IMP

Process View

Homo sapiens

47 genes annotated in human

regulation of receptor activity

Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of receptor activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of receptor activity" (in gray)

Name	Description	Probability	Func Analog Organism
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.566
EGFR	epidermal growth factor receptor	0.485
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.384
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.369
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.334
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.328
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.226
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.217
IER3	immediate early response 3	0.199
PLAU	plasminogen activator, urokinase	0.191
ABI2	abl-interactor 2	0.161
ESR1	estrogen receptor 1	0.125
PRKCA	protein kinase C, alpha	0.119
PSEN1	presenilin 1	0.117	Mouse
AR	androgen receptor	0.116
SNX9	sorting nexin 9	0.112
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.111
GRB2	growth factor receptor-bound protein 2	0.106	Fly
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.099
CREBBP	CREB binding protein	0.096
EPOR	erythropoietin receptor	0.091
MPDZ	multiple PDZ domain protein	0.091
DLG4	discs, large homolog 4 (Drosophila)	0.091	Rat
PTK2	PTK2 protein tyrosine kinase 2	0.085
SPOP	speckle-type POZ protein	0.083
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.081	Human Fly
PLCG1	phospholipase C, gamma 1	0.079
ESRRG	estrogen-related receptor gamma	0.073
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.072
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.071
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.071
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.069
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.065
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.064
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.062
PDCD6IP	programmed cell death 6 interacting protein	0.062
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.059
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.058
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.056
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.055
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.053
HDAC4	histone deacetylase 4	0.053
PLAT	plasminogen activator, tissue	0.052	Human
CTNND1	catenin (cadherin-associated protein), delta 1	0.052
PPARG	peroxisome proliferator-activated receptor gamma	0.047
MAPT	microtubule-associated protein tau	0.046
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.045
LCK	lymphocyte-specific protein tyrosine kinase	0.045
SMAD9	SMAD family member 9	0.044
SOCS2	suppressor of cytokine signaling 2	0.043	Human
APP	amyloid beta (A4) precursor protein	0.043	Mouse
FLNB	filamin B, beta	0.043
SKIL	SKI-like oncogene	0.042
CRHR1	corticotropin releasing hormone receptor 1	0.039
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.039
SOCS3	suppressor of cytokine signaling 3	0.038	Human
SPRR2A	small proline-rich protein 2A	0.038
DLG1	discs, large homolog 1 (Drosophila)	0.036
NCOR1	nuclear receptor corepressor 1	0.034
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.033
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.033
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.033
MUC1	mucin 1, cell surface associated	0.032
IGFBP3	insulin-like growth factor binding protein 3	0.032
NCOR2	nuclear receptor corepressor 2	0.031
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.030
CAPRIN2	caprin family member 2	0.030
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.030
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.030
SH3KBP1	SH3-domain kinase binding protein 1	0.029
PLAUR	plasminogen activator, urokinase receptor	0.029
LRP1	low density lipoprotein receptor-related protein 1	0.029	Human
DNM1	dynamin 1	0.028
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.028
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.028
ADRBK1	adrenergic, beta, receptor kinase 1	0.027
SFN	stratifin	0.027
SORBS3	sorbin and SH3 domain containing 3	0.027
NCSTN	nicastrin	0.027
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.026
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.026
SH3D19	SH3 domain containing 19	0.026
SPTBN1	spectrin, beta, non-erythrocytic 1	0.025
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.025
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.025
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.025
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.025
LDLR	low density lipoprotein receptor	0.025
PDIA3	protein disulfide isomerase family A, member 3	0.024
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.024
MATK	megakaryocyte-associated tyrosine kinase	0.024
MED24	mediator complex subunit 24	0.023
NCOA3	nuclear receptor coactivator 3	0.023
GAB1	GRB2-associated binding protein 1	0.023
MED10	mediator complex subunit 10	0.023
FHL2	four and a half LIM domains 2	0.023
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.023
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0.023
MED12	mediator complex subunit 12	0.022
SH3GL2	SH3-domain GRB2-like 2	0.022
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.022
ARRDC3	arrestin domain containing 3	0.022
ESR2	estrogen receptor 2 (ER beta)	0.021
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.021
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.021
NCK1	NCK adaptor protein 1	0.021
TRRAP	transformation/transcription domain-associated protein	0.021
SOCS1	suppressor of cytokine signaling 1	0.021	Human
CTTN	cortactin	0.020
COMMD1	copper metabolism (Murr1) domain containing 1	0.020
SNX33	sorting nexin 33	0.020
ARNT	aryl hydrocarbon receptor nuclear translocator	0.020
WASL	Wiskott-Aldrich syndrome-like	0.020
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.020
PKP4	plakophilin 4	0.020
VAV1	vav 1 guanine nucleotide exchange factor	0.019
SH3BP2	SH3-domain binding protein 2	0.019
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.019	Mouse
IGF2R	insulin-like growth factor 2 receptor	0.019
PSEN2	presenilin 2 (Alzheimer disease 4)	0.019	Mouse
TNK2	tyrosine kinase, non-receptor, 2	0.019
GRB10	growth factor receptor-bound protein 10	0.019
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.018
ADAM10	ADAM metallopeptidase domain 10	0.018
MYOZ1	myozenin 1	0.018
DAXX	death-domain associated protein	0.018
EPAS1	endothelial PAS domain protein 1	0.018
MED29	mediator complex subunit 29	0.018
EP300	E1A binding protein p300	0.018
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.018
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.018
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.017
CCDC6	coiled-coil domain containing 6	0.017
PTEN	phosphatase and tensin homolog	0.017
SH2D3A	SH2 domain containing 3A	0.017
CDK19	cyclin-dependent kinase 19	0.017
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.017
DDX4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	0.017
HDAC9	histone deacetylase 9	0.017
KNG1	kininogen 1	0.017
CHD4	chromodomain helicase DNA binding protein 4	0.017
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.017
CXXC5	CXXC finger protein 5	0.017
CIB1	calcium and integrin binding 1 (calmyrin)	0.017
HNF4A	hepatocyte nuclear factor 4, alpha	0.017
NIN	ninein (GSK3B interacting protein)	0.017
SMAD3	SMAD family member 3	0.016
MEF2A	myocyte enhancer factor 2A	0.016
JAG1	jagged 1	0.016
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.016
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.016
BAI1	brain-specific angiogenesis inhibitor 1	0.016
ARHGAP5	Rho GTPase activating protein 5	0.016
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.015
PTPRA	protein tyrosine phosphatase, receptor type, A	0.015
KAT2A	K(lysine) acetyltransferase 2A	0.015
ADAM15	ADAM metallopeptidase domain 15	0.015	Human
PROX1	prospero homeobox 1	0.015
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.015
CRMP1	collapsin response mediator protein 1	0.015
GNS	glucosamine (N-acetyl)-6-sulfatase	0.015
BAD	BCL2-associated agonist of cell death	0.015
MMS22L	MMS22-like, DNA repair protein	0.015
CD28	CD28 molecule	0.015
BLNK	B-cell linker	0.015
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.015
SH3PXD2A	SH3 and PX domains 2A	0.014
MAP1S	microtubule-associated protein 1S	0.014
IGFBP5	insulin-like growth factor binding protein 5	0.014
PTPRF	protein tyrosine phosphatase, receptor type, F	0.014
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.014
CLIC4	chloride intracellular channel 4	0.014
PITPNM1	phosphatidylinositol transfer protein, membrane-associated 1	0.014
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.014
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.014
DEDD	death effector domain containing	0.014
ACVR1	activin A receptor, type I	0.014
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.014
CUL2	cullin 2	0.014
NLGN1	neuroligin 1	0.014	Mouse Rat
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.013
VAV2	vav 2 guanine nucleotide exchange factor	0.013
TCF4	transcription factor 4	0.013
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.013	Human
SOS1	son of sevenless homolog 1 (Drosophila)	0.013
TP53BP2	tumor protein p53 binding protein, 2	0.013
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.013
CRP	C-reactive protein, pentraxin-related	0.013
MAPK11	mitogen-activated protein kinase 11	0.013
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.013
TNS4	tensin 4	0.013
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.013
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.013
TTN	titin	0.013
FAF1	Fas (TNFRSF6) associated factor 1	0.013
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.013
ADRB2	adrenergic, beta-2-, receptor, surface	0.013	Human
IRS4	insulin receptor substrate 4	0.013
SH2B1	SH2B adaptor protein 1	0.013
ELK1	ELK1, member of ETS oncogene family	0.013
KIFC2	kinesin family member C2	0.013
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.013
BTRC	beta-transducin repeat containing	0.012
CISH	cytokine inducible SH2-containing protein	0.012	Human
CABLES1	Cdk5 and Abl enzyme substrate 1	0.012
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.012
DIAPH1	diaphanous homolog 1 (Drosophila)	0.012
DOK4	docking protein 4	0.012
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.012
BAI2	brain-specific angiogenesis inhibitor 2	0.012
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.012
MAP2K1	mitogen-activated protein kinase kinase 1	0.012
TGFA	transforming growth factor, alpha	0.012
LRRK2	leucine-rich repeat kinase 2	0.012
PTPRB	protein tyrosine phosphatase, receptor type, B	0.012
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.012
FOXO1	forkhead box O1	0.012
MBL2	mannose-binding lectin (protein C) 2, soluble	0.012
TF	transferrin	0.012
RUNX1	runt-related transcription factor 1	0.012
NACAD	NAC alpha domain containing	0.012
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.012
ATXN7	ataxin 7	0.012
SOD1	superoxide dismutase 1, soluble	0.012
FYN	FYN oncogene related to SRC, FGR, YES	0.011
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.011
AHNAK	AHNAK nucleoprotein	0.011
PLXNB1	plexin B1	0.011
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.011
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.011
TRIM63	tripartite motif containing 63	0.011
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.011
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.011
CCNE1	cyclin E1	0.011
ORM1	orosomucoid 1	0.011
TRAF4	TNF receptor-associated factor 4	0.011
NRXN1	neurexin 1	0.011	Mouse
CRY1	cryptochrome 1 (photolyase-like)	0.011
MAP3K10	mitogen-activated protein kinase kinase kinase 10	0.011
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.011
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.011
MED28	mediator complex subunit 28	0.011
TNC	tenascin C	0.011
ASB2	ankyrin repeat and SOCS box containing 2	0.011
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.011
LAMA5	laminin, alpha 5	0.011
HDAC7	histone deacetylase 7	0.011
SSTR3	somatostatin receptor 3	0.011
NLGN3	neuroligin 3	0.011	Mouse
UROD	uroporphyrinogen decarboxylase	0.011
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.011
EGF	epidermal growth factor	0.011
PRNP	prion protein	0.011
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.011
NCK2	NCK adaptor protein 2	0.011
NPHP1	nephronophthisis 1 (juvenile)	0.011
GLIS2	GLIS family zinc finger 2	0.011
SH3GL3	SH3-domain GRB2-like 3	0.011
APBA3	amyloid beta (A4) precursor protein-binding, family A, member 3	0.011
UBQLN1	ubiquilin 1	0.011
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.011
WNT3A	wingless-type MMTV integration site family, member 3A	0.010
IRF3	interferon regulatory factor 3	0.010
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.010
STC2	stanniocalcin 2	0.010
PSD	pleckstrin and Sec7 domain containing	0.010
TFPI2	tissue factor pathway inhibitor 2	0.010
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.010
FOXG1	forkhead box G1	0.010
DOK6	docking protein 6	0.010
SOCS4	suppressor of cytokine signaling 4	0.010
RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	0.010
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.010
LTBP4	latent transforming growth factor beta binding protein 4	0.010
DLG2	discs, large homolog 2 (Drosophila)	0.010
THBS2	thrombospondin 2	0.010
GSK3B	glycogen synthase kinase 3 beta	0.010
E4F1	E4F transcription factor 1	0.010
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.010
TGOLN2	trans-golgi network protein 2	0.010