IMP

Process View

Mus musculus

25 genes annotated in mouse

Multi-species View

melanocyte differentiation

GO:0030318

The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "melanocyte differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "melanocyte differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Mitf	microphthalmia-associated transcription factor	1.000
Lyst	lysosomal trafficking regulator	1.000
Kit	kit oncogene	1.000
a	nonagouti	0.998
Trp53	transformation related protein 53	0.998
Pax3	paired box gene 3	0.997
Rab27a	RAB27A, member RAS oncogene family	0.996
Gli3	GLI-Kruppel family member GLI3	0.996
Hps1	Hermansky-Pudlak syndrome 1 homolog (human)	0.996
Tyrp1	tyrosinase-related protein 1	0.996
Pax6	paired box gene 6	0.990
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.990
Sox9	SRY-box containing gene 9	0.987	Mouse
Tyr	tyrosinase	0.985	Mouse
Ednrb	endothelin receptor type B	0.984
Oca2	oculocutaneous albinism II	0.961
Prrx1	paired related homeobox 1	0.958
Sox2	SRY-box containing gene 2	0.953	Mouse
Bmp4	bone morphogenetic protein 4	0.937
Vegfa	vascular endothelial growth factor A	0.929
Fgfr2	fibroblast growth factor receptor 2	0.906
Runx2	runt related transcription factor 2	0.906
Kdr	kinase insert domain protein receptor	0.895	Mouse
Ap3b1	adaptor-related protein complex 3, beta 1 subunit	0.883
Tcfap2a	transcription factor AP-2, alpha	0.877	Zebrafish
Fgf8	fibroblast growth factor 8	0.854
Foxc2	forkhead box C2	0.841
Psen1	presenilin 1	0.812	Zebrafish
Hps6	Hermansky-Pudlak syndrome 6	0.807
Pou5f1	POU domain, class 5, transcription factor 1	0.793
Pten	phosphatase and tensin homolog	0.791
Notch2	Notch gene homolog 2 (Drosophila)	0.756
Pitx2	paired-like homeodomain transcription factor 2	0.740
Bax	BCL2-associated X protein	0.725	Mouse
Hand1	heart and neural crest derivatives expressed transcript 1	0.671
Rarb	retinoic acid receptor, beta	0.663
Meox2	mesenchyme homeobox 2	0.645
Gli2	GLI-Kruppel family member GLI2	0.635	Mouse
Msx2	homeobox, msh-like 2	0.623
Ap3d1	adaptor-related protein complex 3, delta 1 subunit	0.606
Tgfb2	transforming growth factor, beta 2	0.585
Cno	cappuccino	0.578
Hps5	Hermansky-Pudlak syndrome 5 homolog (human)	0.550
Mef2c	myocyte enhancer factor 2C	0.548
Mlph	melanophilin	0.544
Msx1	homeobox, msh-like 1	0.540
Bcl2	B-cell leukemia/lymphoma 2	0.523
Foxc1	forkhead box C1	0.520
Shh	sonic hedgehog	0.515
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.492	Mouse
Prf1	perforin 1 (pore forming protein)	0.489
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.439
Cd2ap	CD2-associated protein	0.397
Tgfb1	transforming growth factor, beta 1	0.370
Notch1	Notch gene homolog 1 (Drosophila)	0.364
Qk	quaking	0.358
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.354
Fgfr1	fibroblast growth factor receptor 1	0.311
Sall4	sal-like 4 (Drosophila)	0.308
Hdac4	histone deacetylase 4	0.301
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.297
Prrx2	paired related homeobox 2	0.279
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.270
Kitl	kit ligand	0.258
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.257
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.255
Eya1	eyes absent 1 homolog (Drosophila)	0.245
Alx4	aristaless-like homeobox 4	0.241
Myo5a	myosin VA	0.239
Csf1	colony stimulating factor 1 (macrophage)	0.227
Rasip1	Ras interacting protein 1	0.226
Ren1	renin 1 structural	0.203
Pmel	premelanosome protein	0.201
Bmp7	bone morphogenetic protein 7	0.189
Isl1	ISL1 transcription factor, LIM/homeodomain	0.178
Cbl	Casitas B-lineage lymphoma	0.174
Fzd4	frizzled homolog 4 (Drosophila)	0.171
Ctnnb1	catenin (cadherin associated protein), beta 1	0.162
Smo	smoothened homolog (Drosophila)	0.147
Mn1	meningioma 1	0.140
Sox10	SRY-box containing gene 10	0.129
Usp8	ubiquitin specific peptidase 8	0.127
Hand2	heart and neural crest derivatives expressed transcript 2	0.125
Ret	ret proto-oncogene	0.125
Eda	ectodysplasin-A	0.124
Cdh5	cadherin 5	0.120
Bmper	BMP-binding endothelial regulator	0.120
Pbx1	pre B-cell leukemia transcription factor 1	0.119
Nf1	neurofibromatosis 1	0.115
Sox11	SRY-box containing gene 11	0.115	Mouse
Muted	muted	0.110
Pldn	pallidin	0.103
Sox4	SRY-box containing gene 4	0.097	Mouse
Acvr1	activin A receptor, type 1	0.091
Rara	retinoic acid receptor, alpha	0.091
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.088
Wdr26	WD repeat domain 26	0.087
Flt4	FMS-like tyrosine kinase 4	0.082	Mouse
Vegfc	vascular endothelial growth factor C	0.080
Fgf10	fibroblast growth factor 10	0.080
Ednra	endothelin receptor type A	0.080	Mouse
Insm1	insulinoma-associated 1	0.077
Igf2	insulin-like growth factor 2	0.076
Smad3	MAD homolog 3 (Drosophila)	0.070
Sox3	SRY-box containing gene 3	0.068	Mouse
Rab38	RAB38, member of RAS oncogene family	0.065
Pcp2	Purkinje cell protein 2 (L7)	0.064
Gna13	guanine nucleotide binding protein, alpha 13	0.062	Mouse
Alx1	ALX homeobox 1	0.061
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.060
Nos3	nitric oxide synthase 3, endothelial cell	0.060
Ikzf1	IKAROS family zinc finger 1	0.059
Fgfr3	fibroblast growth factor receptor 3	0.057
Emcn	endomucin	0.057
Col1a1	collagen, type I, alpha 1	0.056
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.055
Flt1	FMS-like tyrosine kinase 1	0.054	Mouse
Grb10	growth factor receptor bound protein 10	0.052
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.052
Hdac7	histone deacetylase 7	0.052
Wsb1	WD repeat and SOCS box-containing 1	0.050
Myh9	myosin, heavy polypeptide 9, non-muscle	0.049
Foxd1	forkhead box D1	0.049
Gsc	goosecoid homeobox	0.048
Hps3	Hermansky-Pudlak syndrome 3 homolog (human)	0.048
Aplnr	apelin receptor	0.048
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.048
Ece1	endothelin converting enzyme 1	0.047
Dlx5	distal-less homeobox 5	0.047
Dll1	delta-like 1 (Drosophila)	0.046
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.046
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.046
Klf6	Kruppel-like factor 6	0.045
Twist2	twist homolog 2 (Drosophila)	0.045
Sall1	sal-like 1 (Drosophila)	0.045
Sall3	sal-like 3 (Drosophila)	0.045
Hdac5	histone deacetylase 5	0.043
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.042
Bak1	BCL2-antagonist/killer 1	0.041	Mouse
Ptch1	patched homolog 1	0.041
Sox7	SRY-box containing gene 7	0.040	Mouse
Yap1	yes-associated protein 1	0.039
Neurog3	neurogenin 3	0.039
Trap1a	tumor rejection antigen P1A	0.037
Foxi3	forkhead box I3	0.037
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.036
Bmp2	bone morphogenetic protein 2	0.035
Otx2	orthodenticle homolog 2 (Drosophila)	0.035
Zic3	zinc finger protein of the cerebellum 3	0.035
Hoxa5	homeobox A5	0.035
Tbx2	T-box 2	0.034
Mef2d	myocyte enhancer factor 2D	0.034	Mouse
Gata6	GATA binding protein 6	0.033
Cav1	caveolin 1, caveolae protein	0.032
Jag1	jagged 1	0.032
Eng	endoglin	0.031
Klf7	Kruppel-like factor 7 (ubiquitous)	0.030
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.028
Tcf4	transcription factor 4	0.028
Pthlh	parathyroid hormone-like peptide	0.028
Ldb2	LIM domain binding 2	0.028
Plac1	placental specific protein 1	0.027
Fuz	fuzzy homolog (Drosophila)	0.027
Pkd1	polycystic kidney disease 1 homolog	0.027
Col4a2	collagen, type IV, alpha 2	0.026
She	src homology 2 domain-containing transforming protein E	0.026
Mab21l2	mab-21-like 2 (C. elegans)	0.026
Col2a1	collagen, type II, alpha 1	0.026
Notch3	Notch gene homolog 3 (Drosophila)	0.026
Cpd	carboxypeptidase D	0.025
Gdnf	glial cell line derived neurotrophic factor	0.025
Ptch2	patched homolog 2	0.025
Slc24a5	solute carrier family 24, member 5	0.025	Zebrafish
Chd7	chromodomain helicase DNA binding protein 7	0.025
Ldlr	low density lipoprotein receptor	0.025
Pomc	pro-opiomelanocortin-alpha	0.024
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.024
Nanog	Nanog homeobox	0.024
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.023
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.023
Mgrn1	mahogunin, ring finger 1	0.023
Hes1	hairy and enhancer of split 1 (Drosophila)	0.023
Ppard	peroxisome proliferator activator receptor delta	0.023
Tcf21	transcription factor 21	0.023
Mcoln3	mucolipin 3	0.023
Syt9	synaptotagmin IX	0.023
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.022
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.022
Pdgfb	platelet derived growth factor, B polypeptide	0.022
Efnb2	ephrin B2	0.022
Smad6	MAD homolog 6 (Drosophila)	0.022
Hesx1	homeobox gene expressed in ES cells	0.022
Esam	endothelial cell-specific adhesion molecule	0.022
Rbm39	RNA binding motif protein 39	0.022
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.021
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.021
Cdh11	cadherin 11	0.021
Ptrf	polymerase I and transcript release factor	0.021
Ptf1a	pancreas specific transcription factor, 1a	0.021
Pip5k1b	phosphatidylinositol-4-phosphate 5-kinase, type 1 beta	0.020
Hif1a	hypoxia inducible factor 1, alpha subunit	0.020
Col4a1	collagen, type IV, alpha 1	0.020
Tbx3	T-box 3	0.020
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.020
Chuk	conserved helix-loop-helix ubiquitous kinase	0.020
Hapln3	hyaluronan and proteoglycan link protein 3	0.020
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.019
Skor1	SKI family transcriptional corepressor 1	0.019
Dtnbp1	dystrobrevin binding protein 1	0.019
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.019
Dll4	delta-like 4 (Drosophila)	0.019
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.018
Ptprm	protein tyrosine phosphatase, receptor type, M	0.018
Bcl2l1	BCL2-like 1	0.018	Mouse
Ebf3	early B-cell factor 3	0.017
Bbc3	BCL2 binding component 3	0.017
Cldn5	claudin 5	0.017
Foxg1	forkhead box G1	0.017
Apaf1	apoptotic peptidase activating factor 1	0.017
Ptprb	protein tyrosine phosphatase, receptor type, B	0.017
Zfp503	zinc finger protein 503	0.017
Cyld	cylindromatosis (turban tumor syndrome)	0.016
Foxf2	forkhead box F2	0.016
Ski	ski sarcoma viral oncogene homolog (avian)	0.016
Nppb	natriuretic peptide type B	0.016
Mc1r	melanocortin 1 receptor	0.016
Ddx3x	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked	0.016
Fhl3	four and a half LIM domains 3	0.016
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.016
Fli1	Friend leukemia integration 1	0.016
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.016
Crebbp	CREB binding protein	0.016
Gata2	GATA binding protein 2	0.016
Ncoa3	nuclear receptor coactivator 3	0.016
Tcfap2c	transcription factor AP-2, gamma	0.016
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.015
Csf3	colony stimulating factor 3 (granulocyte)	0.015
Npr3	natriuretic peptide receptor 3	0.015
Cux1	cut-like homeobox 1	0.015
Sp1	trans-acting transcription factor 1	0.015
Edar	ectodysplasin-A receptor	0.015
Bdkrb2	bradykinin receptor, beta 2	0.015
Hoxa3	homeobox A3	0.015
Twist1	twist homolog 1 (Drosophila)	0.015
Sox15	SRY-box containing gene 15	0.015	Mouse
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.014
Tmem204	transmembrane protein 204	0.014
Sirpa	signal-regulatory protein alpha	0.014
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.014
Bmp8a	bone morphogenetic protein 8a	0.014
5730559C18Rik	RIKEN cDNA 5730559C18 gene	0.014
Gpr124	G protein-coupled receptor 124	0.014
Tbx15	T-box 15	0.014
Drd4	dopamine receptor D4	0.014
Adamts2	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2	0.014
Acvr2b	activin receptor IIB	0.014
2810422J05Rik	RIKEN cDNA 2810422J05 gene	0.014
Rgs5	regulator of G-protein signaling 5	0.014
Wwtr1	WW domain containing transcription regulator 1	0.014
Fyn	Fyn proto-oncogene	0.014
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.014
Epas1	endothelial PAS domain protein 1	0.013
Mta1	metastasis associated 1	0.013
Kctd12	potassium channel tetramerisation domain containing 12	0.013
Zic2	zinc finger protein of the cerebellum 2	0.013
Crxos1	Crx opposite strand transcript 1	0.013
Plvap	plasmalemma vesicle associated protein	0.013
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.013
Smad1	MAD homolog 1 (Drosophila)	0.013
Vangl2	vang-like 2 (van gogh, Drosophila)	0.013
Pou3f3	POU domain, class 3, transcription factor 3	0.013
Il6st	interleukin 6 signal transducer	0.013
Hipk2	homeodomain interacting protein kinase 2	0.013	Zebrafish
Lyz2	lysozyme 2	0.013
Mfn2	mitofusin 2	0.013
Tbk1	TANK-binding kinase 1	0.012
Ephb2	Eph receptor B2	0.012
Lpo	lactoperoxidase	0.012
Krt32	keratin 32	0.012
Ctbp1	C-terminal binding protein 1	0.012
Tmem119	transmembrane protein 119	0.012
Rbms1	RNA binding motif, single stranded interacting protein 1	0.012
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.012
Cxcl12	chemokine (C-X-C motif) ligand 12	0.012
Tnfaip6	tumor necrosis factor alpha induced protein 6	0.012
Igfbpl1	insulin-like growth factor binding protein-like 1	0.012
Plxnd1	plexin D1	0.012
Hip1	huntingtin interacting protein 1	0.012
Fgf4	fibroblast growth factor 4	0.012
Mdm2	transformed mouse 3T3 cell double minute 2	0.012
Gna12	guanine nucleotide binding protein, alpha 12	0.012	Mouse
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.012
Id1	inhibitor of DNA binding 1	0.011
Sytl5	synaptotagmin-like 5	0.011
Tead4	TEA domain family member 4	0.011
Insr	insulin receptor	0.011
Tcstv1	2-cell-stage, variable group, member 1	0.011
Tek	endothelial-specific receptor tyrosine kinase	0.011
Hoxb4	homeobox B4	0.011
Svs5	seminal vesicle secretory protein 5	0.011
Rarg	retinoic acid receptor, gamma	0.011
Gpd2	glycerol phosphate dehydrogenase 2, mitochondrial	0.011
Sox13	SRY-box containing gene 13	0.011
Edn1	endothelin 1	0.011	Mouse
Gbx2	gastrulation brain homeobox 2	0.011
Otog	otogelin	0.011
Col13a1	collagen, type XIII, alpha 1	0.011
Ctgf	connective tissue growth factor	0.011
Pcdha10	protocadherin alpha 10	0.011
Hoxd3	homeobox D3	0.011
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.011
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.011
Trp73	transformation related protein 73	0.011
Hrh2	histamine receptor H2	0.011
Abcd1	ATP-binding cassette, sub-family D (ALD), member 1	0.011
Bach1	BTB and CNC homology 1	0.011
Cdk14	cyclin-dependent kinase 14	0.011
Igh	immunoglobulin heavy chain complex	0.011
Car6	carbonic anhydrase 6	0.011
Wnt6	wingless-related MMTV integration site 6	0.011
Slc45a2	solute carrier family 45, member 2	0.010
Fstl1	follistatin-like 1	0.010
Btg1	B-cell translocation gene 1, anti-proliferative	0.010
Zeb1	zinc finger E-box binding homeobox 1	0.010	Mouse
Lefty1	left right determination factor 1	0.010
Shbg	sex hormone binding globulin	0.010
Thbd	thrombomodulin	0.010
Pitx1	paired-like homeodomain transcription factor 1	0.010
Slc4a7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	0.010
Gm14743	predicted gene 14743	0.010
Hhex	hematopoietically expressed homeobox	0.010
Plxna2	plexin A2	0.010
Neurog2	neurogenin 2	0.010
Hoxa2	homeobox A2	0.010
Gas1	growth arrest specific 1	0.010
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.010
Eif2c2	eukaryotic translation initiation factor 2C, 2	0.010
Ncstn	nicastrin	0.010
Wwc2	WW, C2 and coiled-coil domain containing 2	0.010
Cckar	cholecystokinin A receptor	0.010