IMP

Process View

Homo sapiens

16 genes annotated in human

appendage morphogenesis

The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "appendage morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "appendage morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
ZNF43	zinc finger protein 43	0.989
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.898	Mouse Fly
ZNF253	zinc finger protein 253	0.807
ZNF273	zinc finger protein 273	0.764	Human
JAG1	jagged 1	0.534	Fly
BMP2	bone morphogenetic protein 2	0.510	Fly
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.448	Mouse
MEIS1	Meis homeobox 1	0.433
PSEN1	presenilin 1	0.408	Mouse
SMAD3	SMAD family member 3	0.395
FKBP1A	FK506 binding protein 1A, 12kDa	0.381
NOTCH3	notch 3	0.362	Fly
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.360
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.358
SOX2	SRY (sex determining region Y)-box 2	0.347
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.335	Human
SKIL	SKI-like oncogene	0.333
ZFYVE9	zinc finger, FYVE domain containing 9	0.307
ZNF675	zinc finger protein 675	0.293	Human
SMAD4	SMAD family member 4	0.291	Fly
HDAC2	histone deacetylase 2	0.287	Mouse
FGF1	fibroblast growth factor 1 (acidic)	0.277
SUFU	suppressor of fused homolog (Drosophila)	0.276
ZNF117	zinc finger protein 117	0.274	Human
TGFB1	transforming growth factor, beta 1	0.250
NOTCH1	notch 1	0.248	Mouse Fly
CREBBP	CREB binding protein	0.240
BMP1	bone morphogenetic protein 1	0.234	Fly
ZNF708	zinc finger protein 708	0.230	Human
SMAD2	SMAD family member 2	0.229
ZNF430	zinc finger protein 430	0.224	Human
BMP7	bone morphogenetic protein 7	0.222	Mouse Fly
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.214
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.211
MDFI	MyoD family inhibitor	0.203
FHL2	four and a half LIM domains 2	0.189
ZNF91	zinc finger protein 91	0.188
AR	androgen receptor	0.175
ZNF93	zinc finger protein 93	0.170
YY1	YY1 transcription factor	0.165
ARRB1	arrestin, beta 1	0.165
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.165	Fly
ZNF680	zinc finger protein 680	0.155	Human
ELL2	elongation factor, RNA polymerase II, 2	0.152
ZNF85	zinc finger protein 85	0.131	Human
HOXA10	homeobox A10	0.129
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.124
TGFBR1	transforming growth factor, beta receptor 1	0.124	Human Fly
BMPR1A	bone morphogenetic protein receptor, type IA	0.117	Human Mouse Fly
SETD8	SET domain containing (lysine methyltransferase) 8	0.114
FGFR2	fibroblast growth factor receptor 2	0.109	Mouse
ZNF254	zinc finger protein 254	0.108	Human
RXRA	retinoid X receptor, alpha	0.100
BMP4	bone morphogenetic protein 4	0.094	Zebrafish Mouse Fly
FGF18	fibroblast growth factor 18	0.093
HDAC1	histone deacetylase 1	0.089	Mouse
COL1A2	collagen, type I, alpha 2	0.089
BCL2L1	BCL2-like 1	0.089
HOXA11	homeobox A11	0.087	Mouse
MEIS2	Meis homeobox 2	0.085
HOXD9	homeobox D9	0.084	Mouse Fly
PML	promyelocytic leukemia	0.082
ATN1	atrophin 1	0.080
TRIP6	thyroid hormone receptor interactor 6	0.079
MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.076
WNT1	wingless-type MMTV integration site family, member 1	0.075	Human Fly
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.075
LRP6	low density lipoprotein receptor-related protein 6	0.074	Mouse
RARA	retinoic acid receptor, alpha	0.072
PSEN2	presenilin 2 (Alzheimer disease 4)	0.072	Mouse
HOXD13	homeobox D13	0.071	Mouse
HOXD11	homeobox D11	0.065	Mouse
SMAD6	SMAD family member 6	0.062	Fly
GATA4	GATA binding protein 4	0.060
HOXB5	homeobox B5	0.059
ACVR1	activin A receptor, type I	0.059	Human Fly
RBBP4	retinoblastoma binding protein 4	0.057
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.056
HOXC6	homeobox C6	0.056
FOXF2	forkhead box F2	0.055
COL7A1	collagen, type VII, alpha 1	0.055
COL2A1	collagen, type II, alpha 1	0.054	Mouse
LBX1	ladybird homeobox 1	0.051	Fly
DLX4	distal-less homeobox 4	0.050	Fly
NGFR	nerve growth factor receptor	0.046
FGFR1	fibroblast growth factor receptor 1	0.045	Mouse
TGFB3	transforming growth factor, beta 3	0.044
PRRX2	paired related homeobox 2	0.042	Mouse
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.042
JAG2	jagged 2	0.041	Fly
TJP1	tight junction protein 1 (zona occludens 1)	0.041
FGF3	fibroblast growth factor 3	0.041
HOXD10	homeobox D10	0.041	Mouse
WNT3A	wingless-type MMTV integration site family, member 3A	0.039
FSTL1	follistatin-like 1	0.039
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.039
THBS1	thrombospondin 1	0.038
FGFR3	fibroblast growth factor receptor 3	0.037
STK36	serine/threonine kinase 36	0.037
HMGA2	high mobility group AT-hook 2	0.036
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.036
CHD8	chromodomain helicase DNA binding protein 8	0.036	Fly
ACAN	aggrecan	0.036
HOXC8	homeobox C8	0.036	Zebrafish
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.035	Human
PRKG1	protein kinase, cGMP-dependent, type I	0.035
NRP2	neuropilin 2	0.035
HNF1B	HNF1 homeobox B	0.034
BARX1	BARX homeobox 1	0.034
ERBB2IP	erbb2 interacting protein	0.034
SFRP1	secreted frizzled-related protein 1	0.033
WNT10A	wingless-type MMTV integration site family, member 10A	0.033	Human
CCNT1	cyclin T1	0.033
FOXC1	forkhead box C1	0.033
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.032	Mouse
HOXC11	homeobox C11	0.032	Mouse
ZNF107	zinc finger protein 107	0.031
PAX2	paired box 2	0.031
NCOA1	nuclear receptor coactivator 1	0.031
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.031
RARG	retinoic acid receptor, gamma	0.031	Mouse
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.031
MSX1	msh homeobox 1	0.030
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.030
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.030
TWIST1	twist homolog 1 (Drosophila)	0.029	Mouse
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.028	Fly
HOXC13	homeobox C13	0.028
AQP5	aquaporin 5	0.028
SMAD1	SMAD family member 1	0.028	Fly
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.028
PDX1	pancreatic and duodenal homeobox 1	0.028
APC	adenomatous polyposis coli	0.027
ZNF682	zinc finger protein 682	0.027	Human
SHOX2	short stature homeobox 2	0.027	Mouse
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.027	Fly
ZNF92	zinc finger protein 92	0.027	Human
LEF1	lymphoid enhancer-binding factor 1	0.027	Zebrafish Mouse Fly
NOG	noggin	0.026
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.026
DLL1	delta-like 1 (Drosophila)	0.026	Fly
SIX2	SIX homeobox 2	0.026
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.026	Mouse
FGF8	fibroblast growth factor 8 (androgen-induced)	0.026
CAPRIN2	caprin family member 2	0.025
SOX11	SRY (sex determining region Y)-box 11	0.025	Mouse
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.025
FGF2	fibroblast growth factor 2 (basic)	0.025
WNT4	wingless-type MMTV integration site family, member 4	0.025	Human
HES2	hairy and enhancer of split 2 (Drosophila)	0.024
NCOA6	nuclear receptor coactivator 6	0.024
GATA2	GATA binding protein 2	0.024
ITGB4	integrin, beta 4	0.024
TBX2	T-box 2	0.024	Human
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.024
RNR2	l-rRNA	0.024
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.023
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.023
PTK7	PTK7 protein tyrosine kinase 7	0.023
GLI1	GLI family zinc finger 1	0.023	Human
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.023
DLX5	distal-less homeobox 5	0.023	Zebrafish Mouse
GLI3	GLI family zinc finger 3	0.023
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.023
NKX3-2	NK3 homeobox 2	0.023
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.022	Fly
KRT5	keratin 5	0.022
PAX3	paired box 3	0.022
ZEB2	zinc finger E-box binding homeobox 2	0.022
CDX2	caudal type homeobox 2	0.022
NOV	nephroblastoma overexpressed gene	0.021
LTBP4	latent transforming growth factor beta binding protein 4	0.021
MSX2	msh homeobox 2	0.020	Human Mouse Fly
FZD1	frizzled homolog 1 (Drosophila)	0.020
FOXL1	forkhead box L1	0.020	Zebrafish
MED13	mediator complex subunit 13	0.020
RUNX2	runt-related transcription factor 2	0.020	Mouse
EPAS1	endothelial PAS domain protein 1	0.020
FZD7	frizzled homolog 7 (Drosophila)	0.019
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.019
GAS1	growth arrest-specific 1	0.019	Mouse
FHL3	four and a half LIM domains 3	0.019
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.019	Fly
GSK3B	glycogen synthase kinase 3 beta	0.019	Fly
HOXA3	homeobox A3	0.019
OTP	orthopedia homeobox	0.019
SIM2	single-minded homolog 2 (Drosophila)	0.019
HOXD12	homeobox D12	0.019	Mouse
FBLN1	fibulin 1	0.019	Zebrafish
CRABP2	cellular retinoic acid binding protein 2	0.019	Mouse
BECN1	beclin 1, autophagy related	0.019
BAK1	BCL2-antagonist/killer 1	0.018
IRX4	iroquois homeobox 4	0.018
MED13L	mediator complex subunit 13-like	0.018
SATB2	SATB homeobox 2	0.018
SMO	smoothened homolog (Drosophila)	0.018	Zebrafish
QKI	quaking homolog, KH domain RNA binding (mouse)	0.018	Fly
CRLF1	cytokine receptor-like factor 1	0.018
WNT11	wingless-type MMTV integration site family, member 11	0.017	Human
HOXB13	homeobox B13	0.017
FEV	FEV (ETS oncogene family)	0.017
GLI2	GLI family zinc finger 2	0.017	Human Mouse
GDF6	growth differentiation factor 6	0.017
EN1	engrailed homeobox 1	0.017	Mouse Fly
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.017
NRP1	neuropilin 1	0.017
DLX2	distal-less homeobox 2	0.017
SP1	Sp1 transcription factor	0.017
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.017
PRPH	peripherin	0.016
SIX1	SIX homeobox 1	0.016
FOXF1	forkhead box F1	0.016
HOXA13	homeobox A13	0.016	Mouse
PRDM8	PR domain containing 8	0.016
EFNB3	ephrin-B3	0.016
CELF1	CUGBP, Elav-like family member 1	0.016	Fly
HOXC10	homeobox C10	0.016	Mouse
FGF7	fibroblast growth factor 7	0.016
SRI	sorcin	0.016
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.016
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.016
HOXB8	homeobox B8	0.016
HOXD8	homeobox D8	0.016
PIAS1	protein inhibitor of activated STAT, 1	0.016
TWIST2	twist homolog 2 (Drosophila)	0.015
AFF2	AF4/FMR2 family, member 2	0.015
MED14	mediator complex subunit 14	0.015
HIC1	hypermethylated in cancer 1	0.015
HOXA6	homeobox A6	0.015
MED25	mediator complex subunit 25	0.015
MYOD1	myogenic differentiation 1	0.015
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.015
CABLES1	Cdk5 and Abl enzyme substrate 1	0.015
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.014
S1PR5	sphingosine-1-phosphate receptor 5	0.014
HOXC5	homeobox C5	0.014
ZMYND11	zinc finger, MYND-type containing 11	0.014
SEC24D	SEC24 family, member D (S. cerevisiae)	0.014
PDGFC	platelet derived growth factor C	0.014
COL11A1	collagen, type XI, alpha 1	0.014
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.014
MXRA8	matrix-remodelling associated 8	0.014
CSNK1D	casein kinase 1, delta	0.014	Fly
SPRED1	sprouty-related, EVH1 domain containing 1	0.014
CDK19	cyclin-dependent kinase 19	0.014	Fly
ATXN3	ataxin 3	0.014
ZNF506	zinc finger protein 506	0.014	Human
HOXA9	homeobox A9	0.014	Mouse Fly
FZD10	frizzled homolog 10 (Drosophila)	0.014
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.014
TP63	tumor protein p63	0.014	Mouse
PAX1	paired box 1	0.013
HOXD3	homeobox D3	0.013
SORBS3	sorbin and SH3 domain containing 3	0.013
RAX	retina and anterior neural fold homeobox	0.013
PBX1	pre-B-cell leukemia homeobox 1	0.013	Mouse
TGFB2	transforming growth factor, beta 2	0.013
ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif, 10	0.013
TCF4	transcription factor 4	0.013
RUNX1	runt-related transcription factor 1	0.013
SIX3	SIX homeobox 3	0.013
PITX2	paired-like homeodomain 2	0.013	Mouse
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.013
COL4A5	collagen, type IV, alpha 5	0.013
LENG8	leukocyte receptor cluster (LRC) member 8	0.013
WT1	Wilms tumor 1	0.013
KCTD1	potassium channel tetramerisation domain containing 1	0.013
WISP1	WNT1 inducible signaling pathway protein 1	0.013
CD248	CD248 molecule, endosialin	0.013
GFI1B	growth factor independent 1B transcription repressor	0.012
PAX7	paired box 7	0.012
FGD1	FYVE, RhoGEF and PH domain containing 1	0.012
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.012
TERT	telomerase reverse transcriptase	0.012
MED6	mediator complex subunit 6	0.012
OAF	OAF homolog (Drosophila)	0.012
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.012
ADAMTSL4	ADAMTS-like 4	0.012
COL4A6	collagen, type IV, alpha 6	0.012
PKNOX1	PBX/knotted 1 homeobox 1	0.012
SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.012
PYY	peptide YY	0.012
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.012
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.012
AGRN	agrin	0.012
PTHLH	parathyroid hormone-like hormone	0.012
HOXA5	homeobox A5	0.012
TERF2	telomeric repeat binding factor 2	0.012
RNF144B	ring finger protein 144B	0.012
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	0.012
DAXX	death-domain associated protein	0.012
TLX1	T-cell leukemia homeobox 1	0.012	Fly
PAX8	paired box 8	0.012
ATF2	activating transcription factor 2	0.012
BMP8A	bone morphogenetic protein 8a	0.012	Fly
BNC1	basonuclin 1	0.012	Fly
IRX5	iroquois homeobox 5	0.012	Fly
PAX9	paired box 9	0.011
GDNF	glial cell derived neurotrophic factor	0.011
HOXD1	homeobox D1	0.011
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.011
FOXG1	forkhead box G1	0.011
PGAM5	phosphoglycerate mutase family member 5	0.011
MAPK8	mitogen-activated protein kinase 8	0.011
ENG	endoglin	0.011
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.011
GATA5	GATA binding protein 5	0.011
ZNF136	zinc finger protein 136	0.011
NCOR1	nuclear receptor corepressor 1	0.011
FOXO1	forkhead box O1	0.011	Fly
KRT6C	keratin 6C	0.011
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.011
WNT3	wingless-type MMTV integration site family, member 3	0.011
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.011
COL13A1	collagen, type XIII, alpha 1	0.011
VAX2	ventral anterior homeobox 2	0.011
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.011
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.011
FOXB1	forkhead box B1	0.011
SOX1	SRY (sex determining region Y)-box 1	0.011
WNT7A	wingless-type MMTV integration site family, member 7A	0.011
SEC31A	SEC31 homolog A (S. cerevisiae)	0.011
AFF1	AF4/FMR2 family, member 1	0.011
EPHB3	EPH receptor B3	0.011
IL11	interleukin 11	0.011
SIX6	SIX homeobox 6	0.010
INHBB	inhibin, beta B	0.010
WIF1	WNT inhibitory factor 1	0.010
EP300	E1A binding protein p300	0.010
PRDM13	PR domain containing 13	0.010
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.010
CRABP1	cellular retinoic acid binding protein 1	0.010
SFRP5	secreted frizzled-related protein 5	0.010
KIAA1199	KIAA1199	0.010
RHOXF2	Rhox homeobox family, member 2	0.010
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.010
BTRC	beta-transducin repeat containing	0.010
GCSH	glycine cleavage system protein H (aminomethyl carrier)	0.010
FLNB	filamin B, beta	0.010
HOXC4	homeobox C4	0.010