0.540
Cd44 CD44 antigen 0.506
Phox2a paired-like homeobox 2a 0.489
Fst follistatin 0.464
Inpp5d inositol polyphosphate-5-phosphatase D 0.458
Rara retinoic acid receptor, alpha 0.449
Psen1 presenilin 1 0.435
Hoxa11 homeobox A11 0.432
Tbx1 T-box 1 0.430
Lyz2 lysozyme 2 0.420
Chrd chordin 0.419
Meox2 mesenchyme homeobox 2 0.419
Isl1 ISL1 transcription factor, LIM/homeodomain 0.419
Cdk4 cyclin-dependent kinase 4 0.407
Col3a1 collagen, type III, alpha 1 0.407
Axin1 axin 1 0.403
Sharpin SHANK-associated RH domain interacting protein 0.399
Nos3 nitric oxide synthase 3, endothelial cell 0.394
Tgfb1 transforming growth factor, beta 1 0.393
Apc adenomatosis polyposis coli 0.386
Vhl von Hippel-Lindau tumor suppressor 0.371
Ntf3 neurotrophin 3 0.368
Gli3 GLI-Kruppel family member GLI3 0.367
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.353
Ccr2 chemokine (C-C motif) receptor 2 0.347
Pthlh parathyroid hormone-like peptide 0.343
Foxc1 forkhead box C1 0.331
Capn6 calpain 6 0.319
Ciita class II transactivator 0.316
Prrx2 paired related homeobox 2 0.308
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.304
Adam17 a disintegrin and metallopeptidase domain 17 0.302
C5ar1 complement component 5a receptor 1 0.301
Selp selectin, platelet 0.296
Fadd Fas (TNFRSF6)-associated via death domain 0.286
Il6st interleukin 6 signal transducer 0.286
Smad3 MAD homolog 3 (Drosophila) 0.284
Wisp2 WNT1 inducible signaling pathway protein 2 0.283
Notch1 Notch gene homolog 1 (Drosophila) 0.280
Lyst lysosomal trafficking regulator 0.278
Tgfb2 transforming growth factor, beta 2 0.276
Kitl kit ligand 0.267
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.262
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.259
Rbl1 retinoblastoma-like 1 (p107) 0.257
Pax8 paired box gene 8 0.256
Elf4 E74-like factor 4 (ets domain transcription factor) 0.255
Il1a interleukin 1 alpha 0.253
Hoxa1 homeobox A1 0.252
Lmna lamin A 0.250
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.247
Gata3 GATA binding protein 3 0.247
Il18rap interleukin 18 receptor accessory protein 0.245
Postn periostin, osteoblast specific factor 0.245
Sgpl1 sphingosine phosphate lyase 1 0.243
Il2rg interleukin 2 receptor, gamma chain 0.243
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.242
Col6a1 collagen, type VI, alpha 1 0.239
Rarg retinoic acid receptor, gamma 0.239
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Rattus norvegicus
Name Description Probability Func Analog Organism
Tcrb T-cell receptor beta chain 0.346
Sirpa signal-regulatory protein alpha 0.101
Pacs1 phosphofurin acidic cluster sorting protein 1 0.074
Ddr1 discoidin domain receptor tyrosine kinase 1 0.071
Epn2 epsin 2 0.064
Ralgds ral guanine nucleotide dissociation stimulator 0.053
Unc5b unc-5 homolog B (C. elegans) 0.049
Ptafr platelet-activating factor receptor 0.044
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.042
Ccnd3 cyclin D3 0.040
Hk1 hexokinase 1 0.040
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.038
Cd86 CD86 molecule 0.038
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.038
Ppp1r9b protein phosphatase 1, regulatory subunit 9B 0.037
Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.029
Ccl3 chemokine (C-C motif) ligand 3 0.028
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.028
Ptpn7 protein tyrosine phosphatase, non-receptor type 7 0.027
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.027
Hck hemopoietic cell kinase 0.027
Rgs19 regulator of G-protein signaling 19 0.026
Il2rb interleukin 2 receptor, beta 0.026
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.025
Adrbk1 adrenergic, beta, receptor kinase 1 0.025
Mprip myosin phosphatase Rho interacting protein 0.024
Mmp12 matrix metallopeptidase 12 0.024
Epn1 Epsin 1 0.024
Ubtf upstream binding transcription factor, RNA polymerase I 0.024
Cd14 CD14 molecule 0.022
Rara retinoic acid receptor, alpha 0.022
Cd38 CD38 molecule 0.021
Prrx1 paired related homeobox 1 0.020
Bcl2l1 Bcl2-like 1 0.020
Gpr176 G protein-coupled receptor 176 0.019
Glg1 golgi apparatus protein 1 0.019
Prdm2 PR domain containing 2, with ZNF domain 0.019
Map3k3 mitogen activated protein kinase kinase kinase 3 0.019
Irf2 interferon regulatory factor 2 0.019
Ccr5 chemokine (C-C motif) receptor 5 0.018
Lnpep leucyl/cystinyl aminopeptidase 0.018
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.017
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.016
Megf10 multiple EGF-like domains 10 0.016
LOC689064 beta-globin 0.015
Usp3 ubiquitin specific peptidase 3 0.015
Il1b interleukin 1 beta 0.015
Inpp5d inositol polyphosphate-5-phosphatase D 0.015
Il2rg interleukin 2 receptor, gamma 0.015
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.015
Spn sialophorin 0.015
Mpp3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.015
Calcoco1 calcium binding and coiled coil domain 1 0.015
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.014
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.014
Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.014
Prkcd protein kinase C, delta 0.014
Homer2 homer homolog 2 (Drosophila) 0.013
Tmed10 transmembrane emp24-like trafficking protein 10 (yeast) 0.013
Zbp1 Z-DNA binding protein 1 0.013
Cd37 CD37 molecule 0.013
Scarb1 scavenger receptor class B, member 1 0.012
Cd53 Cd53 molecule 0.012
Csf1 colony stimulating factor 1 (macrophage) 0.012
Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.012
S100a9 S100 calcium binding protein A9 0.012
RGD1559588 similar to cell surface receptor FDFACT 0.011
Met met proto-oncogene 0.011
Elf1 E74-like factor 1 0.011
Tgfb1 transforming growth factor, beta 1 0.011
Calcrl calcitonin receptor-like 0.011
Adora2a adenosine A2a receptor 0.010
Fam108a1 family with sequence similarity 108, member A1 0.010
RGD1561143 similar to cell surface receptor FDFACT 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism