The network for 'cellular response to radiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to radiation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.

Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 0.981
BRCA1 breast cancer 1, early onset 0.942
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.899
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.896
HSPB1 heat shock 27kDa protein 1 0.875
CRYAB crystallin, alpha B 0.862
TEK TEK tyrosine kinase, endothelial 0.697
ARRB1 arrestin, beta 1 0.690
HIST1H2BG histone cluster 1, H2bg 0.666
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.645
SMAD4 SMAD family member 4 0.617
CUL4A cullin 4A 0.507
YY1 YY1 transcription factor 0.502
BCL2 B-cell CLL/lymphoma 2 0.448
RUVBL1 RuvB-like 1 (E. coli) 0.443
INO80 INO80 homolog (S. cerevisiae) 0.400
XIAP X-linked inhibitor of apoptosis 0.385
HIST1H1C histone cluster 1, H1c 0.383
NBN nibrin 0.383
HIST1H2AJ histone cluster 1, H2aj 0.353
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.344
WRN Werner syndrome, RecQ helicase-like 0.340
DDB1 damage-specific DNA binding protein 1, 127kDa 0.338
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.337
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.316
HIST1H2AI histone cluster 1, H2ai 0.301
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.264
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.262
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.260
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.257
BTRC beta-transducin repeat containing 0.246
CFLAR CASP8 and FADD-like apoptosis regulator 0.243
KIAA1377 KIAA1377 0.235
CRYBB2 crystallin, beta B2 0.223
FBXW11 F-box and WD repeat domain containing 11 0.219
RHOA ras homolog gene family, member A 0.219
CLSPN claspin 0.219
HDAC6 histone deacetylase 6 0.218
HSPB2 heat shock 27kDa protein 2 0.218
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.214
CRYGC crystallin, gamma C 0.210
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.200
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.200
BAK1 BCL2-antagonist/killer 1 0.195
SKP1 S-phase kinase-associated protein 1 0.194
SMAD3 SMAD family member 3 0.184
JUN jun proto-oncogene 0.182
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.177
IRAK2 interleukin-1 receptor-associated kinase 2 0.173
TAL1 T-cell acute lymphocytic leukemia 1 0.169
CAV1 caveolin 1, caveolae protein, 22kDa 0.158
DUSP1 dual specificity phosphatase 1 0.147
MAP2K4 mitogen-activated protein kinase kinase 4 0.147
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.140
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.136
ARHGAP1 Rho GTPase activating protein 1 0.135
HIST1H3D histone cluster 1, H3d 0.135
NRP1 neuropilin 1 0.134
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.128
NMI N-myc (and STAT) interactor 0.127
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.126
HIPK2 homeodomain interacting protein kinase 2 0.122
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.120
HSPB8 heat shock 22kDa protein 8 0.120
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.116
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.114
SIRT1 sirtuin 1 0.111
INCENP inner centromere protein antigens 135/155kDa 0.110
RIPK2 receptor-interacting serine-threonine kinase 2 0.103
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.101
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.099
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.098
EP300 E1A binding protein p300 0.096
CCNE1 cyclin E1 0.094
ARRB2 arrestin, beta 2 0.093
PLCG1 phospholipase C, gamma 1 0.093
DTL denticleless homolog (Drosophila) 0.093
HIST1H2BJ histone cluster 1, H2bj 0.093
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.093
WWOX WW domain containing oxidoreductase 0.092
HIST1H2BI histone cluster 1, H2bi 0.092
AR androgen receptor 0.089
FADD Fas (TNFRSF6)-associated via death domain 0.088
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.087
BCL2L1 BCL2-like 1 0.087
BAX BCL2-associated X protein 0.086
HIST1H2BE histone cluster 1, H2be 0.086
RYBP RING1 and YY1 binding protein 0.086
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.086
RAD17 RAD17 homolog (S. pombe) 0.086
BHLHE40 basic helix-loop-helix family, member e40 0.085
HIST1H2BF histone cluster 1, H2bf 0.085
RAD52 RAD52 homolog (S. cerevisiae) 0.082
NLRC4 NLR family, CARD domain containing 4 0.080
CREBBP CREB binding protein 0.078
IFI16 interferon, gamma-inducible protein 16 0.076
RICTOR RPTOR independent companion of MTOR, complex 2 0.075
CDC25A cell division cycle 25 homolog A (S. pombe) 0.074
IL4R interleukin 4 receptor 0.074
HIST1H2BD histone cluster 1, H2bd 0.074
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
CELE_ZK829.7 Protein ZK829.7 0.012
fan-1 Protein FAN-1 0.011
C44E4.5 Protein C44E4.5 0.011
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Danio rerio
Name Description Probability Func Analog Organism
gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.719
opn1lw1 opsin 1 (cone pigments), long-wave-sensitive, 1 0.670
gc3 guanylyl cyclase 3 0.667
opn1sw1 opsin 1 (cone pigments), short-wave-sensitive 1 0.645
gnat1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 0.621
rho rhodopsin 0.573
arr3a arrestin 3a, retinal (X-arrestin) 0.475
rx1 retinal homeobox gene 1 0.471
opn1sw2 opsin 1 (cone pigments), short-wave-sensitive 2 0.433
opn1mw1 opsin 1 (cone pigments), medium-wave-sensitive, 1 0.431
opn4l opsin 4, like 0.348
gucy2f guanylate cyclase 2F, retinal 0.324
grk7a G-protein-coupled receptor kinase 7a 0.301
cry5 cryptochrome 5 0.282
pde6c phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.268
guca1c guanylate cyclase activator 1C 0.261
crb1 crumbs homolog 1 (Drosophila) 0.259
opn4a opsin 4a (melanopsin) 0.257
cdh1 cadherin 1, epithelial 0.249
opn4x1 opsin 4x1 0.240
bbc3 BCL2 binding component 3 0.234
itgb1a integrin, beta 1a 0.217
mych myelocytomatosis oncogene homolog 0.207
zgc:56548 zgc:56548 0.201
nbl1 neuroblastoma, suppression of tumorigenicity 1 0.192
crb2b crumbs homolog 2b 0.191
kif17 kinesin family member 17 0.190
clock clock 0.188
notch2 notch homolog 2 0.183
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.175
rdh5 retinol dehydrogenase 5 (11-cis/9-cis) 0.172
guca1d guanylate cyclase activator 1d 0.164
wls wntless homolog (Drosophila) 0.162
rasl11b RAS-like, family 11, member B 0.154
otx5 orthodenticle homolog 5 0.152
gins2 GINS complex subunit 2 0.149
gc2 guanylyl cyclase 2 0.133
baxa bcl2-associated X protein, a 0.132
crx cone-rod homeobox 0.132
crb3a crumbs homolog 3a 0.131
cry-dash cryptochrome DASH 0.130
arr3b arrestin 3b, retinal (X-arrestin) 0.128
aanat2 arylalkylamine N-acetyltransferase 0.123
dkk1a dickkopf 1a 0.120
crb3b crumbs homolog 3b 0.120
grk1b G protein-coupled receptor kinase 1 b 0.113
rcv1 recoverin 0.112
nrl neural retina leucine zipper 0.105
LOC568691 opsin-3-like 0.104
cluap1 clusterin associated protein 1 0.103
mpp5b membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b) 0.100
chat choline acetyltransferase 0.092
fzd7a frizzled homolog 7a 0.089
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.089
gsc goosecoid 0.088
pola2 polymerase (DNA directed), alpha 2 0.087
fn1 fibronectin 1 0.086
zfyve26 zinc finger, FYVE domain containing 26 0.085
per2 period homolog 2 (Drosophila) 0.084
pdzd7a PDZ domain containing 7a 0.083
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.083
saga S-antigen; retina and pineal gland (arrestin) a 0.083
zgc:73336 zgc:73336 0.081
rp2 retinitis pigmentosa 2 (X-linked recessive) 0.081
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.080
cxadr coxsackie virus and adenovirus receptor 0.078
ivns1abpa influenza virus NS1A binding protein a 0.077
celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 0.074
rx2 retinal homeobox gene 2 0.074
irbp interphotoreceptor retinoid-binding protein 0.074
pdlim1 PDZ and LIM domain 1 (elfin) 0.074
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.073
guk1 guanylate kinase 1 0.072
cdc45 CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.070
hirip3 HIRA interacting protein 3 0.070
atf3 activating transcription factor 3 0.069
pik3ip1 phosphoinositide-3-kinase interacting protein 1 0.068
sgk1 serum/glucocorticoid regulated kinase 1 0.068
wdr76 WD repeat domain 76 0.067
xpc xeroderma pigmentosum, complementation group C 0.066
scn1ba sodium channel, voltage-gated, type I, beta a 0.066
cplx4a complexin 4a 0.065
hnrpr heterogeneous nuclear ribonucleoprotein R 0.064
si:dkey-21k24.2 si:dkey-21k24.2 0.063
lin7a lin-7 homolog A (C. elegans) 0.062
arf1 ADP-ribosylation factor 1 0.062
postn periostin, osteoblast specific factor 0.062
zgc:55813 zgc:55813 0.061
parapinopsinb parapinopsin b 0.061
fes feline sarcoma oncogene 0.061
zgc:73155 zgc:73155 0.060
dync1h1 dynein, cytoplasmic 1, heavy chain 1 0.060
spry4 sprouty (Drosophila) homolog 4 0.060
ift57 intraflagellar transport protein 57 0.059
gadd45g growth arrest and DNA-damage-inducible, gamma 0.059
zgc:77752 zgc:77752 0.059
cx52.6 connexin 52.6 0.059
rtn4r reticulon 4 receptor 0.058
zgc:162213 zgc:162213 0.058
midn midnolin 0.057
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Drosophila melanogaster
Name Description Probability Func Analog Organism
inaD inactivation no afterpotential D 1.000
trp transient receptor potential 0.999
trpl trp-like 0.995
Arr2 Arrestin 2 0.983
inaC inactivation no afterpotential C 0.973
Gbeta76C G protein beta-subunit 76C 0.971
norpA no receptor potential A 0.960
ninaC neither inactivation nor afterpotential C 0.939
ninaA neither inactivation nor afterpotential A 0.935
Rh3 Rhodopsin 3 0.860
Arr1 Arrestin 1 0.841
Gyc-89Db Guanylyl cyclase at 89Db 0.800
Rh6 Rhodopsin 6 0.795
rl rolled 0.783
ninaE neither inactivation nor afterpotential E 0.773
inaF-D CG42563 gene product from transcript CG42563-RB 0.745
Rh5 Rhodopsin 5 0.671
Hsp27 Heat shock protein 27 0.656
rdgB retinal degeneration B 0.645
elav embryonic lethal abnormal vision 0.635
rdgC retinal degeneration C 0.551
tadr torn and diminished rhabdomeres 0.489
mus205 mutagen-sensitive 205 0.421
Fhos CG42610 gene product from transcript CG42610-RC 0.417
Cng Cyclic-nucleotide-gated ion channel protein 0.409
rdgA retinal degeneration A 0.384
CG1572 CG1572 gene product from transcript CG1572-RA 0.352
stumps CG31317 gene product from transcript CG31317-RC 0.339
l(2)gl lethal (2) giant larvae 0.311
CG13704 CG13704 gene product from transcript CG13704-RA 0.309
Calx Na/Ca-exchange protein 0.295
ImpL2 Ecdysone-inducible gene L2 0.293
dco discs overgrown 0.285
Timp Tissue inhibitor of metalloproteases 0.280
Gyc-89Da Guanylyl cyclase at 89Da 0.278
chp chaoptic 0.274
CG14686 CG14686 gene product from transcript CG14686-RA 0.270
SuUR Suppressor of Under-Replication 0.269
Sin3A CG8815 gene product from transcript CG8815-RC 0.259
Tsp42El Tetraspanin 42El 0.257
Galpha49B G protein alpha49B 0.242
Gyc88E Guanylyl cyclase at 88E 0.228
CG6191 CG6191 gene product from transcript CG6191-RA 0.224
Ggamma30A G protein gamma30A 0.206
Tsp42Ef Tetraspanin 42Ef 0.204
Tsp42Ej Tetraspanin 42Ej 0.201
CG9628 CG9628 gene product from transcript CG9628-RA 0.200
insc inscuteable 0.199
CG1681 CG1681 gene product from transcript CG1681-RA 0.189
sev sevenless 0.174
debcl death executioner Bcl-2 homologue 0.174
Tsp42Ei Tetraspanin 42Ei 0.172
p53 CG33336 gene product from transcript CG33336-RB 0.172
Ubqn Ubiquilin 0.167
mus101 mutagen-sensitive 101 0.162
ben bendless 0.155
Dsp1 Dorsal switch protein 1 0.151
t tan 0.151
Tsp29Fb Tetraspanin 29Fb 0.150
Esyt2 CG6643 gene product from transcript CG6643-RA 0.146
G-salpha60A G protein salpha 60A 0.141
mei-9 meiotic 9 0.140
Cat Catalase 0.140
loqs loquacious 0.138
shakB shaking B 0.137
Pk61C Protein kinase 61C 0.136
mub mushroom-body expressed 0.135
Eip63E Ecdysone-induced protein 63E 0.135
CG9772 CG9772 gene product from transcript CG9772-RB 0.135
MED4 Mediator complex subunit 4 0.130
Tsp42Eh Tetraspanin 42Eh 0.128
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.124
kek5 kekkon5 0.122
CG5524 CG5524 gene product from transcript CG5524-RA 0.122
sxc super sex combs 0.121
hpo hippo 0.120
lgs legless 0.118
myoglianin CG1838 gene product from transcript CG1838-RD 0.118
Mad Mothers against dpp 0.118
Rm62 CG10279 gene product from transcript CG10279-RD 0.116
CG8086 CG8086 gene product from transcript CG8086-RF 0.115
CRMP Collapsin Response Mediator Protein 0.114
Bj1 Bj1 protein 0.113
prc pericardin 0.111
rad50 CG6339 gene product from transcript CG6339-RD 0.111
per period 0.109
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.109
CG5273 CG5273 gene product from transcript CG5273-RA 0.106
Ggamma1 G protein gamma 1 0.103
nbs CG6754 gene product from transcript CG6754-RC 0.100
CG5973 CG5973 gene product from transcript CG5973-RA 0.100
osa CG7467 gene product from transcript CG7467-RD 0.098
ric8a CG15797 gene product from transcript CG15797-RA 0.098
rpr reaper 0.094
nrv3 nervana 3 0.093
Clk Clock 0.093
lok loki 0.092
l(2)efl lethal (2) essential for life 0.091
CG9990 CG9990 gene product from transcript CG9990-RA 0.090
RecQ5 homolog of RecQ 0.089
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Pten phosphatase and tensin homolog 1.000
Bcl2 B-cell leukemia/lymphoma 2 0.998
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.985
Kit kit oncogene 0.968
Brca2 breast cancer 2 0.954
Bax BCL2-associated X protein 0.894
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.851
Brca1 breast cancer 1 0.825
Stat5a signal transducer and activator of transcription 5A 0.813
Rho rhodopsin 0.775
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.756
Apc adenomatosis polyposis coli 0.715
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.714
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.713
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.700
Mapk8 mitogen-activated protein kinase 8 0.683
Rbl1 retinoblastoma-like 1 (p107) 0.678
Ep300 E1A binding protein p300 0.657
Notch2 Notch gene homolog 2 (Drosophila) 0.636
Cbl Casitas B-lineage lymphoma 0.577
Ar androgen receptor 0.538
Trp73 transformation related protein 73 0.535
Trp63 transformation related protein 63 0.535
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.513
Msh2 mutS homolog 2 (E. coli) 0.480
Tgfb1 transforming growth factor, beta 1 0.472
Vhl von Hippel-Lindau tumor suppressor 0.467
Cyld cylindromatosis (turban tumor syndrome) 0.456
Dbp D site albumin promoter binding protein 0.446
Bcl2l1 BCL2-like 1 0.444
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.428
Dcx doublecortin 0.412
Braf Braf transforming gene 0.406
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.397
Mdm2 transformed mouse 3T3 cell double minute 2 0.356
Kitl kit ligand 0.353
Atf2 activating transcription factor 2 0.346
Ncoa3 nuclear receptor coactivator 3 0.331
Dclk1 doublecortin-like kinase 1 0.319
Foxp3 forkhead box P3 0.315
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.312
Ptk2 PTK2 protein tyrosine kinase 2 0.309
Mdm4 transformed mouse 3T3 cell double minute 4 0.309
Skil SKI-like 0.274
Sfrp2 secreted frizzled-related protein 2 0.267
Stat3 signal transducer and activator of transcription 3 0.252
Stat5b signal transducer and activator of transcription 5B 0.250
Thra thyroid hormone receptor alpha 0.245
Sp1 trans-acting transcription factor 1 0.244
Rxra retinoid X receptor alpha 0.239
Gna11 guanine nucleotide binding protein, alpha 11 0.237
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.231
Egr2 early growth response 2 0.227
Ahr aryl-hydrocarbon receptor 0.226
Pax2 paired box gene 2 0.212
Thrb thyroid hormone receptor beta 0.204
Mapk14 mitogen-activated protein kinase 14 0.204
Sav1 salvador homolog 1 (Drosophila) 0.203
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.195
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.186
Hr hairless 0.178
Notch1 Notch gene homolog 1 (Drosophila) 0.170
Fos FBJ osteosarcoma oncogene 0.169
Sfrp1 secreted frizzled-related protein 1 0.156
Runx1 runt related transcription factor 1 0.148
Chd2 chromodomain helicase DNA binding protein 2 0.143
Med1 mediator complex subunit 1 0.136
Ifngr1 interferon gamma receptor 1 0.136
Nab2 Ngfi-A binding protein 2 0.132
Flt4 FMS-like tyrosine kinase 4 0.132
Usp9x ubiquitin specific peptidase 9, X chromosome 0.131
Ghr growth hormone receptor 0.129
Smn1 survival motor neuron 1 0.126
Lif leukemia inhibitory factor 0.124
Clock circadian locomotor output cycles kaput 0.124
Kdr kinase insert domain protein receptor 0.121
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.120
Wwtr1 WW domain containing transcription regulator 1 0.116
Stat6 signal transducer and activator of transcription 6 0.113
Lepr leptin receptor 0.111
Pik3cb phosphatidylinositol 3-kinase, catalytic, beta polypeptide 0.110
Lyst lysosomal trafficking regulator 0.106
Pole polymerase (DNA directed), epsilon 0.105
Huwe1 HECT, UBA and WWE domain containing 1 0.103
Aipl1 aryl hydrocarbon receptor-interacting protein-like 1 0.103
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.100
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.095
Pvrl3 poliovirus receptor-related 3 0.092
Pola1 polymerase (DNA directed), alpha 1 0.092
Zmym5 zinc finger, MYM-type 5 0.090
Plxnd1 plexin D1 0.088
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.087
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.086
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.082
Rbl2 retinoblastoma-like 2 0.082
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.081
Cdca7 cell division cycle associated 7 0.080
Foxo1 forkhead box O1 0.080
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.079
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism