IMP

Process View

Homo sapiens

39 genes annotated in human

epidermal growth factor receptor signaling pathway

A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "epidermal growth factor receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "epidermal growth factor receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.982
EGFR	epidermal growth factor receptor	0.962
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.641	Human
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.338	Human Fly
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.306	Mouse Fly
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.219
DLG1	discs, large homolog 1 (Drosophila)	0.175	Fly
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.160	Human
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.159	Mouse
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.158	Human
GRB2	growth factor receptor-bound protein 2	0.147	Fly
UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.104
GHR	growth hormone receptor	0.095
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.087
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.081	Fly
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.078	Human Rat
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.076	Fly
PSEN1	presenilin 1	0.074	Mouse
PTK2	PTK2 protein tyrosine kinase 2	0.073	Fly
GAB1	GRB2-associated binding protein 1	0.067	Mouse
ESR1	estrogen receptor 1	0.064	Rat
SPRR2A	small proline-rich protein 2A	0.057
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.057
SOS1	son of sevenless homolog 1 (Drosophila)	0.054
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.054
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.053
CTNND1	catenin (cadherin-associated protein), delta 1	0.052
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.052	Mouse Fly
EIF4A3	eukaryotic translation initiation factor 4A3	0.052
LAT	linker for activation of T cells	0.051
GDA	guanine deaminase	0.051
VAV1	vav 1 guanine nucleotide exchange factor	0.050
NCK1	NCK adaptor protein 1	0.046
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.045
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.043	Fly
MUC1	mucin 1, cell surface associated	0.043
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.042
APP	amyloid beta (A4) precursor protein	0.041	Mouse
SOCS1	suppressor of cytokine signaling 1	0.039	Human
CAV1	caveolin 1, caveolae protein, 22kDa	0.038
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.038
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.037
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.037	Human
DLG4	discs, large homolog 4 (Drosophila)	0.036	Fly
ABI2	abl-interactor 2	0.035
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.033
PDCD6IP	programmed cell death 6 interacting protein	0.032
SH3KBP1	SH3-domain kinase binding protein 1	0.032
ARID1A	AT rich interactive domain 1A (SWI-like)	0.031
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.031
TFF1	trefoil factor 1	0.031
FBLN1	fibulin 1	0.029	Human
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.028
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.028
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.028
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.028
ARHGAP1	Rho GTPase activating protein 1	0.027
TSG101	tumor susceptibility gene 101	0.027
PBK	PDZ binding kinase	0.026
STAMBP	STAM binding protein	0.026
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.026
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.025
MPDZ	multiple PDZ domain protein	0.025
PBRM1	polybromo 1	0.025
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.025
PRPF6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	0.024
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.024
PTPRA	protein tyrosine phosphatase, receptor type, A	0.023
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.023	Fly
FYB	FYN binding protein	0.023
MED28	mediator complex subunit 28	0.023
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.023
MAP2K1	mitogen-activated protein kinase kinase 1	0.022
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.022
PXN	paxillin	0.022
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.022
PLCG1	phospholipase C, gamma 1	0.022
TOM1L1	target of myb1 (chicken)-like 1	0.022
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.021
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.021
TNRC6B	trinucleotide repeat containing 6B	0.021
CCDC6	coiled-coil domain containing 6	0.021
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.021
LRRK2	leucine-rich repeat kinase 2	0.020
SH2D3A	SH2 domain containing 3A	0.020
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.020	Rat Fly
EPOR	erythropoietin receptor	0.020
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.020
ATN1	atrophin 1	0.020
DSG2	desmoglein 2	0.020
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.020	Mouse
IGFBP3	insulin-like growth factor binding protein 3	0.020
FBN1	fibrillin 1	0.020
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.019
SH3BP4	SH3-domain binding protein 4	0.019
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.019
SOCS2	suppressor of cytokine signaling 2	0.019	Human
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.019
FBLN5	fibulin 5	0.019	Human
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.019
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.019
SOS2	son of sevenless homolog 2 (Drosophila)	0.019
BCAR1	breast cancer anti-estrogen resistance 1	0.019	Rat
RIN1	Ras and Rab interactor 1	0.018
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.018	Fly
ARHGAP5	Rho GTPase activating protein 5	0.018
CLASP1	cytoplasmic linker associated protein 1	0.018
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.018
UBQLN1	ubiquilin 1	0.018
ABI1	abl-interactor 1	0.018
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.018	Fly
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.018
HDAC4	histone deacetylase 4	0.018
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.018	Worm
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.018
PRKCA	protein kinase C, alpha	0.017
FSTL1	follistatin-like 1	0.017
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.017	Fly
SH3GL2	SH3-domain GRB2-like 2	0.017
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.017	Worm
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.017	Human
NCOR1	nuclear receptor corepressor 1	0.017
ADNP	activity-dependent neuroprotector homeobox	0.017
DNM2	dynamin 2	0.017
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0.016
AHNAK	AHNAK nucleoprotein	0.016
YAP1	Yes-associated protein 1	0.016
ADRBK1	adrenergic, beta, receptor kinase 1	0.016
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.016
TLN1	talin 1	0.016
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.016
TRIP6	thyroid hormone receptor interactor 6	0.015
FYN	FYN oncogene related to SRC, FGR, YES	0.015
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.015	Fly
CMTM8	CKLF-like MARVEL transmembrane domain containing 8	0.015
PPP5C	protein phosphatase 5, catalytic subunit	0.015
CAV2	caveolin 2	0.015
IRS4	insulin receptor substrate 4	0.015
SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.015
ZNF746	zinc finger protein 746	0.015
GRAP2	GRB2-related adaptor protein 2	0.015	Fly
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.015
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.015	Fly
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.015
LOXL1	lysyl oxidase-like 1	0.014
SRCIN1	SRC kinase signaling inhibitor 1	0.014
DOK4	docking protein 4	0.014
SKIL	SKI-like oncogene	0.014
FLNB	filamin B, beta	0.014
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.014
TNK2	tyrosine kinase, non-receptor, 2	0.014
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.014
ADORA2A	adenosine A2a receptor	0.014
JUP	junction plakoglobin	0.014
BLNK	B-cell linker	0.014
WASL	Wiskott-Aldrich syndrome-like	0.013
CISH	cytokine inducible SH2-containing protein	0.013	Human
DNM1	dynamin 1	0.013
EXOC5	exocyst complex component 5	0.013
DPPA4	developmental pluripotency associated 4	0.013
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.013
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.013
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.013	Rat
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.013
EGF	epidermal growth factor	0.013
S100A4	S100 calcium binding protein A4	0.013
CDK8	cyclin-dependent kinase 8	0.013
SOCS3	suppressor of cytokine signaling 3	0.013	Human
EZR	ezrin	0.013
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.013
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.013
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.013
VEGFA	vascular endothelial growth factor A	0.013
GRB10	growth factor receptor-bound protein 10	0.013
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.013	Human Fly
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.012
ANXA1	annexin A1	0.012
RALBP1	ralA binding protein 1	0.012
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.012
LTBP4	latent transforming growth factor beta binding protein 4	0.012	Human
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.012
JAK1	Janus kinase 1	0.012
SH3RF1	SH3 domain containing ring finger 1	0.012
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.012	Worm
RABGGTB	Rab geranylgeranyltransferase, beta subunit	0.012
ZNF512B	zinc finger protein 512B	0.012
ARF6	ADP-ribosylation factor 6	0.012
LAMB2	laminin, beta 2 (laminin S)	0.012
LTBP2	latent transforming growth factor beta binding protein 2	0.012	Human
CSNK1G3	casein kinase 1, gamma 3	0.012
MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5	0.012	Fly
ZNF775	zinc finger protein 775	0.012
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.012
RHEB	Ras homolog enriched in brain	0.012
MATK	megakaryocyte-associated tyrosine kinase	0.012
DAZ1	deleted in azoospermia 1	0.012
VAV2	vav 2 guanine nucleotide exchange factor	0.012
ENG	endoglin	0.012
AGRN	agrin	0.012
PUM2	pumilio homolog 2 (Drosophila)	0.012	Fly
MPP5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.012
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.012
SORBS3	sorbin and SH3 domain containing 3	0.012
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.012
SH3D19	SH3 domain containing 19	0.012
CDT1	chromatin licensing and DNA replication factor 1	0.011
ARRB1	arrestin, beta 1	0.011
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.011
SH3BP2	SH3-domain binding protein 2	0.011
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.011
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.011
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.011
PDE4DIP	phosphodiesterase 4D interacting protein	0.011
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.011
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.011
DEGS1	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	0.011
BLK	B lymphoid tyrosine kinase	0.011
KIF5B	kinesin family member 5B	0.011
EEA1	early endosome antigen 1	0.011
CHMP4B	chromatin modifying protein 4B	0.011
ADAM10	ADAM metallopeptidase domain 10	0.011
SPTBN1	spectrin, beta, non-erythrocytic 1	0.011
FN1	fibronectin 1	0.011
UPF3B	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.011
NUP54	nucleoporin 54kDa	0.011
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.011
ZNF644	zinc finger protein 644	0.011
UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	0.011
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.011	Human Fly
JAK2	Janus kinase 2	0.011
HCK	hemopoietic cell kinase	0.011
LRP1	low density lipoprotein receptor-related protein 1	0.011	Human
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.011	Fly
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.011
ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A	0.011
ELL	elongation factor RNA polymerase II	0.011
PRPF4B	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.011
SS18	synovial sarcoma translocation, chromosome 18	0.011
SLK	STE20-like kinase	0.011
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.011	Fly
TMOD3	tropomodulin 3 (ubiquitous)	0.011
LMAN1	lectin, mannose-binding, 1	0.011
BAIAP2	BAI1-associated protein 2	0.011
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.011
ADRM1	adhesion regulating molecule 1	0.011
PCNP	PEST proteolytic signal containing nuclear protein	0.011
TNS4	tensin 4	0.011
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.011	Fly
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.011
MAP1S	microtubule-associated protein 1S	0.010
DPYSL4	dihydropyrimidinase-like 4	0.010
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.010
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.010
PTPRB	protein tyrosine phosphatase, receptor type, B	0.010	Human
TNRC6C	trinucleotide repeat containing 6C	0.010
ENO1	enolase 1, (alpha)	0.010
MAP2K2	mitogen-activated protein kinase kinase 2	0.010
CDCP1	CUB domain containing protein 1	0.010
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.010
PRKCE	protein kinase C, epsilon	0.010
EIF1AX	eukaryotic translation initiation factor 1A, X-linked	0.010
TGFB3	transforming growth factor, beta 3	0.010
RYK	RYK receptor-like tyrosine kinase	0.010
DLG2	discs, large homolog 2 (Drosophila)	0.010	Fly
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.010
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.010