IMP

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Homo sapiens

36 genes annotated in human

Multi-species View

peptidyl tyrosine dephosphorylation

GO:0035335

The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "peptidyl tyrosine dephosphorylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "peptidyl tyrosine dephosphorylation" (in gray)

Name	Description	Probability	Func Analog Organism
MAPK1	mitogen-activated protein kinase 1	1.000
MAPK14	mitogen-activated protein kinase 14	1.000
GHR	growth hormone receptor	0.999
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.999
DUSP1	dual specificity phosphatase 1	0.977	Human
DUSP7	dual specificity phosphatase 7	0.958
MAP2K1	mitogen-activated protein kinase kinase 1	0.915	Mouse
LCK	lymphocyte-specific protein tyrosine kinase	0.902
YAP1	Yes-associated protein 1	0.774
PTPRB	protein tyrosine phosphatase, receptor type, B	0.749	Human Fly
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.747
MAPK3	mitogen-activated protein kinase 3	0.730
PTPRR	protein tyrosine phosphatase, receptor type, R	0.707	Mouse Fly
DUSP5	dual specificity phosphatase 5	0.702	Human
DUSP3	dual specificity phosphatase 3	0.671
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.655
SYK	spleen tyrosine kinase	0.632
PEA15	phosphoprotein enriched in astrocytes 15	0.518
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.482
DUSP6	dual specificity phosphatase 6	0.431
RB1	retinoblastoma 1	0.429
CCNB2	cyclin B2	0.423
CCNE1	cyclin E1	0.387
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.376
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.371
ARHGAP9	Rho GTPase activating protein 9	0.367
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.350
CD247	CD247 molecule	0.342
PTP4A2	protein tyrosine phosphatase type IVA, member 2	0.316
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.298
RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	0.275
PTK2	PTK2 protein tyrosine kinase 2	0.244
RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	0.234
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.229
CHMP4B	chromatin modifying protein 4B	0.178
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.173	Fly
CAV2	caveolin 2	0.166
DPYSL4	dihydropyrimidinase-like 4	0.142
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.133
MBP	myelin basic protein	0.122
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.116
CTNND1	catenin (cadherin-associated protein), delta 1	0.110
MTPN	myotrophin	0.109
IQGAP1	IQ motif containing GTPase activating protein 1	0.105
MTMR9	myotubularin related protein 9	0.105
CDK2	cyclin-dependent kinase 2	0.102
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.101
ADAM15	ADAM metallopeptidase domain 15	0.091
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.086
PKN2	protein kinase N2	0.084
SOCS2	suppressor of cytokine signaling 2	0.082
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.082
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.077
SIRT2	sirtuin 2	0.077
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.075
SRCIN1	SRC kinase signaling inhibitor 1	0.072
MAP2K4	mitogen-activated protein kinase kinase 4	0.070
KIAA1377	KIAA1377	0.069
PAFAH1B2	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	0.065
IER3	immediate early response 3	0.064
DPPA4	developmental pluripotency associated 4	0.064
SH3GL3	SH3-domain GRB2-like 3	0.059
ALK	anaplastic lymphoma receptor tyrosine kinase	0.057
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.053
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.052	Fly
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.049
DNM1	dynamin 1	0.047
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.047
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.045	Fly
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.044
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.043
WEE1	WEE1 homolog (S. pombe)	0.042
TSC22D4	TSC22 domain family, member 4	0.042
CSK	c-src tyrosine kinase	0.041
CSDA	cold shock domain protein A	0.041
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.039
PTPN9	protein tyrosine phosphatase, non-receptor type 9	0.039
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.038
ARHGAP29	Rho GTPase activating protein 29	0.037
CKS2	CDC28 protein kinase regulatory subunit 2	0.037
CDT1	chromatin licensing and DNA replication factor 1	0.036
THAP2	THAP domain containing, apoptosis associated protein 2	0.034
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.034
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.034
ATF3	activating transcription factor 3	0.032
SH3GL2	SH3-domain GRB2-like 2	0.032
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.031
MAP2K6	mitogen-activated protein kinase kinase 6	0.031
FOXM1	forkhead box M1	0.030
ANAPC1	anaphase promoting complex subunit 1	0.029
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.028
DUSP9	dual specificity phosphatase 9	0.028	Human
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.028
GAB1	GRB2-associated binding protein 1	0.027
PXN	paxillin	0.026
RNF6	ring finger protein (C3H2C3 type) 6	0.026
SIX1	SIX homeobox 1	0.026
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.026
EGR3	early growth response 3	0.025
ZNF512B	zinc finger protein 512B	0.025
TUBA3E	tubulin, alpha 3e	0.025
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.025
TUBB2A	tubulin, beta 2A	0.025
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.025
IER2	immediate early response 2	0.024
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.024	Fly
FAS	Fas (TNF receptor superfamily, member 6)	0.024
CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.024
DUSP4	dual specificity phosphatase 4	0.024	Human
HIPK3	homeodomain interacting protein kinase 3	0.024
KLHL2	kelch-like 2, Mayven (Drosophila)	0.024
IER5	immediate early response 5	0.023
ADRB2	adrenergic, beta-2-, receptor, surface	0.023
MAP2K3	mitogen-activated protein kinase kinase 3	0.023
ADAM17	ADAM metallopeptidase domain 17	0.023
SH2D2A	SH2 domain containing 2A	0.022
TRIB1	tribbles homolog 1 (Drosophila)	0.022
MPDZ	multiple PDZ domain protein	0.022
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.022	Human Rat
KBTBD7	kelch repeat and BTB (POZ) domain containing 7	0.022
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.022
GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	0.022
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.021
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.021
TSC2	tuberous sclerosis 2	0.021
LAT	linker for activation of T cells	0.021
BCAR1	breast cancer anti-estrogen resistance 1	0.020
SPRY2	sprouty homolog 2 (Drosophila)	0.020
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.020
WWC1	WW and C2 domain containing 1	0.020
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.020
RBM19	RNA binding motif protein 19	0.020
BNIP2	BCL2/adenovirus E1B 19kDa interacting protein 2	0.019
PPP1R3C	protein phosphatase 1, regulatory (inhibitor) subunit 3C	0.019
CREM	cAMP responsive element modulator	0.019
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.019
BID	BH3 interacting domain death agonist	0.019
ELK1	ELK1, member of ETS oncogene family	0.019
PDCD6IP	programmed cell death 6 interacting protein	0.018
ZNF267	zinc finger protein 267	0.018
PTPRA	protein tyrosine phosphatase, receptor type, A	0.018	Human Rat Fly
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.018
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.018
SPRR2A	small proline-rich protein 2A	0.018
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.017
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.017
SPTBN1	spectrin, beta, non-erythrocytic 1	0.017
CD22	CD22 molecule	0.017
ABHD13	abhydrolase domain containing 13	0.017
SH2B3	SH2B adaptor protein 3	0.017
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.016
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.016
FAM193B	family with sequence similarity 193, member B	0.016
ALS2	amyotrophic lateral sclerosis 2 (juvenile)	0.016
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.016
EGR2	early growth response 2	0.016
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.015
AHR	aryl hydrocarbon receptor	0.015
NSF	N-ethylmaleimide-sensitive factor	0.015
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.015
DUSP16	dual specificity phosphatase 16	0.015	Human
PIGA	phosphatidylinositol glycan anchor biosynthesis, class A	0.015
ERRFI1	ERBB receptor feedback inhibitor 1	0.015
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.015
HBEGF	heparin-binding EGF-like growth factor	0.015
GRB10	growth factor receptor-bound protein 10	0.015
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.014
MYO1D	myosin ID	0.014
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.014
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.014
ITGA1	integrin, alpha 1	0.014
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.014
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.014
PRKAA2	protein kinase, AMP-activated, alpha 2 catalytic subunit	0.014
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.014
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.014
REPS2	RALBP1 associated Eps domain containing 2	0.014
MUC1	mucin 1, cell surface associated	0.014
KLF6	Kruppel-like factor 6	0.014
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.013
JUP	junction plakoglobin	0.013
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.013
DOCK4	dedicator of cytokinesis 4	0.013
DOCK1	dedicator of cytokinesis 1	0.013
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.013
SMAD5	SMAD family member 5	0.013
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.013
CLSPN	claspin	0.013
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.013
TNIP1	TNFAIP3 interacting protein 1	0.013
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.013
DENND4A	DENN/MADD domain containing 4A	0.013
CCNH	cyclin H	0.013
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.012
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	0.012
MAPK11	mitogen-activated protein kinase 11	0.012
STK17A	serine/threonine kinase 17a	0.012
UTRN	utrophin	0.012
EPHA2	EPH receptor A2	0.012
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.012
TSC22D2	TSC22 domain family, member 2	0.012
NUPL1	nucleoporin like 1	0.012
DGKA	diacylglycerol kinase, alpha 80kDa	0.012
FAM190B	family with sequence similarity 190, member B	0.012
TXNRD1	thioredoxin reductase 1	0.012
TRDMT1	tRNA aspartic acid methyltransferase 1	0.012
SLC4A7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	0.012
CD2	CD2 molecule	0.012
FAM48A	family with sequence similarity 48, member A	0.012
ETV5	ets variant 5	0.012
GNPTAB	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
CDCP1	CUB domain containing protein 1	0.012
CNTN1	contactin 1	0.012
NHLRC1	NHL repeat containing 1	0.012
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.012
PIK3R4	phosphoinositide-3-kinase, regulatory subunit 4	0.012
RAP2C	RAP2C, member of RAS oncogene family	0.012
MYO1B	myosin IB	0.012
CHGB	chromogranin B (secretogranin 1)	0.012
EFR3A	EFR3 homolog A (S. cerevisiae)	0.012
PTP4A1	protein tyrosine phosphatase type IVA, member 1	0.012	Rat
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.012
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.012
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.011
DAPK1	death-associated protein kinase 1	0.011
RGS1	regulator of G-protein signaling 1	0.011
CORO1C	coronin, actin binding protein, 1C	0.011
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.011
STK38L	serine/threonine kinase 38 like	0.011
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.011
NAV1	neuron navigator 1	0.011
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.011
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.011
PTPRD	protein tyrosine phosphatase, receptor type, D	0.011	Human Fly
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.011
HIST1H3B	histone cluster 1, H3b	0.011
MTIF3	mitochondrial translational initiation factor 3	0.011
SDPR	serum deprivation response	0.011
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.011
DUSP2	dual specificity phosphatase 2	0.011	Human
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.011
NAMPT	nicotinamide phosphoribosyltransferase	0.011
ARL3	ADP-ribosylation factor-like 3	0.011
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.011
CBX4	chromobox homolog 4	0.011
ZFAND5	zinc finger, AN1-type domain 5	0.011
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.010
APOA1	apolipoprotein A-I	0.010
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.010
SOX5	SRY (sex determining region Y)-box 5	0.010
YTHDF3	YTH domain family, member 3	0.010
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.010
SLX1B	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)	0.010
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.010
TOM1L1	target of myb1 (chicken)-like 1	0.010
KIAA0930	KIAA0930	0.010
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.010
EVI2A	ecotropic viral integration site 2A	0.010
CRTC2	CREB regulated transcription coactivator 2	0.010
TMEM108	transmembrane protein 108	0.010