The network for 'osteoclast differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

osteoclast differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 0.979
Csf1 colony stimulating factor 1 (macrophage) 0.978
Tnf tumor necrosis factor 0.976
Efnb2 ephrin B2 0.973
Mapk14 mitogen-activated protein kinase 14 0.954
Jun Jun oncogene 0.946
Thra thyroid hormone receptor alpha 0.858
Cbl Casitas B-lineage lymphoma 0.828
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.827
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.780
Ikzf1 IKAROS family zinc finger 1 0.772
Egr1 early growth response 1 0.701
Fos FBJ osteosarcoma oncogene 0.697
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.696
Duox2 dual oxidase 2 0.680
Shc1 src homology 2 domain-containing transforming protein C1 0.678
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.668
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.634
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.634
Mdm2 transformed mouse 3T3 cell double minute 2 0.626
Pten phosphatase and tensin homolog 0.608
Ptprc protein tyrosine phosphatase, receptor type, C 0.600
Ephb2 Eph receptor B2 0.586
Inpp5d inositol polyphosphate-5-phosphatase D 0.564
Prkce protein kinase C, epsilon 0.556
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.552
Chuk conserved helix-loop-helix ubiquitous kinase 0.549
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.540
Igh immunoglobulin heavy chain complex 0.538
Kiss1r KISS1 receptor 0.526
Kiss1 KiSS-1 metastasis-suppressor 0.523
Slit3 slit homolog 3 (Drosophila) 0.522
Ctsk cathepsin K 0.514
Sfrp2 secreted frizzled-related protein 2 0.510
Flt4 FMS-like tyrosine kinase 4 0.476
Notch1 Notch gene homolog 1 (Drosophila) 0.451
Atf2 activating transcription factor 2 0.442
Btk Bruton agammaglobulinemia tyrosine kinase 0.429
Cd19 CD19 antigen 0.426
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.408
Runx2 runt related transcription factor 2 0.406
Psen1 presenilin 1 0.390
Robo1 roundabout homolog 1 (Drosophila) 0.387
Tgfb1 transforming growth factor, beta 1 0.386
Hcst hematopoietic cell signal transducer 0.385
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.360
Grb2 growth factor receptor bound protein 2 0.359
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.357
Ikbkg inhibitor of kappaB kinase gamma 0.336
Mefv Mediterranean fever 0.321
Epha4 Eph receptor A4 0.320
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.318
Slit2 slit homolog 2 (Drosophila) 0.318
Cd247 CD247 antigen 0.317
Zfp36 zinc finger protein 36 0.316
Cd40 CD40 antigen 0.304
Dusp1 dual specificity phosphatase 1 0.287
Sfrp1 secreted frizzled-related protein 1 0.284
Rel reticuloendotheliosis oncogene 0.282
Efnb1 ephrin B1 0.276
Fes feline sarcoma oncogene 0.271
Vdr vitamin D receptor 0.260
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.257
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.249
Mcl1 myeloid cell leukemia sequence 1 0.247
Card11 caspase recruitment domain family, member 11 0.243
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.240
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.236
Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) 0.234
Dock1 dedicator of cytokinesis 1 0.229
Ccr1 chemokine (C-C motif) receptor 1 0.228
Ltb lymphotoxin B 0.219
Grb10 growth factor receptor bound protein 10 0.218
Was Wiskott-Aldrich syndrome homolog (human) 0.218
Gnrhr gonadotropin releasing hormone receptor 0.218
Nos2 nitric oxide synthase 2, inducible 0.217
Fas Fas (TNF receptor superfamily member 6) 0.215
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.215
Wnt5a wingless-related MMTV integration site 5A 0.212
Ptpre protein tyrosine phosphatase, receptor type, E 0.211
Plcg1 phospholipase C, gamma 1 0.210
Mavs mitochondrial antiviral signaling protein 0.209
Ptch1 patched homolog 1 0.206
Kitl kit ligand 0.205
Atf3 activating transcription factor 3 0.203
Tcf7l2 transcription factor 7-like 2, T-cell specific, HMG-box 0.201
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.191
Dysf dysferlin 0.191
Cd4 CD4 antigen 0.185
Cd28 CD28 antigen 0.184
Btg2 B-cell translocation gene 2, anti-proliferative 0.183
Ephb3 Eph receptor B3 0.182
Epor erythropoietin receptor 0.180
Iqgap1 IQ motif containing GTPase activating protein 1 0.180
Fgfr2 fibroblast growth factor receptor 2 0.177
Lepr leptin receptor 0.176
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.176
Cx3cr1 chemokine (C-X3-C) receptor 1 0.172
Vegfa vascular endothelial growth factor A 0.171
Robo2 roundabout homolog 2 (Drosophila) 0.171
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cdh5 cadherin 5 0.699
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.356
LOC100331484 hypothetical protein LOC100331484 0.256
cmyb transcription factor cmyb 0.249
nf1a neurofibromin 1a 0.229
hbaa1 hemoglobin alpha adult-1 0.160
tfr1a transferrin receptor 1a 0.156
si:ch211-235f6.2 si:ch211-235f6.2 0.154
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.134
notch3 notch homolog 3 0.133
junb jun B proto-oncogene 0.130
mitfa microphthalmia-associated transcription factor a 0.125
csf1ra colony stimulating factor 1 receptor, a 0.124
hbbe1.1 hemoglobin beta embryonic-1.1 0.119
urod uroporphyrinogen decarboxylase 0.118
fn1b fibronectin 1b 0.112
socs3a suppressor of cytokine signaling 3a 0.111
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.110
aco1 aconitase 1, soluble 0.109
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.107
foxi3a forkhead box I3a 0.104
dusp2 dual specificity phosphatase 2 0.102
gng8 guanine nucleotide binding protein (G protein), gamma 8 0.100
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.094
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.091
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.090
comta catechol-O-methyltransferase a 0.089
grnb granulin b 0.088
sox10 SRY-box containing gene 10 0.085
zgc:92851 zgc:92851 0.083
hbae3 hemoglobin alpha embryonic-3 0.081
lef1 lymphocyte enhancer binding factor 1 0.080
ednrb1 endothelin receptor B 0.077
fzd7b frizzled homolog 7b 0.077
tlr3 toll-like receptor 3 0.076
nf1b neurofibromin 1b 0.075
celf1 cugbp, Elav-like family member 1 0.074
chrna6 cholinergic receptor, nicotinic, alpha 6 0.070
rag1 recombination activating gene 1 0.069
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.068
gng12a guanine nucleotide binding protein (G protein), gamma 12a 0.068
tie1 endothelium-specific receptor tyrosine kinase 1 0.066
paqr8 progestin and adipoQ receptor family member VIII 0.066
elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.065
sulf1 sulfatase 1 0.065
cpox coproporphyrinogen oxidase 0.064
tie2 endothelium-specific receptor tyrosine kinase 2 0.064
tagln2 transgelin 2 0.063
adcyap1a adenylate cyclase activating polypeptide 1a 0.062
lhcgr luteinizing hormone/choriogonadotropin receptor 0.061
hsp47 heat shock protein 47 0.061
hbae1 hemoglobin alpha embryonic-1 0.060
mmp13a matrix metalloproteinase 13a 0.058
jun jun proto-oncogene 0.057
gadd45bb growth arrest and DNA-damage-inducible, beta b 0.055
slc25a37 solute carrier family 25, member 37 0.055
hmbsb hydroxymethylbilane synthase, b 0.054
mmp9 matrix metalloproteinase 9 0.054
tyr tyrosinase 0.054
etv2 ets variant gene 2 0.054
runx1 runt-related transcription factor 1 0.053
fzd2 frizzled homolog 2 0.052
gata1a GATA binding protein 1a 0.052
jag1b jagged 1b 0.052
ptgs2a prostaglandin-endoperoxide synthase 2a 0.052
nrp1a neuropilin 1a 0.052
wnt3a wingless-type MMTV integration site family, member 3A 0.050
junbl jun B proto-oncogene, like 0.050
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.048
ppox protoporphyrinogen oxidase 0.048
efnb2a ephrin B2a 0.048
mpx myeloid-specific peroxidase 0.048
anxa1a annexin A1a 0.048
zgc:112329 zgc:112329 0.048
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.046
LOC100000332 e3 ubiquitin-protein ligase RNF182-like 0.045
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.045
s100a10b S100 calcium binding protein A10b 0.045
si:ch73-60e21.1 si:ch73-60e21.1 0.042
fev FEV (ETS oncogene family) 0.041
appa amyloid beta (A4) precursor protein a 0.041
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.041
abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.041
mmp2 matrix metalloproteinase 2 0.040
fosl2 fos-like antigen 2 0.040
dusp5 dual specificity phosphatase 5 0.040
pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.039
lin28a lin-28 homolog A (C. elegans) 0.038
zgc:193613 zgc:193613 0.038
egr1 early growth response 1 0.038
fgfr1b fibroblast growth factor receptor 1b 0.037
atf3 activating transcription factor 3 0.037
spry4 sprouty (Drosophila) homolog 4 0.037
wt1b wilms tumor 1b 0.037
prdx2 peroxiredoxin 2 0.037
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.036
fes feline sarcoma oncogene 0.035
igfbp1a insulin-like growth factor binding protein 1a 0.035
mapk3 mitogen-activated protein kinase 3 0.034
kita kit receptor a 0.034
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TRAF1 TNF receptor-associated factor 1 1.000
CCR5 chemokine (C-C motif) receptor 5 0.999
ZNF43 zinc finger protein 43 0.999
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.994
IL4R interleukin 4 receptor 0.994
CD40 CD40 molecule, TNF receptor superfamily member 5 0.985
CCL4 chemokine (C-C motif) ligand 4 0.972
ZNF273 zinc finger protein 273 0.971
TRAF5 TNF receptor-associated factor 5 0.963
ZNF253 zinc finger protein 253 0.943
TRAF2 TNF receptor-associated factor 2 0.930
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.926
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.909
CCL5 chemokine (C-C motif) ligand 5 0.876
TRADD TNFRSF1A-associated via death domain 0.856
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.855
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.812
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.787
TRAF3 TNF receptor-associated factor 3 0.765
CCR7 chemokine (C-C motif) receptor 7 0.726
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.716
ZNF675 zinc finger protein 675 0.713
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.712
TNF tumor necrosis factor 0.683
BIRC3 baculoviral IAP repeat containing 3 0.676
IFNG interferon, gamma 0.675
CXCL9 chemokine (C-X-C motif) ligand 9 0.672
JUN jun proto-oncogene 0.668
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.617
CCL22 chemokine (C-C motif) ligand 22 0.601
IL2RG interleukin 2 receptor, gamma 0.582
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.579
ZNF91 zinc finger protein 91 0.533
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.532
CCR4 chemokine (C-C motif) receptor 4 0.520
CCR1 chemokine (C-C motif) receptor 1 0.513
IL2RB interleukin 2 receptor, beta 0.497
ZNF254 zinc finger protein 254 0.493
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.487
ANXA1 annexin A1 0.482
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.472
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.466
ZNF93 zinc finger protein 93 0.448
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.435
SLAMF1 signaling lymphocytic activation molecule family member 1 0.390
IL23A interleukin 23, alpha subunit p19 0.386
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.380
PILRA paired immunoglobin-like type 2 receptor alpha 0.367
S100A10 S100 calcium binding protein A10 0.361
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.353
CCL2 chemokine (C-C motif) ligand 2 0.345
ZMYND11 zinc finger, MYND-type containing 11 0.306
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.280
ZNF117 zinc finger protein 117 0.278
ZNF430 zinc finger protein 430 0.274
CD14 CD14 molecule 0.269
PECAM1 platelet/endothelial cell adhesion molecule 0.264
APP amyloid beta (A4) precursor protein 0.249
CAV1 caveolin 1, caveolae protein, 22kDa 0.243
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.237
ZNF85 zinc finger protein 85 0.221
IL10 interleukin 10 0.218
GRB2 growth factor receptor-bound protein 2 0.207
BCL3 B-cell CLL/lymphoma 3 0.206
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.203
ZNF708 zinc finger protein 708 0.203
CCL7 chemokine (C-C motif) ligand 7 0.197
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.192
IRF4 interferon regulatory factor 4 0.173
ANXA7 annexin A7 0.171
IL4 interleukin 4 0.158
CCL8 chemokine (C-C motif) ligand 8 0.157
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.156
CCL3 chemokine (C-C motif) ligand 3 0.155
SLAMF7 SLAM family member 7 0.151
TMSB4X thymosin beta 4, X-linked 0.148
CXCL13 chemokine (C-X-C motif) ligand 13 0.147
CXCR3 chemokine (C-X-C motif) receptor 3 0.144
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.137
GRAP2 GRB2-related adaptor protein 2 0.137
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.128
CXCL10 chemokine (C-X-C motif) ligand 10 0.119
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.119
CD28 CD28 molecule 0.116
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.113
ICAM1 intercellular adhesion molecule 1 0.111
CD40LG CD40 ligand 0.108
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.106
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.106
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.106
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.102
CCL13 chemokine (C-C motif) ligand 13 0.101
TGFB1 transforming growth factor, beta 1 0.101
CCL11 chemokine (C-C motif) ligand 11 0.101
IL1B interleukin 1, beta 0.092
ATF3 activating transcription factor 3 0.089
RIPK2 receptor-interacting serine-threonine kinase 2 0.088
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.085
IDE insulin-degrading enzyme 0.080
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.079
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Rattus norvegicus
Name Description Probability Func Analog Organism
Il2rb interleukin 2 receptor, beta 0.175
Egr1 early growth response 1 0.146
Egr2 early growth response 2 0.081
Il1rl1 interleukin 1 receptor-like 1 0.075
Atf3 activating transcription factor 3 0.072
Cfp complement factor properdin 0.061
Btg2 BTG family, member 2 0.054
Cd68 Cd68 molecule 0.054
Ccl3 chemokine (C-C motif) ligand 3 0.051
Ccl4 chemokine (C-C motif) ligand 4 0.049
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.038
Prf1 perforin 1 (pore forming protein) 0.037
Il1b interleukin 1 beta 0.025
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.024
Lrp1 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) 0.023
Il1a interleukin 1 alpha 0.020
Gzmb granzyme B 0.017
Fam65a family with sequence similarity 65, member A 0.016
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.016
Lect1 leukocyte cell derived chemotaxin 1 0.015
Cst7 cystatin F (leukocystatin) 0.015
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.015
Ddr2 discoidin domain receptor tyrosine kinase 2 0.015
Ptgfr prostaglandin F receptor 0.014
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.014
Dchs1 dachsous 1 (Drosophila) 0.013
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.013
Prl8a7 prolactin family 8, subfamily a, member 7 0.013
Xcl1 chemokine (C motif) ligand 1 0.013
Klf4 Kruppel-like factor 4 (gut) 0.013
Guca2a guanylate cyclase activator 2a (guanylin) 0.013
Nkg7 natural killer cell group 7 sequence 0.013
Prrx1 paired related homeobox 1 0.012
Cthrc1 collagen triple helix repeat containing 1 0.012
Rcvrn recoverin 0.012
Il8rb interleukin 8 receptor, beta 0.012
Irf2 interferon regulatory factor 2 0.011
Acacb acetyl-Coenzyme A carboxylase beta 0.011
Itgad integrin, alpha D 0.011
Runx1 runt-related transcription factor 1 0.011
Ednra endothelin receptor type A 0.011
Gpr182 G protein-coupled receptor 182 0.010
Grm3 glutamate receptor, metabotropic 3 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism