IMP

Process View

Homo sapiens

16 genes annotated in human

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

GO:2001240

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2L1	BCL2-like 1	1.000	Human
BCL2	B-cell CLL/lymphoma 2	1.000
BAX	BCL2-associated X protein	1.000	Human
IL8	interleukin 8	1.000
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.999
TAL1	T-cell acute lymphocytic leukemia 1	0.999
HSPA1A	heat shock 70kDa protein 1A	0.999
IL1B	interleukin 1, beta	0.995
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.992	Human
CXCL2	chemokine (C-X-C motif) ligand 2	0.986
HSPA1B	heat shock 70kDa protein 1B	0.986
BAD	BCL2-associated agonist of cell death	0.983
CXCL3	chemokine (C-X-C motif) ligand 3	0.973	Human
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.967
CCL20	chemokine (C-C motif) ligand 20	0.959
IL1R1	interleukin 1 receptor, type I	0.939
TRAF1	TNF receptor-associated factor 1	0.936
BID	BH3 interacting domain death agonist	0.935
TRADD	TNFRSF1A-associated via death domain	0.934
TNF	tumor necrosis factor	0.926
BIRC3	baculoviral IAP repeat containing 3	0.872
PML	promyelocytic leukemia	0.839
CXCL10	chemokine (C-X-C motif) ligand 10	0.829	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.777	Human
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.749
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.739
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.720
IL6	interleukin 6 (interferon, beta 2)	0.713
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.712
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.681
BCL2A1	BCL2-related protein A1	0.670	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.667
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.660
TRAF2	TNF receptor-associated factor 2	0.635
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.605
BAK1	BCL2-antagonist/killer 1	0.566	Human
CXCL5	chemokine (C-X-C motif) ligand 5	0.548	Human
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.483
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.467
BAG3	BCL2-associated athanogene 3	0.464
CCL4	chemokine (C-C motif) ligand 4	0.446
IL1R2	interleukin 1 receptor, type II	0.397
IL1RN	interleukin 1 receptor antagonist	0.294	Human
PF4	platelet factor 4	0.290
MAPK7	mitogen-activated protein kinase 7	0.287
CCL8	chemokine (C-C motif) ligand 8	0.275
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.271
FADD	Fas (TNFRSF6)-associated via death domain	0.270
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.259	Human
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.245
RIPK3	receptor-interacting serine-threonine kinase 3	0.227
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.218
MAP2K5	mitogen-activated protein kinase kinase 5	0.207	Rat
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.200	Mouse
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.179
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.171
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.162
CCL2	chemokine (C-C motif) ligand 2	0.143
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.130
CFLAR	CASP8 and FADD-like apoptosis regulator	0.128
SOD2	superoxide dismutase 2, mitochondrial	0.126
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.124	Human
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.121
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.112
STK11	serine/threonine kinase 11	0.111
VDAC1	voltage-dependent anion channel 1	0.111
RUNX1	runt-related transcription factor 1	0.108
ICAM1	intercellular adhesion molecule 1	0.107
HSPH1	heat shock 105kDa/110kDa protein 1	0.100
GSK3B	glycogen synthase kinase 3 beta	0.094
ISG15	ISG15 ubiquitin-like modifier	0.084
CXCL9	chemokine (C-X-C motif) ligand 9	0.079	Human
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.079
CD83	CD83 molecule	0.076
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.075
BANP	BTG3 associated nuclear protein	0.074
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.073
DPP4	dipeptidyl-peptidase 4	0.073
BAG1	BCL2-associated athanogene	0.072
CSF3	colony stimulating factor 3 (granulocyte)	0.071
IL1RAP	interleukin 1 receptor accessory protein	0.071
PI3	peptidase inhibitor 3, skin-derived	0.070
UBD	ubiquitin D	0.065
IFNG	interferon, gamma	0.064
RSAD2	radical S-adenosyl methionine domain containing 2	0.064
RNF144B	ring finger protein 144B	0.061
RIPK2	receptor-interacting serine-threonine kinase 2	0.060
ASRGL1	asparaginase like 1	0.059
TBX5	T-box 5	0.058
IER3	immediate early response 3	0.056
ZC3H12A	zinc finger CCCH-type containing 12A	0.055
IFI27	interferon, alpha-inducible protein 27	0.050	Human
HUWE1	HECT, UBA and WWE domain containing 1	0.048
HBB	hemoglobin, beta	0.047
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.046
ZBTB16	zinc finger and BTB domain containing 16	0.046
STAT5A	signal transducer and activator of transcription 5A	0.045
PPP5C	protein phosphatase 5, catalytic subunit	0.043
IL7R	interleukin 7 receptor	0.043
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.042
PF4V1	platelet factor 4 variant 1	0.041	Human
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.040
RNR2	l-rRNA	0.038
UBE2L6	ubiquitin-conjugating enzyme E2L 6	0.037
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.037
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.037
IFI44L	interferon-induced protein 44-like	0.036
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.036
SMG6	Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.036
CD320	CD320 molecule	0.036
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.036
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.035
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.034
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.034
TP53BP2	tumor protein p53 binding protein, 2	0.034
BBC3	BCL2 binding component 3	0.032
IDO1	indoleamine 2,3-dioxygenase 1	0.032
GPR109B	G protein-coupled receptor 109B	0.031
BIK	BCL2-interacting killer (apoptosis-inducing)	0.031
RPS27	ribosomal protein S27	0.031
IL1A	interleukin 1, alpha	0.031	Human
KLF13	Kruppel-like factor 13	0.031
CCL7	chemokine (C-C motif) ligand 7	0.030
GATA2	GATA binding protein 2	0.030	Human
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.030
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.028
JUP	junction plakoglobin	0.027
DBN1	drebrin 1	0.027
HBA2	hemoglobin, alpha 2	0.027
TP73	tumor protein p73	0.027
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.027
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.026
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.026
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.026
PSEN1	presenilin 1	0.025
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.025
AXIN1	axin 1	0.025
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.024
MAPK8	mitogen-activated protein kinase 8	0.024
RGS1	regulator of G-protein signaling 1	0.024
CH25H	cholesterol 25-hydroxylase	0.024
PLAUR	plasminogen activator, urokinase receptor	0.023
BCL2L2	BCL2-like 2	0.023	Human
MEOX2	mesenchyme homeobox 2	0.023
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.023
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.023
HSPA1L	heat shock 70kDa protein 1-like	0.022	Human
OASL	2'-5'-oligoadenylate synthetase-like	0.022
CXCL13	chemokine (C-X-C motif) ligand 13	0.021
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.021
CXCR3	chemokine (C-X-C motif) receptor 3	0.021
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.021
INHBA	inhibin, beta A	0.021
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.020
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.020
CCL5	chemokine (C-C motif) ligand 5	0.020
SELE	selectin E	0.020
LAMP3	lysosomal-associated membrane protein 3	0.020
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.020
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.019
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.019
PLEK	pleckstrin	0.018
BAG2	BCL2-associated athanogene 2	0.018
SQSTM1	sequestosome 1	0.018
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.017
KYNU	kynureninase	0.017
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.017
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.016
HBG2	hemoglobin, gamma G	0.016
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.016
BECN1	beclin 1, autophagy related	0.016
TLR2	toll-like receptor 2	0.016
CD69	CD69 molecule	0.015
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.015
CTNND1	catenin (cadherin-associated protein), delta 1	0.015
ZFPM1	zinc finger protein, multitype 1	0.015
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.015
APC	adenomatous polyposis coli	0.015
TGIF1	TGFB-induced factor homeobox 1	0.015
CYLD	cylindromatosis (turban tumor syndrome)	0.015
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.015
CD274	CD274 molecule	0.015
EFNA1	ephrin-A1	0.015
DTX1	deltex homolog 1 (Drosophila)	0.014
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.014
TREM1	triggering receptor expressed on myeloid cells 1	0.014
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.014
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.014
BIRC2	baculoviral IAP repeat containing 2	0.013
HSPB1	heat shock 27kDa protein 1	0.013
PTX3	pentraxin 3, long	0.013
HBD	hemoglobin, delta	0.013
TFPI2	tissue factor pathway inhibitor 2	0.012
AQP9	aquaporin 9	0.012
IL1F9	interleukin 1 family, member 9	0.012	Human
SNX18	sorting nexin 18	0.012
ANXA1	annexin A1	0.012
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.011
DHH	desert hedgehog	0.011
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.011
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.011
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.011
DAXX	death-domain associated protein	0.011
EREG	epiregulin	0.011
CCR7	chemokine (C-C motif) receptor 7	0.011
MOBKL2B	MOB1, Mps One Binder kinase activator-like 2B (yeast)	0.011
PTPRE	protein tyrosine phosphatase, receptor type, E	0.011
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.010
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.010
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.010
BMP2	bone morphogenetic protein 2	0.010
IL11	interleukin 11	0.010
RHAG	Rh-associated glycoprotein	0.010
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.010
TRAF3	TNF receptor-associated factor 3	0.010