The network for 'autophagy' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

autophagy

The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Sqstm1 sequestosome 1 0.997
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.989
Pten phosphatase and tensin homolog 0.983
Ulk1 Unc-51 like kinase 1 (C. elegans) 0.977
Psen1 presenilin 1 0.951
Rb1 retinoblastoma 1 0.944
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.925
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.911
Ctnnb1 catenin (cadherin associated protein), beta 1 0.902
Atg12 autophagy-related 12 (yeast) 0.838
Hif1a hypoxia inducible factor 1, alpha subunit 0.824
Cyld cylindromatosis (turban tumor syndrome) 0.814
Notch2 Notch gene homolog 2 (Drosophila) 0.788
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.777
Gbp2 guanylate binding protein 2 0.773
Pparg peroxisome proliferator activated receptor gamma 0.680
Braf Braf transforming gene 0.677
Stat1 signal transducer and activator of transcription 1 0.659
Vhl von Hippel-Lindau tumor suppressor 0.607
Iigp1 interferon inducible GTPase 1 0.606
Atf2 activating transcription factor 2 0.593
Pycard PYD and CARD domain containing 0.586
Gbp7 guanylate binding protein 7 0.572
Tsc1 tuberous sclerosis 1 0.565
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.540
Notch1 Notch gene homolog 1 (Drosophila) 0.531
Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.528
Igtp interferon gamma induced GTPase 0.523
Mapk14 mitogen-activated protein kinase 14 0.523
Src Rous sarcoma oncogene 0.505
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.492
Mdm2 transformed mouse 3T3 cell double minute 2 0.481
Casp1 caspase 1 0.481
Irgm2 immunity-related GTPase family M member 2 0.466
Nf1 neurofibromatosis 1 0.462
Ifi47 interferon gamma inducible protein 47 0.447
Raf1 v-raf-leukemia viral oncogene 1 0.434
Tgtp2 T-cell specific GTPase 2 0.432
Mapkap1 mitogen-activated protein kinase associated protein 1 0.428
Becn1 beclin 1, autophagy related 0.408
Ctsd cathepsin D 0.405
Tsc2 tuberous sclerosis 2 0.400
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.380
Gbp3 guanylate binding protein 3 0.369
Atg3 autophagy-related 3 (yeast) 0.343
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.320
Irgm1 immunity-related GTPase family M member 1 0.315
Lyz2 lysozyme 2 0.313
Prkce protein kinase C, epsilon 0.300
Trp53 transformation related protein 53 0.296
Foxo1 forkhead box O1 0.284
Cftr cystic fibrosis transmembrane conductance regulator homolog 0.266
Mapk1 mitogen-activated protein kinase 1 0.265
Foxa2 forkhead box A2 0.253
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.251
Gabarap gamma-aminobutyric acid receptor associated protein 0.251
Gbp5 guanylate binding protein 5 0.246
Gabarapl1 gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 0.246
Lepr leptin receptor 0.238
Irs2 insulin receptor substrate 2 0.238
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.231
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.221
Tgfbr1 transforming growth factor, beta receptor I 0.220
Fkbp8 FK506 binding protein 8 0.216
Ifih1 interferon induced with helicase C domain 1 0.212
Igbp1 immunoglobulin (CD79A) binding protein 1 0.209
Cd40 CD40 antigen 0.200
Lpin1 lipin 1 0.196
Ctsl cathepsin L 0.195
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.191
Apc adenomatosis polyposis coli 0.191
Mndal myeloid nuclear differentiation antigen like 0.180
Pnpla2 patatin-like phospholipase domain containing 2 0.179
Ptk2 PTK2 protein tyrosine kinase 2 0.176
Wbp2 WW domain binding protein 2 0.169
Atg13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.169
Csf1 colony stimulating factor 1 (macrophage) 0.159
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.159
Wdr45 WD repeat domain 45 0.157
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.152
Atg5 autophagy-related 5 (yeast) 0.152
Wdr81 WD repeat domain 81 0.151
Map1lc3b microtubule-associated protein 1 light chain 3 beta 0.151
Pim3 proviral integration site 3 0.151
Rac1 RAS-related C3 botulinum substrate 1 0.147
Ypel3 yippee-like 3 (Drosophila) 0.146
Trp73 transformation related protein 73 0.145
Rptor regulatory associated protein of MTOR, complex 1 0.143
Map2k4 mitogen-activated protein kinase kinase 4 0.142
Traf6 TNF receptor-associated factor 6 0.141
Plcg1 phospholipase C, gamma 1 0.140
Rxra retinoid X receptor alpha 0.139
Hbb-b1 hemoglobin, beta adult major chain 0.139
Ikbkg inhibitor of kappaB kinase gamma 0.136
Sav1 salvador homolog 1 (Drosophila) 0.136
Rfwd2 ring finger and WD repeat domain 2 0.133
Shc1 src homology 2 domain-containing transforming protein C1 0.133
Ngp neutrophilic granule protein 0.133
Irf1 interferon regulatory factor 1 0.132
Nf2 neurofibromatosis 2 0.130
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
wdfy-2 Protein WDFY-2 0.581
rpm-1 Protein RPM-1 0.542
atg-18 Protein ATG-18 0.493
unc-51 Protein UNC-51 0.455
let-60 Protein LET-60 0.443
C36C9.1 Protein C36C9.1 0.347
clec-65 Protein CLEC-65 0.332
R12E2.2 Protein R12E2.2 0.305
pal-1 Protein PAL-1 0.253
bec-1 Protein BEC-1 0.250
pcm-1 Protein PCM-1 0.243
glp-1 Protein GLP-1 0.232
hnd-1 Protein HND-1 0.206
unc-14 Protein UNC-14 0.205
skr-16 Protein SKR-16 0.196
C34D10.2 Protein C34D10.2 0.193
sams-4 Protein SAMS-4 0.188
fat-3 Protein FAT-3 0.170
trap-1 Protein TRAP-1 0.167
atg-4.1 Protein ATG-4.1 0.165
ogt-1 Protein OGT-1 0.164
CELE_F53H1.3 Protein F53H1.3 0.163
lgg-2 Protein LGG-2 0.147
fshr-1 Protein FSHR-1 0.141
F52H2.5 Protein F52H2.5 0.141
aak-2 Protein AAK-2 0.136
atg-13 Protein ATG-13 0.129
F26F12.3 Protein F26F12.3 0.120
mvb-12 Protein MVB-12 0.114
CELE_C17F4.7 Protein C17F4.7 0.114
ain-1 Protein AIN-1 0.113
K12H6.6 Protein K12H6.6 0.104
CELE_Y57E12AL.1 Protein Y57E12AL.1 0.099
T01H3.3 Protein T01H3.3 0.096
T16G1.4 Protein T16G1.4 0.091
nhr-22 Protein NHR-22 0.089
C02F5.7 Protein C02F5.7 0.088
F57F5.1 Protein F57F5.1 0.087
hsb-1 Protein HSB-1 0.087
sma-9 Protein SMA-9 0.086
cpd-1 Protein CPD-1 0.086
Y82E9BR.13 Protein Y82E9BR.13 0.085
F42G2.2 Protein F42G2.2 0.083
T23F11.1 Protein T23F11.1 0.083
sur-2 Protein SUR-2 0.082
rbg-1 Protein RBG-1 0.082
CELE_M01B12.4 Protein M01B12.4 0.081
asah-1 Protein ASAH-1 0.081
rpt-3 Protein RPT-3 0.079
eff-1 Protein EFF-1 0.077
fkh-2 Protein FKH-2 0.077
egl-18 Protein EGL-18 0.074
ZC328.3 Protein ZC328.3 0.073
dnj-25 Protein DNJ-25 0.073
elt-6 Protein ELT-6 0.072
W06B4.2 Protein W06B4.2 0.072
F53F10.2 Protein F53F10.2 0.072
drap-1 Protein DRAP-1 0.070
T10B5.7 Protein T10B5.7 0.070
mek-2 Protein MEK-2 0.069
spp-8 Protein SPP-8 0.067
mif-3 Protein MIF-3 0.067
kle-2 Protein KLE-2 0.065
elt-7 Protein ELT-7 0.065
T03F1.1 Protein T03F1.1 0.064
M02E1.1 Protein M02E1.1 0.063
daf-11 Protein DAF-11 0.062
CELE_C44C10.4 Protein C44C10.4 0.060
cutl-26 Protein CUTL-26 0.060
hpo-31 Protein HPO-31 0.060
unc-108 Protein UNC-108 0.059
F25G6.8 Protein F25G6.8 0.059
sft-4 Protein SFT-4 0.059
miz-1 Protein MIZ-1 0.058
vps-39 Protein VPS-39 0.057
sand-1 Protein SAND-1 0.056
unc-62 Protein UNC-62 0.056
ztf-2 Protein ZTF-2 0.056
pfd-4 Protein PFD-4 0.055
egl-46 Protein EGL-46 0.055
W07E11.1 Protein W07E11.1 0.053
ten-1 Protein TEN-1 0.053
mis-12 Protein MIS-12 0.053
hgo-1 Protein HGO-1 0.053
dcn-1 Protein DCN-1 0.052
pqn-59 Protein PQN-59 0.052
ceh-44 Protein CEH-44 0.052
fut-3 Protein FUT-3 0.050
egl-27 Protein EGL-27 0.050
Y102A11A.3 Protein Y102A11A.3 0.050
lec-8 Protein LEC-8 0.049
lin-40 Protein LIN-40 0.049
Y51F10.7 Protein Y51F10.7 0.049
fat-2 Protein FAT-2 0.049
ZK858.6 Protein ZK858.6 0.048
lat-1 Protein LAT-1 0.048
ZK686.3 Protein ZK686.3 0.047
vps-18 Protein VPS-18 0.047
lgg-1 Protein LGG-1 0.047
pmk-1 Protein PMK-1 0.047
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.859
ripk2 receptor-interacting serine-threonine kinase 2 0.672
map1lc3b microtubule-associated protein 1 light chain 3 beta 0.644
igf1rb insulin-like growth factor 1b receptor 0.571
tnrc5 trinucleotide repeat containing 5 0.523
ntla no tail a 0.454
cdh1 cadherin 1, epithelial 0.400
limk2 LIM domain kinase 2 0.369
card9 caspase recruitment domain family, member 9 0.354
mxi1 max interacting protein 0.349
zgc:92606 zgc:92606 0.303
fmr1 fragile X mental retardation 1 0.286
tax1bp1b Tax1 (human T-cell leukemia virus type I) binding protein 1b 0.283
trim13 tripartite motif-containing 13 0.280
prkar1aa protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a 0.273
rab2a RAB2A, member RAS oncogene family 0.258
xbp1 X-box binding protein 1 0.256
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.251
crb2a crumbs homolog 2a 0.232
faf2 Fas associated factor family member 2 0.228
ctsf cathepsin F 0.228
gata3 GATA-binding protein 3 0.218
adipor2 adiponectin receptor 2 0.216
atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.216
mbnl2 muscleblind-like 2 (Drosophila) 0.211
ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 0.188
brd2a bromodomain-containing 2a 0.187
npc1 Niemann-Pick disease, type C1 0.186
wnt10a wingless-type MMTV integration site family, member 10a 0.186
zgc:153148 zgc:153148 0.184
LOC100003514 protein kinase C alpha type-like 0.184
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.182
ctsd cathepsin D 0.181
pou5f1 POU domain, class 5, transcription factor 1 0.181
zbtb4 zinc finger and BTB domain containing 4 0.180
zgc:101761 zgc:101761 0.179
gata6 GATA-binding protein 6 0.178
npc2 Niemann-Pick disease, type C2 0.172
foxa3 forkhead box A3 0.171
dlg1 discs, large (Drosophila) homolog 1 0.170
mapk3 mitogen-activated protein kinase 3 0.169
sox9b SRY-box containing gene 9b 0.164
bc2 putative breast adenocarcinoma marker 0.161
usp10 ubiquitin specific peptidase 10 0.160
fcho2 FCH domain only 2 0.159
ube4b ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 0.157
fbxo45 F-box protein 45 0.152
nudc nuclear distribution gene C homolog 0.151
actn4 actinin, alpha 4 0.149
tmprss4a transmembrane protease, serine 4a 0.148
slc30a9 solute carrier family 30 (zinc transporter), member 9 0.146
ap1b1 adaptor-related protein complex 1, beta 1 subunit 0.144
npnt nephronectin 0.140
calm3b calmodulin 3b (phosphorylase kinase, delta) 0.139
eif4g2a eukaryotic translation initiation factor 4, gamma 2a 0.139
arf2 ADP-ribosylation factor 2 0.138
csad cysteine sulfinic acid decarboxylase 0.137
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.135
mapk1 mitogen-activated protein kinase 1 0.133
rab5aa RAB5A, member RAS oncogene family, a 0.133
slc39a1 solute carrier family 39 (zinc transporter), member 1 0.132
ppp2r1b protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform 0.131
glb1 galactosidase, beta 1 0.130
odc1 ornithine decarboxylase 1 0.129
ldb1a LIM-domain binding factor 1a 0.128
pfn2l profilin 2 like 0.128
si:ch211-146l10.2 si:ch211-146l10.2 0.126
rogdi rogdi homolog (Drosophila) 0.126
zgc:56136 zgc:56136 0.126
maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) 0.125
gabarapa GABA(A) receptor-associated protein a 0.124
fzd5 frizzled homolog 5 0.124
hdac4 histone deacetylase 4 0.122
bmp2b bone morphogenetic protein 2b 0.122
dusp4 dual specificity phosphatase 4 0.122
rab1a RAB1A, member RAS oncogene family 0.120
gpr126 G protein-coupled receptor 126 0.119
grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.118
sdf4 stromal cell derived factor 4 0.118
slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.116
tm9sf2 transmembrane 9 superfamily member 2 0.115
si:dkey-8l13.4 si:dkey-8l13.4 0.115
psen1 presenilin 1 0.115
pabpc1a poly A binding protein, cytoplasmic 1 a 0.114
smad2 MAD homolog 2 (Drosophila) 0.114
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.114
ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.113
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.113
ctsl1a cathepsin L, 1 a 0.111
arf5 ADP-ribosylation factor 5 0.111
plxnb2a plexin b2a 0.110
smu1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 0.110
rhoaa ras homolog gene family, member Aa 0.110
zgc:112986 zgc:112986 0.110
ap1g1 adaptor-related protein complex 1, gamma 1 subunit 0.109
cul2 cullin 2 0.107
ikbkg inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.107
atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.107
tp53 tumor protein p53 0.107
thoc2 THO complex 2 0.107
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.999
Atg8a Autophagy-specific gene 8a 0.997
Atg18 Autophagy-specific gene 18 0.997
Ras85D Ras oncogene at 85D 0.995
Atg1 Autophagy-specific gene 1 0.989
car carnation 0.988
shn schnurri 0.973
gig gigas 0.961
dm diminutive 0.952
CG11347 CG11347 gene product from transcript CG11347-RE 0.946
rl rolled 0.935
Rheb CG1081 gene product from transcript CG1081-RA 0.922
Dcr-2 Dicer-2 0.886
Pten CG5671 gene product from transcript CG5671-RB 0.877
RagA CG11968 gene product from transcript CG11968-RA 0.873
aop anterior open 0.872
Pi3K59F Phosphotidylinositol 3 kinase 59F 0.854
Atg2 Autophagy-specific gene 2 0.831
Atg4 Autophagy-specific gene 4 0.782
bsk basket 0.756
Mad Mothers against dpp 0.748
shi shibire 0.722
p53 CG33336 gene product from transcript CG33336-RB 0.713
Aut1 CG6877 gene product from transcript CG6877-RA 0.706
CG1347 CG1347 gene product from transcript CG1347-RB 0.703
CG32581 CG32581 gene product from transcript CG32581-RB 0.702
scny scrawny 0.698
pr-set7 CG3307 gene product from transcript CG3307-RC 0.688
Syx17 Syntaxin 17 0.686
drpr draper 0.680
Atg13 Autophagy-specific gene 13 0.677
p38b CG7393 gene product from transcript CG7393-RA 0.677
Pink1 PTEN-induced putative kinase 1 0.665
trpml transient receptor potential mucolipin 0.650
bchs blue cheese 0.644
gbb glass bottom boat 0.640
chico CG5686 gene product from transcript CG5686-RB 0.621
usnp ubisnap 0.580
Vps16A Vacuolar protein sorting 16A 0.576
S6k RPS6-p70-protein kinase 0.572
Atg6 Autophagy-specific gene 6 0.564
CG10277 CG10277 gene product from transcript CG10277-RB 0.559
babo baboon 0.544
Stam Signal transducing adaptor molecule 0.543
neur neuralized 0.538
Atg9 Autophagy-specific gene 9 0.533
hep hemipterous 0.521
Rpn2 CG11888 gene product from transcript CG11888-RA 0.520
ird1 immune response deficient 1 0.508
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.507
l(2)gl lethal (2) giant larvae 0.504
Sox14 Sox box protein 14 0.497
spin spinster 0.483
Rala Ras-related protein 0.470
Stat92E Signal-transducer and activator of transcription protein at 92E 0.468
Rab7 Rab-protein 7 0.466
SNF1A SNF1A/AMP-activated protein kinase 0.463
CG42863 CG42863 gene product from transcript CG42863-RB 0.458
Rel Relish 0.436
Dcp-1 Death caspase-1 0.424
CG6116 CG6116 gene product from transcript CG6116-RA 0.420
TBPH CG10327 gene product from transcript CG10327-RC 0.417
Atg7 Autophagy-specific gene 7 0.405
sty sprouty 0.394
unk unkempt 0.386
sra sarah 0.383
L Lobe 0.382
kay kayak 0.380
cathD CG1548 gene product from transcript CG1548-RA 0.376
nej nejire 0.375
InR Insulin-like receptor 0.352
CG8709 CG8709 gene product from transcript CG8709-RK 0.345
yki yorkie 0.338
bowl brother of odd with entrails limited 0.338
Lnk CG17367 gene product from transcript CG17367-RC 0.333
Ice CG7788 gene product from transcript CG7788-RA 0.332
tkv thickveins 0.321
dpp decapentaplegic 0.319
CG11877 CG11877 gene product from transcript CG11877-RA 0.307
Rfabg Retinoid- and fatty acid-binding glycoprotein 0.305
B52 CG10851 gene product from transcript CG10851-RB 0.300
rb ruby 0.298
loqs loquacious 0.291
spas spastin 0.285
Pp2B-14D Protein phosphatase 2B at 14D 0.279
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.279
drk downstream of receptor kinase 0.278
lt light 0.276
cpa capping protein alpha 0.273
vps2 CG14542 gene product from transcript CG14542-RA 0.270
Gie novel GTPase indispensable for equal segregation of chromosomes 0.265
emc extra macrochaetae 0.261
ninaE neither inactivation nor afterpotential E 0.258
fkh fork head 0.254
g garnet 0.254
milt milton 0.244
Jra Jun-related antigen 0.234
step steppke 0.233
loco locomotion defects 0.230
CG7967 CG7967 gene product from transcript CG7967-RA 0.230
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
SQSTM1 sequestosome 1 1.000
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.999
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.999
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.999
GABARAP GABA(A) receptor-associated protein 0.997
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.994
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.991
ULK1 unc-51-like kinase 1 (C. elegans) 0.988
PINK1 PTEN induced putative kinase 1 0.958
S100A6 S100 calcium binding protein A6 0.947
UBC ubiquitin C 0.944
GABARAPL1 GABA(A) receptor-associated protein like 1 0.941
NBR1 neighbor of BRCA1 gene 1 0.940
TSC2 tuberous sclerosis 2 0.892
BECN1 beclin 1, autophagy related 0.887
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.869
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.868
PTK2 PTK2 protein tyrosine kinase 2 0.868
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.842
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.831
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.825
OPTN optineurin 0.816
GSK3B glycogen synthase kinase 3 beta 0.813
ATG13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.791
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.783
CREBBP CREB binding protein 0.714
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.680
EGFR epidermal growth factor receptor 0.675
FKBP1A FK506 binding protein 1A, 12kDa 0.622
UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.613
GRB2 growth factor receptor-bound protein 2 0.604
TP53 tumor protein p53 0.590
SIRT1 sirtuin 1 0.585
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.582
RB1CC1 RB1-inducible coiled-coil 1 0.560
AR androgen receptor 0.543
S100B S100 calcium binding protein B 0.535
S100A8 S100 calcium binding protein A8 0.514
SMN1 survival of motor neuron 1, telomeric 0.501
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.501
PIK3C3 phosphoinositide-3-kinase, class 3 0.496
MAPK8 mitogen-activated protein kinase 8 0.495
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.494
ANXA2 annexin A2 0.490
FUNDC2 FUN14 domain containing 2 0.484
S100A10 S100 calcium binding protein A10 0.463
S100A9 S100 calcium binding protein A9 0.458
BCL2 B-cell CLL/lymphoma 2 0.454
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.436
ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae) 0.419
MPDZ multiple PDZ domain protein 0.407
SMAD3 SMAD family member 3 0.406
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.380
JUN jun proto-oncogene 0.362
MAP2K1 mitogen-activated protein kinase kinase 1 0.350
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.339
UBXN6 UBX domain protein 6 0.338
TFRC transferrin receptor (p90, CD71) 0.332
SESN2 sestrin 2 0.330
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.320
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.311
MAPK1 mitogen-activated protein kinase 1 0.308
IRS2 insulin receptor substrate 2 0.304
STX5 syntaxin 5 0.302
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.291
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.289
BCAR1 breast cancer anti-estrogen resistance 1 0.287
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.284
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.281
RAD23A RAD23 homolog A (S. cerevisiae) 0.268
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.263
SMAD4 SMAD family member 4 0.263
KIF5B kinesin family member 5B 0.259
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.259
NLRC4 NLR family, CARD domain containing 4 0.257
TOLLIP toll interacting protein 0.249
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.239
DAPK1 death-associated protein kinase 1 0.237
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.233
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.232
IRAK2 interleukin-1 receptor-associated kinase 2 0.228
FLNA filamin A, alpha 0.225
FKBP4 FK506 binding protein 4, 59kDa 0.224
MAPK14 mitogen-activated protein kinase 14 0.220
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.220
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.218
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.216
TSG101 tumor susceptibility gene 101 0.216
VTI1B vesicle transport through interaction with t-SNAREs homolog 1B (yeast) 0.216
TRIM63 tripartite motif containing 63 0.210
ATXN3 ataxin 3 0.208
RAB1A RAB1A, member RAS oncogene family 0.197
NSF N-ethylmaleimide-sensitive factor 0.197
RHEB Ras homolog enriched in brain 0.194
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.192
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.191
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.189
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.186
RRAGA Ras-related GTP binding A 0.183
MAPK3 mitogen-activated protein kinase 3 0.182
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Tmbim6 transmembrane BAX inhibitor motif containing 6 0.275
St13 suppression of tumorigenicity 13 0.174
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.162
Eef2 eukaryotic translation elongation factor 2 0.124
Jak1 Janus kinase 1 0.105
Arf1 ADP-ribosylation factor 1 0.085
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.082
Ctsl1 cathepsin L1 0.060
Ctsd cathepsin D 0.050
Map2k1 mitogen activated protein kinase kinase 1 0.048
Ubqln1 ubiquilin 1 0.044
Ptov1 prostate tumor overexpressed 1 0.042
Cyth1 cytohesin 1 0.041
Atp6v1b2 ATPase, H transporting, lysosomal V1 subunit B2 0.041
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.034
Taf10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.034
Strap serine/threonine kinase receptor associated protein 0.034
Trim23 tripartite motif-containing 23 0.031
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.030
Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.030
Fbxo3 F-box protein 3 0.029
Rab1b RAB1B, member RAS oncogene family 0.028
Casp3 caspase 3 0.028
Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.027
Ghitm growth hormone inducible transmembrane protein 0.026
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.026
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.025
Rab5a RAB5A, member RAS oncogene family 0.025
Stxbp3 syntaxin binding protein 3 0.024
Gja1 gap junction protein, alpha 1 0.024
Syngr2 synaptogyrin 2 0.024
LOC362855 P55 0.023
Zfand6 zinc finger, AN1-type domain 6 0.023
Usf2 upstream transcription factor 2, c-fos interacting 0.022
Hbp1 HMG-box transcription factor 1 0.021
Psap prosaposin 0.021
Dcaf7 DDB1 and CUL4 associated factor 7 0.020
Morf4l2 mortality factor 4 like 2 0.020
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.020
Cacnb3 calcium channel, voltage-dependent, beta 3 subunit 0.020
Rab11a RAB11a, member RAS oncogene family 0.020
Glul glutamate-ammonia ligase (glutamine synthetase) 0.020
Ftl ferritin, light polypeptide 0.019
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.018
Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform 0.018
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.018
Snx4 sorting nexin 4 0.017
Cript cysteine-rich PDZ-binding protein 0.017
Bnip3l BCL2/adenovirus E1B interacting protein 3-like 0.017
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.017
Tm9sf4 transmembrane 9 superfamily protein member 4 0.017
Cox8a cytochrome c oxidase subunit VIIIa 0.017
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.017
Chd6 chromodomain helicase DNA binding protein 6 0.016
Dnm1l dynamin 1-like 0.016
Ube2b ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae) 0.016
Ccr1 chemokine (C-C motif) receptor 1 0.016
Pdia3 protein disulfide isomerase family A, member 3 0.015
Bet1 blocked early in transport 1 homolog (S. cerevisiae) 0.015
Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 0.015
Ap2s1 adaptor-related protein complex 2, sigma 1 subunit 0.014
Ptprc protein tyrosine phosphatase, receptor type, C 0.014
Flcn folliculin 0.014
Foxd4 forkhead box D4 0.014
Jtb jumping translocation breakpoint 0.014
Vdac1 voltage-dependent anion channel 1 0.014
Rab4a RAB4A, member RAS oncogene family 0.014
Nmt1 N-myristoyltransferase 1 0.014
Lifr leukemia inhibitory factor receptor alpha 0.013
Mapk6 mitogen-activated protein kinase 6 0.013
Copb1 coatomer protein complex, subunit beta 1 0.013
Vegfa vascular endothelial growth factor A 0.013
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.013
P4hb prolyl 4-hydroxylase, beta polypeptide 0.013
Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform 0.013
Adar adenosine deaminase, RNA-specific 0.013
Akap1 A kinase (PRKA) anchor protein 1 0.013
Snap23 synaptosomal-associated protein 23 0.013
Hist1h1a histone cluster 1, H1a 0.013
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.013
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.012
Ube2a ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.012
Calm3 calmodulin 3 0.012
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.012
Sqstm1 sequestosome 1 0.012
Rab11b RAB11B, member RAS oncogene family 0.012
Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.012
Ensa endosulfine alpha 0.012
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.012
Gria2 glutamate receptor, ionotropic, AMPA 2 0.012
Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.012
Cyfip2 cytoplasmic FMR1 interacting protein 2 0.012
Camk4 calcium/calmodulin-dependent protein kinase IV 0.012
Ngly1 N-glycanase 1 0.012
Ndfip2 Nedd4 family interacting protein 2 0.012
Arl11 ADP-ribosylation factor-like 11 0.011
Snx3 sorting nexin 3 0.011
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.011
Scamp1 secretory carrier membrane protein 1 0.011
Dctn1 dynactin 1 0.011
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ATG1 Atg1p 0.999
ATG13 Atg13p 0.998
SNX4 Snx4p 0.995
ATG20 Atg20p 0.991
ATG12 Atg12p 0.987
ATG29 Atg29p 0.982
ATG21 Atg21p 0.980
ATG9 Atg9p 0.976
ATG11 Atg11p 0.948
KSP1 Ksp1p 0.946
VAC8 Vac8p 0.945
ATG3 Atg3p 0.943
SLT2 Slt2p 0.934
CDC55 Cdc55p 0.934
SLG1 Slg1p 0.927
ATG4 Atg4p 0.913
ATG23 Atg23p 0.911
ATG16 Atg16p 0.899
ATG7 Atg7p 0.893
TOR1 Tor1p 0.889
VPS41 Vps41p 0.885
ATG14 Atg14p 0.870
HSV2 Hsv2p 0.848
ATG5 Atg5p 0.826
SEC2 Sec2p 0.823
VAM3 Vam3p 0.784
YPT1 Ypt1p 0.783
CIS1 Cis1p 0.768
ATG8 Atg8p 0.766
COG6 Cog6p 0.762
ATG2 Atg2p 0.759
CCZ1 Ccz1p 0.756
ESA1 Esa1p 0.730
PHO81 Pho81p 0.725
ATG18 Atg18p 0.714
ATG26 Atg26p 0.683
VTC3 Vtc3p 0.669
MON1 Mon1p 0.608
VTC1 Vtc1p 0.606
VAM7 Vam7p 0.583
SEC17 Sec17p 0.573
KOG1 Kog1p 0.555
VPS30 Vps30p 0.550
PHO85 Pho85p 0.524
ARG82 Arg82p 0.498
VPS3 Vps3p 0.493
BRE5 Bre5p 0.484
VPS36 Vps36p 0.483
YKT6 Ykt6p 0.478
VAM6 Vam6p 0.465
SEC4 Sec4p 0.454
YIL165C hypothetical protein 0.453
TCO89 Tco89p 0.451
NPR2 Npr2p 0.449
PKH2 Pkh2p 0.423
VTC4 Vtc4p 0.419
MKS1 Mks1p 0.413
PEP5 Pep5p 0.409
CAK1 Cak1p 0.402
KIN2 Kin2p 0.389
VPS16 Vps16p 0.362
VTC2 Vtc2p 0.358
VPS38 Vps38p 0.350
VTI1 Vti1p 0.344
TPK1 Tpk1p 0.315
BMH1 Bmh1p 0.312
ATG10 Atg10p 0.285
ATG15 Atg15p 0.276
YPL247C hypothetical protein 0.273
PIK1 Pik1p 0.269
SSK1 Ssk1p 0.266
PBS2 Pbs2p 0.251
VPS15 Vps15p 0.247
TLG2 Tlg2p 0.245
RTS3 Rts3p 0.237
COT1 Cot1p 0.236
GTR1 Gtr1p 0.229
NUP170 Nup170p 0.227
ATG19 Atg19p 0.222
TRS85 Trs85p 0.219
BCK1 Bck1p 0.209
MDM10 Mdm10p 0.209
PTC1 Ptc1p 0.207
PPZ1 Ppz1p 0.207
YPL260W hypothetical protein 0.202
PTC6 Ptc6p 0.193
SHP1 Shp1p 0.191
YIP4 Yip4p 0.189
HOG1 Hog1p 0.185
SAP185 Sap185p 0.185
SEC21 Sec21p 0.184
CLN1 Cln1p 0.181
RPO21 Rpo21p 0.179
PEP12 Pep12p 0.176
NYV1 Nyv1p 0.175
ICY2 Icy2p 0.173
HSP31 Hsp31p 0.172
AKL1 Akl1p 0.170
VPS28 Vps28p 0.168
STB3 Stb3p 0.166