The network for 'cellular response to cytokine stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to cytokine stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
STAT1 signal transducer and activator of transcription 1, 91kDa 0.997
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.988
BIRC3 baculoviral IAP repeat containing 3 0.988
TRAF6 TNF receptor-associated factor 6 0.986
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.980
CAV1 caveolin 1, caveolae protein, 22kDa 0.978
MT1H metallothionein 1H 0.965
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.958
SOCS3 suppressor of cytokine signaling 3 0.958
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.958
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.952
IL1B interleukin 1, beta 0.952
MT1F metallothionein 1F 0.949
GHR growth hormone receptor 0.933
MT1X metallothionein 1X 0.933
IL1R1 interleukin 1 receptor, type I 0.932
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.928
ZNF43 zinc finger protein 43 0.927
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.924
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.912
MT2A metallothionein 2A 0.907
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.905
MT1E metallothionein 1E 0.901
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.890
TRAF5 TNF receptor-associated factor 5 0.887
MAPK1 mitogen-activated protein kinase 1 0.880
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.873
IRAK1 interleukin-1 receptor-associated kinase 1 0.861
SOCS1 suppressor of cytokine signaling 1 0.854
FAS Fas (TNF receptor superfamily, member 6) 0.852
CCR7 chemokine (C-C motif) receptor 7 0.852
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.847
CCL5 chemokine (C-C motif) ligand 5 0.840
ISG15 ISG15 ubiquitin-like modifier 0.838
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.833
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.831
TAL1 T-cell acute lymphocytic leukemia 1 0.830
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.823
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.802
C1QA complement component 1, q subcomponent, A chain 0.802
NCOR1 nuclear receptor corepressor 1 0.771
IRF9 interferon regulatory factor 9 0.764
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.755
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.753
CXCL9 chemokine (C-X-C motif) ligand 9 0.751
TNF tumor necrosis factor 0.748
GRB2 growth factor receptor-bound protein 2 0.745
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.737
CCR5 chemokine (C-C motif) receptor 5 0.733
SIRT1 sirtuin 1 0.732
RUNX1 runt-related transcription factor 1 0.731
CCL22 chemokine (C-C motif) ligand 22 0.729
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.724
IL2RB interleukin 2 receptor, beta 0.722
ICAM1 intercellular adhesion molecule 1 0.721
ZNF273 zinc finger protein 273 0.718
NMI N-myc (and STAT) interactor 0.710
CCL2 chemokine (C-C motif) ligand 2 0.707
HCK hemopoietic cell kinase 0.701
TRADD TNFRSF1A-associated via death domain 0.697
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.693
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.690
IRAK2 interleukin-1 receptor-associated kinase 2 0.685
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.683
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.667
IL1R2 interleukin 1 receptor, type II 0.665
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.657
MAPK14 mitogen-activated protein kinase 14 0.634
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.625
CCL4 chemokine (C-C motif) ligand 4 0.623
IL1RN interleukin 1 receptor antagonist 0.622
ZNF253 zinc finger protein 253 0.619
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.593
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.580
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.579
TUBB tubulin, beta 0.575
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.572
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.558
CXCL3 chemokine (C-X-C motif) ligand 3 0.547
GDF9 growth differentiation factor 9 0.545
IRF1 interferon regulatory factor 1 0.541
TRAF2 TNF receptor-associated factor 2 0.538
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.536
CXCL5 chemokine (C-X-C motif) ligand 5 0.527
IL6 interleukin 6 (interferon, beta 2) 0.524
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.521
STAT2 signal transducer and activator of transcription 2, 113kDa 0.519
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.516
PDZD3 PDZ domain containing 3 0.514
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.513
SQSTM1 sequestosome 1 0.509
IL10 interleukin 10 0.502
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.501
KEAP1 kelch-like ECH-associated protein 1 0.497
IFNG interferon, gamma 0.496
CXCL10 chemokine (C-X-C motif) ligand 10 0.492
PTPRJ protein tyrosine phosphatase, receptor type, J 0.491
JAK1 Janus kinase 1 0.491
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.485
IL8 interleukin 8 0.483
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ef1a elongation factor 1-alpha 0.117
spry4 sprouty (Drosophila) homolog 4 0.096
mmp9 matrix metalloproteinase 9 0.093
cxcr4b chemokine (C-X-C motif), receptor 4b 0.059
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.058
anxa1a annexin A1a 0.057
il6r interleukin 6 receptor 0.051
il6st interleukin 6 signal transducer 0.033
rag1 recombination activating gene 1 0.026
tlr3 toll-like receptor 3 0.025
mapk3 mitogen-activated protein kinase 3 0.025
junb jun B proto-oncogene 0.025
cdh1 cadherin 1, epithelial 0.024
nrp2b neuropilin 2b 0.023
bmp4 bone morphogenetic protein 4 0.022
col1a2 collagen, type I, alpha 2 0.020
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.020
hspd1 heat shock 60kD protein 1 (chaperonin) 0.019
met met proto-oncogene (hepatocyte growth factor receptor) 0.017
elovl2 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 0.016
socs3a suppressor of cytokine signaling 3a 0.016
ghra growth hormone receptor a 0.014
bcl2l1 bcl2-like 1 0.014
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.014
fabp2 fatty acid binding protein 2, intestinal 0.014
il7r interleukin 7 receptor 0.013
fzd7b frizzled homolog 7b 0.013
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.013
stc1l stanniocalcin 1, like 0.013
jag1a jagged 1a 0.012
cyt1 type I cytokeratin, enveloping layer 0.012
stat3 signal transduction and activation of transcription 3 0.012
stat1b signal transducer and activator of transcription 1b 0.012
spi1l spleen focus forming virus (SFFV) proviral integration oncogene spi1 like 0.012
ntn2 netrin 2 0.012
slc2a1b solute carrier family 2 (facilitated glucose transporter), member 1b 0.012
lmo4a LIM domain only 4a 0.011
hoxd3a homeo box D3a 0.011
ighz immunoglobulin heavy constant zeta 0.010
cast calpastatin 0.010
adipor1a adiponectin receptor 1a 0.010
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.010
mapk4 mitogen-activated protein kinase 4 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Ifng interferon gamma 1.000
Il1r1 interleukin 1 receptor, type I 0.999
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.999
Ccr2 chemokine (C-C motif) receptor 2 0.999
Lyz2 lysozyme 2 0.998
Jak2 Janus kinase 2 0.998
Stat3 signal transducer and activator of transcription 3 0.997
Lepr leptin receptor 0.995
Ccl2 chemokine (C-C motif) ligand 2 0.990
Myd88 myeloid differentiation primary response gene 88 0.985
Casp1 caspase 1 0.983
Cd44 CD44 antigen 0.978
Csf1 colony stimulating factor 1 (macrophage) 0.977
Tlr4 toll-like receptor 4 0.977
Stat6 signal transducer and activator of transcription 6 0.975
Apc adenomatosis polyposis coli 0.974
Apoe apolipoprotein E 0.971
Stat1 signal transducer and activator of transcription 1 0.962
Il4 interleukin 4 0.959
Gbp7 guanylate binding protein 7 0.953
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.953
Irf9 interferon regulatory factor 9 0.948
Nos2 nitric oxide synthase 2, inducible 0.942
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.941
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.940
Igtp interferon gamma induced GTPase 0.939
Il6 interleukin 6 0.930
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.921
Ifngr1 interferon gamma receptor 1 0.917
Ccr1 chemokine (C-C motif) receptor 1 0.915
Cd40 CD40 antigen 0.914
Irf1 interferon regulatory factor 1 0.911
Cxcl10 chemokine (C-X-C motif) ligand 10 0.909
Il1b interleukin 1 beta 0.902
Mmp9 matrix metallopeptidase 9 0.899
Icos inducible T-cell co-stimulator 0.892
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.888
Ar androgen receptor 0.877
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.869
Ltb lymphotoxin B 0.866
Gbp2 guanylate binding protein 2 0.865
Socs3 suppressor of cytokine signaling 3 0.863
Batf basic leucine zipper transcription factor, ATF-like 0.857
Fas Fas (TNF receptor superfamily member 6) 0.856
Iigp1 interferon inducible GTPase 1 0.856
Ptgs2 prostaglandin-endoperoxide synthase 2 0.853
Il10 interleukin 10 0.851
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.849
Cd86 CD86 antigen 0.843
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.835
Ikzf1 IKAROS family zinc finger 1 0.828
Mx2 myxovirus (influenza virus) resistance 2 0.826
Birc3 baculoviral IAP repeat-containing 3 0.804
Krt17 keratin 17 0.804
Plcg1 phospholipase C, gamma 1 0.798
Selp selectin, platelet 0.793
Il1rn interleukin 1 receptor antagonist 0.788
Lep leptin 0.783
Prf1 perforin 1 (pore forming protein) 0.772
Ccl8 chemokine (C-C motif) ligand 8 0.771
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.764
Cxcl13 chemokine (C-X-C motif) ligand 13 0.764
Ch25h cholesterol 25-hydroxylase 0.755
Nlrp3 NLR family, pyrin domain containing 3 0.753
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.751
Il18rap interleukin 18 receptor accessory protein 0.745
Btk Bruton agammaglobulinemia tyrosine kinase 0.743
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.738
H2-Aa histocompatibility 2, class II antigen A, alpha 0.733
Osmr oncostatin M receptor 0.731
Bbs4 Bardet-Biedl syndrome 4 (human) 0.728
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.726
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.726
Nos1 nitric oxide synthase 1, neuronal 0.723
Mndal myeloid nuclear differentiation antigen like 0.706
Ccl9 chemokine (C-C motif) ligand 9 0.691
Tlr2 toll-like receptor 2 0.691
Cxcl12 chemokine (C-X-C motif) ligand 12 0.688
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.684
Trp63 transformation related protein 63 0.684
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.683
Esr1 estrogen receptor 1 (alpha) 0.676
C3 complement component 3 0.674
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.673
Foxp3 forkhead box P3 0.670
Pycard PYD and CARD domain containing 0.670
Egfr epidermal growth factor receptor 0.657
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.657
Gbp5 guanylate binding protein 5 0.655
Itgb2 integrin beta 2 0.652
Rpl6 ribosomal protein L6 0.650
Aim2 absent in melanoma 2 0.637
C1qa complement component 1, q subcomponent, alpha polypeptide 0.636
Fcgr1 Fc receptor, IgG, high affinity I 0.636
Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G 0.636
Il18r1 interleukin 18 receptor 1 0.632
Il12rb2 interleukin 12 receptor, beta 2 0.622
Rps2 ribosomal protein S2 0.622
Tgtp2 T-cell specific GTPase 2 0.615
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Rattus norvegicus
Name Description Probability Func Analog Organism
Il6 interleukin 6 0.888
Il1r1 interleukin 1 receptor, type I 0.809
Cxcl10 chemokine (C-X-C motif) ligand 10 0.761
Il1b interleukin 1 beta 0.754
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.691
RT1-Ba RT1 class II, locus Ba 0.685
Col1a1 collagen, type I, alpha 1 0.641
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.637
Hck hemopoietic cell kinase 0.604
RGD1564599 RGD1564599 0.582
Ccl4 chemokine (C-C motif) ligand 4 0.577
Orm1 orosomucoid 1 0.572
Socs3 suppressor of cytokine signaling 3 0.569
Sell selectin L 0.547
Mmp12 matrix metallopeptidase 12 0.540
Cxcl2 chemokine (C-X-C motif) ligand 2 0.491
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.455
Bgn biglycan 0.454
Ccl2 chemokine (C-C motif) ligand 2 0.450
Fosl1 fos-like antigen 1 0.441
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.433
Mmp3 matrix metallopeptidase 3 0.431
Ccl20 chemokine (C-C motif) ligand 20 0.426
RT1-Db1 RT1 class II, locus Db1 0.393
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.383
Vcan versican 0.367
Col3a1 collagen, type III, alpha 1 0.359
Ggt1 gamma-glutamyltransferase 1 0.358
Ccl5 chemokine (C-C motif) ligand 5 0.357
Fshb follicle stimulating hormone, beta polypeptide 0.346
Eln elastin 0.346
Mx1 myxovirus (influenza virus) resistance 1 0.340
Fos FBJ osteosarcoma oncogene 0.318
Cd14 CD14 molecule 0.316
Col1a2 collagen, type I, alpha 2 0.309
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.307
Stat3 signal transducer and activator of transcription 3 0.307
Junb jun B proto-oncogene 0.302
Ripk3 receptor-interacting serine-threonine kinase 3 0.292
Il2ra interleukin 2 receptor, alpha 0.291
Tgm1 transglutaminase 1, K polypeptide 0.291
Tpo thyroid peroxidase 0.285
Egr2 early growth response 2 0.285
Il6st interleukin 6 signal transducer 0.284
Icam1 intercellular adhesion molecule 1 0.278
Usp18 ubiquitin specific peptidase 18 0.274
Ehf ets homologous factor 0.271
Il4ra interleukin 4 receptor, alpha 0.270
Bdkrb1 bradykinin receptor B1 0.270
Dnase1l3 deoxyribonuclease 1-like 3 0.270
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.268
Runx1 runt-related transcription factor 1 0.268
Krt18 keratin 18 0.260
Ier3 immediate early response 3 0.258
Nos3 nitric oxide synthase 3, endothelial cell 0.256
Ccr2 chemokine (C-C motif) receptor 2 0.251
Atf3 activating transcription factor 3 0.248
Flt1 FMS-related tyrosine kinase 1 0.243
Bcl2 B-cell CLL/lymphoma 2 0.242
Nos2 nitric oxide synthase 2, inducible 0.227
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.227
Ptgs2 prostaglandin-endoperoxide synthase 2 0.226
Eif5a eukaryotic translation initiation factor 5A 0.224
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.224
Reg3g regenerating islet-derived 3 gamma 0.223
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.221
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.220
Ptgis prostaglandin I2 (prostacyclin) synthase 0.218
Mmp7 matrix metallopeptidase 7 0.215
Ier2 immediate early response 2 0.211
Cebpe CCAAT/enhancer binding protein (C/EBP), epsilon 0.208
Cd44 Cd44 molecule 0.206
Itgam integrin, alpha M 0.204
Kynu kynureninase (L-kynurenine hydrolase) 0.203
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.201
Ccl3 chemokine (C-C motif) ligand 3 0.201
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.200
Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.198
Slit3 slit homolog 3 (Drosophila) 0.198
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.198
Il8rb interleukin 8 receptor, beta 0.192
Cd2 Cd2 molecule 0.192
C1s complement component 1, s subcomponent 0.187
Jak2 Janus kinase 2 0.187
Calcb calcitonin-related polypeptide, beta 0.183
Col5a1 collagen, type V, alpha 1 0.182
Ctsk cathepsin K 0.181
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.181
Angpt2 angiopoietin 2 0.179
Itgad integrin, alpha D 0.177
Nrg1 neuregulin 1 0.172
Fas Fas (TNF receptor superfamily, member 6) 0.169
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.169
Ms4a11 membrane-spanning 4-domains, subfamily A, member 11 0.168
Inhba inhibin beta-A 0.168
Sct secretin 0.167
Plau plasminogen activator, urokinase 0.165
Pde3a phosphodiesterase 3A, cGMP inhibited 0.165
Kcnt1 potassium channel, subfamily T, member 1 0.165
Gzmc granzyme C 0.164
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism