The network for 'response to steroid hormone' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to steroid hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.

Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.979
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.927
Esr1 estrogen receptor 1 (alpha) 0.912
Stat3 signal transducer and activator of transcription 3 0.889
Rxra retinoid X receptor alpha 0.869
Nos1 nitric oxide synthase 1, neuronal 0.839
Trp53 transformation related protein 53 0.820
Pten phosphatase and tensin homolog 0.804
Apoe apolipoprotein E 0.776
Drd2 dopamine receptor D2 0.721
Bglap bone gamma carboxyglutamate protein 0.702
Tgfbr2 transforming growth factor, beta receptor II 0.698
Fshr follicle stimulating hormone receptor 0.687
Vegfa vascular endothelial growth factor A 0.678
Ar androgen receptor 0.676
Ptgs2 prostaglandin-endoperoxide synthase 2 0.612
Lep leptin 0.607
Fbn1 fibrillin 1 0.602
Lyz2 lysozyme 2 0.570
Prlr prolactin receptor 0.512
Kl klotho 0.497
Ghr growth hormone receptor 0.488
Csf1 colony stimulating factor 1 (macrophage) 0.437
Pparg peroxisome proliferator activated receptor gamma 0.430
Foxp3 forkhead box P3 0.404
Cdk4 cyclin-dependent kinase 4 0.389
Robo1 roundabout homolog 1 (Drosophila) 0.382
Pax8 paired box gene 8 0.382
Notch2 Notch gene homolog 2 (Drosophila) 0.379
Fgfr2 fibroblast growth factor receptor 2 0.368
Nos3 nitric oxide synthase 3, endothelial cell 0.366
Tgfb2 transforming growth factor, beta 2 0.364
Ldlr low density lipoprotein receptor 0.353
Gdnf glial cell line derived neurotrophic factor 0.349
Kit kit oncogene 0.332
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.330
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.328
Fas Fas (TNF receptor superfamily member 6) 0.327
Gpc3 glypican 3 0.320
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.313
Tgfb1 transforming growth factor, beta 1 0.313
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.311
Mstn myostatin 0.305
Mup5 major urinary protein 5 0.285
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.285
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.275
Kiss1 KiSS-1 metastasis-suppressor 0.265
Dlx5 distal-less homeobox 5 0.261
Ahr aryl-hydrocarbon receptor 0.260
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.257
Egfr epidermal growth factor receptor 0.252
Il1r1 interleukin 1 receptor, type I 0.247
Oprm1 opioid receptor, mu 1 0.239
Wt1 Wilms tumor 1 homolog 0.238
LOC100048884 novel member of the major urinary protein (Mup) gene family 0.231
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.231
Mup19 major urinary protein 19 0.229
Hbb-b1 hemoglobin, beta adult major chain 0.227
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.226
Fgfr1 fibroblast growth factor receptor 1 0.220
Jak2 Janus kinase 2 0.220
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.218
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.217
Apoa1 apolipoprotein A-I 0.213
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.207
Jag1 jagged 1 0.207
Inpp5d inositol polyphosphate-5-phosphatase D 0.203
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.196
Ccl2 chemokine (C-C motif) ligand 2 0.195
Dsg4 desmoglein 4 0.192
Inhba inhibin beta-A 0.189
Amhr2 anti-Mullerian hormone type 2 receptor 0.189
Cfh complement component factor h 0.186
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.183
Pgr progesterone receptor 0.182
Il6 interleukin 6 0.178
Stat5a signal transducer and activator of transcription 5A 0.177
Gpr50 G-protein-coupled receptor 50 0.174
Mmp9 matrix metallopeptidase 9 0.171
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.171
Socs1 suppressor of cytokine signaling 1 0.171
Mesp1 mesoderm posterior 1 0.170
Ret ret proto-oncogene 0.164
Cdk2 cyclin-dependent kinase 2 0.162
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.162
Shh sonic hedgehog 0.161
Fgf8 fibroblast growth factor 8 0.160
Bmp2 bone morphogenetic protein 2 0.160
Npy2r neuropeptide Y receptor Y2 0.158
Nos2 nitric oxide synthase 2, inducible 0.158
Npy1r neuropeptide Y receptor Y1 0.158
Isl1 ISL1 transcription factor, LIM/homeodomain 0.157
Hr hairless 0.151
Rbbp5 retinoblastoma binding protein 5 0.151
Sfrp1 secreted frizzled-related protein 1 0.151
Ren1 renin 1 structural 0.147
Cnr1 cannabinoid receptor 1 (brain) 0.147
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.145
Pomc pro-opiomelanocortin-alpha 0.145
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.145
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
rbp4 retinol binding protein 4, plasma 0.581
th tyrosine hydroxylase 0.536
vtg3 vitellogenin 3, phosvitinless 0.515
slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.472
bmp2b bone morphogenetic protein 2b 0.443
hmgb1a high-mobility group box 1a 0.436
aldob aldolase b, fructose-bisphosphate 0.433
alcama activated leukocyte cell adhesion molecule a 0.398
epas1b endothelial PAS domain protein 1b 0.320
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.307
vasa vasa homolog 0.292
pcna proliferating cell nuclear antigen 0.280
bdnf brain-derived neurotrophic factor 0.271
igf1 insulin-like growth factor 1 0.259
mcoln1 mucolipin 1 0.254
esr1 estrogen receptor 1 0.242
ptmaa prothymosin, alpha a 0.224
rspo1 R-spondin homolog (Xenopus laevis) 0.218
foxa3 forkhead box A3 0.214
wnt10a wingless-type MMTV integration site family, member 10a 0.208
cyp11a1 cytochrome P450, subfamily XIA, polypeptide 1 0.202
notch1a notch homolog 1a 0.193
plcg1 phospholipase C, gamma 1 0.190
ghrb growth hormone receptor b 0.183
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.183
fbp1b fructose-1,6-bisphosphatase 1b 0.175
anxa1b annexin A1b 0.173
casrl calcium-sensing receptor, like 0.170
nrg2a neuregulin 2a 0.163
myod1 myogenic differentiation 1 0.162
atp1b1b ATPase, Na+/K+ transporting, beta 1b polypeptide 0.159
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.159
sepp1a selenoprotein P, plasma, 1a 0.157
lhcgr luteinizing hormone/choriogonadotropin receptor 0.147
robo3 roundabout homolog 3 0.146
apoeb apolipoprotein Eb 0.145
evpl envoplakin 0.137
bcl2l1 bcl2-like 1 0.127
ptgs2a prostaglandin-endoperoxide synthase 2a 0.126
ppargc1al peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like 0.124
mt2 metallothionein 2 0.122
myog myogenin 0.121
gnrh3 gonadotropin-releasing hormone 3 0.121
socs3a suppressor of cytokine signaling 3a 0.121
cnr1 cannabinoid receptor 1 0.120
igf2b insulin-like growth factor 2b 0.119
osr1 odd-skipped related 1 (Drosophila) 0.119
fabp11a fatty acid binding protein 11a 0.117
mapk12 mitogen-activated protein kinase 12 0.115
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.114
otpa orthopedia homolog a 0.111
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.107
bcl2 B-cell leukemia/lymphoma 2 0.107
id1 inhibitor of DNA binding 1 0.105
krt18 keratin 18 0.105
hspb1 heat shock protein, alpha-crystallin-related, 1 0.104
zgc:193505 zgc:193505 0.103
serpinc1 serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 0.102
wnt11r wingless-type MMTV integration site family, member 11, related 0.100
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.100
zgc:66382 zgc:66382 0.098
hspa5 heat shock protein 5 0.098
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.097
gamt guanidinoacetate N-methyltransferase 0.096
egr2b early growth response 2b 0.095
rbp1a retinol binding protein 1a, cellular 0.095
junbl jun B proto-oncogene, like 0.094
prox1 prospero-related homeobox gene 1 0.093
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.093
cpt1b carnitine palmitoyltransferase 1B (muscle) 0.093
nrp2a neuropilin 2a 0.092
rag1 recombination activating gene 1 0.091
cyp1a cytochrome P450, family 1, subfamily A 0.090
krit1 KRIT1, ankyrin repeat containing 0.090
zgc:77714 zgc:77714 0.087
c3c complement component c3c 0.087
ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.086
tp53bp2 tumor protein p53 binding protein, 2 0.086
tnnt2a troponin T2a, cardiac 0.086
zgc:56326 zgc:56326 0.085
csad cysteine sulfinic acid decarboxylase 0.084
ca2 carbonic anhydrase II 0.083
cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.083
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.083
cdkn1a cyclin-dependent kinase inhibitor 1A 0.082
fn1b fibronectin 1b 0.082
grnb granulin b 0.082
cav1 caveolin 1 0.081
sgpl1 sphingosine-1-phosphate lyase 1 0.081
cldnh claudin h 0.080
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.080
dab1a disabled homolog 1a (Drosophila) 0.079
shbg sex hormone binding globulin 0.078
igf2a insulin-like growth factor 2a 0.078
cp ceruloplasmin 0.077
atp1b2b ATPase, Na+/K+ transporting, beta 2b polypeptide 0.076
vdra vitamin D receptor a 0.074
crabp2a cellular retinoic acid binding protein 2, a 0.073
card14 caspase recruitment domain family, member 14 0.070
il8 interleukin 8 0.070
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ESR1 estrogen receptor 1 1.000
EGFR epidermal growth factor receptor 0.999
TP53 tumor protein p53 0.989
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.986
CREBBP CREB binding protein 0.981
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.980
CAV1 caveolin 1, caveolae protein, 22kDa 0.963
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.894
BRCA1 breast cancer 1, early onset 0.866
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.856
HNF4A hepatocyte nuclear factor 4, alpha 0.757
NCOA6 nuclear receptor coactivator 6 0.756
ANXA1 annexin A1 0.732
IL8 interleukin 8 0.721
SMAD2 SMAD family member 2 0.719
GSTM1 glutathione S-transferase mu 1 0.711
AR androgen receptor 0.709
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.663
ATF2 activating transcription factor 2 0.571
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.568
SMN1 survival of motor neuron 1, telomeric 0.542
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.529
SMAD4 SMAD family member 4 0.527
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.519
FGFR2 fibroblast growth factor receptor 2 0.510
EPOR erythropoietin receptor 0.506
JUN jun proto-oncogene 0.488
HDAC1 histone deacetylase 1 0.486
NCOR2 nuclear receptor corepressor 2 0.470
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.468
NCOA1 nuclear receptor coactivator 1 0.455
TRADD TNFRSF1A-associated via death domain 0.412
WDR5 WD repeat domain 5 0.410
ARIH2 ariadne homolog 2 (Drosophila) 0.409
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.400
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.385
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 0.382
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.379
XIAP X-linked inhibitor of apoptosis 0.369
BCAR1 breast cancer anti-estrogen resistance 1 0.359
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.352
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.350
THBS1 thrombospondin 1 0.345
IL1R1 interleukin 1 receptor, type I 0.341
SOCS3 suppressor of cytokine signaling 3 0.325
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.323
RBBP5 retinoblastoma binding protein 5 0.321
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.311
KRT6B keratin 6B 0.308
BCL2 B-cell CLL/lymphoma 2 0.307
SOCS1 suppressor of cytokine signaling 1 0.301
RNF144B ring finger protein 144B 0.290
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.280
GSTM2 glutathione S-transferase mu 2 (muscle) 0.272
TGFB1 transforming growth factor, beta 1 0.266
IL6 interleukin 6 (interferon, beta 2) 0.262
TAL1 T-cell acute lymphocytic leukemia 1 0.259
RXRA retinoid X receptor, alpha 0.258
NRP1 neuropilin 1 0.257
CDK11B cyclin-dependent kinase 11B 0.255
BAX BCL2-associated X protein 0.254
SKIL SKI-like oncogene 0.254
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.249
GHR growth hormone receptor 0.240
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.234
GSN gelsolin 0.233
HDAC2 histone deacetylase 2 0.233
PLAU plasminogen activator, urokinase 0.231
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.230
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 0.229
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.228
TSC22D1 TSC22 domain family, member 1 0.227
CDK2 cyclin-dependent kinase 2 0.226
EP300 E1A binding protein p300 0.225
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.222
STAT1 signal transducer and activator of transcription 1, 91kDa 0.221
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.217
MTA3 metastasis associated 1 family, member 3 0.215
RB1 retinoblastoma 1 0.209
RARA retinoic acid receptor, alpha 0.209
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.208
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 0.207
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.205
POU5F1 POU class 5 homeobox 1 0.203
PTEN phosphatase and tensin homolog 0.202
APP amyloid beta (A4) precursor protein 0.200
FOXO1 forkhead box O1 0.198
KRT8 keratin 8 0.194
TEK TEK tyrosine kinase, endothelial 0.194
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.188
MAPK3 mitogen-activated protein kinase 3 0.187
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.184
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.181
NCF4 neutrophil cytosolic factor 4, 40kDa 0.181
ESR2 estrogen receptor 2 (ER beta) 0.180
NRIP1 nuclear receptor interacting protein 1 0.180
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.180
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.179
APAF1 apoptotic peptidase activating factor 1 0.177
MAPK14 mitogen-activated protein kinase 14 0.174
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism