IMP

Process View

Homo sapiens

4 genes annotated in human

reciprocal meiotic recombination

The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "reciprocal meiotic recombination"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "reciprocal meiotic recombination" (in gray)

Name	Description	Probability	Func Analog Organism
RPA1	replication protein A1, 70kDa	1.000	Yeast
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.999	Yeast
RPA3	replication protein A3, 14kDa	0.963
BRCA1	breast cancer 1, early onset	0.952
RFC1	replication factor C (activator 1) 1, 145kDa	0.951
BLM	Bloom syndrome, RecQ helicase-like	0.910	Worm Fly
APITD1	apoptosis-inducing, TAF9-like domain 1	0.908
PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.854
BRCA2	breast cancer 2, early onset	0.850
MCM6	minichromosome maintenance complex component 6	0.804
MSH5	mutS homolog 5 (E. coli)	0.737	Yeast Worm
RPA2	replication protein A2, 32kDa	0.728	Yeast
RFC2	replication factor C (activator 1) 2, 40kDa	0.719
RFC4	replication factor C (activator 1) 4, 37kDa	0.678
MSH4	mutS homolog 4 (E. coli)	0.633	Yeast
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.623
RFC3	replication factor C (activator 1) 3, 38kDa	0.608
WRN	Werner syndrome, RecQ helicase-like	0.565
MDC1	mediator of DNA-damage checkpoint 1	0.542
PCNA	proliferating cell nuclear antigen	0.510
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.510
MCMBP	minichromosome maintenance complex binding protein	0.501
RAD50	RAD50 homolog (S. cerevisiae)	0.443
RAD18	RAD18 homolog (S. cerevisiae)	0.373
FANCB	Fanconi anemia, complementation group B	0.301
MCM4	minichromosome maintenance complex component 4	0.295
RAD21	RAD21 homolog (S. pombe)	0.256
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.236
ORC3	origin recognition complex, subunit 3	0.224
SMC1A	structural maintenance of chromosomes 1A	0.207
MCM3	minichromosome maintenance complex component 3	0.201
RFC5	replication factor C (activator 1) 5, 36.5kDa	0.193
MCM2	minichromosome maintenance complex component 2	0.169
NBN	nibrin	0.163
FANCD2	Fanconi anemia, complementation group D2	0.154
STRA13	stimulated by retinoic acid 13 homolog (mouse)	0.144
FANCM	Fanconi anemia, complementation group M	0.136
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.120
RAD51AP1	RAD51 associated protein 1	0.100
MSH6	mutS homolog 6 (E. coli)	0.097
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.094
PRC1	protein regulator of cytokinesis 1	0.090
DSCC1	defective in sister chromatid cohesion 1 homolog (S. cerevisiae)	0.087
HLTF	helicase-like transcription factor	0.084
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.081
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.076
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.075
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.070
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.066
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.066
RAD9A	RAD9 homolog A (S. pombe)	0.066
ORC1	origin recognition complex, subunit 1	0.062
RMI1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)	0.061
PRIM1	primase, DNA, polypeptide 1 (49kDa)	0.061
MCM7	minichromosome maintenance complex component 7	0.061
ORC6	origin recognition complex, subunit 6	0.061
RAD52	RAD52 homolog (S. cerevisiae)	0.060	Yeast
PALB2	partner and localizer of BRCA2	0.060
SYCP3	synaptonemal complex protein 3	0.056
PRNP	prion protein	0.053
FANCG	Fanconi anemia, complementation group G	0.049
ATM	ataxia telangiectasia mutated	0.048
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.048
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.048	Yeast
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.047
TERF2	telomeric repeat binding factor 2	0.046
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.044
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.043
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.042
RAD54B	RAD54 homolog B (S. cerevisiae)	0.042	Yeast
CENPE	centromere protein E, 312kDa	0.039
H2AFX	H2A histone family, member X	0.036
C19orf39	chromosome 19 open reading frame 39	0.036
FANCA	Fanconi anemia, complementation group A	0.036
KNTC1	kinetochore associated 1	0.032
RIF1	RAP1 interacting factor homolog (yeast)	0.031
CENPM	centromere protein M	0.031
CLIP1	CAP-GLY domain containing linker protein 1	0.031
TPR	translocated promoter region (to activated MET oncogene)	0.030
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.029
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.029
RNF20	ring finger protein 20	0.028
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.028
ZNF337	zinc finger protein 337	0.028	Human
C16orf75	chromosome 16 open reading frame 75	0.027
ZNF133	zinc finger protein 133	0.027	Human
MSH3	mutS homolog 3 (E. coli)	0.027
DCTPP1	dCTP pyrophosphatase 1	0.026
GINS2	GINS complex subunit 2 (Psf2 homolog)	0.025
DTL	denticleless homolog (Drosophila)	0.024
KIF20B	kinesin family member 20B	0.024
TMEM106C	transmembrane protein 106C	0.024
RNASEH2A	ribonuclease H2, subunit A	0.023
PTTG1	pituitary tumor-transforming 1	0.023
CENPW	centromere protein W	0.023
TOP3A	topoisomerase (DNA) III alpha	0.023
RRM1	ribonucleotide reductase M1	0.022
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.022
PARP1	poly (ADP-ribose) polymerase 1	0.021
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.021
MCM8	minichromosome maintenance complex component 8	0.021	Fly
PSIP1	PC4 and SFRS1 interacting protein 1	0.021
COMMD4	COMM domain containing 4	0.021
EXO1	exonuclease 1	0.021
TRIM37	tripartite motif containing 37	0.021
POLH	polymerase (DNA directed), eta	0.020
SMC2	structural maintenance of chromosomes 2	0.020
MNS1	meiosis-specific nuclear structural 1	0.020
PRIM2	primase, DNA, polypeptide 2 (58kDa)	0.020
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.019
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.019
KIF11	kinesin family member 11	0.018
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.018
MCM10	minichromosome maintenance complex component 10	0.018
APC	adenomatous polyposis coli	0.018
NUP155	nucleoporin 155kDa	0.017
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.017
AKTIP	AKT interacting protein	0.017
CKAP5	cytoskeleton associated protein 5	0.017
MED31	mediator complex subunit 31	0.017
HMGN2	high mobility group nucleosomal binding domain 2	0.016
STIL	SCL/TAL1 interrupting locus	0.016
GPSM2	G-protein signaling modulator 2	0.016
FAM190B	family with sequence similarity 190, member B	0.016
RAD1	RAD1 homolog (S. pombe)	0.016
LOC81691	exonuclease NEF-sp	0.015
WASF1	WAS protein family, member 1	0.015
FANCI	Fanconi anemia, complementation group I	0.015
SEPT7	septin 7	0.015
NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	0.015
ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	0.015
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.015
XPA	xeroderma pigmentosum, complementation group A	0.015
ZNF187	zinc finger protein 187	0.015
STMN1	stathmin 1	0.015
MLH3	mutL homolog 3 (E. coli)	0.015
GPS2	G protein pathway suppressor 2	0.014
ITGB3BP	integrin beta 3 binding protein (beta3-endonexin)	0.014
BRCC3	BRCA1/BRCA2-containing complex, subunit 3	0.014
TRIM23	tripartite motif containing 23	0.014
DCLRE1A	DNA cross-link repair 1A	0.014
DZIP3	DAZ interacting protein 3, zinc finger	0.014
EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.014
TDP1	tyrosyl-DNA phosphodiesterase 1	0.014
CENPF	centromere protein F, 350/400kDa (mitosin)	0.013
SPRR2A	small proline-rich protein 2A	0.013
ARL11	ADP-ribosylation factor-like 11	0.013
KIF23	kinesin family member 23	0.013
UNG	uracil-DNA glycosylase	0.013
ZMYND11	zinc finger, MYND-type containing 11	0.013
ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4	0.013
MIS18BP1	MIS18 binding protein 1	0.013
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.013
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.013
ESCO2	establishment of cohesion 1 homolog 2 (S. cerevisiae)	0.013
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.013
ZNF862	zinc finger protein 862	0.013
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.013	Yeast Zebrafish Mouse
HDAC8	histone deacetylase 8	0.013
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.012
TUBA4A	tubulin, alpha 4a	0.012
HIPK2	homeodomain interacting protein kinase 2	0.012
POP5	processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)	0.012
PFN1	profilin 1	0.012
TMSB4X	thymosin beta 4, X-linked	0.012
FANCL	Fanconi anemia, complementation group L	0.012
ACYP1	acylphosphatase 1, erythrocyte (common) type	0.012
TOPBP1	topoisomerase (DNA) II binding protein 1	0.012
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.012
DDX46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.012
LOXL4	lysyl oxidase-like 4	0.011
CENPJ	centromere protein J	0.011
USP9X	ubiquitin specific peptidase 9, X-linked	0.011
FKBP5	FK506 binding protein 5	0.011
STAG1	stromal antigen 1	0.011
ORC2	origin recognition complex, subunit 2	0.011
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.011
FN3KRP	fructosamine 3 kinase related protein	0.011
CLASP2	cytoplasmic linker associated protein 2	0.011
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.011
PARP2	poly (ADP-ribose) polymerase 2	0.011
TOP1	topoisomerase (DNA) I	0.011
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.011
RECQL5	RecQ protein-like 5	0.011
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.010
CCDC77	coiled-coil domain containing 77	0.010
PLK4	polo-like kinase 4	0.010
FANCE	Fanconi anemia, complementation group E	0.010
GPSM1	G-protein signaling modulator 1	0.010
ALS2CR4	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4	0.010
MLF1IP	MLF1 interacting protein	0.010
TMEM194A	transmembrane protein 194A	0.010
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.010
CENPI	centromere protein I	0.010
ZNF16	zinc finger protein 16	0.010
PDSS1	prenyl (decaprenyl) diphosphate synthase, subunit 1	0.010
CSPP1	centrosome and spindle pole associated protein 1	0.010
NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.010
KIF15	kinesin family member 15	0.010
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.010
POC5	POC5 centriolar protein homolog (Chlamydomonas)	0.010