The network for 'negative regulation of immune effector process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of immune effector process

Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.

Mus musculus
Name Description Probability Func Analog Organism
Lyz2 lysozyme 2 0.959
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.890
Traf6 TNF receptor-associated factor 6 0.834
Slamf1 signaling lymphocytic activation molecule family member 1 0.815
Prf1 perforin 1 (pore forming protein) 0.774
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.721
Inpp5d inositol polyphosphate-5-phosphatase D 0.665
Mefv Mediterranean fever 0.662
Cd40 CD40 antigen 0.661
Batf basic leucine zipper transcription factor, ATF-like 0.652
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.595
Ikzf1 IKAROS family zinc finger 1 0.589
Sfpi1 SFFV proviral integration 1 0.554
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.535
Prdm1 PR domain containing 1, with ZNF domain 0.533
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.532
Zeb1 zinc finger E-box binding homeobox 1 0.509
Jak2 Janus kinase 2 0.505
Stat2 signal transducer and activator of transcription 2 0.499
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.498
Ifnar2 interferon (alpha and beta) receptor 2 0.494
Socs1 suppressor of cytokine signaling 1 0.489
Ccr1 chemokine (C-C motif) receptor 1 0.468
Cd7 CD7 antigen 0.446
Stat1 signal transducer and activator of transcription 1 0.430
Icos inducible T-cell co-stimulator 0.414
Tapbp TAP binding protein 0.407
Stat6 signal transducer and activator of transcription 6 0.385
Stat3 signal transducer and activator of transcription 3 0.377
Irf1 interferon regulatory factor 1 0.360
Cd247 CD247 antigen 0.337
Ptprc protein tyrosine phosphatase, receptor type, C 0.316
Rc3h1 RING CCCH (C3H) domains 1 0.309
Il6st interleukin 6 signal transducer 0.283
Unc93b1 unc-93 homolog B1 (C. elegans) 0.282
Ccr6 chemokine (C-C motif) receptor 6 0.277
Foxp3 forkhead box P3 0.265
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.262
Il4 interleukin 4 0.257
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.257
Arrb1 arrestin, beta 1 0.252
Cd59a CD59a antigen 0.248
Fcrla Fc receptor-like A 0.243
Ncr1 natural cytotoxicity triggering receptor 1 0.240
Fasl Fas ligand (TNF superfamily, member 6) 0.239
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.222
Il1r1 interleukin 1 receptor, type I 0.220
Stat5b signal transducer and activator of transcription 5B 0.219
Ifi35 interferon-induced protein 35 0.215
Cish cytokine inducible SH2-containing protein 0.215
AF251705 cDNA sequence AF251705 0.212
Trem3 triggering receptor expressed on myeloid cells 3 0.211
Hhex hematopoietically expressed homeobox 0.208
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.206
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.198
B2m beta-2 microglobulin 0.192
Clec4d C-type lectin domain family 4, member d 0.190
Myd88 myeloid differentiation primary response gene 88 0.188
Pik3cg phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.182
Ccr7 chemokine (C-C motif) receptor 7 0.177
Clec4n C-type lectin domain family 4, member n 0.177
Fyn Fyn proto-oncogene 0.176
Il18r1 interleukin 18 receptor 1 0.175
Tlr8 toll-like receptor 8 0.175
Cd22 CD22 antigen 0.173
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.161
Il27ra interleukin 27 receptor, alpha 0.160
Uba7 ubiquitin-like modifier activating enzyme 7 0.160
Trim21 tripartite motif-containing 21 0.156
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.153
H2-DMb2 histocompatibility 2, class II, locus Mb2 0.152
Bcl3 B-cell leukemia/lymphoma 3 0.150
Il2 interleukin 2 0.149
Lat linker for activation of T cells 0.148
Ccr5 chemokine (C-C motif) receptor 5 0.145
Blk B lymphoid kinase 0.144
Il1f9 interleukin 1 family, member 9 0.143
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.143
Tlr7 toll-like receptor 7 0.141
Cd4 CD4 antigen 0.140
H2-K1 histocompatibility 2, K1, K region 0.139
Ido1 indoleamine 2,3-dioxygenase 1 0.138
H2-D1 histocompatibility 2, D region locus 1 0.138
Ifng interferon gamma 0.138
Rag1 recombination activating gene 1 0.138
Gbp7 guanylate binding protein 7 0.135
Ifngr1 interferon gamma receptor 1 0.133
Lta lymphotoxin A 0.132
Cd209b CD209b antigen 0.129
Gpr33 G protein-coupled receptor 33 0.129
Ciita class II transactivator 0.126
Klrb1a killer cell lectin-like receptor subfamily B member 1A 0.125
Il21r interleukin 21 receptor 0.125
Tmem106a transmembrane protein 106A 0.124
Parp12 poly (ADP-ribose) polymerase family, member 12 0.121
Cd180 CD180 antigen 0.121
Zfp36 zinc finger protein 36 0.120
Elk4 ELK4, member of ETS oncogene family 0.118
Hcst hematopoietic cell signal transducer 0.118
Cd6 CD6 antigen 0.118
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG12424 CG12424 gene product from transcript CG12424-RC 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
B2M beta-2-microglobulin 0.931
IL4R interleukin 4 receptor 0.870
HLA-G major histocompatibility complex, class I, G 0.776
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.776
HLA-C major histocompatibility complex, class I, C 0.740
C1S complement component 1, s subcomponent 0.706
HLA-B major histocompatibility complex, class I, B 0.583
CCR5 chemokine (C-C motif) receptor 5 0.546
HLA-A major histocompatibility complex, class I, A 0.532
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.529
TAPBP TAP binding protein (tapasin) 0.515
C1R complement component 1, r subcomponent 0.514
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.507
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.478
SMAD4 SMAD family member 4 0.458
CD14 CD14 molecule 0.401
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.383
APOE apolipoprotein E 0.367
HLA-E major histocompatibility complex, class I, E 0.363
ALB albumin 0.312
HLA-F major histocompatibility complex, class I, F 0.295
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.289
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.287
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.286
DICER1 dicer 1, ribonuclease type III 0.278
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.270
IL1B interleukin 1, beta 0.267
IL2RG interleukin 2 receptor, gamma 0.211
PILRA paired immunoglobin-like type 2 receptor alpha 0.205
ZNF830 zinc finger protein 830 0.204
HP haptoglobin 0.179
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.165
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.160
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.157
CD84 CD84 molecule 0.155
SYK spleen tyrosine kinase 0.146
ISG15 ISG15 ubiquitin-like modifier 0.143
CXCL9 chemokine (C-X-C motif) ligand 9 0.140
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.139
THOC5 THO complex 5 0.137
CCR1 chemokine (C-C motif) receptor 1 0.132
CCL4 chemokine (C-C motif) ligand 4 0.132
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.128
CYLD cylindromatosis (turban tumor syndrome) 0.121
SH2D1A SH2 domain containing 1A 0.114
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.114
MICA MHC class I polypeptide-related sequence A 0.110
APOC1 apolipoprotein C-I 0.099
LCAT lecithin-cholesterol acyltransferase 0.096
C3 complement component 3 0.094
SLAMF1 signaling lymphocytic activation molecule family member 1 0.093
TARBP2 TAR (HIV-1) RNA binding protein 2 0.093
CCL13 chemokine (C-C motif) ligand 13 0.092
IL4 interleukin 4 0.091
CD22 CD22 molecule 0.091
TGFB1 transforming growth factor, beta 1 0.090
SIGLEC7 sialic acid binding Ig-like lectin 7 0.084
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.083
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.083
ITGB1BP3 integrin beta 1 binding protein 3 0.083
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.080
RANBP3 RAN binding protein 3 0.077
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.073
PECAM1 platelet/endothelial cell adhesion molecule 0.072
CFH complement factor H 0.069
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.069
IL22RA1 interleukin 22 receptor, alpha 1 0.069
CD163 CD163 molecule 0.069
CCL8 chemokine (C-C motif) ligand 8 0.069
CCL2 chemokine (C-C motif) ligand 2 0.067
CCL7 chemokine (C-C motif) ligand 7 0.066
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.063
A2M alpha-2-macroglobulin 0.062
CCL22 chemokine (C-C motif) ligand 22 0.062
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.062
IRF7 interferon regulatory factor 7 0.061
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.061
CXCL10 chemokine (C-X-C motif) ligand 10 0.057
C19orf50 chromosome 19 open reading frame 50 0.057
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.057
IL22RA2 interleukin 22 receptor, alpha 2 0.055
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.055
CCR7 chemokine (C-C motif) receptor 7 0.054
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.053
MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse) 0.052
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.050
IL10 interleukin 10 0.049
LGALS3 lectin, galactoside-binding, soluble, 3 0.049
IL6 interleukin 6 (interferon, beta 2) 0.049
ENG endoglin 0.049
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.048
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.048
ARRB2 arrestin, beta 2 0.047
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.046
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.046
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.045
CXCL11 chemokine (C-X-C motif) ligand 11 0.044
SP110 SP110 nuclear body protein 0.043
C2 complement component 2 0.042
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.041
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.123
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.041
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.025
RT1-S3 RT1 class Ib, locus S3 0.022
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.020
Mmp12 matrix metallopeptidase 12 0.019
Tfec transcription factor EC 0.018
Ppp3r2 protein phosphatase 3, regulatory subunit B, beta isoform 0.017
Icam1 intercellular adhesion molecule 1 0.017
Cp ceruloplasmin 0.016
Gzmb granzyme B 0.016
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.016
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.015
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.015
Fgg fibrinogen gamma chain 0.014
Gzmk granzyme K 0.014
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.014
Cxcl10 chemokine (C-X-C motif) ligand 10 0.013
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.013
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.012
Aif1 allograft inflammatory factor 1 0.012
Blnk B-cell linker 0.011
Il1b interleukin 1 beta 0.011
Hes2 hairy and enhancer of split 2 (Drosophila) 0.011
Irf2 interferon regulatory factor 2 0.011
Igsf6 immunoglobulin superfamily, member 6 0.011
RT1-M3-1 RT1 class Ib, locus M3, gene 1 0.010
Vom1r93 vomeronasal 1 receptor 93 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism