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Process View

Homo sapiens

19 genes annotated in human

stem cell maintenance

GO:0019827

The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "stem cell maintenance"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "stem cell maintenance" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD4	SMAD family member 4	0.995	Fly
SMAD3	SMAD family member 3	0.995
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.983	Fly
SMAD7	SMAD family member 7	0.964	Fly
NOTCH1	notch 1	0.911
WAPAL	wings apart-like homolog (Drosophila)	0.909
JAG1	jagged 1	0.907
EGFR	epidermal growth factor receptor	0.852	Fly
DICER1	dicer 1, ribonuclease type III	0.836	Mouse
SMAD1	SMAD family member 1	0.820	Fly
TAL1	T-cell acute lymphocytic leukemia 1	0.724	Mouse
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.661
SP1	Sp1 transcription factor	0.647
CDK8	cyclin-dependent kinase 8	0.637
CSNK1E	casein kinase 1, epsilon	0.603
ATF2	activating transcription factor 2	0.501
EP300	E1A binding protein p300	0.463
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.446	Fly
AXIN1	axin 1	0.393	Fly
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.371	Fly
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.326
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.255
NOTCH3	notch 3	0.253	Human Zebrafish Fly
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.231
RAD21	RAD21 homolog (S. pombe)	0.230
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.222
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.219	Fly
CNOT8	CCR4-NOT transcription complex, subunit 8	0.216
CREBBP	CREB binding protein	0.212	Mouse
TP53	tumor protein p53	0.208
YAP1	Yes-associated protein 1	0.207	Mouse
APLF	aprataxin and PNKP like factor	0.207
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.206
BBS10	Bardet-Biedl syndrome 10	0.200
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.189
PUM1	pumilio homolog 1 (Drosophila)	0.185
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.184	Fly
FUBP1	far upstream element (FUSE) binding protein 1	0.181
SMAD2	SMAD family member 2	0.170
CDK2	cyclin-dependent kinase 2	0.162
AR	androgen receptor	0.159
RUNX1	runt-related transcription factor 1	0.155
SMAD5	SMAD family member 5	0.148	Fly
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.146
LMO4	LIM domain only 4	0.144
CTR9	Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.137
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.133
JAK2	Janus kinase 2	0.132	Fly
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.132	Fly
APC	adenomatous polyposis coli	0.130	Mouse
CNOT2	CCR4-NOT transcription complex, subunit 2	0.127
POU5F1	POU class 5 homeobox 1	0.120
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.111
IL4R	interleukin 4 receptor	0.108
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.105
BMP7	bone morphogenetic protein 7	0.104	Mouse
CREB1	cAMP responsive element binding protein 1	0.104
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.099
PDS5A	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.094
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.092	Mouse
CUL2	cullin 2	0.091
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.086
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.086	Fly
SOX2	SRY (sex determining region Y)-box 2	0.083
FOXD3	forkhead box D3	0.081
MBNL1	muscleblind-like (Drosophila)	0.081
TRIM33	tripartite motif containing 33	0.081
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.078	Mouse
QKI	quaking homolog, KH domain RNA binding (mouse)	0.078	Fly
TCF12	transcription factor 12	0.076	Fly
INSR	insulin receptor	0.072
PAX3	paired box 3	0.071
CNOT6	CCR4-NOT transcription complex, subunit 6	0.069
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.067
NCOA2	nuclear receptor coactivator 2	0.067
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.066
HNF4A	hepatocyte nuclear factor 4, alpha	0.063
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.062
FGF1	fibroblast growth factor 1 (acidic)	0.060
NFYC	nuclear transcription factor Y, gamma	0.059
CNOT3	CCR4-NOT transcription complex, subunit 3	0.059
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.055
HCFC1	host cell factor C1 (VP16-accessory protein)	0.054
GATA2	GATA binding protein 2	0.053	Mouse
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.053	Fly
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.053
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.050
SSU72	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0.050
CAND1	cullin-associated and neddylation-dissociated 1	0.048
FBLN1	fibulin 1	0.047
LAT	linker for activation of T cells	0.045
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.044	Fly
DMAP1	DNA methyltransferase 1 associated protein 1	0.044
E2F1	E2F transcription factor 1	0.044
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.043
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.043
SOX11	SRY (sex determining region Y)-box 11	0.043	Human
PTCH1	patched 1	0.042
TPR	translocated promoter region (to activated MET oncogene)	0.041
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.041
PABPC1	poly(A) binding protein, cytoplasmic 1	0.040
MED10	mediator complex subunit 10	0.040
STAT5A	signal transducer and activator of transcription 5A	0.039	Fly
LRP6	low density lipoprotein receptor-related protein 6	0.039
HNF1A	HNF1 homeobox A	0.037
KIF1B	kinesin family member 1B	0.037
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.036
TRIM71	tripartite motif containing 71	0.035
MED29	mediator complex subunit 29	0.034
HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	0.034
CYTH1	cytohesin 1	0.033
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.033
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.031
SOCS1	suppressor of cytokine signaling 1	0.030
MAML1	mastermind-like 1 (Drosophila)	0.030
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.030
BBS4	Bardet-Biedl syndrome 4	0.030
MED6	mediator complex subunit 6	0.030
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.029
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.029
SFPQ	splicing factor proline/glutamine-rich	0.029
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.028
MYOD1	myogenic differentiation 1	0.026
JAK1	Janus kinase 1	0.026	Fly
CUL4B	cullin 4B	0.025
CDK19	cyclin-dependent kinase 19	0.025
WDR61	WD repeat domain 61	0.025
SFRP1	secreted frizzled-related protein 1	0.024	Mouse
GRB7	growth factor receptor-bound protein 7	0.024
NKX2-1	NK2 homeobox 1	0.024
CTCF	CCCTC-binding factor (zinc finger protein)	0.024
RAP1A	RAP1A, member of RAS oncogene family	0.024	Fly
RLIM	ring finger protein, LIM domain interacting	0.024
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.023
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.023	Fly
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.022
NOTCH2	notch 2	0.021	Human Fly
WT1	Wilms tumor 1	0.021
ZFYVE9	zinc finger, FYVE domain containing 9	0.021
MED23	mediator complex subunit 23	0.021
WDR26	WD repeat domain 26	0.021
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.020
SOX9	SRY (sex determining region Y)-box 9	0.020	Human Mouse
DLL1	delta-like 1 (Drosophila)	0.020
CTNNBIP1	catenin, beta interacting protein 1	0.020
SREBF2	sterol regulatory element binding transcription factor 2	0.020
MEOX2	mesenchyme homeobox 2	0.020
APPBP2	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	0.019
CUL3	cullin 3	0.019
NFYB	nuclear transcription factor Y, beta	0.019
MED12	mediator complex subunit 12	0.018	Mouse
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.018
KITLG	KIT ligand	0.018
POU3F2	POU class 3 homeobox 2	0.018	Human
MYO10	myosin X	0.018
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.018
PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.018
GDF5	growth differentiation factor 5	0.017
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.017
BMPR1A	bone morphogenetic protein receptor, type IA	0.017	Mouse Fly
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.017
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.017	Mouse
RAB11FIP1	RAB11 family interacting protein 1 (class I)	0.017
STAT2	signal transducer and activator of transcription 2, 113kDa	0.016
POGZ	pogo transposable element with ZNF domain	0.016
TCF4	transcription factor 4	0.016	Fly
ZEB2	zinc finger E-box binding homeobox 2	0.016
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.016
MED13	mediator complex subunit 13	0.016
DLG4	discs, large homolog 4 (Drosophila)	0.016
PKN2	protein kinase N2	0.016
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.016	Mouse
MFAP1	microfibrillar-associated protein 1	0.015
ATN1	atrophin 1	0.015
FOXA2	forkhead box A2	0.015
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.015
HNF1B	HNF1 homeobox B	0.015	Mouse
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.015
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.015
WNT5A	wingless-type MMTV integration site family, member 5A	0.015
FZD7	frizzled homolog 7 (Drosophila)	0.015
FOXO1	forkhead box O1	0.015	Mouse Fly
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.014
CNOT1	CCR4-NOT transcription complex, subunit 1	0.014
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.014
CSNK1D	casein kinase 1, delta	0.014
WNT3A	wingless-type MMTV integration site family, member 3A	0.014
CCNB2	cyclin B2	0.014
BTG1	B-cell translocation gene 1, anti-proliferative	0.014
XIAP	X-linked inhibitor of apoptosis	0.013
FOXC1	forkhead box C1	0.013
CCNA2	cyclin A2	0.013
GRB2	growth factor receptor-bound protein 2	0.013
TP73	tumor protein p73	0.013
FGFR1	fibroblast growth factor receptor 1	0.013	Rat
SOCS3	suppressor of cytokine signaling 3	0.013
ESR1	estrogen receptor 1	0.013
STAG1	stromal antigen 1	0.013
SMAD6	SMAD family member 6	0.013	Fly
PLEC	plectin	0.013
STAT5B	signal transducer and activator of transcription 5B	0.012	Fly
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.012
ERBB2IP	erbb2 interacting protein	0.012
HIC1	hypermethylated in cancer 1	0.012
STAT1	signal transducer and activator of transcription 1, 91kDa	0.012
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.012
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.012
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.012
EGFL7	EGF-like-domain, multiple 7	0.012
FBXW11	F-box and WD repeat domain containing 11	0.012
RBMX	RNA binding motif protein, X-linked	0.012
SNW1	SNW domain containing 1	0.011
JAG2	jagged 2	0.011	Human Fly
NUP133	nucleoporin 133kDa	0.011
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.011
MED4	mediator complex subunit 4	0.011
HMGA2	high mobility group AT-hook 2	0.011
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.011
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.011
MAVS	mitochondrial antiviral signaling protein	0.011
ANXA5	annexin A5	0.011
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.011
MED13L	mediator complex subunit 13-like	0.011
MED27	mediator complex subunit 27	0.011
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.011
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.011
FERMT2	fermitin family member 2	0.010
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.010
BMP4	bone morphogenetic protein 4	0.010	Fly
IGF1R	insulin-like growth factor 1 receptor	0.010
SOX21	SRY (sex determining region Y)-box 21	0.010
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.010	Mouse
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.010
MTA1	metastasis associated 1	0.010
PLDN	pallidin homolog (mouse)	0.010
CCNB1	cyclin B1	0.010
BMP2	bone morphogenetic protein 2	0.010	Fly
NOG	noggin	0.010
TARBP2	TAR (HIV-1) RNA binding protein 2	0.010	Fly