IMP

Process View

Homo sapiens

23 genes annotated in human

appendage development

The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "appendage development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "appendage development" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	1.000	Human
FHL2	four and a half LIM domains 2	0.976
ZNF43	zinc finger protein 43	0.867
SMAD3	SMAD family member 3	0.827
JAG1	jagged 1	0.621	Fly
TGFB1	transforming growth factor, beta 1	0.550
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.548
SUFU	suppressor of fused homolog (Drosophila)	0.526
ZNF253	zinc finger protein 253	0.436
FN1	fibronectin 1	0.420
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.401
ENG	endoglin	0.398
ZNF273	zinc finger protein 273	0.380	Human
ZNF675	zinc finger protein 675	0.299	Human
COL1A1	collagen, type I, alpha 1	0.288	Zebrafish
MEIS1	Meis homeobox 1	0.272
BMP2	bone morphogenetic protein 2	0.271	Fly
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.260
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.241	Human Fly
SKIL	SKI-like oncogene	0.231
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.180
PAX3	paired box 3	0.155
ZNF91	zinc finger protein 91	0.151
BMP1	bone morphogenetic protein 1	0.129	Zebrafish Fly
COL7A1	collagen, type VII, alpha 1	0.127
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.126
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.124	Human Mouse
HDAC1	histone deacetylase 1	0.117	Mouse
COL6A1	collagen, type VI, alpha 1	0.114
BMPR1A	bone morphogenetic protein receptor, type IA	0.112	Human Mouse Fly
ZNF708	zinc finger protein 708	0.111	Human
HOXA10	homeobox A10	0.109
FBLN1	fibulin 1	0.105	Zebrafish
TGFBR1	transforming growth factor, beta receptor 1	0.101	Human Fly
CHRD	chordin	0.099	Zebrafish Fly
ZNF430	zinc finger protein 430	0.091	Human
PDZD11	PDZ domain containing 11	0.087
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.086
ATN1	atrophin 1	0.085
PSEN1	presenilin 1	0.084	Mouse
ZNF85	zinc finger protein 85	0.080	Human
FLNA	filamin A, alpha	0.080
ZNF93	zinc finger protein 93	0.080
SMAD4	SMAD family member 4	0.073	Fly
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.071	Human
GDF5	growth differentiation factor 5	0.071	Mouse
PPARA	peroxisome proliferator-activated receptor alpha	0.070
ACVR1	activin A receptor, type I	0.069	Human Fly
CHD7	chromodomain helicase DNA binding protein 7	0.069
HOXC8	homeobox C8	0.066	Zebrafish
BMPR1B	bone morphogenetic protein receptor, type IB	0.064
MEIS2	Meis homeobox 2	0.061
GATA4	GATA binding protein 4	0.057
ARRB1	arrestin, beta 1	0.057
BMP4	bone morphogenetic protein 4	0.056	Zebrafish Mouse Fly
HOXD13	homeobox D13	0.056	Mouse
BMP7	bone morphogenetic protein 7	0.056	Mouse Fly
HOXC11	homeobox C11	0.055	Mouse
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.054	Fly
THBS1	thrombospondin 1	0.054	Human
FGF10	fibroblast growth factor 10	0.054
FSTL1	follistatin-like 1	0.053
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.052
ZNF117	zinc finger protein 117	0.050	Human
TLN1	talin 1	0.049
HOXD9	homeobox D9	0.049	Mouse Fly
RXRA	retinoid X receptor, alpha	0.048
CHD4	chromodomain helicase DNA binding protein 4	0.048
RARG	retinoic acid receptor, gamma	0.047	Mouse
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.047
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.047	Mouse Fly
NCOR2	nuclear receptor corepressor 2	0.046
TJP1	tight junction protein 1 (zona occludens 1)	0.044
COL2A1	collagen, type II, alpha 1	0.044	Mouse
RBBP4	retinoblastoma binding protein 4	0.044
EPS8	epidermal growth factor receptor pathway substrate 8	0.044
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.043	Human Fly
SOX2	SRY (sex determining region Y)-box 2	0.040
FKBP1A	FK506 binding protein 1A, 12kDa	0.040
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.039
SETD8	SET domain containing (lysine methyltransferase) 8	0.038
DLX4	distal-less homeobox 4	0.038	Fly
RAB14	RAB14, member RAS oncogene family	0.038
ATP6V1G1	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1	0.038
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.037
DLX5	distal-less homeobox 5	0.036	Zebrafish Mouse
BAK1	BCL2-antagonist/killer 1	0.036
LBX1	ladybird homeobox 1	0.036	Fly
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.036
ZNF254	zinc finger protein 254	0.036	Human
APP	amyloid beta (A4) precursor protein	0.035
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.033
WNT1	wingless-type MMTV integration site family, member 1	0.033	Human Fly
PIAS1	protein inhibitor of activated STAT, 1	0.033
FOXF2	forkhead box F2	0.032
ATP6V1D	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D	0.031
NGFR	nerve growth factor receptor	0.031
LRP6	low density lipoprotein receptor-related protein 6	0.031	Human Mouse
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.031
COL1A2	collagen, type I, alpha 2	0.029
FGF18	fibroblast growth factor 18	0.029
SMAD6	SMAD family member 6	0.029	Fly
ACAN	aggrecan	0.029
CTGF	connective tissue growth factor	0.029
ELL2	elongation factor, RNA polymerase II, 2	0.029
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.028
CTCF	CCCTC-binding factor (zinc finger protein)	0.028
HOXC6	homeobox C6	0.028
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.028	Mouse
HOXD11	homeobox D11	0.028	Mouse
YY1	YY1 transcription factor	0.028
ZNF680	zinc finger protein 680	0.028	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.027
BAX	BCL2-associated X protein	0.027	Mouse
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.027	Mouse
NCOR1	nuclear receptor corepressor 1	0.027
BMI1	BMI1 polycomb ring finger oncogene	0.027
FOXC1	forkhead box C1	0.026
AQP5	aquaporin 5	0.026
FOXD3	forkhead box D3	0.026
PXN	paxillin	0.026
FBLN2	fibulin 2	0.025
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.025
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.025
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.025
HES2	hairy and enhancer of split 2 (Drosophila)	0.025
CRLF1	cytokine receptor-like factor 1	0.025
BARX1	BARX homeobox 1	0.025
SIX2	SIX homeobox 2	0.025
NOG	noggin	0.024
CDX2	caudal type homeobox 2	0.024
MSX2	msh homeobox 2	0.024	Human Mouse Fly
TBX5	T-box 5	0.024
GLI3	GLI family zinc finger 3	0.024
PRRX2	paired related homeobox 2	0.024	Mouse
SATB2	SATB homeobox 2	0.024
CBX8	chromobox homolog 8	0.023
ZNF92	zinc finger protein 92	0.023	Human
COL4A2	collagen, type IV, alpha 2	0.023
PAX2	paired box 2	0.023
MYOD1	myogenic differentiation 1	0.023
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.023
SMAD1	SMAD family member 1	0.022	Fly
OTP	orthopedia homeobox	0.022
PCGF2	polycomb group ring finger 2	0.022
TWIST1	twist homolog 1 (Drosophila)	0.022	Mouse
ITGA6	integrin, alpha 6	0.022
TRIP6	thyroid hormone receptor interactor 6	0.022
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.022
RBBP5	retinoblastoma binding protein 5	0.022
AR	androgen receptor	0.022
TCF12	transcription factor 12	0.022
SMO	smoothened homolog (Drosophila)	0.021	Zebrafish
HOXC13	homeobox C13	0.021	Mouse
MSX1	msh homeobox 1	0.021
PRKG1	protein kinase, cGMP-dependent, type I	0.021
HNF1B	HNF1 homeobox B	0.021
AFF1	AF4/FMR2 family, member 1	0.021
MYO10	myosin X	0.021
MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.021
WISP1	WNT1 inducible signaling pathway protein 1	0.020
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.020
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.020
CD248	CD248 molecule, endosialin	0.020
TBX2	T-box 2	0.020	Human
SFRP1	secreted frizzled-related protein 1	0.020
COL11A1	collagen, type XI, alpha 1	0.020
HOXB13	homeobox B13	0.020
PDX1	pancreatic and duodenal homeobox 1	0.019
NKX3-2	NK3 homeobox 2	0.019
XIAP	X-linked inhibitor of apoptosis	0.019
HOXD12	homeobox D12	0.019	Mouse
EXOC5	exocyst complex component 5	0.019
GATA5	GATA binding protein 5	0.019
NRP1	neuropilin 1	0.018
HSPG2	heparan sulfate proteoglycan 2	0.018
HOXC10	homeobox C10	0.018	Mouse
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.018
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.018
NCOA1	nuclear receptor coactivator 1	0.018
HOXA3	homeobox A3	0.018
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.018
RARA	retinoic acid receptor, alpha	0.018	Zebrafish Mouse
BCL2L1	BCL2-like 1	0.018
NOTCH3	notch 3	0.018	Fly
CCNT1	cyclin T1	0.017
HOXA11	homeobox A11	0.017	Mouse
FGF3	fibroblast growth factor 3	0.017
ZMYM2	zinc finger, MYM-type 2	0.017
HIC1	hypermethylated in cancer 1	0.017
WNT10A	wingless-type MMTV integration site family, member 10A	0.017	Human
SHOX2	short stature homeobox 2	0.017	Mouse
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.017
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.016
IGFBP3	insulin-like growth factor binding protein 3	0.016
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.016
WNT11	wingless-type MMTV integration site family, member 11	0.016	Human
HOXD10	homeobox D10	0.016	Mouse
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.016
FGF2	fibroblast growth factor 2 (basic)	0.016
TGFB3	transforming growth factor, beta 3	0.016
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.016
TNC	tenascin C	0.016
HMGA2	high mobility group AT-hook 2	0.016
IRX4	iroquois homeobox 4	0.016
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.016
GDF6	growth differentiation factor 6	0.016
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.016	Fly
SOX11	SRY (sex determining region Y)-box 11	0.016	Mouse
VCAN	versican	0.016
JAG2	jagged 2	0.016	Fly
BTRC	beta-transducin repeat containing	0.016
TGFB2	transforming growth factor, beta 2	0.015
PSEN2	presenilin 2 (Alzheimer disease 4)	0.015	Mouse
ZNF682	zinc finger protein 682	0.015	Human
DIO3	deiodinase, iodothyronine, type III	0.015
ZNF107	zinc finger protein 107	0.015
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.015
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.015
BAD	BCL2-associated agonist of cell death	0.015
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.015	Fly
HOXB5	homeobox B5	0.015
AGTR1	angiotensin II receptor, type 1	0.015
CABLES1	Cdk5 and Abl enzyme substrate 1	0.015
ANTXR2	anthrax toxin receptor 2	0.014
RNF144B	ring finger protein 144B	0.014
TERF2	telomeric repeat binding factor 2	0.014
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.014
DLX2	distal-less homeobox 2	0.014
KCTD1	potassium channel tetramerisation domain containing 1	0.014
PAX6	paired box 6	0.014
WIF1	WNT inhibitory factor 1	0.014
FKBP10	FK506 binding protein 10, 65 kDa	0.014
IGFBP5	insulin-like growth factor binding protein 5	0.014
FKBP8	FK506 binding protein 8, 38kDa	0.014
PLEC	plectin	0.014
PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.014
PKNOX1	PBX/knotted 1 homeobox 1	0.014
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.013
CDK8	cyclin-dependent kinase 8	0.013	Fly
PAX9	paired box 9	0.013
PDGFC	platelet derived growth factor C	0.013
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.013
SEC24D	SEC24 family, member D (S. cerevisiae)	0.013
DOCK7	dedicator of cytokinesis 7	0.013
FZD7	frizzled homolog 7 (Drosophila)	0.013
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	0.013
C7orf64	chromosome 7 open reading frame 64	0.013
SFRP2	secreted frizzled-related protein 2	0.013	Mouse
FGF7	fibroblast growth factor 7	0.013
LUM	lumican	0.013
PAX8	paired box 8	0.013
TLX1	T-cell leukemia homeobox 1	0.013	Fly
WNT4	wingless-type MMTV integration site family, member 4	0.013	Human
MAPK8	mitogen-activated protein kinase 8	0.013
GDNF	glial cell derived neurotrophic factor	0.013
HOXD3	homeobox D3	0.013
HOXC9	homeobox C9	0.013	Fly
PAX7	paired box 7	0.013
FZD10	frizzled homolog 10 (Drosophila)	0.013
SIX6	SIX homeobox 6	0.013
EYA2	eyes absent homolog 2 (Drosophila)	0.013
RNR2	l-rRNA	0.012
ZFYVE9	zinc finger, FYVE domain containing 9	0.012
COMP	cartilage oligomeric matrix protein	0.012
FOXF1	forkhead box F1	0.012
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.012	Human
POU3F1	POU class 3 homeobox 1	0.012
SIM2	single-minded homolog 2 (Drosophila)	0.012
TUBB8	tubulin, beta 8	0.012
ADAMTSL4	ADAMTS-like 4	0.012
HCFC1	host cell factor C1 (VP16-accessory protein)	0.012
FLNB	filamin B, beta	0.012
DLL1	delta-like 1 (Drosophila)	0.012	Fly
GAS1	growth arrest-specific 1	0.012	Mouse
COL17A1	collagen, type XVII, alpha 1	0.012
MESDC2	mesoderm development candidate 2	0.012
ATF2	activating transcription factor 2	0.012
CAPRIN2	caprin family member 2	0.012
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.012	Zebrafish
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.012
RAX	retina and anterior neural fold homeobox	0.012	Mouse
RING1	ring finger protein 1	0.012
EN1	engrailed homeobox 1	0.012	Mouse Fly
FBN1	fibrillin 1	0.012
ADAM10	ADAM metallopeptidase domain 10	0.012
PLCG1	phospholipase C, gamma 1	0.012
COL10A1	collagen, type X, alpha 1	0.012
CHD8	chromodomain helicase DNA binding protein 8	0.012	Human Fly
PYY	peptide YY	0.012
ALX3	ALX homeobox 3	0.012	Mouse
HOXB6	homeobox B6	0.012
PRDM8	PR domain containing 8	0.012
WT1	Wilms tumor 1	0.012
FOXB1	forkhead box B1	0.012
LTBP4	latent transforming growth factor beta binding protein 4	0.011
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.011
HOXA6	homeobox A6	0.011
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.011
GATA2	GATA binding protein 2	0.011
HOXB7	homeobox B7	0.011
BNC1	basonuclin 1	0.011	Fly
PAX1	paired box 1	0.011
FEV	FEV (ETS oncogene family)	0.011
TWIST2	twist homolog 2 (Drosophila)	0.011
TBX1	T-box 1	0.011	Human
HOXB9	homeobox B9	0.011	Fly
FOXL1	forkhead box L1	0.011	Zebrafish
HOXB8	homeobox B8	0.011
CELF1	CUGBP, Elav-like family member 1	0.011	Fly
PTK7	PTK7 protein tyrosine kinase 7	0.011
GSTM4	glutathione S-transferase mu 4	0.011
MDFI	MyoD family inhibitor	0.011
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.011
KRT6C	keratin 6C	0.011
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.011
SIX1	SIX homeobox 1	0.011
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.011
HMX1	H6 family homeobox 1	0.011
ALX4	ALX homeobox 4	0.011	Mouse
USP11	ubiquitin specific peptidase 11	0.011
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.011	Zebrafish
WNT3A	wingless-type MMTV integration site family, member 3A	0.011
HUWE1	HECT, UBA and WWE domain containing 1	0.011
TMSB4X	thymosin beta 4, X-linked	0.011
GAPVD1	GTPase activating protein and VPS9 domains 1	0.011
HR	hairless homolog (mouse)	0.011
PRPH	peripherin	0.011
SMAD2	SMAD family member 2	0.011
NRP2	neuropilin 2	0.011
PCGF5	polycomb group ring finger 5	0.011
NRIP1	nuclear receptor interacting protein 1	0.011
SFRP5	secreted frizzled-related protein 5	0.010
SORBS3	sorbin and SH3 domain containing 3	0.010
PTEN	phosphatase and tensin homolog	0.010
HOXC5	homeobox C5	0.010
EEA1	early endosome antigen 1	0.010
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.010
HOXA9	homeobox A9	0.010	Mouse Fly
HOXD8	homeobox D8	0.010
ANKRD17	ankyrin repeat domain 17	0.010
PHTF2	putative homeodomain transcription factor 2	0.010
VCAM1	vascular cell adhesion molecule 1	0.010
POU4F1	POU class 4 homeobox 1	0.010
BIK	BCL2-interacting killer (apoptosis-inducing)	0.010
ZNF506	zinc finger protein 506	0.010	Human
HTRA3	HtrA serine peptidase 3	0.010
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.010
VSX1	visual system homeobox 1	0.010
AFF2	AF4/FMR2 family, member 2	0.010
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.010
COL4A5	collagen, type IV, alpha 5	0.010
VAX2	ventral anterior homeobox 2	0.010