IMP

Process View

Mus musculus

3 genes annotated in mouse

pro t cell differentiation

The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "pro t cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "pro t cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Vegfa	vascular endothelial growth factor A	0.996
Rxra	retinoid X receptor alpha	0.988
Nos3	nitric oxide synthase 3, endothelial cell	0.985
Kdr	kinase insert domain protein receptor	0.957	Mouse
Gata6	GATA binding protein 6	0.934	Mouse
Jag1	jagged 1	0.829
Pitx2	paired-like homeodomain transcription factor 2	0.664
Cdh5	cadherin 5	0.652
Tgfb2	transforming growth factor, beta 2	0.606
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.548
Foxc2	forkhead box C2	0.471
Tgfbr2	transforming growth factor, beta receptor II	0.465
Flt4	FMS-like tyrosine kinase 4	0.464	Mouse
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.451	Mouse
Ptprb	protein tyrosine phosphatase, receptor type, B	0.447
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.405
Efnb2	ephrin B2	0.389
Csf1	colony stimulating factor 1 (macrophage)	0.376
Bmp4	bone morphogenetic protein 4	0.356
She	src homology 2 domain-containing transforming protein E	0.337
Acvr1	activin A receptor, type 1	0.273
Tgfb1	transforming growth factor, beta 1	0.266
Hoxa1	homeobox A1	0.220
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.219	Mouse
Eng	endoglin	0.206
Smad6	MAD homolog 6 (Drosophila)	0.202
Meox2	mesenchyme homeobox 2	0.197
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.194
Fgfr2	fibroblast growth factor receptor 2	0.190
Notch1	Notch gene homolog 1 (Drosophila)	0.174
Apc	adenomatosis polyposis coli	0.166
Vegfc	vascular endothelial growth factor C	0.162
Sox18	SRY-box containing gene 18	0.159
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.152
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.135
Esam	endothelial cell-specific adhesion molecule	0.134
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.129
Tbx3	T-box 3	0.129
Tek	endothelial-specific receptor tyrosine kinase	0.128
Stat3	signal transducer and activator of transcription 3	0.124
Flt1	FMS-like tyrosine kinase 1	0.120	Mouse
Klf3	Kruppel-like factor 3 (basic)	0.118
Inpp5d	inositol polyphosphate-5-phosphatase D	0.108
Kitl	kit ligand	0.108
Col1a1	collagen, type I, alpha 1	0.108
Nrp1	neuropilin 1	0.104
Ikzf1	IKAROS family zinc finger 1	0.100
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.097
Sox7	SRY-box containing gene 7	0.095
Acvrl1	activin A receptor, type II-like 1	0.091
Efnb1	ephrin B1	0.091
Tal1	T-cell acute lymphocytic leukemia 1	0.088
Adcy4	adenylate cyclase 4	0.086
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.084
Trp53	transformation related protein 53	0.084
Tbx2	T-box 2	0.082
Hand2	heart and neural crest derivatives expressed transcript 2	0.081
Pten	phosphatase and tensin homolog	0.077
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.076
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.074
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.073
Thbd	thrombomodulin	0.072
Ece1	endothelin converting enzyme 1	0.071
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.069
Sox17	SRY-box containing gene 17	0.069
Gja1	gap junction protein, alpha 1	0.068
Zfpm2	zinc finger protein, multitype 2	0.066
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.064
Lepr	leptin receptor	0.062
Dll1	delta-like 1 (Drosophila)	0.057
Fyn	Fyn proto-oncogene	0.056
Chd7	chromodomain helicase DNA binding protein 7	0.055
Aplnr	apelin receptor	0.054
Pdgfb	platelet derived growth factor, B polypeptide	0.054
Cxcl12	chemokine (C-X-C motif) ligand 12	0.054
Plxnd1	plexin D1	0.053
Fzd4	frizzled homolog 4 (Drosophila)	0.053
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.051
Epas1	endothelial PAS domain protein 1	0.051
Podxl	podocalyxin-like	0.049
Zfp362	zinc finger protein 362	0.048
Zeb1	zinc finger E-box binding homeobox 1	0.046
Smad7	MAD homolog 7 (Drosophila)	0.045
Emcn	endomucin	0.043
S1pr2	sphingosine-1-phosphate receptor 2	0.043
Egfl7	EGF-like domain 7	0.042
Snai1	snail homolog 1 (Drosophila)	0.040
Hic1	hypermethylated in cancer 1	0.040
Kit	kit oncogene	0.039	Mouse
Fgf8	fibroblast growth factor 8	0.038
Sox4	SRY-box containing gene 4	0.038
Nid1	nidogen 1	0.037
Col4a1	collagen, type IV, alpha 1	0.037
Npr1	natriuretic peptide receptor 1	0.037
Col4a2	collagen, type IV, alpha 2	0.037
Robo4	roundabout homolog 4 (Drosophila)	0.036
Ednra	endothelin receptor type A	0.036
Cbl	Casitas B-lineage lymphoma	0.036
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.035
Notch2	Notch gene homolog 2 (Drosophila)	0.035
Tmem204	transmembrane protein 204	0.035
Ldlr	low density lipoprotein receptor	0.035
Bmp2	bone morphogenetic protein 2	0.035
Wwc2	WW, C2 and coiled-coil domain containing 2	0.033
Dab2	disabled homolog 2 (Drosophila)	0.033
Shank3	SH3/ankyrin domain gene 3	0.033
Tenc1	tensin like C1 domain-containing phosphatase	0.032
Wwtr1	WW domain containing transcription regulator 1	0.032
Lrp1	low density lipoprotein receptor-related protein 1	0.032
Fbln1	fibulin 1	0.032
Foxg1	forkhead box G1	0.031
Mitf	microphthalmia-associated transcription factor	0.031
Ednrb	endothelin receptor type B	0.031
Foxf1a	forkhead box F1a	0.030
Zfpm1	zinc finger protein, multitype 1	0.030
Msx1	homeobox, msh-like 1	0.030
Apoe	apolipoprotein E	0.030
Myo6	myosin VI	0.029
Fli1	Friend leukemia integration 1	0.029
Gpr182	G protein-coupled receptor 182	0.029
Pax2	paired box gene 2	0.029
Ar	androgen receptor	0.029
Bcl2	B-cell leukemia/lymphoma 2	0.028
Dll4	delta-like 4 (Drosophila)	0.028
Tyrobp	TYRO protein tyrosine kinase binding protein	0.027
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.027
Notch3	Notch gene homolog 3 (Drosophila)	0.027
Gbx2	gastrulation brain homeobox 2	0.027
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.027
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.026
Gpr97	G protein-coupled receptor 97	0.026
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.026
Foxc1	forkhead box C1	0.026
Wt1	Wilms tumor 1 homolog	0.026
Epor	erythropoietin receptor	0.026
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.025
Plvap	plasmalemma vesicle associated protein	0.024
Sorbs3	sorbin and SH3 domain containing 3	0.024
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.024
Stab1	stabilin 1	0.024
Tbx1	T-box 1	0.024
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.023
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.023
Hlx	H2.0-like homeobox	0.023
Hhex	hematopoietically expressed homeobox	0.023
Cd93	CD93 antigen	0.023
Cldn5	claudin 5	0.023
Ntf3	neurotrophin 3	0.023
Ctnnb1	catenin (cadherin associated protein), beta 1	0.022
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.022
Irx3	Iroquois related homeobox 3 (Drosophila)	0.022
Smo	smoothened homolog (Drosophila)	0.022
Runx1	runt related transcription factor 1	0.022
Rasip1	Ras interacting protein 1	0.022
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.022
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.021
Jun	Jun oncogene	0.021
Adam17	a disintegrin and metallopeptidase domain 17	0.021
Tcf21	transcription factor 21	0.020
Hand1	heart and neural crest derivatives expressed transcript 1	0.020
Nynrin	NYN domain and retroviral integrase containing	0.020
Tead3	TEA domain family member 3	0.020
Yap1	yes-associated protein 1	0.019
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.019
Gata4	GATA binding protein 4	0.019	Mouse
Pkd1	polycystic kidney disease 1 homolog	0.019
Cd151	CD151 antigen	0.018
Mmrn2	multimerin 2	0.018
Fgfr1	fibroblast growth factor receptor 1	0.018
Gata2	GATA binding protein 2	0.018	Mouse
Smad4	MAD homolog 4 (Drosophila)	0.018
Fubp3	far upstream element (FUSE) binding protein 3	0.017
Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.017
Lyz2	lysozyme 2	0.017
Itgb3	integrin beta 3	0.017
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.017
Mmp11	matrix metallopeptidase 11	0.017
Eltd1	EGF, latrophilin seven transmembrane domain containing 1	0.017
Tgfbr3	transforming growth factor, beta receptor III	0.017
Zbtb46	zinc finger and BTB domain containing 46	0.017
Casp8ap2	caspase 8 associated protein 2	0.017
Elk3	ELK3, member of ETS oncogene family	0.017
F2r	coagulation factor II (thrombin) receptor	0.017
Gja4	gap junction protein, alpha 4	0.017
Sox9	SRY-box containing gene 9	0.017
Efna1	ephrin A1	0.017
Tmem150a	transmembrane protein 150A	0.017
Clec14a	C-type lectin domain family 14, member a	0.016
Lama5	laminin, alpha 5	0.016
Ptprm	protein tyrosine phosphatase, receptor type, M	0.016
Tnks1bp1	tankyrase 1 binding protein 1	0.016
Timp3	tissue inhibitor of metalloproteinase 3	0.016
Lamb1	laminin B1	0.016
Bgn	biglycan	0.016
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.016
Lama4	laminin, alpha 4	0.016
Heg1	HEG homolog 1 (zebrafish)	0.016
Amotl2	angiomotin-like 2	0.016
S1pr1	sphingosine-1-phosphate receptor 1	0.016
Myst3	MYST histone acetyltransferase (monocytic leukemia) 3	0.016
Cd97	CD97 antigen	0.015
Ephb4	Eph receptor B4	0.015
Psen1	presenilin 1	0.015
Sct	secretin	0.015
Apaf1	apoptotic peptidase activating factor 1	0.015
Gpc3	glypican 3	0.015
Pecam1	platelet/endothelial cell adhesion molecule 1	0.015
Itga3	integrin alpha 3	0.014
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.014
Map3k3	mitogen-activated protein kinase kinase kinase 3	0.014
Vwf	Von Willebrand factor homolog	0.014
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.014
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.014
Slc12a2	solute carrier family 12, member 2	0.014
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.014
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.014
Fn1	fibronectin 1	0.014
Cyr61	cysteine rich protein 61	0.014
Tspan9	tetraspanin 9	0.013
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.013
Card10	caspase recruitment domain family, member 10	0.013
Hoxb4	homeobox B4	0.013
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.013
Bcl6b	B-cell CLL/lymphoma 6, member B	0.013
4632428N05Rik	RIKEN cDNA 4632428N05 gene	0.013
Ltbp1	latent transforming growth factor beta binding protein 1	0.013
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.013
Npr2	natriuretic peptide receptor 2	0.013
Hdac7	histone deacetylase 7	0.013
Caskin2	CASK-interacting protein 2	0.013
Ahr	aryl-hydrocarbon receptor	0.013
Jak2	Janus kinase 2	0.013
Prf1	perforin 1 (pore forming protein)	0.013
Grap2	GRB2-related adaptor protein 2	0.013
Rbpms	RNA binding protein gene with multiple splicing	0.013
Mylk	myosin, light polypeptide kinase	0.013
Bmp6	bone morphogenetic protein 6	0.013
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.013
Klf7	Kruppel-like factor 7 (ubiquitous)	0.013
Itgb5	integrin beta 5	0.013
Esr1	estrogen receptor 1 (alpha)	0.013
Rb1	retinoblastoma 1	0.013
Cxcr4	chemokine (C-X-C motif) receptor 4	0.012
Reck	reversion-inducing-cysteine-rich protein with kazal motifs	0.012
Samd4b	sterile alpha motif domain containing 4B	0.012
Gli3	GLI-Kruppel family member GLI3	0.012
Cd19	CD19 antigen	0.012
Mmp2	matrix metallopeptidase 2	0.012
Gab2	growth factor receptor bound protein 2-associated protein 2	0.012
Pparg	peroxisome proliferator activated receptor gamma	0.012
Ppara	peroxisome proliferator activated receptor alpha	0.012
Hif1a	hypoxia inducible factor 1, alpha subunit	0.012
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.012
Frmd6	FERM domain containing 6	0.012
Zfp503	zinc finger protein 503	0.012
Dennd5a	DENN/MADD domain containing 5A	0.012
Pcsk6	proprotein convertase subtilisin/kexin type 6	0.012
BC020535	cDNA sequence BC020535	0.012
Wipf1	WAS/WASL interacting protein family, member 1	0.012
Sh2b3	SH2B adaptor protein 3	0.012
Igfbp3	insulin-like growth factor binding protein 3	0.011
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.011
Phldb2	pleckstrin homology-like domain, family B, member 2	0.011
Smoc1	SPARC related modular calcium binding 1	0.011
Il6st	interleukin 6 signal transducer	0.011
Mmp9	matrix metallopeptidase 9	0.011
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.011
Npr3	natriuretic peptide receptor 3	0.011
Jup	junction plakoglobin	0.011
Stk40	serine/threonine kinase 40	0.011
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.011
Rarg	retinoic acid receptor, gamma	0.011
Gata3	GATA binding protein 3	0.011
Tnxb	tenascin XB	0.011
Ptpn21	protein tyrosine phosphatase, non-receptor type 21	0.010
Vhl	von Hippel-Lindau tumor suppressor	0.010
Sgpl1	sphingosine phosphate lyase 1	0.010
Lmna	lamin A	0.010
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.010
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.010
Plekho2	pleckstrin homology domain containing, family O member 2	0.010
Ldb2	LIM domain binding 2	0.010
Skil	SKI-like	0.010
Meis2	Meis homeobox 2	0.010
Egfr	epidermal growth factor receptor	0.010
Ushbp1	Usher syndrome 1C binding protein 1	0.010
Eif4ebp2	eukaryotic translation initiation factor 4E binding protein 2	0.010
Smad3	MAD homolog 3 (Drosophila)	0.010
Rasgrp2	RAS, guanyl releasing protein 2	0.010
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.010
Lamc1	laminin, gamma 1	0.010
Pcdh1	protocadherin 1	0.010
Lzts2	leucine zipper, putative tumor suppressor 2	0.010
Fermt2	fermitin family homolog 2 (Drosophila)	0.010