IMP

Process View

Homo sapiens

48 genes annotated in human

Multi-species View

nuclear transcribed mrna catabolic process

GO:0000956

The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "nuclear transcribed mrna catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "nuclear transcribed mrna catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
PABPC1	poly(A) binding protein, cytoplasmic 1	1.000
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	1.000
RBM8A	RNA binding motif protein 8A	1.000
UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	0.999
SMG1	SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)	0.998
UPF3B	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.997
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.994
TNRC6A	trinucleotide repeat containing 6A	0.992	Human
EXOSC3	exosome component 3	0.991
TOB1	transducer of ERBB2, 1	0.987
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.987
PAN3	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.954	Yeast Mouse
DIS3L	DIS3 mitotic control homolog (S. cerevisiae)-like	0.940
TNRC6B	trinucleotide repeat containing 6B	0.926
EXOSC10	exosome component 10	0.912
UPF3A	UPF3 regulator of nonsense transcripts homolog A (yeast)	0.894	Human Worm
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.864	Human Mouse
THOC4	THO complex 4	0.860
CNOT8	CCR4-NOT transcription complex, subunit 8	0.839
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.807	Human
EXOSC2	exosome component 2	0.790	Yeast
EXOSC7	exosome component 7	0.756
BTG1	B-cell translocation gene 1, anti-proliferative	0.732	Human
TNRC6C	trinucleotide repeat containing 6C	0.689
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.681
CNOT7	CCR4-NOT transcription complex, subunit 7	0.654
EXOSC4	exosome component 4	0.632
CNOT1	CCR4-NOT transcription complex, subunit 1	0.594
MED10	mediator complex subunit 10	0.584
BTG2	BTG family, member 2	0.548
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.500
EXOSC5	exosome component 5	0.457
EIF4A3	eukaryotic translation initiation factor 4A3	0.441
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.426
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.347
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.342
CNOT2	CCR4-NOT transcription complex, subunit 2	0.337
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.307	Human
EDC3	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	0.305
EXOSC8	exosome component 8	0.264
EIF3B	eukaryotic translation initiation factor 3, subunit B	0.254
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.253	Human Yeast Mouse
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.247
DIS3	DIS3 mitotic control homolog (S. cerevisiae)	0.245
SRPK2	SRSF protein kinase 2	0.239
YBX1	Y box binding protein 1	0.235
PCBP2	poly(rC) binding protein 2	0.222
NCF1	neutrophil cytosolic factor 1	0.209
PCBP1	poly(rC) binding protein 1	0.175
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.171
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.150
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.133
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.133
SRSF2	serine/arginine-rich splicing factor 2	0.129
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.128	Yeast
ILF2	interleukin enhancer binding factor 2, 45kDa	0.127
NOXA1	NADPH oxidase activator 1	0.121
EIF3A	eukaryotic translation initiation factor 3, subunit A	0.113
PPIH	peptidylprolyl isomerase H (cyclophilin H)	0.110
EMG1	EMG1 nucleolar protein homolog (S. cerevisiae)	0.108
CNOT6	CCR4-NOT transcription complex, subunit 6	0.106
DUSP1	dual specificity phosphatase 1	0.105
PAIP2	poly(A) binding protein interacting protein 2	0.097
TERT	telomerase reverse transcriptase	0.093
LSM6	LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.088
CAND1	cullin-associated and neddylation-dissociated 1	0.085
PABPC3	poly(A) binding protein, cytoplasmic 3	0.085	Human Yeast
GSPT1	G1 to S phase transition 1	0.082	Yeast
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.079
SRRM1	serine/arginine repetitive matrix 1	0.078
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.078
EIF3G	eukaryotic translation initiation factor 3, subunit G	0.076
NCOA3	nuclear receptor coactivator 3	0.075
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.073
CPEB4	cytoplasmic polyadenylation element binding protein 4	0.072	Human
CUL2	cullin 2	0.069
RBX1	ring-box 1, E3 ubiquitin protein ligase	0.069
IER2	immediate early response 2	0.068
EIF4B	eukaryotic translation initiation factor 4B	0.067
DICER1	dicer 1, ribonuclease type III	0.066
MED1	mediator complex subunit 1	0.065
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.065
EIF4A1	eukaryotic translation initiation factor 4A1	0.064
EIF3D	eukaryotic translation initiation factor 3, subunit D	0.063
NCBP1	nuclear cap binding protein subunit 1, 80kDa	0.063
NCBP2	nuclear cap binding protein subunit 2, 20kDa	0.063
LUC7L2	LUC7-like 2 (S. cerevisiae)	0.062
CNOT3	CCR4-NOT transcription complex, subunit 3	0.061	Yeast
TARDBP	TAR DNA binding protein	0.061
FYN	FYN oncogene related to SRC, FGR, YES	0.059
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.058
RBMX	RNA binding motif protein, X-linked	0.057
SMG7	Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.052	Human
SRSF4	serine/arginine-rich splicing factor 4	0.051
IPO8	importin 8	0.051
CARD11	caspase recruitment domain family, member 11	0.051
SNRPF	small nuclear ribonucleoprotein polypeptide F	0.049
ACIN1	apoptotic chromatin condensation inducer 1	0.049
NCL	nucleolin	0.047
EXOSC1	exosome component 1	0.046	Yeast
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.046
MPHOSPH6	M-phase phosphoprotein 6	0.046
SNRPD3	small nuclear ribonucleoprotein D3 polypeptide 18kDa	0.045
CELF1	CUGBP, Elav-like family member 1	0.043
ERH	enhancer of rudimentary homolog (Drosophila)	0.042
LSM3	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.039
C19orf61	chromosome 19 open reading frame 61	0.039
PUF60	poly-U binding splicing factor 60KDa	0.038
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.037
MTA1	metastasis associated 1	0.037
PNRC1	proline-rich nuclear receptor coactivator 1	0.036	Human
GABARAPL1	GABA(A) receptor-associated protein like 1	0.036
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.035
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.035
TRA2B	transformer 2 beta homolog (Drosophila)	0.034
EEF2	eukaryotic translation elongation factor 2	0.034
MATR3	matrin 3	0.033
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.032
MED29	mediator complex subunit 29	0.032
AEBP2	AE binding protein 2	0.032
ARGLU1	arginine and glutamate rich 1	0.031
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.031	Yeast
SERBP1	SERPINE1 mRNA binding protein 1	0.031
NCOA2	nuclear receptor coactivator 2	0.030
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	0.029
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.029
CUL3	cullin 3	0.029
PRKCZ	protein kinase C, zeta	0.028	Yeast
LSM7	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.028	Yeast
NONO	non-POU domain containing, octamer-binding	0.028
JUNB	jun B proto-oncogene	0.028
ATMIN	ATM interactor	0.027
C5orf41	chromosome 5 open reading frame 41	0.027
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.027
ETF1	eukaryotic translation termination factor 1	0.027
BCLAF1	BCL2-associated transcription factor 1	0.027
KLF4	Kruppel-like factor 4 (gut)	0.027
RARA	retinoic acid receptor, alpha	0.026
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.026
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.026
SRSF9	serine/arginine-rich splicing factor 9	0.026	Yeast
GSPT2	G1 to S phase transition 2	0.026	Yeast
MED26	mediator complex subunit 26	0.026
C1QBP	complement component 1, q subcomponent binding protein	0.026
PICK1	protein interacting with PRKCA 1	0.026
C17orf85	chromosome 17 open reading frame 85	0.025
TOPBP1	topoisomerase (DNA) II binding protein 1	0.024
PPM1G	protein phosphatase, Mg2+/Mn2+ dependent, 1G	0.024
EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	0.024
PTBP1	polypyrimidine tract binding protein 1	0.023
CDCP1	CUB domain containing protein 1	0.023
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.023
PNN	pinin, desmosome associated protein	0.023
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.023	Yeast
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.023
EIF3I	eukaryotic translation initiation factor 3, subunit I	0.022
PAN2	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.022	Yeast Fly
SRSF1	serine/arginine-rich splicing factor 1	0.022	Yeast
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.022
NFIL3	nuclear factor, interleukin 3 regulated	0.022
PRRC2A	proline-rich coiled-coil 2A	0.022
ACD	adrenocortical dysplasia homolog (mouse)	0.022
BANF1	barrier to autointegration factor 1	0.022
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.021
LSM4	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.021
EDC4	enhancer of mRNA decapping 4	0.021
NUMB	numb homolog (Drosophila)	0.021
XRN2	5'-3' exoribonuclease 2	0.021
C17orf71	chromosome 17 open reading frame 71	0.020
AHSA2	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)	0.020
RANBP1	RAN binding protein 1	0.020
BRCA1	breast cancer 1, early onset	0.020
ITPA	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	0.020
SART3	squamous cell carcinoma antigen recognized by T cells 3	0.020
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.020
VHL	von Hippel-Lindau tumor suppressor	0.020
PAFAH1B2	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	0.019
SEC61G	Sec61 gamma subunit	0.019
DCLRE1C	DNA cross-link repair 1C	0.019
RBM4	RNA binding motif protein 4	0.019
LUC7L3	LUC7-like 3 (S. cerevisiae)	0.019
ZMYM4	zinc finger, MYM-type 4	0.019
ZNHIT1	zinc finger, HIT-type containing 1	0.019
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.019
FNIP1	folliculin interacting protein 1	0.019
KLHL24	kelch-like 24 (Drosophila)	0.019
MAGOHB	mago-nashi homolog B (Drosophila)	0.019	Human
RBM42	RNA binding motif protein 42	0.018
HMGA1	high mobility group AT-hook 1	0.018
CPEB3	cytoplasmic polyadenylation element binding protein 3	0.018
ZNF692	zinc finger protein 692	0.018
CCNI	cyclin I	0.018
SNRPG	small nuclear ribonucleoprotein polypeptide G	0.018
AFF4	AF4/FMR2 family, member 4	0.018
CSRNP1	cysteine-serine-rich nuclear protein 1	0.018
RNPS1	RNA binding protein S1, serine-rich domain	0.018
JUND	jun D proto-oncogene	0.018
C1orf93	chromosome 1 open reading frame 93	0.018
NME1	non-metastatic cells 1, protein (NM23A) expressed in	0.017
EFHC1	EF-hand domain (C-terminal) containing 1	0.017
FUBP1	far upstream element (FUSE) binding protein 1	0.017
PRKCB	protein kinase C, beta	0.017
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.017
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	0.017
PAIP1	poly(A) binding protein interacting protein 1	0.017
DKC1	dyskeratosis congenita 1, dyskerin	0.017
SBF1	SET binding factor 1	0.017
GNB2L1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.017
SH3RF1	SH3 domain containing ring finger 1	0.017
GLOD4	glyoxalase domain containing 4	0.017
NAP1L1	nucleosome assembly protein 1-like 1	0.016
MED21	mediator complex subunit 21	0.016
NHP2L1	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)	0.016
PCMTD2	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.016
TOB2	transducer of ERBB2, 2	0.016
ATXN2	ataxin 2	0.016
C16orf80	chromosome 16 open reading frame 80	0.016
SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.016
S100PBP	S100P binding protein	0.016
SRSF6	serine/arginine-rich splicing factor 6	0.016
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.016
PPP4C	protein phosphatase 4, catalytic subunit	0.016
BARD1	BRCA1 associated RING domain 1	0.016
SNRNP40	small nuclear ribonucleoprotein 40kDa (U5)	0.015
LCOR	ligand dependent nuclear receptor corepressor	0.015
HN1	hematological and neurological expressed 1	0.015
RICTOR	RPTOR independent companion of MTOR, complex 2	0.015
CCNG1	cyclin G1	0.015
FAM126B	family with sequence similarity 126, member B	0.015
GTF2E1	general transcription factor IIE, polypeptide 1, alpha 56kDa	0.015
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.015
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.014
EIF2A	eukaryotic translation initiation factor 2A, 65kDa	0.014
GLRX3	glutaredoxin 3	0.014
GPBP1L1	GC-rich promoter binding protein 1-like 1	0.014
PARN	poly(A)-specific ribonuclease (deadenylation nuclease)	0.014
NAA38	N(alpha)-acetyltransferase 38, NatC auxiliary subunit	0.014
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.014
RQCD1	RCD1 required for cell differentiation1 homolog (S. pombe)	0.014
HMGN1	high mobility group nucleosome binding domain 1	0.014
ESR2	estrogen receptor 2 (ER beta)	0.014
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.014
MXI1	MAX interactor 1	0.014
POLDIP3	polymerase (DNA-directed), delta interacting protein 3	0.014
NACA	nascent polypeptide-associated complex alpha subunit	0.014
MED13	mediator complex subunit 13	0.014
RPL11	ribosomal protein L11	0.014
ZBTB48	zinc finger and BTB domain containing 48	0.013
LUC7L	LUC7-like (S. cerevisiae)	0.013
FBL	fibrillarin	0.013
ACTB	actin, beta	0.013
BTF3	basic transcription factor 3	0.013
TOE1	target of EGR1, member 1 (nuclear)	0.013
RC3H2	ring finger and CCCH-type domains 2	0.013
INTS6	integrator complex subunit 6	0.013
LTA4H	leukotriene A4 hydrolase	0.013
CNOT10	CCR4-NOT transcription complex, subunit 10	0.013
FBXO33	F-box protein 33	0.013
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.013
PPWD1	peptidylprolyl isomerase domain and WD repeat containing 1	0.013
MED16	mediator complex subunit 16	0.013
TRIM9	tripartite motif containing 9	0.013
CSTF3	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	0.013
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.013
ZNF195	zinc finger protein 195	0.013
CBWD2	COBW domain containing 2	0.012
CCNC	cyclin C	0.012
BAG3	BCL2-associated athanogene 3	0.012
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.012
DDX20	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	0.012
EP300	E1A binding protein p300	0.012
EXOSC6	exosome component 6	0.012
TRMT112	tRNA methyltransferase 11-2 homolog (S. cerevisiae)	0.012
DLG1	discs, large homolog 1 (Drosophila)	0.012
CPSF3	cleavage and polyadenylation specific factor 3, 73kDa	0.012
POLR2B	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	0.012
DDX21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	0.012
FAM118B	family with sequence similarity 118, member B	0.012
CPSF1	cleavage and polyadenylation specific factor 1, 160kDa	0.012
POLR2D	polymerase (RNA) II (DNA directed) polypeptide D	0.012
ZDHHC17	zinc finger, DHHC-type containing 17	0.012
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.012
POLG2	polymerase (DNA directed), gamma 2, accessory subunit	0.012
PPHLN1	periphilin 1	0.012
HABP4	hyaluronan binding protein 4	0.012
FOSL2	FOS-like antigen 2	0.011
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.011
CDK5RAP3	CDK5 regulatory subunit associated protein 3	0.011
COPS3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	0.011
MED30	mediator complex subunit 30	0.011
RPP30	ribonuclease P/MRP 30kDa subunit	0.011
ACP1	acid phosphatase 1, soluble	0.011
LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.011
NMT2	N-myristoyltransferase 2	0.011
KIF1B	kinesin family member 1B	0.011
CUL4B	cullin 4B	0.011
LMO3	LIM domain only 3 (rhombotin-like 2)	0.011
GDI2	GDP dissociation inhibitor 2	0.011
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.011
ERC1	ELKS/RAB6-interacting/CAST family member 1	0.011
NOC2L	nucleolar complex associated 2 homolog (S. cerevisiae)	0.011
RALY	RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))	0.011	Yeast
KLF6	Kruppel-like factor 6	0.011
EIF4A2	eukaryotic translation initiation factor 4A2	0.011
CCL14	chemokine (C-C motif) ligand 14	0.011
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.011
SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	0.011
METTL3	methyltransferase like 3	0.011
NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	0.011
RBM6	RNA binding motif protein 6	0.011
CLNS1A	chloride channel, nucleotide-sensitive, 1A	0.011
CYBA	cytochrome b-245, alpha polypeptide	0.011
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.011
METTL4	methyltransferase like 4	0.011
POGZ	pogo transposable element with ZNF domain	0.011
MYO9B	myosin IXB	0.011
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.011
DDX46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.011
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.010
GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.010
SF1	splicing factor 1	0.010
AHCY	adenosylhomocysteinase	0.010
CDK19	cyclin-dependent kinase 19	0.010	Yeast
RAD17	RAD17 homolog (S. pombe)	0.010
MED28	mediator complex subunit 28	0.010
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.010
KAT2A	K(lysine) acetyltransferase 2A	0.010
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.010
HERC4	hect domain and RLD 4	0.010
SENP7	SUMO1/sentrin specific peptidase 7	0.010
SBNO2	strawberry notch homolog 2 (Drosophila)	0.010
KIAA0528	KIAA0528	0.010
POFUT1	protein O-fucosyltransferase 1	0.010
LNPEP	leucyl/cystinyl aminopeptidase	0.010
INTS8	integrator complex subunit 8	0.010
SH2D1A	SH2 domain containing 1A	0.010
HNRNPR	heterogeneous nuclear ribonucleoprotein R	0.010
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.010