The network for 'regulation of defense response to bacterium' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of defense response to bacterium

Any process that modulates the frequency, rate or extent of defense response to bacterium.

Mus musculus
Name Description Probability Func Analog Organism
Ikbkg inhibitor of kappaB kinase gamma 1.000
Casp4 caspase 4, apoptosis-related cysteine peptidase 1.000
Tnf tumor necrosis factor 0.999
Ikbkb inhibitor of kappaB kinase beta 0.991
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.984
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.981
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.978
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.957
Lyz2 lysozyme 2 0.945
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.943
Trp53 transformation related protein 53 0.903
Pycard PYD and CARD domain containing 0.883
Il1b interleukin 1 beta 0.868
Cd44 CD44 antigen 0.848
Gbp2 guanylate binding protein 2 0.702
Gbp3 guanylate binding protein 3 0.652
Casp1 caspase 1 0.621
Irf1 interferon regulatory factor 1 0.614
Fas Fas (TNF receptor superfamily member 6) 0.599
Iigp1 interferon inducible GTPase 1 0.582
Cxcl1 chemokine (C-X-C motif) ligand 1 0.543
Cd14 CD14 antigen 0.539
Nlrp3 NLR family, pyrin domain containing 3 0.526
Gbp7 guanylate binding protein 7 0.522
Il18 interleukin 18 0.492
Cxcl2 chemokine (C-X-C motif) ligand 2 0.481
Bcl3 B-cell leukemia/lymphoma 3 0.478
Tlr4 toll-like receptor 4 0.472
Il1rn interleukin 1 receptor antagonist 0.456
Stat3 signal transducer and activator of transcription 3 0.449
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.428
Per1 period homolog 1 (Drosophila) 0.408
Ccl2 chemokine (C-C motif) ligand 2 0.378
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.355
Socs1 suppressor of cytokine signaling 1 0.331
Gbp5 guanylate binding protein 5 0.329
Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.307
Il10 interleukin 10 0.304
Csf1 colony stimulating factor 1 (macrophage) 0.287
Mmp13 matrix metallopeptidase 13 0.277
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.263
Myd88 myeloid differentiation primary response gene 88 0.258
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.256
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.240
Cxcl10 chemokine (C-X-C motif) ligand 10 0.230
Ccl7 chemokine (C-C motif) ligand 7 0.225
Ccl12 chemokine (C-C motif) ligand 12 0.218
Il6 interleukin 6 0.216
Irg1 immunoresponsive gene 1 0.214
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.213
Per2 period homolog 2 (Drosophila) 0.213
Ccr1 chemokine (C-C motif) receptor 1 0.209
Cd40 CD40 antigen 0.208
Aim2 absent in melanoma 2 0.207
Irgm1 immunity-related GTPase family M member 1 0.193
Traf6 TNF receptor-associated factor 6 0.193
Igh immunoglobulin heavy chain complex 0.189
Ifih1 interferon induced with helicase C domain 1 0.183
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.178
Ccl4 chemokine (C-C motif) ligand 4 0.171
Irgm2 immunity-related GTPase family M member 2 0.159
Ccl3 chemokine (C-C motif) ligand 3 0.156
Ifi44 interferon-induced protein 44 0.155
Ubd ubiquitin D 0.143
Il1r1 interleukin 1 receptor, type I 0.139
Ticam1 toll-like receptor adaptor molecule 1 0.135
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.134
Runx1 runt related transcription factor 1 0.133
Chuk conserved helix-loop-helix ubiquitous kinase 0.130
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.127
Igtp interferon gamma induced GTPase 0.124
Ifi47 interferon gamma inducible protein 47 0.123
Rsad2 radical S-adenosyl methionine domain containing 2 0.121
Tgtp2 T-cell specific GTPase 2 0.118
Clec4d C-type lectin domain family 4, member d 0.115
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.114
Rnf31 ring finger protein 31 0.113
Ooep oocyte expressed protein homolog (dog) 0.109
Cry2 cryptochrome 2 (photolyase-like) 0.107
Crebbp CREB binding protein 0.107
Msr1 macrophage scavenger receptor 1 0.104
E2f1 E2F transcription factor 1 0.102
Mefv Mediterranean fever 0.102
C3ar1 complement component 3a receptor 1 0.096
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.091
Bcl6 B-cell leukemia/lymphoma 6 0.091
Saa3 serum amyloid A 3 0.090
Zc3h12a zinc finger CCCH type containing 12A 0.089
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.088
Irf7 interferon regulatory factor 7 0.088
Niacr1 niacin receptor 1 0.087
Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 0.086
Il2rg interleukin 2 receptor, gamma chain 0.085
Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 0.080
Stk4 serine/threonine kinase 4 0.080
Smad1 MAD homolog 1 (Drosophila) 0.079
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.079
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.078
Mx2 myxovirus (influenza virus) resistance 2 0.077
2410004A20Rik RIKEN cDNA 2410004A20 gene 0.076
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rel Relish 0.999
PGRP-LC Peptidoglycan recognition protein LC 0.997
AttA Attacin-A 0.985
ird5 immune response deficient 5 0.908
DptB Diptericin B 0.897
PGRP-SA Peptidoglycan recognition protein SA 0.881
Spn27A Serpin 27A 0.864
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.739
Irc Immune-regulated catalase 0.703
grass Gram-positive Specific Serine protease 0.667
Mtk Metchnikowin 0.630
imd immune deficiency 0.628
Spn1 Serine protease inhibitor 1 0.586
spz spatzle 0.508
PGRP-LF Peptidoglycan recognition protein LF 0.407
PGRP-LB Peptidoglycan recognition protein LB 0.386
BG4 CG12297 gene product from transcript CG12297-RA 0.360
AttC Attacin-C 0.343
cact cactus 0.339
fon fondue 0.336
Sp7 Serine protease 7 0.285
CG9184 CG9184 gene product from transcript CG9184-RB 0.282
key kenny 0.259
Spn28D Serpin 28D 0.251
PGRP-SC1a CG14746 gene product from transcript CG14746-RA 0.247
Mpk2 CG5475 gene product from transcript CG5475-RB 0.228
PGRP-SC1b CG8577 gene product from transcript CG8577-RA 0.199
scny scrawny 0.158
Drs Drosomycin 0.147
Myd88 CG2078 gene product from transcript CG2078-RA 0.140
CG32185 CG32185 gene product from transcript CG32185-RA 0.138
pirk poor Imd response upon knock-in 0.127
Lac Lachesin 0.120
Mekk1 CG7717 gene product from transcript CG7717-RB 0.108
modSP modular serine protease 0.106
CG15065 CG15065 gene product from transcript CG15065-RA 0.100
Dredd Death related ced-3/Nedd2-like protein 0.100
Eip71CD Ecdysone-induced protein 28/29kD 0.097
CG6361 CG6361 gene product from transcript CG6361-RA 0.091
Dpt Diptericin 0.089
th thread 0.086
GNBP1 Gram-negative bacteria binding protein 1 0.084
GNBP3 Gram-negative bacteria binding protein 3 0.080
CecA2 Cecropin A2 0.077
ird1 immune response deficient 1 0.076
CG18594 CG18594 gene product from transcript CG18594-RA 0.074
SPE Spatzle-Processing Enzyme 0.070
CG13422 CG13422 gene product from transcript CG13422-RA 0.069
spirit Serine Protease Immune Response Integrator 0.066
Duox Dual oxidase 0.062
Ice CG7788 gene product from transcript CG7788-RA 0.061
pie pineapple eye 0.060
CecC Cecropin C 0.054
Tak1 TGF-beta activated kinase 1 0.054
CG13641 CG13641 gene product from transcript CG13641-RA 0.049
eater CG6124 gene product from transcript CG6124-RB 0.047
IM18 Immune induced molecule 18 0.046
Nc Nedd2-like caspase 0.044
pzg putzig 0.043
He Hemese 0.043
CG5791 CG5791 gene product from transcript CG5791-RA 0.043
PGRP-SB1 CG9681 gene product from transcript CG9681-RA 0.042
upd3 unpaired 3 0.041
PGRP-LE Peptidoglycan recognition protein LE 0.036
Csk C-terminal Src kinase 0.035
CycJ Cyclin J 0.033
CG15917 CG15917 gene product from transcript CG15917-RA 0.032
Ark Apaf-1-related-killer 0.032
CG31038 CG31038 gene product from transcript CG31038-RA 0.032
CG14567 CG14567 gene product from transcript CG14567-RA 0.032
CG12766 CG12766 gene product from transcript CG12766-RA 0.031
bbg big bang 0.031
CG16772 CG16772 gene product from transcript CG16772-RA 0.030
Spn4 Serine protease inhibitor 4 0.030
CG42863 CG42863 gene product from transcript CG42863-RB 0.030
Traf4 TNF-receptor-associated factor 4 0.029
TepIII Thiolester containing protein III 0.029
18w 18 wheeler 0.028
Oat Ornithine aminotransferase precursor 0.028
caz cabeza 0.028
CG18067 CG18067 gene product from transcript CG18067-RA 0.028
CG16718 CG16718 gene product from transcript CG16718-RA 0.027
tna tonalli 0.027
Glt Glutactin 0.027
CG16836 CG16836 gene product from transcript CG16836-RA 0.027
CG13962 CG13962 gene product from transcript CG13962-RA 0.026
TM9SF4 CG7364 gene product from transcript CG7364-RA 0.026
Traf6 TNF-receptor-associated factor 6 0.026
CG1103 CG1103 gene product from transcript CG1103-RA 0.025
upd2 unpaired 2 0.024
Med Medea 0.023
Jupiter CG31363 gene product from transcript CG31363-RD 0.022
CG11841 CG11841 gene product from transcript CG11841-RA 0.022
nAcRbeta-21C nicotinic acetylcholine receptor beta 21C 0.022
IM10 Immune induced molecule 10 0.022
Apc2 Adenomatous polyposis coli tumor suppressor homolog 2 0.022
CG9812 CG9812 gene product from transcript CG9812-RB 0.022
Dro Drosocin 0.021
CG14317 CG14317 gene product from transcript CG14317-RA 0.021
Tab2 TAK1-associated binding protein 2 0.021
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Homo sapiens
Name Description Probability Func Analog Organism
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.998
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.991
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.979
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.890
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.870
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.833
CHUK conserved helix-loop-helix ubiquitous kinase 0.819
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.769
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.346
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.331
TNIP2 TNFAIP3 interacting protein 2 0.278
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.205
NLRC4 NLR family, CARD domain containing 4 0.197
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.168
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.163
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.118
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.089
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.069
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.065
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.062
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.050
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.047
RIPK2 receptor-interacting serine-threonine kinase 2 0.046
BTRC beta-transducin repeat containing 0.025
PYCARD PYD and CARD domain containing 0.024
BCL3 B-cell CLL/lymphoma 3 0.024
SQSTM1 sequestosome 1 0.022
FKBP5 FK506 binding protein 5 0.022
NLRC5 NLR family, CARD domain containing 5 0.022
KCNQ1 potassium voltage-gated channel, KQT-like subfamily, member 1 0.021
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.021
SFRS18 splicing factor, arginine/serine-rich 18 0.020
ITGB1BP1 integrin beta 1 binding protein 1 0.020
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.020
ATM ataxia telangiectasia mutated 0.019
CARD11 caspase recruitment domain family, member 11 0.018
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.017
TRAF6 TNF receptor-associated factor 6 0.017
ELF4 E74-like factor 4 (ets domain transcription factor) 0.017
KEAP1 kelch-like ECH-associated protein 1 0.017
CARD16 caspase recruitment domain family, member 16 0.016
GOLGA6L9 golgin A6 family-like 9 0.016
IL18 interleukin 18 (interferon-gamma-inducing factor) 0.015
CAV1 caveolin 1, caveolae protein, 22kDa 0.015
USP20 ubiquitin specific peptidase 20 0.014
INADL InaD-like (Drosophila) 0.014
BCL10 B-cell CLL/lymphoma 10 0.013
UROD uroporphyrinogen decarboxylase 0.013
XIAP X-linked inhibitor of apoptosis 0.013
MED12 mediator complex subunit 12 0.013
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.013
MDN1 MDN1, midasin homolog (yeast) 0.013
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.012
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.012
BEND5 BEN domain containing 5 0.012
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 0.011
DCLRE1C DNA cross-link repair 1C 0.011
IFI16 interferon, gamma-inducible protein 16 0.011
ELP2 elongation protein 2 homolog (S. cerevisiae) 0.011
MEN1 multiple endocrine neoplasia I 0.011
TNIP1 TNFAIP3 interacting protein 1 0.010
PSME4 proteasome (prosome, macropain) activator subunit 4 0.010
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.010
NCOA5 nuclear receptor coactivator 5 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism