The network for 'ovarian follicle development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ovarian follicle development

The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.

Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 1.000
Amhr2 anti-Mullerian hormone type 2 receptor 0.999
Nos3 nitric oxide synthase 3, endothelial cell 0.999
Fshr follicle stimulating hormone receptor 0.999
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.998
Kiss1 KiSS-1 metastasis-suppressor 0.996
Pax8 paired box gene 8 0.995
Trp53 transformation related protein 53 0.995
Tgfbr2 transforming growth factor, beta receptor II 0.994
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.983
Fgfr2 fibroblast growth factor receptor 2 0.979
Bcl2 B-cell leukemia/lymphoma 2 0.962
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.961
Csf1 colony stimulating factor 1 (macrophage) 0.958
Esr1 estrogen receptor 1 (alpha) 0.951
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.938
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.918
Ar androgen receptor 0.915
Inhba inhibin beta-A 0.913
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.895
Tgfb2 transforming growth factor, beta 2 0.842
Ghr growth hormone receptor 0.819
Kit kit oncogene 0.811
Cdk2 cyclin-dependent kinase 2 0.806
Nog noggin 0.788
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.784
Pax2 paired box gene 2 0.762
Ctnnb1 catenin (cadherin associated protein), beta 1 0.755
Egfr epidermal growth factor receptor 0.746
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.706
Esr2 estrogen receptor 2 (beta) 0.660
Vegfa vascular endothelial growth factor A 0.656
Bmp4 bone morphogenetic protein 4 0.650
Fbn1 fibrillin 1 0.635
Fst follistatin 0.621
Lox lysyl oxidase 0.620
Flt4 FMS-like tyrosine kinase 4 0.595
Bax BCL2-associated X protein 0.580
Nkx2-1 NK2 homeobox 1 0.561
Apc adenomatosis polyposis coli 0.554
Hoxa1 homeobox A1 0.549
Tgfbr3 transforming growth factor, beta receptor III 0.544
Duox2 dual oxidase 2 0.539
Foxc1 forkhead box C1 0.536
Notch2 Notch gene homolog 2 (Drosophila) 0.535
Fgfr1 fibroblast growth factor receptor 1 0.522
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.502
Kiss1r KISS1 receptor 0.492
Amh anti-Mullerian hormone 0.489
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.473
Kdr kinase insert domain protein receptor 0.469
Lhx3 LIM homeobox protein 3 0.455
Ldlr low density lipoprotein receptor 0.449
Fgfr3 fibroblast growth factor receptor 3 0.449
Lepr leptin receptor 0.448
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.434
Notch1 Notch gene homolog 1 (Drosophila) 0.426
Cbl Casitas B-lineage lymphoma 0.400
Mmp9 matrix metallopeptidase 9 0.369
Tgfb1 transforming growth factor, beta 1 0.351
Kl klotho 0.330
Eng endoglin 0.314
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.303
Gnrhr gonadotropin releasing hormone receptor 0.302
Mmp2 matrix metallopeptidase 2 0.293
Foxc2 forkhead box C2 0.289
Jag1 jagged 1 0.280
Dhh desert hedgehog 0.272
Gnrh1 gonadotropin releasing hormone 1 0.266
Cdh5 cadherin 5 0.258
Psen1 presenilin 1 0.254
Sall4 sal-like 4 (Drosophila) 0.252
Fgf8 fibroblast growth factor 8 0.247
Pgr progesterone receptor 0.245
Hoxd9 homeobox D9 0.239
Col1a1 collagen, type I, alpha 1 0.237
Cga glycoprotein hormones, alpha subunit 0.231
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.228
Adam17 a disintegrin and metallopeptidase domain 17 0.226
Cdk6 cyclin-dependent kinase 6 0.222
Bmpr1a bone morphogenetic protein receptor, type 1A 0.221
Acvrl1 activin A receptor, type II-like 1 0.215
Rxra retinoid X receptor alpha 0.213
Tcl1 T-cell lymphoma breakpoint 1 0.212
Acvr1 activin A receptor, type 1 0.211
Efnb2 ephrin B2 0.209
Meox2 mesenchyme homeobox 2 0.202
Shh sonic hedgehog 0.201
Klf5 Kruppel-like factor 5 0.191
Hif1a hypoxia inducible factor 1, alpha subunit 0.187
Tgfbr1 transforming growth factor, beta receptor I 0.177
Inhbb inhibin beta-B 0.172
Runx2 runt related transcription factor 2 0.170
Smad3 MAD homolog 3 (Drosophila) 0.169
Lep leptin 0.167
Gata6 GATA binding protein 6 0.166
Prlr prolactin receptor 0.164
Stat3 signal transducer and activator of transcription 3 0.155
Tbx1 T-box 1 0.153
Kitl kit ligand 0.151
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cyp19a1a cytochrome P450, family 19, subfamily A, polypeptide 1a 0.728
bdnf brain-derived neurotrophic factor 0.321
paqr7b progestin and adipoQ receptor family member VII, b 0.303
bmp2b bone morphogenetic protein 2b 0.298
gdf9 growth differentiation factor 9 0.276
bmp15 bone morphogenetic protein 15 0.222
rag1 recombination activating gene 1 0.202
igf3 insulin-like growth factor 3 0.192
paqr8 progestin and adipoQ receptor family member VIII 0.178
cldn2 claudin 2 0.172
ptgs1 prostaglandin-endoperoxide synthase 1 0.154
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.152
fshr follicle stimulating hormone receptor 0.138
sox7 SRY-box containing gene 7 0.137
esr1 estrogen receptor 1 0.134
gnrh2 gonadotropin-releasing hormone 2 0.123
cpla2 cytosolic phospholipase a2 0.109
gsc goosecoid 0.109
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.106
cyp11a1 cytochrome P450, subfamily XIA, polypeptide 1 0.094
runx1 runt-related transcription factor 1 0.089
hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.081
csf1ra colony stimulating factor 1 receptor, a 0.080
ptgs2a prostaglandin-endoperoxide synthase 2a 0.080
cldnd claudin d 0.077
fabp11a fatty acid binding protein 11a 0.077
cyp17a1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.072
pitx2 paired-like homeodomain transcription factor 2 0.070
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.067
kiss1rb KISS1 receptor b 0.065
tbx2b T-box 2b 0.064
rbm24a RNA binding motif protein 24a 0.064
igf1 insulin-like growth factor 1 0.063
pou1f1 POU domain, class 1, transcription factor 1 0.060
mmp9 matrix metalloproteinase 9 0.059
inhbaa inhibin, beta Aa 0.058
acvr2a activin receptor IIa 0.058
osr1 odd-skipped related 1 (Drosophila) 0.057
hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 0.056
ptprb protein tyrosine phosphatase, receptor type, b 0.055
prdm1a PR domain containing 1a, with ZNF domain 0.052
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.050
ptgesl prostaglandin E synthase 2-like 0.048
vegfaa vascular endothelial growth factor Aa 0.048
brca2 breast cancer 2, early onset 0.048
star steroidogenic acute regulatory protein 0.047
hbbe1.1 hemoglobin beta embryonic-1.1 0.047
prox1 prospero-related homeobox gene 1 0.047
spry4 sprouty (Drosophila) homolog 4 0.047
cdh23 cadherin-like 23 0.047
bbc3 BCL2 binding component 3 0.046
spns2 spinster homolog 2 (Drosophila) 0.045
frzb frizzled-related protein 0.045
cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b 0.045
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.043
cdh5 cadherin 5 0.043
vasa vasa homolog 0.042
fabp10a fatty acid binding protein 10a, liver basic 0.042
aplnrb apelin receptor b 0.042
plcg1 phospholipase C, gamma 1 0.041
cbr1l carbonyl reductase 1-like 0.040
cdkn1a cyclin-dependent kinase inhibitor 1A 0.039
bmper BMP binding endothelial regulator 0.039
baxa bcl2-associated X protein, a 0.038
sod2 superoxide dismutase 2, mitochondrial 0.037
lhb luteinizing hormone, beta polypeptide 0.037
rspo1 R-spondin homolog (Xenopus laevis) 0.037
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.036
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.036
klf4 Kruppel-like factor 4 0.036
nanos3 nanos homolog 3 0.035
ddx41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.035
fanci Fanconi anemia, complementation group I 0.035
tagln2 transgelin 2 0.035
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.035
per2 period homolog 2 (Drosophila) 0.034
syce2 synaptonemal complex central element protein 2 0.034
amotl2a angiomotin like 2a 0.033
epas1b endothelial PAS domain protein 1b 0.033
fancl Fanconi anemia, complementation group L 0.033
smyd3 SET and MYND domain containing 3 0.033
evx1 even-skipped homeobox 1 0.032
mt2 metallothionein 2 0.032
foxo3b forkhead box O3b 0.032
podxl podocalyxin-like 0.031
zgc:111821 zgc:111821 0.031
arid4a AT rich interactive domain 4A (RBP1-like) 0.031
ldb2b LIM-domain binding factor 2b 0.030
appa amyloid beta (A4) precursor protein a 0.030
esr2b estrogen receptor 2b 0.030
kiss1 KiSS-1 metastasis-suppressor 0.030
bcl2l1 bcl2-like 1 0.029
tbx20 T-box 20 0.029
tnfaip1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.029
pomca proopiomelanocortin a 0.029
si:dkey-22a1.3 si:dkey-22a1.3 0.029
alcama activated leukocyte cell adhesion molecule a 0.028
cry1a cryptochrome 1a 0.028
fzd7a frizzled homolog 7a 0.028
cyp2p6 cytochrome P450, family 2, subfamily P, polypeptide 6 0.027
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.776
NRP1 neuropilin 1 0.533
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.431
BCL2L1 BCL2-like 1 0.356
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 0.244
TIMP2 TIMP metallopeptidase inhibitor 2 0.221
POU5F1 POU class 5 homeobox 1 0.159
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.155
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.140
TEK TEK tyrosine kinase, endothelial 0.120
PCGF2 polycomb group ring finger 2 0.097
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.063
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.052
BCL2 B-cell CLL/lymphoma 2 0.048
FGFR2 fibroblast growth factor receptor 2 0.041
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.038
HDAC6 histone deacetylase 6 0.035
BAK1 BCL2-antagonist/killer 1 0.031
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.030
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.026
RNR2 l-rRNA 0.026
PPP5C protein phosphatase 5, catalytic subunit 0.022
FOXO1 forkhead box O1 0.020
HTT huntingtin 0.019
TBP TATA box binding protein 0.017
BAD BCL2-associated agonist of cell death 0.017
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.016
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.016
MYLK2 myosin light chain kinase 2 0.015
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.014
RNF144B ring finger protein 144B 0.013
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.013
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.013
GDF5 growth differentiation factor 5 0.012
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.011
KITLG KIT ligand 0.011
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.011
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.011
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ednra endothelin receptor type A 0.030
Pip prolactin induced protein 0.028
Prrx1 paired related homeobox 1 0.026
Cast calpastatin 0.023
Fgf10 fibroblast growth factor 10 0.021
Homer3 homer homolog 3 (Drosophila) 0.021
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.020
Igfbp5 insulin-like growth factor binding protein 5 0.020
Smad7 SMAD family member 7 0.019
Foxd3 forkhead box D3 0.019
Tgfbr3 transforming growth factor, beta receptor III 0.017
F13a1 coagulation factor XIII, A1 polypeptide 0.017
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.017
LOC100360587 hypothetical protein LOC100360587 0.017
Ucn urocortin 0.016
Lamc1 laminin, gamma 1 0.016
Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.016
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.016
Padi1 peptidyl arginine deiminase, type I 0.016
RGD1564327 similar to integrin alpha 8 0.016
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.016
Galr2 galanin receptor 2 0.015
Foxs1 forkhead box S1 0.015
Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.015
Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 0.015
Efnb1 ephrin B1 0.015
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.015
Mtus1 mitochondrial tumor suppressor 1 0.014
Defb1 defensin beta 1 0.014
Lepr leptin receptor 0.014
Slc22a2 solute carrier family 22 (organic cation transporter), member 2 0.014
Tgfbr2 transforming growth factor, beta receptor II 0.014
Cpxm2 carboxypeptidase X (M14 family), member 2 0.014
Ccr1 chemokine (C-C motif) receptor 1 0.014
Gucy2f guanylate cyclase 2F 0.013
Cyb5r1 cytochrome b5 reductase 1 0.013
Star steroidogenic acute regulatory protein 0.013
Tyms thymidylate synthetase 0.013
Shc3 SHC (Src homology 2 domain containing) transforming protein 3 0.013
Gja5 gap junction protein, alpha 5 0.013
Chad chondroadherin 0.013
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.013
Cercam cerebral endothelial cell adhesion molecule 0.013
Emp1 epithelial membrane protein 1 0.013
Arnt aryl hydrocarbon receptor nuclear translocator 0.012
Vcan versican 0.012
Tpo thyroid peroxidase 0.012
Manea mannosidase, endo-alpha 0.012
Wnt5a wingless-type MMTV integration site family, member 5A 0.012
Ctrc chymotrypsin C (caldecrin) 0.012
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.012
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.012
Crygc crystallin, gamma C 0.012
Mybph myosin binding protein H 0.012
Kitlg KIT ligand 0.012
Chrnb4 cholinergic receptor, nicotinic, beta 4 0.012
Kcna6 potassium voltage gated channel, shaker related subfamily, member 6 0.012
Ccl28 chemokine (C-C motif) ligand 28 0.012
Tcof1 Treacher Collins-Franceschetti syndrome 1 homolog (human) 0.012
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.012
Gja4 gap junction protein, alpha 4 0.012
RY2G5 potential ligand-binding protein 0.012
Pdyn prodynorphin 0.012
Tpc1808 tropic 1808 0.012
Olfml2b olfactomedin-like 2B 0.011
Il12b interleukin 12B 0.011
Pdpn podoplanin 0.011
Angptl4 angiopoietin-like 4 0.011
Sirpa signal-regulatory protein alpha 0.011
Plin perilipin 0.011
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.011
Cel carboxyl ester lipase 0.011
A3galt2 alpha 1,3-galactosyltransferase 2 0.011
Lin7c lin-7 homolog C (C. elegans) 0.011
Adcy5 adenylate cyclase 5 0.011
Cdc25a cell division cycle 25 homolog A (S. pombe) 0.011
Ucn2 urocortin 2 0.011
Ednrb endothelin receptor type B 0.011
Ptgfr prostaglandin F receptor 0.011
Fbln5 fibulin 5 0.011
Il1rap interleukin 1 receptor accessory protein 0.011
Bst1 bone marrow stromal cell antigen 1 0.011
Sulf1 sulfatase 1 0.011
LOC286980 putative pheromone receptor (Go-VN13B) 0.011
Ddr2 discoidin domain receptor tyrosine kinase 2 0.011
Lmna lamin A 0.010
Trhr thyrotropin releasing hormone receptor 0.010
Foxd4 forkhead box D4 0.010
Pth parathyroid hormone 0.010
Nos2 nitric oxide synthase 2, inducible 0.010
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.010
Rfc1 replication factor C (activator 1) 1 0.010
Adrb1 adrenergic, beta-1-, receptor 0.010
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.010
Ldhc lactate dehydrogenase C 0.010
Ampd1 adenosine monophosphate deaminase 1 (isoform M) 0.010
Acaa2 acetyl-Coenzyme A acyltransferase 2 0.010
Csf3 colony stimulating factor 3 (granulocyte) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism