IMP

Process View

Homo sapiens

32 genes annotated in human

telomere maintenance

Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "telomere maintenance"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "telomere maintenance" (in gray)

Name	Description	Probability	Func Analog Organism
TERF2	telomeric repeat binding factor 2	1.000
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	1.000	Yeast
BLM	Bloom syndrome, RecQ helicase-like	0.999	Mouse
WRN	Werner syndrome, RecQ helicase-like	0.991
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.964
NBN	nibrin	0.954
H2AFX	H2A histone family, member X	0.951
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.928
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.918
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.876
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.856
BRCA1	breast cancer 1, early onset	0.810
ACD	adrenocortical dysplasia homolog (mouse)	0.762
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.703
RAD51C	RAD51 homolog C (S. cerevisiae)	0.667
RIF1	RAP1 interacting factor homolog (yeast)	0.659
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.535
RAD50	RAD50 homolog (S. cerevisiae)	0.519
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.503	Fly
FANCD2	Fanconi anemia, complementation group D2	0.492
OSGEP	O-sialoglycoprotein endopeptidase	0.479	Yeast
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.445
EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.436
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.415
ATM	ataxia telangiectasia mutated	0.410	Fly
MSH6	mutS homolog 6 (E. coli)	0.353
TOP3A	topoisomerase (DNA) III alpha	0.290
TERT	telomerase reverse transcriptase	0.244
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.242
MSH3	mutS homolog 3 (E. coli)	0.239
XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	0.236
RPA2	replication protein A2, 32kDa	0.221
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.208
C19orf39	chromosome 19 open reading frame 39	0.202
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.201
FANCA	Fanconi anemia, complementation group A	0.198
HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	0.195
YY1	YY1 transcription factor	0.176
ORC2	origin recognition complex, subunit 2	0.162
RAD18	RAD18 homolog (S. cerevisiae)	0.153
ORC1	origin recognition complex, subunit 1	0.147
PCNA	proliferating cell nuclear antigen	0.146
C20orf94	chromosome 20 open reading frame 94	0.135
WDR5	WD repeat domain 5	0.114
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.114
SP100	SP100 nuclear antigen	0.110
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.109
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.108
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.108
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.101
SMG1	SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)	0.099
MYST1	MYST histone acetyltransferase 1	0.098
INO80E	INO80 complex subunit E	0.096
RAD17	RAD17 homolog (S. pombe)	0.088
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.086	Yeast
HLTF	helicase-like transcription factor	0.079
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.079
RECQL4	RecQ protein-like 4	0.069
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.067
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.063
NAP1L1	nucleosome assembly protein 1-like 1	0.055
HUS1	HUS1 checkpoint homolog (S. pombe)	0.049
CDK2	cyclin-dependent kinase 2	0.049
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.049
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.048
RAD52	RAD52 homolog (S. cerevisiae)	0.047	Yeast
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.046
AFF1	AF4/FMR2 family, member 1	0.045
POGZ	pogo transposable element with ZNF domain	0.042
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.041
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.040
YAF2	YY1 associated factor 2	0.040
RBL1	retinoblastoma-like 1 (p107)	0.037
RBBP8	retinoblastoma binding protein 8	0.037
ACTR5	ARP5 actin-related protein 5 homolog (yeast)	0.037
SLX1B	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)	0.034
AFF4	AF4/FMR2 family, member 4	0.031
TOPBP1	topoisomerase (DNA) II binding protein 1	0.031
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.030
BARD1	BRCA1 associated RING domain 1	0.030
MDC1	mediator of DNA-damage checkpoint 1	0.028
CCNT1	cyclin T1	0.028
SMG6	Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.028
POLQ	polymerase (DNA directed), theta	0.028
PRIM2	primase, DNA, polypeptide 2 (58kDa)	0.027
PARP1	poly (ADP-ribose) polymerase 1	0.027	Mouse
CHTF18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.027
RNF20	ring finger protein 20	0.026
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.026
ZNF775	zinc finger protein 775	0.025
STAG1	stromal antigen 1	0.025
EXO1	exonuclease 1	0.025	Yeast
RMI1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)	0.025
BRCA2	breast cancer 2, early onset	0.024
SKP1	S-phase kinase-associated protein 1	0.024
DAXX	death-domain associated protein	0.024
ACTR8	ARP8 actin-related protein 8 homolog (yeast)	0.023
LNPEP	leucyl/cystinyl aminopeptidase	0.023
LAGE3	L antigen family, member 3	0.023
PML	promyelocytic leukemia	0.022
TAF2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	0.022
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.022
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.022
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.021
E2F1	E2F transcription factor 1	0.021
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.021
DTL	denticleless homolog (Drosophila)	0.021
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.021
C19orf61	chromosome 19 open reading frame 61	0.019
NMI	N-myc (and STAT) interactor	0.019
CUL1	cullin 1	0.019
CASP8AP2	caspase 8 associated protein 2	0.019
CCNE1	cyclin E1	0.019
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.019
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.019
TP53RK	TP53 regulating kinase	0.019	Yeast
CDCA7	cell division cycle associated 7	0.018
H1F0	H1 histone family, member 0	0.018
TGIF1	TGFB-induced factor homeobox 1	0.018
C16orf59	chromosome 16 open reading frame 59	0.018
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.018
SMC1A	structural maintenance of chromosomes 1A	0.018
SIP1	survival of motor neuron protein interacting protein 1	0.017
LENG1	leukocyte receptor cluster (LRC) member 1	0.017
FAM190B	family with sequence similarity 190, member B	0.017
HCFC1	host cell factor C1 (VP16-accessory protein)	0.017
RNF19A	ring finger protein 19A	0.017
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.017
PLK1	polo-like kinase 1	0.017
MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.016
CBX1	chromobox homolog 1	0.016	Fly
SP140L	SP140 nuclear body protein-like	0.016	Human
CLSPN	claspin	0.016
IFI16	interferon, gamma-inducible protein 16	0.016
FKBP3	FK506 binding protein 3, 25kDa	0.016
RPAP3	RNA polymerase II associated protein 3	0.016
ADAR	adenosine deaminase, RNA-specific	0.016
DDX20	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	0.016
TBCD	tubulin folding cofactor D	0.015
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.015
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.015
C19orf60	chromosome 19 open reading frame 60	0.015
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.015
PSIP1	PC4 and SFRS1 interacting protein 1	0.015
DCLRE1B	DNA cross-link repair 1B	0.014
INO80D	INO80 complex subunit D	0.014
BANP	BTG3 associated nuclear protein	0.014
MUS81	MUS81 endonuclease homolog (S. cerevisiae)	0.014
MAPK7	mitogen-activated protein kinase 7	0.014
TRIM21	tripartite motif containing 21	0.014
NVL	nuclear VCP-like	0.014
RPA1	replication protein A1, 70kDa	0.014
ATR	ataxia telangiectasia and Rad3 related	0.013	Yeast Fly
NEIL3	nei endonuclease VIII-like 3 (E. coli)	0.013
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.013
NCAPH2	non-SMC condensin II complex, subunit H2	0.013
RPA3	replication protein A3, 14kDa	0.013
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.013
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.013
TPRKB	TP53RK binding protein	0.013
PARP12	poly (ADP-ribose) polymerase family, member 12	0.013
CBX5	chromobox homolog 5	0.013	Fly
DDB1	damage-specific DNA binding protein 1, 127kDa	0.013
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.013
CREB1	cAMP responsive element binding protein 1	0.013
CDK6	cyclin-dependent kinase 6	0.013
C18orf54	chromosome 18 open reading frame 54	0.012
C1orf135	chromosome 1 open reading frame 135	0.012
SH3BP2	SH3-domain binding protein 2	0.012
FNBP1	formin binding protein 1	0.012
HIST2H3C	histone cluster 2, H3c	0.012
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.012
TCOF1	Treacher Collins-Franceschetti syndrome 1	0.012
APLF	aprataxin and PNKP like factor	0.012
ACTL6A	actin-like 6A	0.012
RFC1	replication factor C (activator 1) 1, 145kDa	0.012
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.012
ADNP2	ADNP homeobox 2	0.012
SPRED1	sprouty-related, EVH1 domain containing 1	0.011
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.011
CHD8	chromodomain helicase DNA binding protein 8	0.011
MUTYH	mutY homolog (E. coli)	0.011
TRMT61A	tRNA methyltransferase 61 homolog A (S. cerevisiae)	0.011
FBXO4	F-box protein 4	0.011
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.011
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.011	Yeast
SAMD9	sterile alpha motif domain containing 9	0.011
ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4	0.011
MAPK14	mitogen-activated protein kinase 14	0.011
RYBP	RING1 and YY1 binding protein	0.011
XPC	xeroderma pigmentosum, complementation group C	0.011
SGOL1	shugoshin-like 1 (S. pombe)	0.011
APTX	aprataxin	0.011
TRIM14	tripartite motif containing 14	0.010
RAD54B	RAD54 homolog B (S. cerevisiae)	0.010
MAX	MYC associated factor X	0.010
PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	0.010
DSCC1	defective in sister chromatid cohesion 1 homolog (S. cerevisiae)	0.010
PHF11	PHD finger protein 11	0.010
WIZ	widely interspaced zinc finger motifs	0.010