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Process View

Homo sapiens

29 genes annotated in human

response to topologically incorrect protein

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to topologically incorrect protein"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to topologically incorrect protein" (in gray)

Name	Description	Probability	Func Analog Organism
VCP	valosin containing protein	1.000	Yeast Worm
HSPA8	heat shock 70kDa protein 8	0.998	Human Fly
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.996	Fly
BCL2L1	BCL2-like 1	0.995	Human
PDIA3	protein disulfide isomerase family A, member 3	0.987
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	0.958
HSPA1B	heat shock 70kDa protein 1B	0.949
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.930
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.926
DERL1	Der1-like domain family, member 1	0.874
HSPA1A	heat shock 70kDa protein 1A	0.796
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.784	Worm
BAG3	BCL2-associated athanogene 3	0.783
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.692	Yeast Mouse Worm
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.651	Yeast
CANX	calnexin	0.649	Worm
SELS	selenoprotein S	0.643
PDIA4	protein disulfide isomerase family A, member 4	0.629	Worm
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.623
STON2	stonin 2	0.507
DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.467
HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.434
BAG2	BCL2-associated athanogene 2	0.390
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.371
HSPB1	heat shock 27kDa protein 1	0.371
GHR	growth hormone receptor	0.360
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.350	Human Yeast
VDAC1	voltage-dependent anion channel 1	0.327
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.317
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.314
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.256	Yeast
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.220
ATF3	activating transcription factor 3	0.215
BCL2	B-cell CLL/lymphoma 2	0.205	Human
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.205	Human
BAG1	BCL2-associated athanogene	0.202
BAX	BCL2-associated X protein	0.172
C4orf14	chromosome 4 open reading frame 14	0.167
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.147
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.146
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.131
NSFL1C	NSFL1 (p97) cofactor (p47)	0.127
UFD1L	ubiquitin fusion degradation 1 like (yeast)	0.127	Worm
WDR83	WD repeat domain 83	0.122
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.112
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.108
ERO1L	ERO1-like (S. cerevisiae)	0.106	Mouse
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.097	Worm
JUN	jun proto-oncogene	0.096
AMFR	autocrine motility factor receptor	0.095
HSPH1	heat shock 105kDa/110kDa protein 1	0.091	Worm
RPN1	ribophorin I	0.089
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.086
SOS1	son of sevenless homolog 1 (Drosophila)	0.085
ATXN3	ataxin 3	0.079	Mouse
XIAP	X-linked inhibitor of apoptosis	0.074
UBE2E3	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)	0.072
SLC33A1	solute carrier family 33 (acetyl-CoA transporter), member 1	0.068
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.062
CALR	calreticulin	0.060	Worm
PTN	pleiotrophin	0.057
PLAUR	plasminogen activator, urokinase receptor	0.056
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.055
DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.054
MKRN1	makorin ring finger protein 1	0.052
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.052
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.051
PTK2	PTK2 protein tyrosine kinase 2	0.050
HSF1	heat shock transcription factor 1	0.050	Worm
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.048
HSPA4	heat shock 70kDa protein 4	0.046	Worm
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.046
UBXN2A	UBX domain protein 2A	0.043
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.043
UBC	ubiquitin C	0.043
FAF2	Fas associated factor family member 2	0.043
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.042
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.041
NCOR2	nuclear receptor corepressor 2	0.041
GANAB	glucosidase, alpha; neutral AB	0.041
JUND	jun D proto-oncogene	0.039
BAD	BCL2-associated agonist of cell death	0.039
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.038
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.037
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.037
ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1	0.036
CCND3	cyclin D3	0.035
UBXN1	UBX domain protein 1	0.034
RNR2	l-rRNA	0.034
KEAP1	kelch-like ECH-associated protein 1	0.034
BAK1	BCL2-antagonist/killer 1	0.034
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.034
ATF2	activating transcription factor 2	0.033
UFM1	ubiquitin-fold modifier 1	0.033
USP46	ubiquitin specific peptidase 46	0.032
HYOU1	hypoxia up-regulated 1	0.031
GRB10	growth factor receptor-bound protein 10	0.031
RNF144B	ring finger protein 144B	0.031
ERO1LB	ERO1-like beta (S. cerevisiae)	0.031
KLHL24	kelch-like 24 (Drosophila)	0.031
PLAU	plasminogen activator, urokinase	0.031	Human
PDIA6	protein disulfide isomerase family A, member 6	0.030	Worm
TCP1	t-complex 1	0.030
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.029
KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.029
HSPB8	heat shock 22kDa protein 8	0.028
UBE3A	ubiquitin protein ligase E3A	0.028
PLAT	plasminogen activator, tissue	0.027	Human
PTPRB	protein tyrosine phosphatase, receptor type, B	0.027
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.025
MIB1	mindbomb homolog 1 (Drosophila)	0.025
GARS	glycyl-tRNA synthetase	0.025
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.024
KPNA5	karyopherin alpha 5 (importin alpha 6)	0.024
RABAC1	Rab acceptor 1 (prenylated)	0.024
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.023
VAPA	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	0.023	Human
PRDX4	peroxiredoxin 4	0.023
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.022
ADRM1	adhesion regulating molecule 1	0.022
UBE2E2	ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)	0.022
VCPIP1	valosin containing protein (p97)/p47 complex interacting protein 1	0.022
FKBP4	FK506 binding protein 4, 59kDa	0.022
PLCG1	phospholipase C, gamma 1	0.022
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.021
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.021
ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40	0.021
NCL	nucleolin	0.020
SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.020
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.020
ARFGAP3	ADP-ribosylation factor GTPase activating protein 3	0.020
IER2	immediate early response 2	0.020
NUCB2	nucleobindin 2	0.020
STX8	syntaxin 8	0.019
COL7A1	collagen, type VII, alpha 1	0.019
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.019
DERL2	Der1-like domain family, member 2	0.019
TTC1	tetratricopeptide repeat domain 1	0.019
RPN2	ribophorin II	0.019
SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)	0.019
TRAP1	TNF receptor-associated protein 1	0.018	Worm
DBP	D site of albumin promoter (albumin D-box) binding protein	0.018
DCBLD1	discoidin, CUB and LCCL domain containing 1	0.018
ZNF654	zinc finger protein 654	0.018
DDIT3	DNA-damage-inducible transcript 3	0.018
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.017
ING4	inhibitor of growth family, member 4	0.017
TUFM	Tu translation elongation factor, mitochondrial	0.017
LDHA	lactate dehydrogenase A	0.016
TRAF6	TNF receptor-associated factor 6	0.016
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.016
HSPA2	heat shock 70kDa protein 2	0.016	Human Fly
PSEN2	presenilin 2 (Alzheimer disease 4)	0.016
PPP5C	protein phosphatase 5, catalytic subunit	0.016
SEC61G	Sec61 gamma subunit	0.016
CYR61	cysteine-rich, angiogenic inducer, 61	0.016
NR1D2	nuclear receptor subfamily 1, group D, member 2	0.016
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.016	Mouse
FOSL2	FOS-like antigen 2	0.015
CTTN	cortactin	0.015
YARS	tyrosyl-tRNA synthetase	0.015
CUL3	cullin 3	0.015
UBL4A	ubiquitin-like 4A	0.015
VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	0.015
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.014
PSAT1	phosphoserine aminotransferase 1	0.014
ITGB5	integrin, beta 5	0.014
NARS	asparaginyl-tRNA synthetase	0.014
STIP1	stress-induced-phosphoprotein 1	0.014
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.014
EIF5	eukaryotic translation initiation factor 5	0.014
CCND1	cyclin D1	0.014	Mouse
ZFYVE1	zinc finger, FYVE domain containing 1	0.014
DBN1	drebrin 1	0.014
PRKCA	protein kinase C, alpha	0.014
PTPN9	protein tyrosine phosphatase, non-receptor type 9	0.014	Human
BHLHE40	basic helix-loop-helix family, member e40	0.014
DYNLT1	dynein, light chain, Tctex-type 1	0.014
EPRS	glutamyl-prolyl-tRNA synthetase	0.014
IFRD1	interferon-related developmental regulator 1	0.013
ZNRF1	zinc and ring finger 1	0.013
FNIP1	folliculin interacting protein 1	0.013
FAF1	Fas (TNFRSF6) associated factor 1	0.013
C5orf41	chromosome 5 open reading frame 41	0.013
GFPT1	glutamine--fructose-6-phosphate transaminase 1	0.013
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.013
HSPBP1	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	0.013	Yeast
PTP4A1	protein tyrosine phosphatase type IVA, member 1	0.013
OSBPL9	oxysterol binding protein-like 9	0.013
JUNB	jun B proto-oncogene	0.013
NFYC	nuclear transcription factor Y, gamma	0.013
MEOX2	mesenchyme homeobox 2	0.013
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.013
GABARAPL1	GABA(A) receptor-associated protein like 1	0.013
PPID	peptidylprolyl isomerase D	0.013
KPNA1	karyopherin alpha 1 (importin alpha 5)	0.013
SART1	squamous cell carcinoma antigen recognized by T cells	0.012
ERN1	endoplasmic reticulum to nucleus signaling 1	0.012
SSR1	signal sequence receptor, alpha	0.012
DNM1	dynamin 1	0.012
FCHSD2	FCH and double SH3 domains 2	0.012
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.012	Mouse
NSF	N-ethylmaleimide-sensitive factor	0.012
CALU	calumenin	0.012
UVRAG	UV radiation resistance associated gene	0.012
CNOT4	CCR4-NOT transcription complex, subunit 4	0.012
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.012
HUWE1	HECT, UBA and WWE domain containing 1	0.012
KNG1	kininogen 1	0.012
SNX16	sorting nexin 16	0.012
HERPUD2	HERPUD family member 2	0.011	Human
IARS	isoleucyl-tRNA synthetase	0.011
PLOD1	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	0.011
ITGA1	integrin, alpha 1	0.011
OSTC	oligosaccharyltransferase complex subunit	0.011
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.011
RNF111	ring finger protein 111	0.011
APP	amyloid beta (A4) precursor protein	0.011
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.011
TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)	0.011
HM13	histocompatibility (minor) 13	0.011
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.011
NGLY1	N-glycanase 1	0.011
ADAM11	ADAM metallopeptidase domain 11	0.011
CRYAB	crystallin, alpha B	0.011
COPG	coatomer protein complex, subunit gamma	0.011
SEC23B	Sec23 homolog B (S. cerevisiae)	0.011
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.011
SENP3	SUMO1/sentrin/SMT3 specific peptidase 3	0.011
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.011
BFAR	bifunctional apoptosis regulator	0.011
GOLGA8A	golgin A8 family, member A	0.010
ARF4	ADP-ribosylation factor 4	0.010
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.010	Human Fly
NFE2L1	nuclear factor (erythroid-derived 2)-like 1	0.010
RB1CC1	RB1-inducible coiled-coil 1	0.010
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.010
OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	0.010
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.010
ZFAND5	zinc finger, AN1-type domain 5	0.010
MAGEA2	melanoma antigen family A, 2	0.010
DUSP5	dual specificity phosphatase 5	0.010