The network for 'regulation of fever generation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of fever generation

Any process that modulates the rate or extent of fever generation.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.963
Ifng interferon gamma 0.928
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.926
Lta lymphotoxin A 0.745
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.652
Il1b interleukin 1 beta 0.560
Ptgs2 prostaglandin-endoperoxide synthase 2 0.510
Cd40 CD40 antigen 0.478
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.407
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.372
Il6 interleukin 6 0.356
Cxcl13 chemokine (C-X-C motif) ligand 13 0.333
Ltb lymphotoxin B 0.278
Nos2 nitric oxide synthase 2, inducible 0.264
Igh immunoglobulin heavy chain complex 0.173
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.172
Ccl2 chemokine (C-C motif) ligand 2 0.114
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.109
Cxcl2 chemokine (C-X-C motif) ligand 2 0.107
Tlr4 toll-like receptor 4 0.104
Il1r1 interleukin 1 receptor, type I 0.103
Il7 interleukin 7 0.098
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.089
Cxcr5 chemokine (C-X-C motif) receptor 5 0.089
Il4 interleukin 4 0.073
Tox thymocyte selection-associated high mobility group box 0.067
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.063
Cd19 CD19 antigen 0.062
Ikzf1 IKAROS family zinc finger 1 0.055
Il1rn interleukin 1 receptor antagonist 0.052
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.051
Ccl4 chemokine (C-C motif) ligand 4 0.045
Irg1 immunoresponsive gene 1 0.040
Btk Bruton agammaglobulinemia tyrosine kinase 0.039
Il10 interleukin 10 0.037
Icos inducible T-cell co-stimulator 0.036
S1pr2 sphingosine-1-phosphate receptor 2 0.033
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.033
Ccr7 chemokine (C-C motif) receptor 7 0.032
Plat plasminogen activator, tissue 0.030
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.027
Bcl3 B-cell leukemia/lymphoma 3 0.027
Rel reticuloendotheliosis oncogene 0.026
Ch25h cholesterol 25-hydroxylase 0.024
Clec4d C-type lectin domain family 4, member d 0.024
Cxcl1 chemokine (C-X-C motif) ligand 1 0.023
Socs1 suppressor of cytokine signaling 1 0.023
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.022
Plau plasminogen activator, urokinase 0.021
Il1a interleukin 1 alpha 0.020
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.020
Il12b interleukin 12b 0.020
Gpr132 G protein-coupled receptor 132 0.020
Selp selectin, platelet 0.019
Nlrp3 NLR family, pyrin domain containing 3 0.019
Traf6 TNF receptor-associated factor 6 0.019
Fas Fas (TNF receptor superfamily member 6) 0.018
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.017
Pou2af1 POU domain, class 2, associating factor 1 0.017
Spp1 secreted phosphoprotein 1 0.017
Casp1 caspase 1 0.016
Mitf microphthalmia-associated transcription factor 0.016
Clec4e C-type lectin domain family 4, member e 0.016
Irak4 interleukin-1 receptor-associated kinase 4 0.015
Fgd3 FYVE, RhoGEF and PH domain containing 3 0.015
Cd80 CD80 antigen 0.015
Hrh2 histamine receptor H2 0.015
Traf2 TNF receptor-associated factor 2 0.014
Il10ra interleukin 10 receptor, alpha 0.014
Ccl7 chemokine (C-C motif) ligand 7 0.014
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.014
Birc3 baculoviral IAP repeat-containing 3 0.013
Slpi secretory leukocyte peptidase inhibitor 0.013
Ccr1 chemokine (C-C motif) receptor 1 0.013
Mmp9 matrix metallopeptidase 9 0.013
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.013
Bcl6 B-cell leukemia/lymphoma 6 0.013
Cd44 CD44 antigen 0.012
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.012
Myd88 myeloid differentiation primary response gene 88 0.012
Il18rap interleukin 18 receptor accessory protein 0.012
Mefv Mediterranean fever 0.011
Ccl17 chemokine (C-C motif) ligand 17 0.011
Cd160 CD160 antigen 0.011
Osmr oncostatin M receptor 0.011
Batf basic leucine zipper transcription factor, ATF-like 0.011
Plaur plasminogen activator, urokinase receptor 0.011
Id2 inhibitor of DNA binding 2 0.011
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Il1b interleukin 1 beta 0.999
Ccl2 chemokine (C-C motif) ligand 2 0.981
Ccl3 chemokine (C-C motif) ligand 3 0.980
Cd14 CD14 molecule 0.941
Il6 interleukin 6 0.889
Ccl4 chemokine (C-C motif) ligand 4 0.873
Cxcl2 chemokine (C-X-C motif) ligand 2 0.847
Il1a interleukin 1 alpha 0.833
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.779
Cxcl10 chemokine (C-X-C motif) ligand 10 0.504
Ccl20 chemokine (C-C motif) ligand 20 0.388
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.386
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.311
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.255
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.213
Mmp12 matrix metallopeptidase 12 0.209
Gzmb granzyme B 0.142
Tgm1 transglutaminase 1, K polypeptide 0.132
Neurl3 neuralized homolog 3 (Drosophila) 0.119
Mca32 mast cell antigen 32 0.118
Cd86 CD86 molecule 0.118
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.116
Fosl1 fos-like antigen 1 0.104
Sell selectin L 0.099
Tfec transcription factor EC 0.091
Il1r2 interleukin 1 receptor, type II 0.089
Rab20 RAB20, member RAS oncogene family 0.073
Nkg7 natural killer cell group 7 sequence 0.072
Prf1 perforin 1 (pore forming protein) 0.072
Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.066
Gzmk granzyme K 0.053
Ccl7 chemokine (C-C motif) ligand 7 0.052
Socs3 suppressor of cytokine signaling 3 0.050
Ccl5 chemokine (C-C motif) ligand 5 0.048
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.048
RT1-Bb RT1 class II, locus Bb 0.047
Xcl1 chemokine (C motif) ligand 1 0.045
Il2rb interleukin 2 receptor, beta 0.043
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.040
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.040
Calcrl calcitonin receptor-like 0.037
Vcan versican 0.036
Cd44 Cd44 molecule 0.036
Thbd thrombomodulin 0.035
Il1rn interleukin 1 receptor antagonist 0.035
Edn1 endothelin 1 0.034
Sele selectin E 0.034
Adora2a adenosine A2a receptor 0.033
Ccr1 chemokine (C-C motif) receptor 1 0.033
Ednrb endothelin receptor type B 0.033
LOC685020 similar to paired immunoglobin-like type 2 receptor alpha 0.033
Hpgds hematopoietic prostaglandin D synthase 0.032
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.031
Aqp4 aquaporin 4 0.031
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.029
Tlr2 toll-like receptor 2 0.029
Lst1 leukocyte specific transcript 1 0.029
RT1-Ba RT1 class II, locus Ba 0.028
Reg3b regenerating islet-derived 3 beta 0.025
Folr2 folate receptor 2 (fetal) 0.025
Mmp3 matrix metallopeptidase 3 0.025
Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.025
Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.024
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.023
Ptafr platelet-activating factor receptor 0.022
Tlr7 toll-like receptor 7 0.021
Rab32 RAB32, member RAS oncogene family 0.021
Tcrb T-cell receptor beta chain 0.021
Cd247 Cd247 molecule 0.021
Clec9a C-type lectin domain family 9, member a 0.020
Casp1 caspase 1 0.019
P2ry14 purinergic receptor P2Y, G-protein coupled, 14 0.019
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.019
Ncf4 neutrophil cytosolic factor 4 0.019
Stx11 syntaxin 11 0.018
Cxcl3 chemokine (C-X-C motif) ligand 3 0.017
Egr2 early growth response 2 0.016
Hck hemopoietic cell kinase 0.016
Ubd ubiquitin D 0.016
Plscr1 phospholipid scramblase 1 0.015
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.015
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.015
Tfpi2 tissue factor pathway inhibitor 2 0.014
Mgst2 microsomal glutathione S-transferase 2 0.014
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.013
Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.013
Plau plasminogen activator, urokinase 0.013
Mcpt8 mast cell protease 8 0.012
Igsf6 immunoglobulin superfamily, member 6 0.012
C5ar1 complement component 5a receptor 1 0.012
Ripk3 receptor-interacting serine-threonine kinase 3 0.011
Arl5c ADP-ribosylation factor-like 5C 0.011
Tnfaip6 tumor necrosis factor alpha induced protein 6 0.011
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.011
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.011
Tlr4 toll-like receptor 4 0.010
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism