The network for 'cellular response to external stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to external stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 0.999
Trp53 transformation related protein 53 0.982
Rb1 retinoblastoma 1 0.955
Col1a1 collagen, type I, alpha 1 0.919
Hif1a hypoxia inducible factor 1, alpha subunit 0.902
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.892
Ctnnb1 catenin (cadherin associated protein), beta 1 0.872
Igh immunoglobulin heavy chain complex 0.829
Ptgs2 prostaglandin-endoperoxide synthase 2 0.823
Trp63 transformation related protein 63 0.820
Pax6 paired box gene 6 0.800
Nos3 nitric oxide synthase 3, endothelial cell 0.792
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.760
Fas Fas (TNF receptor superfamily member 6) 0.755
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.753
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.746
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.739
Mmp9 matrix metallopeptidase 9 0.728
Kitl kit ligand 0.723
Nf1 neurofibromatosis 1 0.700
Sqstm1 sequestosome 1 0.673
Fgfr2 fibroblast growth factor receptor 2 0.669
Notch2 Notch gene homolog 2 (Drosophila) 0.661
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.646
Axl AXL receptor tyrosine kinase 0.643
Vdr vitamin D receptor 0.635
Tnf tumor necrosis factor 0.629
Atg12 autophagy-related 12 (yeast) 0.620
Pparg peroxisome proliferator activated receptor gamma 0.615
Bcl2 B-cell leukemia/lymphoma 2 0.613
Braf Braf transforming gene 0.581
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.572
Fos FBJ osteosarcoma oncogene 0.566
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.535
Lepr leptin receptor 0.520
Insr insulin receptor 0.517
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.515
Cav1 caveolin 1, caveolae protein 0.514
Gdnf glial cell line derived neurotrophic factor 0.499
Gli3 GLI-Kruppel family member GLI3 0.495
Ep300 E1A binding protein p300 0.494
Nos2 nitric oxide synthase 2, inducible 0.459
Amh anti-Mullerian hormone 0.455
Lep leptin 0.441
Bglap bone gamma carboxyglutamate protein 0.423
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.416
Notch1 Notch gene homolog 1 (Drosophila) 0.413
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.413
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.397
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.390
Otx2 orthodenticle homolog 2 (Drosophila) 0.381
Foxa2 forkhead box A2 0.372
Shh sonic hedgehog 0.366
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.366
Mecp2 methyl CpG binding protein 2 0.362
Fst follistatin 0.361
Mdm2 transformed mouse 3T3 cell double minute 2 0.338
Eda ectodysplasin-A 0.338
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.324
Myf5 myogenic factor 5 0.321
Aldoa aldolase A, fructose-bisphosphate 0.320
Fzd4 frizzled homolog 4 (Drosophila) 0.310
Ctsl cathepsin L 0.310
Vegfa vascular endothelial growth factor A 0.308
Arid1b AT rich interactive domain 1B (SWI-like) 0.306
Pax3 paired box gene 3 0.305
Lyz2 lysozyme 2 0.302
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.297
Gata4 GATA binding protein 4 0.294
Ifng interferon gamma 0.294
Wnt1 wingless-related MMTV integration site 1 0.293
Vav2 vav 2 oncogene 0.292
Runx2 runt related transcription factor 2 0.292
Hbb-b1 hemoglobin, beta adult major chain 0.291
Tgfb1 transforming growth factor, beta 1 0.283
Ccr2 chemokine (C-C motif) receptor 2 0.282
Tlr4 toll-like receptor 4 0.280
Myc myelocytomatosis oncogene 0.279
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.273
Foxo1 forkhead box O1 0.273
Psen1 presenilin 1 0.271
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.270
Igf1 insulin-like growth factor 1 0.266
Isl1 ISL1 transcription factor, LIM/homeodomain 0.265
Thbs1 thrombospondin 1 0.257
Apc adenomatosis polyposis coli 0.255
Alx4 aristaless-like homeobox 4 0.253
Cd40 CD40 antigen 0.250
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.247
Foxf1a forkhead box F1a 0.237
Rxra retinoid X receptor alpha 0.230
Lef1 lymphoid enhancer binding factor 1 0.226
Foxc1 forkhead box C1 0.225
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.223
Atf2 activating transcription factor 2 0.223
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.222
Bhlhe40 basic helix-loop-helix family, member e40 0.221
3110079O15Rik RIKEN cDNA 3110079O15 gene 0.220
Ulk1 Unc-51 like kinase 1 (C. elegans) 0.218
Gli2 GLI-Kruppel family member GLI2 0.218
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.082
atg-18 Protein ATG-18 0.049
egl-30 Protein EGL-30 0.049
cpr-4 Protein CPR-4 0.042
ifg-1 Protein IFG-1 0.038
rpn-2 Protein RPN-2 0.035
R12E2.2 Protein R12E2.2 0.035
par-5 Protein PAR-5 0.030
npp-4 Protein NPP-4 0.024
hnd-1 Protein HND-1 0.023
tam-1 Protein TAM-1 0.022
aak-2 Protein AAK-2 0.019
K10C8.3 Protein K10C8.3 0.019
unc-62 Protein UNC-62 0.019
clec-65 Protein CLEC-65 0.018
rskd-1 Protein RSKD-1 0.018
C02F12.8 Protein C02F12.8 0.016
mtm-9 Protein MTM-9 0.016
egl-46 Protein EGL-46 0.016
ess-2 Protein ESS-2 0.015
Y76A2B.4 Protein Y76A2B.4 0.015
CELE_C01G6.4 Protein C01G6.4 0.015
mom-4 Protein MOM-4 0.015
glp-1 Protein GLP-1 0.014
vps-11 Protein VPS-11 0.014
frm-4 Protein FRM-4 0.013
F26F12.3 Protein F26F12.3 0.013
fshr-1 Protein FSHR-1 0.013
T21H3.1 Protein T21H3.1 0.013
lin-45 Protein LIN-45 0.013
miz-1 Protein MIZ-1 0.013
F46C5.6 Protein F46C5.6 0.013
rrf-1 Protein RRF-1 0.013
gpb-1 Protein GPB-1 0.011
lin-7 Protein LIN-7 0.011
asah-1 Protein ASAH-1 0.011
bar-1 Protein BAR-1 0.011
scav-3 Protein SCAV-3 0.011
sams-4 Protein SAMS-4 0.011
F53F10.2 Protein F53F10.2 0.011
CELE_H28G03.1 Protein H28G03.1 0.011
Y50D7A.8 Protein Y50D7A.8 0.010
pad-1 Protein PAD-1 0.010
rsd-3 Protein RSD-3 0.010
rpm-1 Protein RPM-1 0.010
ces-2 Protein CES-2 0.010
Y110A7A.4 Protein Y110A7A.4 0.010
hsr-9 Protein HSR-9 0.010
sur-2 Protein SUR-2 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.901
bmp2b bone morphogenetic protein 2b 0.708
fgf3 fibroblast growth factor 3 0.650
foxa3 forkhead box A3 0.611
frzb frizzled-related protein 0.562
ef1a elongation factor 1-alpha 0.488
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.482
sid4 secreted immunoglobulin domain 4 0.472
tm9sf2 transmembrane 9 superfamily member 2 0.468
th tyrosine hydroxylase 0.449
spry4 sprouty (Drosophila) homolog 4 0.448
jag1b jagged 1b 0.415
sox2 SRY-box containing gene 2 0.412
wnt11r wingless-type MMTV integration site family, member 11, related 0.395
lama5 laminin, alpha 5 0.385
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.379
si:dkey-8l13.4 si:dkey-8l13.4 0.375
mapk3 mitogen-activated protein kinase 3 0.372
mt2 metallothionein 2 0.361
rbp4 retinol binding protein 4, plasma 0.350
helt hey-like transcription factor 0.348
nrg2a neuregulin 2a 0.345
sox9b SRY-box containing gene 9b 0.342
wnt4b wingless-type MMTV integration site family, member 4b 0.335
per3 period homolog 3 (Drosophila) 0.332
notch2 notch homolog 2 0.331
ctgf connective tissue growth factor 0.329
wnt10a wingless-type MMTV integration site family, member 10a 0.320
gpia glucose phosphate isomerase a 0.317
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.314
col1a2 collagen, type I, alpha 2 0.312
igfbp7 insulin-like growth factor binding protein 7 0.311
hnf1ba HNF1 homeobox Ba 0.311
mfn2 mitofusin 2 0.307
atp1b1b ATPase, Na+/K+ transporting, beta 1b polypeptide 0.305
insrb insulin receptor b 0.293
spon1b spondin 1b 0.292
zfand5a zinc finger, AN1-type domain 5a 0.285
hk1 hexokinase 1 0.279
tspan7b tetraspanin 7b 0.275
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.271
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.271
sgk1 serum/glucocorticoid regulated kinase 1 0.270
ctsl1a cathepsin L, 1 a 0.261
ca2 carbonic anhydrase II 0.253
rab2a RAB2A, member RAS oncogene family 0.245
cyp24a1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.242
naa15b N(alpha)-acetyltransferase 15, NatA auxiliary subunit b 0.237
tbx1 T-box 1 0.236
dag1 dystroglycan 1 0.233
wls wntless homolog (Drosophila) 0.231
fzd5 frizzled homolog 5 0.230
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.225
bcl2l1 bcl2-like 1 0.218
shha sonic hedgehog a 0.214
gclc glutamate-cysteine ligase, catalytic subunit 0.211
tagln2 transgelin 2 0.210
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.209
cldne claudin e 0.208
actn1 actinin, alpha 1 0.208
aldoaa aldolase a, fructose-bisphosphate, a 0.207
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.206
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.204
nr3c2 nuclear receptor subfamily 3, group C, member 2 0.203
sfrp5 secreted frizzled-related protein 5 0.199
foxa2 forkhead box A2 0.199
fgf19 fibroblast growth factor 19 0.198
nr4a2b nuclear receptor subfamily 4, group A, member 2b 0.198
itgb1b.1 integrin, beta 1b.1 0.198
mapk4 mitogen-activated protein kinase 4 0.196
tal1 T-cell acute lymphocytic leukemia 1 0.195
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.193
col5a2l collagen, type V, alpha 2-like 0.192
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.191
ccng1 cyclin G1 0.188
stc1l stanniocalcin 1, like 0.188
socs3a suppressor of cytokine signaling 3a 0.184
bactin2 bactin2 0.181
arf5 ADP-ribosylation factor 5 0.171
hcrt hypocretin (orexin) neuropeptide precursor 0.170
sdcbp syndecan binding protein (syntenin) 0.168
egr1 early growth response 1 0.167
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.167
ncor1 nuclear receptor co-repressor 1 0.165
creb3l3l cAMP responsive element binding protein 3-like 3 like 0.164
hmx1 H6 homeo box 1 0.164
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.164
has2 hyaluronan synthase 2 0.163
atp1a1a.3 ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide 0.163
col5a1 procollagen, type V, alpha 1 0.163
gsnb gelsolin b 0.162
tie1 endothelium-specific receptor tyrosine kinase 1 0.161
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.160
bhlhe40 basic helix-loop-helix family, member e40 0.159
tm4sf4 transmembrane 4 L six family member 4 0.159
col11a1a collagen, type XI, alpha 1a 0.159
esf1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.158
pycard PYD and CARD domain containing 0.156
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.156
smad1 MAD homolog 1 (Drosophila) 0.154
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Atg18 Autophagy-specific gene 18 0.959
Atg8a Autophagy-specific gene 8a 0.938
aop anterior open 0.937
Rheb CG1081 gene product from transcript CG1081-RA 0.772
S6k RPS6-p70-protein kinase 0.757
Atg9 Autophagy-specific gene 9 0.752
RagA CG11968 gene product from transcript CG11968-RA 0.735
Vps16A Vacuolar protein sorting 16A 0.659
Ppcs Phosphopantothenoylcysteine synthetase 0.593
hep hemipterous 0.584
Atg2 Autophagy-specific gene 2 0.577
Rfabg Retinoid- and fatty acid-binding glycoprotein 0.551
CG3004 CG3004 gene product from transcript CG3004-RA 0.543
egr eiger 0.520
shn schnurri 0.519
Lk6 CG17342 gene product from transcript CG17342-RA 0.510
rpr reaper 0.448
dm diminutive 0.442
ci cubitus interruptus 0.421
phyl phyllopod 0.416
Atg7 Autophagy-specific gene 7 0.411
Atg6 Autophagy-specific gene 6 0.405
Tor Target of rapamycin 0.398
pan pangolin 0.394
CG1347 CG1347 gene product from transcript CG1347-RB 0.380
Atg1 Autophagy-specific gene 1 0.376
p38b CG7393 gene product from transcript CG7393-RA 0.360
Rel Relish 0.342
foxo forkhead box, sub-group O 0.340
Zyx102EF CG32018 gene product from transcript CG32018-RA 0.321
18w 18 wheeler 0.314
sd scalloped 0.302
bsk basket 0.283
Dcp-1 Death caspase-1 0.282
Syx17 Syntaxin 17 0.280
tai taiman 0.265
Akt1 CG4006 gene product from transcript CG4006-RA 0.264
Rab5 Rab-protein 5 0.257
p53 CG33336 gene product from transcript CG33336-RB 0.243
Lsd-2 Lipid storage droplet-2 0.239
Pkc98E Protein C kinase 98E 0.237
CYLD cylindromatosis 0.223
rl rolled 0.222
TBPH CG10327 gene product from transcript CG10327-RC 0.219
Rab7 Rab-protein 7 0.217
Ras85D Ras oncogene at 85D 0.215
Pi3K59F Phosphotidylinositol 3 kinase 59F 0.214
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.208
ird5 immune response deficient 5 0.185
Sox14 Sox box protein 14 0.185
shd shade 0.183
cno canoe 0.179
Myd88 CG2078 gene product from transcript CG2078-RA 0.171
th thread 0.170
Thor CG8846 gene product from transcript CG8846-RA 0.152
chico CG5686 gene product from transcript CG5686-RB 0.149
CycD Cyclin D 0.149
dnc dunce 0.146
Mad Mothers against dpp 0.145
cathD CG1548 gene product from transcript CG1548-RA 0.139
ird1 immune response deficient 1 0.138
gig gigas 0.134
BG4 CG12297 gene product from transcript CG12297-RA 0.128
Hcf Host cell factor 0.127
kuz kuzbanian 0.126
ari-1 ariadne 0.125
Toll-6 CG7250 gene product from transcript CG7250-RA 0.122
CG11347 CG11347 gene product from transcript CG11347-RE 0.121
ftz-f1 ftz transcription factor 1 0.119
nej nejire 0.118
Syb Synaptobrevin 0.114
Atg13 Autophagy-specific gene 13 0.111
CG10277 CG10277 gene product from transcript CG10277-RB 0.107
Hr96 Hormone receptor-like in 96 0.105
gammaSnap gamma-soluble NSF attachment protein 0.105
l(3)82Fd CG32464 gene product from transcript CG32464-RR 0.102
cer crammer 0.098
CG11055 CG11055 gene product from transcript CG11055-RB 0.098
Atg4 Autophagy-specific gene 4 0.098
klu klumpfuss 0.096
poly CG9829 gene product from transcript CG9829-RB 0.095
hppy happyhour 0.091
Df31 Decondensation factor 31 0.087
Aut1 CG6877 gene product from transcript CG6877-RA 0.086
east enhanced adult sensory threshold 0.085
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.085
prel preli-like 0.084
Pka-C1 cAMP-dependent protein kinase 1 0.082
lok loki 0.081
mys myospheroid 0.080
Trxr-1 Thioredoxin reductase-1 0.079
Gp150 CG5820 gene product from transcript CG5820-RA 0.076
egg eggless 0.076
eyg eyegone 0.075
imd immune deficiency 0.075
Ptp61F Protein tyrosine phosphatase 61F 0.073
spin spinster 0.073
trpml transient receptor potential mucolipin 0.072
crp cropped 0.071
CG8709 CG8709 gene product from transcript CG8709-RK 0.071
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 0.999
MAPK8 mitogen-activated protein kinase 8 0.998
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.996
SIRT1 sirtuin 1 0.994
TP53 tumor protein p53 0.992
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.978
KAT2B K(lysine) acetyltransferase 2B 0.971
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.967
ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae) 0.955
EP300 E1A binding protein p300 0.955
BCL2L1 BCL2-like 1 0.944
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.928
CREBBP CREB binding protein 0.924
NCOR1 nuclear receptor corepressor 1 0.913
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.907
ATF2 activating transcription factor 2 0.898
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.862
AR androgen receptor 0.861
EGFR epidermal growth factor receptor 0.854
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.851
FAS Fas (TNF receptor superfamily, member 6) 0.848
TRAF1 TNF receptor-associated factor 1 0.847
SQSTM1 sequestosome 1 0.847
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.846
CFLAR CASP8 and FADD-like apoptosis regulator 0.842
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.832
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.821
GABARAP GABA(A) receptor-associated protein 0.817
MAP2K4 mitogen-activated protein kinase kinase 4 0.810
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.808
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.799
MYD88 myeloid differentiation primary response gene (88) 0.798
NCOR2 nuclear receptor corepressor 2 0.794
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.787
HDAC1 histone deacetylase 1 0.786
BID BH3 interacting domain death agonist 0.784
TRAF2 TNF receptor-associated factor 2 0.744
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.741
JUN jun proto-oncogene 0.739
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.727
BECN1 beclin 1, autophagy related 0.726
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.721
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.720
INSR insulin receptor 0.719
SMAD2 SMAD family member 2 0.719
MAPK1 mitogen-activated protein kinase 1 0.719
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.715
FKBP1A FK506 binding protein 1A, 12kDa 0.706
UBC ubiquitin C 0.702
RB1CC1 RB1-inducible coiled-coil 1 0.701
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.701
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.693
BRCA1 breast cancer 1, early onset 0.692
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.685
IL1R1 interleukin 1 receptor, type I 0.681
BMPR1A bone morphogenetic protein receptor, type IA 0.672
RIPK2 receptor-interacting serine-threonine kinase 2 0.651
SMAD3 SMAD family member 3 0.624
ATG13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.622
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.610
BIRC3 baculoviral IAP repeat containing 3 0.607
TRAF3 TNF receptor-associated factor 3 0.603
TRADD TNFRSF1A-associated via death domain 0.596
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.591
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.591
ULK1 unc-51-like kinase 1 (C. elegans) 0.590
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.589
ZMYND11 zinc finger, MYND-type containing 11 0.588
RXRA retinoid X receptor, alpha 0.582
BAD BCL2-associated agonist of cell death 0.572
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.568
IRS2 insulin receptor substrate 2 0.564
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.535
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.524
FADD Fas (TNFRSF6)-associated via death domain 0.513
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.501
SP1 Sp1 transcription factor 0.484
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.481
DUSP1 dual specificity phosphatase 1 0.480
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.469
XIAP X-linked inhibitor of apoptosis 0.467
TRAF6 TNF receptor-associated factor 6 0.462
PIK3C3 phosphoinositide-3-kinase, class 3 0.456
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.449
RRAGA Ras-related GTP binding A 0.439
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.438
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.433
OPTN optineurin 0.417
BAX BCL2-associated X protein 0.411
BMP2 bone morphogenetic protein 2 0.393
JUNB jun B proto-oncogene 0.392
MAPK14 mitogen-activated protein kinase 14 0.387
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.387
TBK1 TANK-binding kinase 1 0.383
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.379
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.377
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.370
HIPK2 homeodomain interacting protein kinase 2 0.369
SMAD7 SMAD family member 7 0.364
APP amyloid beta (A4) precursor protein 0.354
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.442
Syngr2 synaptogyrin 2 0.394
Mmp7 matrix metallopeptidase 7 0.360
Il1b interleukin 1 beta 0.354
Orm1 orosomucoid 1 0.354
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.334
Col1a1 collagen, type I, alpha 1 0.329
RT1-EC2 RT1 class Ib, locus EC2 0.318
Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.307
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.304
Txnrd1 thioredoxin reductase 1 0.299
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.260
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.257
Gja1 gap junction protein, alpha 1 0.243
Cd38 CD38 molecule 0.241
Mmp12 matrix metallopeptidase 12 0.237
Ctsd cathepsin D 0.237
Mmp3 matrix metallopeptidase 3 0.236
Igfals insulin-like growth factor binding protein, acid labile subunit 0.232
Foxd3 forkhead box D3 0.219
Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 0.207
Mt2A metallothionein 2A 0.204
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.203
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.202
Cdk2 cyclin dependent kinase 2 0.201
Gfap glial fibrillary acidic protein 0.198
Hrh2 histamine receptor H 2 0.197
Fn1 fibronectin 1 0.197
Hnrnpab heterogeneous nuclear ribonucleoprotein A/B 0.192
Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 0.192
Calcb calcitonin-related polypeptide, beta 0.190
Gckr glucokinase (hexokinase 4) regulator 0.188
RT1-N3 RT1 class Ib, locus N3 0.184
Il1a interleukin 1 alpha 0.180
Cd14 CD14 molecule 0.177
RGD1561143 similar to cell surface receptor FDFACT 0.176
Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi 0.174
Apol3 apolipoprotein L, 3 0.169
Egr4 early growth response 4 0.169
Ttc36 tetratricopeptide repeat domain 36 0.165
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.162
Mgst1 microsomal glutathione S-transferase 1 0.159
Bgn biglycan 0.159
Apoc4 apolipoprotein C-IV 0.157
Ccl4 chemokine (C-C motif) ligand 4 0.156
LOC100362824 caveolin 2-like 0.155
Mgat1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.153
Il6 interleukin 6 0.151
Col14a1 collagen, type XIV, alpha 1 0.149
Ptprh protein tyrosine phosphatase, receptor type, H 0.148
Reg3g regenerating islet-derived 3 gamma 0.147
Tgfb1 transforming growth factor, beta 1 0.145
Casp1 caspase 1 0.144
Col1a2 collagen, type I, alpha 2 0.144
Agtr2 angiotensin II receptor, type 2 0.144
Ephx1 epoxide hydrolase 1, microsomal 0.144
Prl8a2 prolactin family 8, subfamily a, member 2 0.143
Dusp6 dual specificity phosphatase 6 0.140
Trhr thyrotropin releasing hormone receptor 0.139
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.138
Ptgds prostaglandin D2 synthase (brain) 0.138
Mc5r melanocortin 5 receptor 0.138
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.137
Acaa1b acetyl-Coenzyme A acyltransferase 1B 0.131
Fcgrt Fc fragment of IgG, receptor, transporter, alpha 0.131
Cxcl10 chemokine (C-X-C motif) ligand 10 0.130
Aif1 allograft inflammatory factor 1 0.130
Gstm1 glutathione S-transferase mu 1 0.128
Pgr progesterone receptor 0.128
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.127
Plek pleckstrin 0.127
Egr2 early growth response 2 0.127
Ptgs2 prostaglandin-endoperoxide synthase 2 0.127
Gc group specific component 0.127
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.126
Dnase1l3 deoxyribonuclease 1-like 3 0.125
Flt1 FMS-related tyrosine kinase 1 0.124
Mmp9 matrix metallopeptidase 9 0.124
Glra3 glycine receptor, alpha 3 0.123
Ly6al lymphocyte antigen 6 complex, locus A-like 0.121
LOC687856 similar to Myeloid cell surface antigen CD33 precursor (Siglec-3) 0.120
Ctsk cathepsin K 0.119
Afp alpha-fetoprotein 0.118
Drd3 dopamine receptor D3 0.118
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.118
Sycp1 synaptonemal complex protein 1 0.118
Sprr1al small proline-rich protein 1A-like 0.118
Loxl1 lysyl oxidase-like 1 0.116
Clcnka chloride channel Ka 0.115
Postn periostin, osteoblast specific factor 0.114
Lst1 leukocyte specific transcript 1 0.113
Gabrr3 gamma-aminobutyric acid (GABA) receptor, rho 3 0.113
Cabp1 calcium binding protein 1 0.112
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.112
Serpina4 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.110
Asip agouti signaling protein 0.110
LOC100361486 rCG55595-like 0.110
Inhbe inhibin beta E 0.109
Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 0.109
Stat6 signal transducer and activator of transcription 6 0.108
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ATG1 Atg1p 0.984
TOR1 Tor1p 0.946
HSP82 Hsp82p 0.904
RTG3 Rtg3p 0.886
ATG21 Atg21p 0.876
SNF5 Snf5p 0.840
ATG13 Atg13p 0.828
GAL11 Gal11p 0.794
VPS30 Vps30p 0.768
ATG12 Atg12p 0.714
GLN3 Gln3p 0.644
HRK1 Hrk1p 0.636
MSN2 Msn2p 0.625
VPS36 Vps36p 0.621
CIS1 Cis1p 0.615
ATG23 Atg23p 0.611
KSP1 Ksp1p 0.608
ESA1 Esa1p 0.601
ATG11 Atg11p 0.574
SLG1 Slg1p 0.568
ATG29 Atg29p 0.566
VAC7 Vac7p 0.565
SSD1 Ssd1p 0.554
MKS1 Mks1p 0.521
HSP32 Hsp32p 0.521
ATG3 Atg3p 0.516
VHS1 Vhs1p 0.512
SEC21 Sec21p 0.512
ASP3-1 Asp3-1p 0.511
PFK26 Pfk26p 0.497
SNF6 Snf6p 0.495
COG6 Cog6p 0.480
GAL4 Gal4p 0.475
AQY2 Aqy2p 0.474
SEC2 Sec2p 0.471
SNF2 Snf2p 0.456
ASP3-3 Asp3-3p 0.454
ASP3-4 Asp3-4p 0.444
SWI3 Swi3p 0.437
MIG1 Mig1p 0.434
ASP3-2 Asp3-2p 0.417
SSN3 Ssn3p 0.408
PHO80 Pho80p 0.406
ATG4 Atg4p 0.405
GAL80 Gal80p 0.399
ATG20 Atg20p 0.389
SWI1 Swi1p 0.370
CAT8 Cat8p 0.362
HSV2 Hsv2p 0.362
MSS4 Mss4p 0.354
STE2 Ste2p 0.352
KGD1 Kgd1p 0.351
ISW1 Isw1p 0.346
PEP5 Pep5p 0.339
BDF1 Bdf1p 0.336
IML1 Iml1p 0.336
SIT4 Sit4p 0.330
SNF4 Snf4p 0.329
ENA5 Ena5p 0.329
SEC26 Sec26p 0.315
NET1 Net1p 0.313
HSP33 Hsp33p 0.312
SIC1 Sic1p 0.311
RIM101 Rim101p 0.305
NPR2 Npr2p 0.303
HDA2 Hda2p 0.298
ATG2 Atg2p 0.294
PCL2 Pcl2p 0.293
PHO11 Pho11p 0.290
YKR015C hypothetical protein 0.289
SHP1 Shp1p 0.287
COG3 Cog3p 0.285
MDS3 Mds3p 0.283
NNK1 Nnk1p 0.282
ATG9 Atg9p 0.277
VPS41 Vps41p 0.272
PCL8 Pcl8p 0.271
SNX4 Snx4p 0.267
RRD1 Rrd1p 0.266
SNF1 Snf1p 0.264
MIG3 Mig3p 0.262
SIP1 Sip1p 0.261
REG1 Reg1p 0.258
KIN1 Kin1p 0.255
VPS15 Vps15p 0.254
ACS1 Acs1p 0.254
PMC1 Pmc1p 0.237
ATG7 Atg7p 0.235
GPR1 Gpr1p 0.230
ENA2 Ena2p 0.230
BET3 Bet3p 0.227
SIP2 Sip2p 0.226
PHM8 Phm8p 0.223
MOB1 Mob1p 0.222
MBR1 Mbr1p 0.218
SSA4 Ssa4p 0.214
STB3 Stb3p 0.211
YDC1 Ydc1p 0.205
NTO1 Nto1p 0.200
CTI6 Cti6p 0.199