The network for 'peptidyl lysine modification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peptidyl lysine modification

The modification of peptidyl-lysine.

Mus musculus
Name Description Probability Func Analog Organism
Rnf2 ring finger protein 2 0.999
Rybp RING1 and YY1 binding protein 0.990
Arid1a AT rich interactive domain 1A (SWI-like) 0.989
Trrap transformation/transcription domain-associated protein 0.976
Kat2a K(lysine) acetyltransferase 2A 0.967
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.966
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.950
Ep300 E1A binding protein p300 0.944
Runx1 runt related transcription factor 1 0.910
Tcfcp2l1 transcription factor CP2-like 1 0.885
Kdm1a lysine (K)-specific demethylase 1A 0.857
Kdm2b lysine (K)-specific demethylase 2B 0.855
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.832
Crebbp CREB binding protein 0.826
Wdr5 WD repeat domain 5 0.812
Tal1 T-cell acute lymphocytic leukemia 1 0.810
Zeb1 zinc finger E-box binding homeobox 1 0.787
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.750
Ep400 E1A binding protein p400 0.747
Sin3a transcriptional regulator, SIN3A (yeast) 0.725
Trp53 transformation related protein 53 0.715
Pou5f1 POU domain, class 5, transcription factor 1 0.694
Yeats2 YEATS domain containing 2 0.689
Jarid2 jumonji, AT rich interactive domain 2 0.677
Hdac2 histone deacetylase 2 0.612
Rxra retinoid X receptor alpha 0.582
Dmap1 DNA methyltransferase 1-associated protein 1 0.575
Smc3 structural maintenace of chromosomes 3 0.551
Cry2 cryptochrome 2 (photolyase-like) 0.543
Ptf1a pancreas specific transcription factor, 1a 0.531
Gata4 GATA binding protein 4 0.524
Tgfbr2 transforming growth factor, beta receptor II 0.506
Mga MAX gene associated 0.497
Rbbp4 retinoblastoma binding protein 4 0.462
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.458
Tada2a transcriptional adaptor 2A 0.458
Brca2 breast cancer 2 0.442
Apc adenomatosis polyposis coli 0.439
Rbl2 retinoblastoma-like 2 0.429
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.426
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.425
Tcf4 transcription factor 4 0.415
Smad5 MAD homolog 5 (Drosophila) 0.410
Klf4 Kruppel-like factor 4 (gut) 0.408
Mdm4 transformed mouse 3T3 cell double minute 4 0.406
Vegfa vascular endothelial growth factor A 0.406
Bcor BCL6 interacting corepressor 0.399
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.398
Polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.395
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.394
Mef2d myocyte enhancer factor 2D 0.384
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.373
Pum1 pumilio 1 (Drosophila) 0.371
Morf4l1 mortality factor 4 like 1 0.365
Chd4 chromodomain helicase DNA binding protein 4 0.357
Gli2 GLI-Kruppel family member GLI2 0.351
Arid2 AT rich interactive domain 2 (ARID, RFX-like) 0.350
Neurod1 neurogenic differentiation 1 0.345
Kat5 K(lysine) acetyltransferase 5 0.319
Ncoa3 nuclear receptor coactivator 3 0.315
Plxnd1 plexin D1 0.312
Mll2 myeloid/lymphoid or mixed-lineage leukemia 2 0.310
Brca1 breast cancer 1 0.299
Mcl1 myeloid cell leukemia sequence 1 0.294
Rbbp7 retinoblastoma binding protein 7 0.289
Creb1 cAMP responsive element binding protein 1 0.283
Kdm5b lysine (K)-specific demethylase 5B 0.280
Ehmt1 euchromatic histone methyltransferase 1 0.279
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.279
Bag6 BCL2-associated athanogene 6 0.269
Ncor1 nuclear receptor co-repressor 1 0.268
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.265
Foxp1 forkhead box P1 0.259
Cbx8 chromobox homolog 8 (Drosophila Pc class) 0.257
Cic capicua homolog (Drosophila) 0.253
Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.241
Atm ataxia telangiectasia mutated homolog (human) 0.240
Ruvbl2 RuvB-like protein 2 0.240
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.238
Rara retinoic acid receptor, alpha 0.237
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.234
Tcf7 transcription factor 7, T-cell specific 0.231
Tbx3 T-box 3 0.230
Tgfb1 transforming growth factor, beta 1 0.229
En1 engrailed 1 0.228
Nbn nibrin 0.228
Trim28 tripartite motif-containing 28 0.225
Inhba inhibin beta-A 0.223
Arid1b AT rich interactive domain 1B (SWI-like) 0.222
Dlx2 distal-less homeobox 2 0.221
Trim24 tripartite motif-containing 24 0.221
Ncoa6 nuclear receptor coactivator 6 0.219
Myod1 myogenic differentiation 1 0.219
Gata1 GATA binding protein 1 0.212
Phf21a PHD finger protein 21A 0.210
Mtf2 metal response element binding transcription factor 2 0.208
Mapk1 mitogen-activated protein kinase 1 0.207
Sertad2 SERTA domain containing 2 0.206
Prkce protein kinase C, epsilon 0.205
Brd4 bromodomain containing 4 0.204
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
hda-2 Protein HDA-2 0.122
trr-1 Protein TRR-1 0.060
CELE_B0238.11 Protein B0238.11 0.033
F44E2.8 Protein F44E2.8 0.024
F33E11.3 Protein F33E11.3 0.023
CELE_Y54G11A.11 Protein Y54G11A.11 0.020
R07G3.7 Protein R07G3.7 0.017
attf-2 Protein ATTF-2 0.016
lin-5 Protein LIN-5 0.016
baf-1 Protein BAF-1 0.016
sas-4 Protein SAS-4 0.015
npp-7 Protein NPP-7 0.014
tim-1 Protein TIM-1 0.013
swsn-6 Protein SWSN-6 0.013
apr-1 Protein APR-1 0.012
Y48G1A.2 Protein Y48G1A.2 0.012
spr-5 Protein SPR-5 0.012
R05D3.2 Protein R05D3.2 0.011
Y87G2A.1 Protein Y87G2A.1 0.010
dcr-1 Protein DCR-1 0.010
eya-1 Protein EYA-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
smyd2a SET and MYND domain containing 2a 0.024
prdm11 PR domain containing 11 0.017
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.016
rbb4 retinoblastoma binding protein 4 0.014
tal1 T-cell acute lymphocytic leukemia 1 0.013
suv420h1 suppressor of variegation 4-20 homolog 1 (Drosophila) 0.013
setdb1a SET domain, bifurcated 1a 0.012
smyd5 SMYD family member 5 0.011
prdm2b PR domain containing 2, with ZNF domain b 0.011
cbx5 chromobox homolog 5 (HP1 alpha homolog, Drosophila) 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Hcf Host cell factor 1.000
Snr1 Snf5-related 1 0.997
CG10414 CG10414 gene product from transcript CG10414-RA 0.989
Rpd3 CG7471 gene product from transcript CG7471-RA 0.974
Pcaf CG4107 gene product from transcript CG4107-RA 0.968
not non-stop 0.948
ash1 absent, small, or homeotic discs 1 0.946
Atac1 ATAC component 1 0.943
dik diskette 0.939
mof males absent on the first 0.898
msl-3 male-specific lethal 3 0.844
wds will die slowly 0.841
CG3363 CG3363 gene product from transcript CG3363-RB 0.774
Pc Polycomb 0.765
dom domino 0.760
msl-1 male-specific lethal 1 0.707
Nf-YB Nuclear factor Y-box B 0.634
Mocs2 Molybdopterin synthase 2 0.619
MRG15 CG6363 gene product from transcript CG6363-RA 0.606
D12 CG13400 gene product from transcript CG13400-RA 0.591
Spt5 CG7626 gene product from transcript CG7626-RA 0.466
Saf6 SAGA factor-like TAF6 0.460
egg eggless 0.453
lid little imaginal discs 0.442
Sgf29 CG30390 gene product from transcript CG30390-RA 0.437
cg combgap 0.397
dalao CG7055 gene product from transcript CG7055-RA 0.381
Su(var)3-7 Suppressor of variegation 3-7 0.372
CG4400 CG4400 gene product from transcript CG4400-RA 0.369
Su(var)3-3 Suppressor of variegation 3-3 0.356
wts warts 0.334
noi noisette 0.329
mod(mdg4) modifier of mdg4 0.325
ph-d polyhomeotic distal 0.325
enok enoki mushroom 0.313
Scm Sex comb on midleg 0.310
Bap55 Brahma associated protein 55kD 0.305
Caf1-180 CG12109 gene product from transcript CG12109-RB 0.298
Deaf1 Deformed epidermal autoregulatory factor-1 0.292
Taf6 TBP-associated factor 6 0.292
ord orientation disruptor 0.271
l(3)mbt lethal (3) malignant brain tumor 0.270
Sam-S S-adenosylmethionine Synthetase 0.264
wapl wings apart-like 0.259
brm brahma 0.259
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.253
Su(H) Suppressor of Hairless 0.252
Sir2 CG5216 gene product from transcript CG5216-RA 0.248
drosha CG8730 gene product from transcript CG8730-RA 0.241
CG10107 CG10107 gene product from transcript CG10107-RA 0.237
polybromo CG11375 gene product from transcript CG11375-RA 0.222
mle maleless 0.219
me31B maternal expression at 31B 0.208
O-fut1 O-fucosyltransferase 1 0.195
Kr Kruppel 0.194
kis kismet 0.192
Bap170 Brahma associated protein 170kD 0.186
Su(z)2 Suppressor of zeste 2 0.186
Pka-C1 cAMP-dependent protein kinase 1 0.184
NC2alpha CG10318 gene product from transcript CG10318-RA 0.182
HP1c CG6990 gene product from transcript CG6990-RA 0.155
fzy fizzy 0.149
Suv4-20 CG13363 gene product from transcript CG13363-RA 0.148
ush u-shaped 0.145
e(y)2 enhancer of yellow 2 0.145
l(2)35Df lethal (2) 35Df 0.144
Mad Mothers against dpp 0.141
Rga Regena 0.137
simj simjang 0.134
MED16 Mediator complex subunit 16 0.132
tsu tsunagi 0.130
msl-2 male-specific lethal 2 0.127
Cdk8 Cyclin-dependent kinase 8 0.127
CG5669 CG5669 gene product from transcript CG5669-RA 0.126
sno strawberry notch 0.126
NC2beta CG4185 gene product from transcript CG4185-RA 0.125
wb wing blister 0.123
dome domeless 0.122
defl deflated 0.121
CG10880 CG10880 gene product from transcript CG10880-RA 0.120
l(2)37Cb lethal (2) 37Cb 0.116
woc without children 0.116
Nipped-A CG33554 gene product from transcript CG33554-RE 0.116
bon bonus 0.114
Vps36 Vacuolar protein sorting 36 0.111
wdn wings down 0.111
mRpL36 mitochondrial ribosomal protein L36 0.109
osa CG7467 gene product from transcript CG7467-RD 0.109
Mes2 CG11100 gene product from transcript CG11100-RB 0.102
CG32343 CG32343 gene product from transcript CG32343-RB 0.099
HLH54F CG5005 gene product from transcript CG5005-RA 0.098
glo glorund 0.097
Chrac-16 CG15736 gene product from transcript CG15736-RA 0.097
U2af38 U2 small nuclear riboprotein auxiliary factor 38 0.097
Fs(2)Ket Female sterile (2) Ketel 0.097
Pcl Polycomblike 0.096
Atu Another transcription unit 0.094
e(y)3 enhancer of yellow 3 0.093
CG4699 CG4699 gene product from transcript CG4699-RJ 0.093
mats mob as tumor suppressor 0.090
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Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 1.000
WDR5 WD repeat domain 5 1.000
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.997
ACTL6A actin-like 6A 0.994
C20orf20 chromosome 20 open reading frame 20 0.991
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.985
CBX5 chromobox homolog 5 0.979
TRRAP transformation/transcription domain-associated protein 0.977
KAT2B K(lysine) acetyltransferase 2B 0.964
CREBBP CREB binding protein 0.956
NCOA6 nuclear receptor coactivator 6 0.956
JUN jun proto-oncogene 0.949
KAT2A K(lysine) acetyltransferase 2A 0.943
MEN1 multiple endocrine neoplasia I 0.941
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.930
AR androgen receptor 0.928
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.924
HDAC1 histone deacetylase 1 0.917
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.916
HDAC2 histone deacetylase 2 0.915
FOS FBJ murine osteosarcoma viral oncogene homolog 0.910
MAPK14 mitogen-activated protein kinase 14 0.909
DUSP1 dual specificity phosphatase 1 0.903
TADA3 transcriptional adaptor 3 0.886
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.881
RB1 retinoblastoma 1 0.878
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.856
MYST1 MYST histone acetyltransferase 1 0.852
HIST1H3B histone cluster 1, H3b 0.841
MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 0.836
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.833
SIRT1 sirtuin 1 0.832
USP22 ubiquitin specific peptidase 22 0.818
EP300 E1A binding protein p300 0.818
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.817
YY1 YY1 transcription factor 0.797
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 0.793
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.771
KDM1A lysine (K)-specific demethylase 1A 0.767
MRFAP1 Morf4 family associated protein 1 0.761
ESR1 estrogen receptor 1 0.755
MBIP MAP3K12 binding inhibitory protein 1 0.749
MAPK3 mitogen-activated protein kinase 3 0.740
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.687
SMN1 survival of motor neuron 1, telomeric 0.681
CFL1 cofilin 1 (non-muscle) 0.676
MORF4L1 mortality factor 4 like 1 0.665
DAXX death-domain associated protein 0.647
CCDC101 coiled-coil domain containing 101 0.639
SETD7 SET domain containing (lysine methyltransferase) 7 0.629
NCOA1 nuclear receptor coactivator 1 0.624
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.610
BRCA1 breast cancer 1, early onset 0.571
HDAC4 histone deacetylase 4 0.564
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.546
ING3 inhibitor of growth family, member 3 0.545
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.545
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 0.534
PCNA proliferating cell nuclear antigen 0.525
SETD8 SET domain containing (lysine methyltransferase) 8 0.523
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.521
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.514
KAT5 K(lysine) acetyltransferase 5 0.493
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.487
KLF6 Kruppel-like factor 6 0.481
SMAD7 SMAD family member 7 0.480
ELP2 elongation protein 2 homolog (S. cerevisiae) 0.478
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.472
RBBP4 retinoblastoma binding protein 4 0.470
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.444
MECP2 methyl CpG binding protein 2 (Rett syndrome) 0.434
NCOR2 nuclear receptor corepressor 2 0.421
HCFC1 host cell factor C1 (VP16-accessory protein) 0.419
NCOA2 nuclear receptor coactivator 2 0.413
HDAC6 histone deacetylase 6 0.412
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.402
CUX1 cut-like homeobox 1 0.402
CTBP1 C-terminal binding protein 1 0.395
PDZD11 PDZ domain containing 11 0.394
TWIST1 twist homolog 1 (Drosophila) 0.392
RBBP5 retinoblastoma binding protein 5 0.385
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.384
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.378
BCL6 B-cell CLL/lymphoma 6 0.364
KLF4 Kruppel-like factor 4 (gut) 0.354
MAPK8 mitogen-activated protein kinase 8 0.354
MEF2C myocyte enhancer factor 2C 0.347
RSBN1 round spermatid basic protein 1 0.346
ADNP activity-dependent neuroprotector homeobox 0.338
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.332
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.316
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 0.315
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.315
CSNK1E casein kinase 1, epsilon 0.311
PAX3 paired box 3 0.307
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.306
NCOR1 nuclear receptor corepressor 1 0.305
RING1 ring finger protein 1 0.304
POU3F2 POU class 3 homeobox 2 0.303
ZNF496 zinc finger protein 496 0.301
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Rattus norvegicus
Name Description Probability Func Analog Organism
Actb actin, beta 0.017
Actg1 actin, gamma 1 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
TRA1 Tra1p 1.000
ADA2 Ada2p 0.998
TAF6 Taf6p 0.998
SPT8 Spt8p 0.995
GCN5 Gcn5p 0.994
TAF12 Taf12p 0.978
NGG1 Ngg1p 0.976
HHT1 Hht1p 0.969
RTF1 Rtf1p 0.969
BDF1 Bdf1p 0.952
EPL1 Epl1p 0.924
HFI1 Hfi1p 0.922
SPT7 Spt7p 0.917
SWD3 Swd3p 0.907
ARP4 Arp4p 0.863
YAF9 Yaf9p 0.835
YNG2 Yng2p 0.783
EAF1 Eaf1p 0.783
SGF29 Sgf29p 0.653
TAF5 Taf5p 0.617
SDC1 Sdc1p 0.611
SPT3 Spt3p 0.584
SPP1 Spp1p 0.545
TAF10 Taf10p 0.527
TAF9 Taf9p 0.492
HAT1 Hat1p 0.438
SET2 Set2p 0.437
SWC4 Swc4p 0.434
TAF3 Taf3p 0.430
SPT20 Spt20p 0.426
HIF1 Hif1p 0.423
ASF1 Asf1p 0.422
SPT15 Spt15p 0.420
ESA1 Esa1p 0.412
ISW1 Isw1p 0.411
SAS4 Sas4p 0.409
SAS5 Sas5p 0.396
ELP6 Elp6p 0.394
EAF3 Eaf3p 0.389
SWD1 Swd1p 0.379
HAT2 Hat2p 0.368
SGF73 Sgf73p 0.357
EAF6 Eaf6p 0.353
LEO1 Leo1p 0.328
SUS1 Sus1p 0.319
EAF5 Eaf5p 0.288
SAS3 Sas3p 0.266
RTT106 Rtt106p 0.261
YNG1 Yng1p 0.231
AHC2 Ahc2p 0.220
RTT109 Rtt109p 0.218
SWI1 Swi1p 0.207
PSH1 Psh1p 0.197
HHF1 Hhf1p 0.188
SNF5 Snf5p 0.186
HIR1 Hir1p 0.185
RPD3 Rpd3p 0.173
HIR2 Hir2p 0.173
SWI3 Swi3p 0.170
HDA1 Hda1p 0.160
ELP4 Elp4p 0.156
RSC2 Rsc2p 0.152
SGF11 Sgf11p 0.151
UBP8 Ubp8p 0.151
BRE2 Bre2p 0.150
RCO1 Rco1p 0.149
NOP10 Nop10p 0.149
CKB1 Ckb1p 0.147
ELP2 Elp2p 0.136
TAF1 Taf1p 0.134
TAF4 Taf4p 0.134
YAT1 Yat1p 0.116
CAC2 Cac2p 0.109
FUS3 Fus3p 0.104
SET1 Set1p 0.103
IKI1 Iki1p 0.093
HPC2 Hpc2p 0.092
YPL068C hypothetical protein 0.091
REI1 Rei1p 0.089
ANB1 Anb1p 0.083
AHC1 Ahc1p 0.083
ORC4 Orc4p 0.082
RMT2 Rmt2p 0.080
RSC4 Rsc4p 0.079
URA6 Ura6p 0.077
POL2 Pol2p 0.076
YCR051W hypothetical protein 0.074
WWM1 Wwm1p 0.072
NSA1 Nsa1p 0.072
FMP52 Fmp52p 0.070
TMA16 Tma16p 0.070
DST1 Dst1p 0.069
RSC1 Rsc1p 0.068
RXT2 Rxt2p 0.068
ADR1 Adr1p 0.067
SAS2 Sas2p 0.066
POP6 Pop6p 0.066
PFD1 Pfd1p 0.062
MED1 Med1p 0.062
ARP8 Arp8p 0.061