IMP

Process View

Mus musculus

2 genes annotated in mouse

microtubule nucleation

The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "microtubule nucleation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "microtubule nucleation" (in gray)

Name	Description	Probability	Func Analog Organism
Pafah1b1	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1	1.000
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.978
Dcx	doublecortin	0.970	Worm
Dclk1	doublecortin-like kinase 1	0.969	Worm
Macf1	microtubule-actin crosslinking factor 1	0.936
Mis18bp1	MIS18 binding protein 1	0.731
Kif2c	kinesin family member 2C	0.393	Worm
Cenpf	centromere protein F	0.392
Th1l	TH1-like homolog (Drosophila)	0.367
Reln	reelin	0.349
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.336
Lancl2	LanC (bacterial lantibiotic synthetase component C)-like 2	0.280
Clip1	CAP-GLY domain containing linker protein 1	0.232
Fam54a	family with sequence similarity 54, member A	0.219
Kif4	kinesin family member 4	0.191
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.149
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.139
Aurkb	aurora kinase B	0.129
Spag5	sperm associated antigen 5	0.129
Fam64a	family with sequence similarity 64, member A	0.129
Casc5	cancer susceptibility candidate 5	0.121
Emx1	empty spiracles homolog 1 (Drosophila)	0.113
Kif23	kinesin family member 23	0.106
Dync1i1	dynein cytoplasmic 1 intermediate chain 1	0.106
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.102
Plk1	polo-like kinase 1 (Drosophila)	0.095	Fly
Cenpm	centromere protein M	0.091
Ctcf	CCCTC-binding factor	0.090
Ckap2	cytoskeleton associated protein 2	0.083
Ckap5	cytoskeleton associated protein 5	0.076
Rad21	RAD21 homolog (S. pombe)	0.073
Ckap2l	cytoskeleton associated protein 2-like	0.072
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.072
Fam83d	family with sequence similarity 83, member D	0.070
Aurka	aurora kinase A	0.065
Mastl	microtubule associated serine/threonine kinase-like	0.064
Ska1	spindle and kinetochore associated complex subunit 1	0.063
Trim59	tripartite motif-containing 59	0.060
Fanci	Fanconi anemia, complementation group I	0.060
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.058
Cdkn3	cyclin-dependent kinase inhibitor 3	0.057
Ndufc2	NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2	0.057
0610010K14Rik	RIKEN cDNA 0610010K14 gene	0.057
Iqgap3	IQ motif containing GTPase activating protein 3	0.054
Dtl	denticleless homolog (Drosophila)	0.054
Racgap1	Rac GTPase-activating protein 1	0.053
Mtap1b	microtubule-associated protein 1B	0.052
Troap	trophinin associated protein	0.051
Neil3	nei like 3 (E. coli)	0.050
Tmpo	thymopoietin	0.050
Kpna3	karyopherin (importin) alpha 3	0.050
Kif20a	kinesin family member 20A	0.049
Dynll1	dynein light chain LC8-type 1	0.049
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.049	Fly
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.049
Ccnf	cyclin F	0.048
Foxm1	forkhead box M1	0.048
Rangap1	RAN GTPase activating protein 1	0.047
Sae1	SUMO1 activating enzyme subunit 1	0.046
Ccnb1	cyclin B1	0.046
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.045
Hcfc1	host cell factor C1	0.044
Ncaph	non-SMC condensin I complex, subunit H	0.043
Kif11	kinesin family member 11	0.041
Cdca2	cell division cycle associated 2	0.041
Cbx5	chromobox homolog 5 (Drosophila HP1a)	0.041
Rev3l	REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)	0.040
Fbxo45	F-box protein 45	0.040
Ncapd2	non-SMC condensin I complex, subunit D2	0.039
Acot7	acyl-CoA thioesterase 7	0.039
Mgea5	meningioma expressed antigen 5 (hyaluronidase)	0.038
Son	Son DNA binding protein	0.037
Sec61a2	Sec61, alpha subunit 2 (S. cerevisiae)	0.035
Pold2	polymerase (DNA directed), delta 2, regulatory subunit	0.035
Top2a	topoisomerase (DNA) II alpha	0.034
Asna1	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	0.034
Clasp2	CLIP associating protein 2	0.034	Human
Usp8	ubiquitin specific peptidase 8	0.034
Sf3b2	splicing factor 3b, subunit 2	0.034
Fancm	Fanconi anemia, complementation group M	0.033
Traf7	TNF receptor-associated factor 7	0.033
Cdca3	cell division cycle associated 3	0.033
Dido1	death inducer-obliterator 1	0.032
Nsmaf	neutral sphingomyelinase (N-SMase) activation associated factor	0.031
Tcerg1	transcription elongation regulator 1 (CA150)	0.031
Top2b	topoisomerase (DNA) II beta	0.030
Wdr37	WD repeat domain 37	0.030
Parp1	poly (ADP-ribose) polymerase family, member 1	0.030
Anln	anillin, actin binding protein	0.030
Ccnb2	cyclin B2	0.030
Tdp1	tyrosyl-DNA phosphodiesterase 1	0.030
Nusap1	nucleolar and spindle associated protein 1	0.030
Haus4	HAUS augmin-like complex, subunit 4	0.029
Cstf2	cleavage stimulation factor, 3' pre-RNA subunit 2	0.029
Rrm1	ribonucleotide reductase M1	0.029
Cenpa	centromere protein A	0.028
Gtse1	G two S phase expressed protein 1	0.028
Kif18b	kinesin family member 18B	0.028
Mapk8	mitogen-activated protein kinase 8	0.028
Pif1	PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)	0.028
Depdc1b	DEP domain containing 1B	0.027
Nxf1	nuclear RNA export factor 1 homolog (S. cerevisiae)	0.027
Pitpnc1	phosphatidylinositol transfer protein, cytoplasmic 1	0.027
Prr11	proline rich 11	0.027
Cdca8	cell division cycle associated 8	0.027
Xrn2	5'-3' exoribonuclease 2	0.026
Rb1	retinoblastoma 1	0.026
Cdc7	cell division cycle 7 (S. cerevisiae)	0.025
Gtf2a1	general transcription factor II A, 1	0.025
Ppp5c	protein phosphatase 5, catalytic subunit	0.025
Cdk1	cyclin-dependent kinase 1	0.025
Taf1b	TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B	0.025
Mdm1	transformed mouse 3T3 cell double minute 1	0.025
Ccna2	cyclin A2	0.025
Mxd3	Max dimerization protein 3	0.024
Lmnb1	lamin B1	0.024
Csde1	cold shock domain containing E1, RNA binding	0.024
Mapre1	microtubule-associated protein, RP/EB family, member 1	0.024
Otud4	OTU domain containing 4	0.024
Hdac3	histone deacetylase 3	0.024
Adsl	adenylosuccinate lyase	0.024
Fmr1	fragile X mental retardation syndrome 1 homolog	0.023
5730590G19Rik	RIKEN cDNA 5730590G19 gene	0.023
Psrc1	proline/serine-rich coiled-coil 1	0.023
Mcrs1	microspherule protein 1	0.023
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.023
Mcm10	minichromosome maintenance deficient 10 (S. cerevisiae)	0.023
Zfx	zinc finger protein X-linked	0.022
Mllt3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	0.022
R3hdm1	R3H domain 1 (binds single-stranded nucleic acids)	0.021
Incenp	inner centromere protein	0.021
1110004F10Rik	RIKEN cDNA 1110004F10 gene	0.021
Ttk	Ttk protein kinase	0.021
Ube2c	ubiquitin-conjugating enzyme E2C	0.021
Akt3	thymoma viral proto-oncogene 3	0.020
Neurod6	neurogenic differentiation 6	0.020
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.020
Pcdhb16	protocadherin beta 16	0.020
Kif22	kinesin family member 22	0.020
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.020
Kat5	K(lysine) acetyltransferase 5	0.019
Tbc1d4	TBC1 domain family, member 4	0.019
Xpr1	xenotropic and polytropic retrovirus receptor 1	0.019
Mbd3	methyl-CpG binding domain protein 3	0.019
Abhd8	abhydrolase domain containing 8	0.019
E2f1	E2F transcription factor 1	0.019
Smc2	structural maintenance of chromosomes 2	0.019
Pnn	pinin	0.019
1500010J02Rik	RIKEN cDNA 1500010J02 gene	0.019
Ptbp2	polypyrimidine tract binding protein 2	0.019
Pcdhb3	protocadherin beta 3	0.018
1700040I03Rik	RIKEN cDNA 1700040I03 gene	0.018
Herc1	hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1	0.018
Mlf2	myeloid leukemia factor 2	0.018
Nt5dc2	5'-nucleotidase domain containing 2	0.018
Ubr7	ubiquitin protein ligase E3 component n-recognin 7 (putative)	0.018
Smc3	structural maintenace of chromosomes 3	0.018
2610021K21Rik	RIKEN cDNA 2610021K21 gene	0.017
Camk4	calcium/calmodulin-dependent protein kinase IV	0.017
Cdc27	cell division cycle 27 homolog (S. cerevisiae)	0.017
Clvs1	clavesin 1	0.017
Med27	mediator complex subunit 27	0.017
E130306D19Rik	RIKEN cDNA E130306D19 gene	0.017
Prpf8	pre-mRNA processing factor 8	0.017
Nrsn1	neurensin 1	0.017
Tpx2	TPX2, microtubule-associated protein homolog (Xenopus laevis)	0.017
Polr3c	polymerase (RNA) III (DNA directed) polypeptide C	0.017
Tacc3	transforming, acidic coiled-coil containing protein 3	0.017
Hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.017
Adss	adenylosuccinate synthetase, non muscle	0.016
Usp15	ubiquitin specific peptidase 15	0.016
Ndufa1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1	0.016
Taf4a	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.016
Zc3hc1	zinc finger, C3HC type 1	0.016
Prc1	protein regulator of cytokinesis 1	0.016
Rgs7	regulator of G protein signaling 7	0.016
Nedd1	neural precursor cell expressed, developmentally down-regulated gene 1	0.016
Tti1	Tel2 interacting protein 1 homolog (S. pombe)	0.016
Vac14	Vac14 homolog (S. cerevisiae)	0.016
H2afx	H2A histone family, member X	0.016
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.016
Arhgap21	Rho GTPase activating protein 21	0.016
Nutf2	nuclear transport factor 2	0.016
Cep170	centrosomal protein 170	0.016
Cul3	cullin 3	0.016
Clasp1	CLIP associating protein 1	0.016	Human
4930427A07Rik	RIKEN cDNA 4930427A07 gene	0.016
Rad51c	RAD51 homolog c (S. cerevisiae)	0.015
Dync1h1	dynein cytoplasmic 1 heavy chain 1	0.015
Rnaseh2a	ribonuclease H2, large subunit	0.015
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.015
Stip1	stress-induced phosphoprotein 1	0.015
Cep55	centrosomal protein 55	0.015
Sun1	Sad1 and UNC84 domain containing 1	0.015
Cdca5	cell division cycle associated 5	0.015
Trip12	thyroid hormone receptor interactor 12	0.015
Pak3	p21 protein (Cdc42/Rac)-activated kinase 3	0.015
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.015
Hnrnpd	heterogeneous nuclear ribonucleoprotein D	0.015
Serpini1	serine (or cysteine) peptidase inhibitor, clade I, member 1	0.015
Eme1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.015
Mybl2	myeloblastosis oncogene-like 2	0.015
BC030867	cDNA sequence BC030867	0.015
Ube2n	ubiquitin-conjugating enzyme E2N	0.015
Ctbp1	C-terminal binding protein 1	0.015
Pcdhb7	protocadherin beta 7	0.015
Rhag	Rhesus blood group-associated A glycoprotein	0.015
Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.015
Cdk5rap2	CDK5 regulatory subunit associated protein 2	0.014
Dnm3	dynamin 3	0.014
Ubqln2	ubiquilin 2	0.014
Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.014
Myo5a	myosin VA	0.014
Suv39h1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.014
2510012J08Rik	RIKEN cDNA 2510012J08 gene	0.014
Actr1a	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	0.014
5430437P03Rik	RIKEN cDNA 5430437P03 gene	0.014
Kif18a	kinesin family member 18A	0.014
Pcdhb21	protocadherin beta 21	0.014
Wdr82	WD repeat domain containing 82	0.014
Bhlhe22	basic helix-loop-helix family, member e22	0.014
Zfp81	zinc finger protein 81	0.014
Coil	coilin	0.014
Fnbp4	formin binding protein 4	0.014
Bnip1	BCL2/adenovirus E1B interacting protein 1	0.014
Nap1l4	nucleosome assembly protein 1-like 4	0.014
Gtf3c2	general transcription factor IIIC, polypeptide 2, beta	0.014
Gdap1	ganglioside-induced differentiation-associated-protein 1	0.014
Calb1	calbindin 1	0.013
Map4k5	mitogen-activated protein kinase kinase kinase kinase 5	0.013
Diap3	diaphanous homolog 3 (Drosophila)	0.013
Oprl1	opioid receptor-like 1	0.013
Pgp	phosphoglycolate phosphatase	0.013
2610002D18Rik	RIKEN cDNA 2610002D18 gene	0.013
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.013
Siah1b	seven in absentia 1B	0.013
Rttn	rotatin	0.013
Smpd4	sphingomyelin phosphodiesterase 4	0.013
Grinl1a	glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A	0.013
Vps26b	vacuolar protein sorting 26 homolog B (yeast)	0.013
Ulk3	unc-51-like kinase 3 (C. elegans)	0.013
Kcnmb2	potassium large conductance calcium-activated channel, subfamily M, beta member 2	0.013
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.013
Dync1li1	dynein cytoplasmic 1 light intermediate chain 1	0.013
Ncaph2	non-SMC condensin II complex, subunit H2	0.013
Matr3	matrin 3	0.013
Agtpbp1	ATP/GTP binding protein 1	0.013
Ankle1	ankyrin repeat and LEM domain containing 1	0.013
Smarcb1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.013
Spire1	spire homolog 1 (Drosophila)	0.013
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.013
Scaf11	SR-related CTD-associated factor 11	0.013
C230052I12Rik	RIKEN cDNA C230052I12 gene	0.013
Sorbs2	sorbin and SH3 domain containing 2	0.013
6330503K22Rik	RIKEN cDNA 6330503K22 gene	0.013
Poc1a	POC1 centriolar protein homolog A (Chlamydomonas)	0.013
Senp1	SUMO1/sentrin specific peptidase 1	0.013
Cdh9	cadherin 9	0.013
R3hcc1	R3H domain and coiled-coil containing 1	0.013
2500003M10Rik	RIKEN cDNA 2500003M10 gene	0.013
Stil	Scl/Tal1 interrupting locus	0.013
Rap1gds1	RAP1, GTP-GDP dissociation stimulator 1	0.013
Pclo	piccolo (presynaptic cytomatrix protein)	0.012
Aaas	achalasia, adrenocortical insufficiency, alacrimia	0.012
Polq	polymerase (DNA directed), theta	0.012
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.012
Arih1	ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)	0.012
Dyrk1a	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	0.012
Drg2	developmentally regulated GTP binding protein 2	0.012
Camk2g	calcium/calmodulin-dependent protein kinase II gamma	0.012
Sms	spermine synthase	0.012
Zik1	zinc finger protein interacting with K protein 1	0.012
Nap1l2	nucleosome assembly protein 1-like 2	0.012
Trim37	tripartite motif-containing 37	0.012
Ilf2	interleukin enhancer binding factor 2	0.012
Ctnnd2	catenin (cadherin associated protein), delta 2	0.012
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.012
Gsg2	germ cell-specific gene 2	0.012
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.012
Zfp54	zinc finger protein 54	0.012
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.012
Bpgm	2,3-bisphosphoglycerate mutase	0.012
Rprd1b	regulation of nuclear pre-mRNA domain containing 1B	0.012
Wrn	Werner syndrome homolog (human)	0.012
Kif2a	kinesin family member 2A	0.011	Worm
2010317E24Rik	RIKEN cDNA 2010317E24 gene	0.011
Cenpn	centromere protein N	0.011
Anapc5	anaphase-promoting complex subunit 5	0.011
Nrp2	neuropilin 2	0.011
Saal1	serum amyloid A-like 1	0.011
Vrk1	vaccinia related kinase 1	0.011
St6galnac5	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	0.011
Mapt	microtubule-associated protein tau	0.011
Ddx5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.011
Tubgcp2	tubulin, gamma complex associated protein 2	0.011	Fly
Tpr	translocated promoter region	0.011
Nsg2	neuron specific gene family member 2	0.011
Odf2	outer dense fiber of sperm tails 2	0.011
Brca1	breast cancer 1	0.011
Epha5	Eph receptor A5	0.011
Thyn1	thymocyte nuclear protein 1	0.011
Gpr85	G protein-coupled receptor 85	0.011
2900092E17Rik	RIKEN cDNA 2900092E17 gene	0.011
E2f8	E2F transcription factor 8	0.011
Ppme1	protein phosphatase methylesterase 1	0.011
Eefsec	eukaryotic elongation factor, selenocysteine-tRNA-specific	0.011
Smap1	stromal membrane-associated protein 1	0.011
Xpo7	exportin 7	0.011
Cdc45	cell division cycle 45 homolog (S. cerevisiae)	0.011
Exosc10	exosome component 10	0.011
Slco5a1	solute carrier organic anion transporter family, member 5A1	0.011
Dcp1b	DCP1 decapping enzyme homolog b (S. cerevisiae)	0.011
Rab12	RAB12, member RAS oncogene family	0.011
Zfp207	zinc finger protein 207	0.011
Casp3	caspase 3	0.011
Ptprr	protein tyrosine phosphatase, receptor type, R	0.011
Mark3	MAP/microtubule affinity-regulating kinase 3	0.011
Scn2a1	sodium channel, voltage-gated, type II, alpha 1	0.011
Snhg5	small nucleolar RNA host gene 5	0.011
Hmbs	hydroxymethylbilane synthase	0.011
Etnk1	ethanolamine kinase 1	0.011
Rnf38	ring finger protein 38	0.011
Sec24b	Sec24 related gene family, member B (S. cerevisiae)	0.011
Ugcg	UDP-glucose ceramide glucosyltransferase	0.011
Znhit1	zinc finger, HIT domain containing 1	0.011
Lbr	lamin B receptor	0.011
Fus	fusion, derived from t(12;16) malignant liposarcoma (human)	0.011
Spag7	sperm associated antigen 7	0.010
Lmnb2	lamin B2	0.010
Qrich1	glutamine-rich 1	0.010
1110049F12Rik	RIKEN cDNA 1110049F12 gene	0.010
Tro	trophinin	0.010
Fancd2	Fanconi anemia, complementation group D2	0.010
Gps1	G protein pathway suppressor 1	0.010
Vdac1	voltage-dependent anion channel 1	0.010
Ndufa12	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12	0.010
Zdhhc3	zinc finger, DHHC domain containing 3	0.010
Npcd	neuronal pentraxin chromo domain	0.010
Max	Max protein	0.010
Pcdhb12	protocadherin beta 12	0.010
Hnrnpr	heterogeneous nuclear ribonucleoprotein R	0.010
Ncald	neurocalcin delta	0.010
Mns1	meiosis-specific nuclear structural protein 1	0.010
2210009G21Rik	RIKEN cDNA 2210009G21 gene	0.010
Gap43	growth associated protein 43	0.010
Cdk2	cyclin-dependent kinase 2	0.010