The network for 'cytokine secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cytokine secretion

The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

Mus musculus
Name Description Probability Func Analog Organism
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.943
Ccr2 chemokine (C-C motif) receptor 2 0.930
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.913
Casp1 caspase 1 0.902
Pax8 paired box gene 8 0.898
Ccl8 chemokine (C-C motif) ligand 8 0.870
Itk IL2-inducible T-cell kinase 0.841
Ccr1 chemokine (C-C motif) receptor 1 0.841
Nlrp3 NLR family, pyrin domain containing 3 0.832
Lyz2 lysozyme 2 0.813
Pdcd1 programmed cell death 1 0.807
Il1r1 interleukin 1 receptor, type I 0.804
Ccl2 chemokine (C-C motif) ligand 2 0.801
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.799
Grap2 GRB2-related adaptor protein 2 0.790
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.780
Il1b interleukin 1 beta 0.777
Il1rl1 interleukin 1 receptor-like 1 0.768
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.729
Selp selectin, platelet 0.720
Ccl22 chemokine (C-C motif) ligand 22 0.713
Il2rb interleukin 2 receptor, beta chain 0.699
Notch1 Notch gene homolog 1 (Drosophila) 0.687
Blk B lymphoid kinase 0.663
Nos2 nitric oxide synthase 2, inducible 0.662
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.657
Il1rn interleukin 1 receptor antagonist 0.652
Cd86 CD86 antigen 0.650
Ncr1 natural cytotoxicity triggering receptor 1 0.644
Clec4d C-type lectin domain family 4, member d 0.632
Fas Fas (TNF receptor superfamily member 6) 0.614
Il10ra interleukin 10 receptor, alpha 0.613
C3ar1 complement component 3a receptor 1 0.611
Tnf tumor necrosis factor 0.598
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.597
Pdcd1lg2 programmed cell death 1 ligand 2 0.592
Il18rap interleukin 18 receptor accessory protein 0.579
Ccl4 chemokine (C-C motif) ligand 4 0.567
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.561
Gata4 GATA binding protein 4 0.539
Mefv Mediterranean fever 0.538
Sfrp4 secreted frizzled-related protein 4 0.536
Cybb cytochrome b-245, beta polypeptide 0.533
Btk Bruton agammaglobulinemia tyrosine kinase 0.517
Fcgr1 Fc receptor, IgG, high affinity I 0.506
Gpr33 G protein-coupled receptor 33 0.506
Cd180 CD180 antigen 0.505
Fasl Fas ligand (TNF superfamily, member 6) 0.502
Socs1 suppressor of cytokine signaling 1 0.489
Folr2 folate receptor 2 (fetal) 0.483
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.482
Tbxas1 thromboxane A synthase 1, platelet 0.479
Gbp5 guanylate binding protein 5 0.470
Icos inducible T-cell co-stimulator 0.461
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.460
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.456
Gzmb granzyme B 0.452
Lepr leptin receptor 0.442
Cd4 CD4 antigen 0.440
Ms4a6c membrane-spanning 4-domains, subfamily A, member 6C 0.427
Cd80 CD80 antigen 0.423
Tlr7 toll-like receptor 7 0.408
Cd247 CD247 antigen 0.401
Sh2d2a SH2 domain protein 2A 0.397
Sfpi1 SFFV proviral integration 1 0.395
Gzma granzyme A 0.393
Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.389
Itgax integrin alpha X 0.386
Dll1 delta-like 1 (Drosophila) 0.386
Snai1 snail homolog 1 (Drosophila) 0.383
Gpr132 G protein-coupled receptor 132 0.373
Mmp12 matrix metallopeptidase 12 0.368
Itgb2 integrin beta 2 0.363
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.358
Nkg7 natural killer cell group 7 sequence 0.357
Ccr3 chemokine (C-C motif) receptor 3 0.356
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.349
Lgals3 lectin, galactose binding, soluble 3 0.348
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.341
Ccl6 chemokine (C-C motif) ligand 6 0.338
Cd22 CD22 antigen 0.335
Clec4e C-type lectin domain family 4, member e 0.335
Ccl24 chemokine (C-C motif) ligand 24 0.326
Ren1 renin 1 structural 0.322
Irg1 immunoresponsive gene 1 0.320
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.318
Cd7 CD7 antigen 0.317
Cd44 CD44 antigen 0.314
Il4ra interleukin 4 receptor, alpha 0.308
Ikzf1 IKAROS family zinc finger 1 0.305
Csf1 colony stimulating factor 1 (macrophage) 0.303
Lta lymphotoxin A 0.301
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.301
Ccl3 chemokine (C-C motif) ligand 3 0.300
Ccl12 chemokine (C-C motif) ligand 12 0.298
Ptgfr prostaglandin F receptor 0.295
Cd33 CD33 antigen 0.290
Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 0.288
Cd96 CD96 antigen 0.280
Msr1 macrophage scavenger receptor 1 0.276
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.970
CD80 CD80 molecule 0.881
ANXA1 annexin A1 0.880
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.871
S100A6 S100 calcium binding protein A6 0.856
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.833
FYN FYN oncogene related to SRC, FGR, YES 0.813
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.733
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.701
BTN3A3 butyrophilin, subfamily 3, member A3 0.677
S100A10 S100 calcium binding protein A10 0.655
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.551
EGFR epidermal growth factor receptor 0.547
APOE apolipoprotein E 0.546
BTN3A2 butyrophilin, subfamily 3, member A2 0.523
ANXA2 annexin A2 0.513
BTN3A1 butyrophilin, subfamily 3, member A1 0.486
PILRA paired immunoglobin-like type 2 receptor alpha 0.450
HLA-DRA major histocompatibility complex, class II, DR alpha 0.443
NLRC4 NLR family, CARD domain containing 4 0.424
S100A16 S100 calcium binding protein A16 0.407
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.392
HLA-DMA major histocompatibility complex, class II, DM alpha 0.351
AXL AXL receptor tyrosine kinase 0.332
IL1R1 interleukin 1 receptor, type I 0.306
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.306
HP haptoglobin 0.305
HLA-DMB major histocompatibility complex, class II, DM beta 0.279
TRAF1 TNF receptor-associated factor 1 0.269
CRP C-reactive protein, pentraxin-related 0.262
CAV1 caveolin 1, caveolae protein, 22kDa 0.259
BCAR1 breast cancer anti-estrogen resistance 1 0.255
IL1B interleukin 1, beta 0.237
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.236
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.234
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.221
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.207
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.206
HCK hemopoietic cell kinase 0.196
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.189
TLR2 toll-like receptor 2 0.186
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.185
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.185
SYK spleen tyrosine kinase 0.182
FGA fibrinogen alpha chain 0.178
EPOR erythropoietin receptor 0.177
JAG1 jagged 1 0.171
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.168
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.166
TAL1 T-cell acute lymphocytic leukemia 1 0.163
ANGPT2 angiopoietin 2 0.156
CCL4 chemokine (C-C motif) ligand 4 0.153
CFH complement factor H 0.152
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.150
TREM1 triggering receptor expressed on myeloid cells 1 0.150
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.148
IL10RA interleukin 10 receptor, alpha 0.146
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.145
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.145
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.143
C19orf50 chromosome 19 open reading frame 50 0.141
XIAP X-linked inhibitor of apoptosis 0.135
BTN2A2 butyrophilin, subfamily 2, member A2 0.132
TRIM5 tripartite motif containing 5 0.123
S100B S100 calcium binding protein B 0.122
FGB fibrinogen beta chain 0.122
LGALS1 lectin, galactoside-binding, soluble, 1 0.120
PYCARD PYD and CARD domain containing 0.118
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.118
PTPRB protein tyrosine phosphatase, receptor type, B 0.117
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.117
CAPG capping protein (actin filament), gelsolin-like 0.112
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.112
GOLGA2 golgin A2 0.112
MEFV Mediterranean fever 0.111
LAT linker for activation of T cells 0.110
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.109
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.106
PECAM1 platelet/endothelial cell adhesion molecule 0.105
CDH5 cadherin 5, type 2 (vascular endothelium) 0.104
ITK IL2-inducible T-cell kinase 0.104
IL1RN interleukin 1 receptor antagonist 0.103
PML promyelocytic leukemia 0.101
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.100
IL22RA1 interleukin 22 receptor, alpha 1 0.100
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.099
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.099
CCR1 chemokine (C-C motif) receptor 1 0.098
IFNG interferon, gamma 0.097
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.096
SIGLEC7 sialic acid binding Ig-like lectin 7 0.095
S100A4 S100 calcium binding protein A4 0.090
FZD1 frizzled homolog 1 (Drosophila) 0.089
NLRP3 NLR family, pyrin domain containing 3 0.089
APOC1 apolipoprotein C-I 0.085
SOS1 son of sevenless homolog 1 (Drosophila) 0.085
IDE insulin-degrading enzyme 0.084
IL6 interleukin 6 (interferon, beta 2) 0.083
ANXA5 annexin A5 0.083
NMI N-myc (and STAT) interactor 0.083
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Rattus norvegicus
Name Description Probability Func Analog Organism
Sirpa signal-regulatory protein alpha 0.303
Ms4a11 membrane-spanning 4-domains, subfamily A, member 11 0.302
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.295
Il1b interleukin 1 beta 0.231
Il2rb interleukin 2 receptor, beta 0.185
Pdcl phosducin-like 0.179
Serp1 stress-associated endoplasmic reticulum protein 1 0.147
Cd80 Cd80 molecule 0.147
Ptprc protein tyrosine phosphatase, receptor type, C 0.127
Casp1 caspase 1 0.119
Selp selectin P 0.113
Folr2 folate receptor 2 (fetal) 0.112
Il1rl1 interleukin 1 receptor-like 1 0.097
Bdkrb2 bradykinin receptor B2 0.087
Cybb cytochrome b-245, beta polypeptide 0.086
Anpep alanyl (membrane) aminopeptidase 0.078
Mca32 mast cell antigen 32 0.078
C5ar1 complement component 5a receptor 1 0.069
Ctsc cathepsin C 0.066
Alb albumin 0.063
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.063
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.062
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.061
Ccr2 chemokine (C-C motif) receptor 2 0.054
Fosl1 fos-like antigen 1 0.053
Cd44 Cd44 molecule 0.053
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.052
C9 complement component 9 0.052
Arl11 ADP-ribosylation factor-like 11 0.051
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.048
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.048
Casp3 caspase 3 0.046
Fgb fibrinogen beta chain 0.046
Il6 interleukin 6 0.046
S1pr2 sphingosine-1-phosphate receptor 2 0.044
Nras neuroblastoma ras oncogene 0.044
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.043
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.043
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.042
Csf1 colony stimulating factor 1 (macrophage) 0.040
LOC299282 Serine protease inhibitor 0.039
Ccl22 chemokine (C-C motif) ligand 22 0.039
Fga fibrinogen alpha chain 0.038
Ccl20 chemokine (C-C motif) ligand 20 0.035
Plau plasminogen activator, urokinase 0.034
Cxcr3 chemokine (C-X-C motif) receptor 3 0.034
Pitx1 paired-like homeodomain 1 0.034
Jak2 Janus kinase 2 0.032
RT1-Ba RT1 class II, locus Ba 0.032
Gzmk granzyme K 0.031
Fcnb ficolin B 0.031
Ccl5 chemokine (C-C motif) ligand 5 0.030
Inhbe inhibin beta E 0.030
Cpa3 carboxypeptidase A3, mast cell 0.029
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.028
Lpl lipoprotein lipase 0.028
Mpeg1 macrophage expressed 1 0.027
Clec4a3 C-type lectin domain family 4, member a3 0.027
Adam17 ADAM metallopeptidase domain 17 0.027
Cybrd1 cytochrome b reductase 1 0.026
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.026
Igsf6 immunoglobulin superfamily, member 6 0.026
Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 0.025
Gja5 gap junction protein, alpha 5 0.025
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.024
Ccl4 chemokine (C-C motif) ligand 4 0.024
Mmp8 matrix metallopeptidase 8 0.024
Ccr5 chemokine (C-C motif) receptor 5 0.024
Olr1082 olfactory receptor 1082 0.024
Nradd neurotrophin receptor associated death domain 0.024
Cfi complement factor I 0.024
Dnase1l3 deoxyribonuclease 1-like 3 0.024
Tbxas1 thromboxane A synthase 1, platelet 0.023
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.023
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.022
Csk c-src tyrosine kinase 0.021
Ly86 lymphocyte antigen 86 0.021
Prap1 proline-rich acidic protein 1 0.021
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.021
Cxcl2 chemokine (C-X-C motif) ligand 2 0.021
Smad1 SMAD family member 1 0.020
Lbp lipopolysaccharide binding protein 0.020
Foxa2 forkhead box A2 0.020
Casp12 caspase 12 0.020
Mov10 Moloney leukemia virus 10 0.020
Tlr4 toll-like receptor 4 0.020
Prrx1 paired related homeobox 1 0.020
Adora2a adenosine A2a receptor 0.020
Ccl3 chemokine (C-C motif) ligand 3 0.019
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.019
Il2rg interleukin 2 receptor, gamma 0.019
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.019
Cp ceruloplasmin 0.018
Apcs amyloid P component, serum 0.018
Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 0.018
Fshb follicle stimulating hormone, beta polypeptide 0.018
Casp8 caspase 8 0.018
Adra2b adrenergic, alpha-2B-, receptor 0.017
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.017
Cxcr4 chemokine (C-X-C motif) receptor 4 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism