IMP

Process View

Homo sapiens

24 genes annotated in human

cellular response to interferon gamma

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to interferon gamma"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to interferon gamma" (in gray)

Name	Description	Probability	Func Analog Organism
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.983	Human
STAT1	signal transducer and activator of transcription 1, 91kDa	0.966
JAK2	Janus kinase 2	0.896	Rat
RXRA	retinoid X receptor, alpha	0.861
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.849
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.762
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.753
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.730	Human
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.626
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.542
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.537
INSR	insulin receptor	0.460
IRF9	interferon regulatory factor 9	0.442
HCK	hemopoietic cell kinase	0.441	Human
CCR5	chemokine (C-C motif) receptor 5	0.407
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.400
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.398
STAT2	signal transducer and activator of transcription 2, 113kDa	0.379	Human
NCK1	NCK adaptor protein 1	0.370
GHR	growth hormone receptor	0.357
GRB2	growth factor receptor-bound protein 2	0.347
CCL2	chemokine (C-C motif) ligand 2	0.314
CCL5	chemokine (C-C motif) ligand 5	0.312
CXCL9	chemokine (C-X-C motif) ligand 9	0.282
HLA-DMB	major histocompatibility complex, class II, DM beta	0.279
CCL4	chemokine (C-C motif) ligand 4	0.275	Human
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.258
GBP4	guanylate binding protein 4	0.257	Mouse
BIRC3	baculoviral IAP repeat containing 3	0.247
EGFR	epidermal growth factor receptor	0.244
CXCL10	chemokine (C-X-C motif) ligand 10	0.213
NCOR2	nuclear receptor corepressor 2	0.200
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.187
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.171
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.166
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.163
ITK	IL2-inducible T-cell kinase	0.154
HNF4A	hepatocyte nuclear factor 4, alpha	0.146
IFNGR1	interferon gamma receptor 1	0.145
PRMT6	protein arginine methyltransferase 6	0.145
DPP4	dipeptidyl-peptidase 4	0.135
PDCD6	programmed cell death 6	0.133
CCL8	chemokine (C-C motif) ligand 8	0.131	Human
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.129
GBP1	guanylate binding protein 1, interferon-inducible	0.126
IDE	insulin-degrading enzyme	0.124
IL2RB	interleukin 2 receptor, beta	0.113
ICAM1	intercellular adhesion molecule 1	0.107
JAK1	Janus kinase 1	0.106
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.103
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.097
MED28	mediator complex subunit 28	0.090
GBP2	guanylate binding protein 2, interferon-inducible	0.090	Mouse
C3	complement component 3	0.087
RIPK2	receptor-interacting serine-threonine kinase 2	0.085
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.081
STAT5A	signal transducer and activator of transcription 5A	0.080	Human
SOCS3	suppressor of cytokine signaling 3	0.079
CCL13	chemokine (C-C motif) ligand 13	0.078	Human
IRF1	interferon regulatory factor 1	0.078	Mouse
CCR7	chemokine (C-C motif) receptor 7	0.077
IL12RB2	interleukin 12 receptor, beta 2	0.072
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.072	Human
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.068
GAS7	growth arrest-specific 7	0.065
GDF9	growth differentiation factor 9	0.060
IL1B	interleukin 1, beta	0.057
CFHR1	complement factor H-related 1	0.056
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.056
CXCL11	chemokine (C-X-C motif) ligand 11	0.053
SH2B1	SH2B adaptor protein 1	0.053
CXCL2	chemokine (C-X-C motif) ligand 2	0.052
IL8	interleukin 8	0.052
CCL3	chemokine (C-C motif) ligand 3	0.051
SPRR2A	small proline-rich protein 2A	0.050
TRAF3	TNF receptor-associated factor 3	0.048
CCL22	chemokine (C-C motif) ligand 22	0.047	Human
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.046	Human
SLA	Src-like-adaptor	0.045
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.045
CXCL3	chemokine (C-X-C motif) ligand 3	0.045
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.045
STAP2	signal transducing adaptor family member 2	0.044
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.044
IFNG	interferon, gamma	0.043
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.042
GRB7	growth factor receptor-bound protein 7	0.042
FYN	FYN oncogene related to SRC, FGR, YES	0.042	Human
NMI	N-myc (and STAT) interactor	0.042
CCR1	chemokine (C-C motif) receptor 1	0.041
KLHL20	kelch-like 20 (Drosophila)	0.041
CCL19	chemokine (C-C motif) ligand 19	0.040	Human
CXCL13	chemokine (C-X-C motif) ligand 13	0.040
TNF	tumor necrosis factor	0.039
IRS1	insulin receptor substrate 1	0.039
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.038
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.037
IL15	interleukin 15	0.036
BTN3A1	butyrophilin, subfamily 3, member A1	0.036
UBD	ubiquitin D	0.036
WIPF1	WAS/WASL interacting protein family, member 1	0.035
ARRB1	arrestin, beta 1	0.034
CD83	CD83 molecule	0.034
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.033
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.033
MAVS	mitochondrial antiviral signaling protein	0.032
HLA-B	major histocompatibility complex, class I, B	0.032
APOL3	apolipoprotein L, 3	0.032
HLA-F	major histocompatibility complex, class I, F	0.031
PLCG1	phospholipase C, gamma 1	0.030
HLA-E	major histocompatibility complex, class I, E	0.029
FZD1	frizzled homolog 1 (Drosophila)	0.029
IL6	interleukin 6 (interferon, beta 2)	0.029
TAPBP	TAP binding protein (tapasin)	0.029
HCP5	HLA complex P5	0.028
CCR4	chemokine (C-C motif) receptor 4	0.027
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.026
OFCC1	orofacial cleft 1 candidate 1	0.026
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.026
ANG	angiogenin, ribonuclease, RNase A family, 5	0.025
COMMD1	copper metabolism (Murr1) domain containing 1	0.025
HR	hairless homolog (mouse)	0.025
UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1	0.025
TNFAIP8	tumor necrosis factor, alpha-induced protein 8	0.024
FUS	fused in sarcoma	0.024
CDK8	cyclin-dependent kinase 8	0.024
HLA-A	major histocompatibility complex, class I, A	0.024
VCAM1	vascular cell adhesion molecule 1	0.024
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.024
IRF4	interferon regulatory factor 4	0.023
CCL7	chemokine (C-C motif) ligand 7	0.023	Human
ESR2	estrogen receptor 2 (ER beta)	0.023
PRMT1	protein arginine methyltransferase 1	0.023
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.022
PML	promyelocytic leukemia	0.022
SOCS1	suppressor of cytokine signaling 1	0.022	Zebrafish
RBMX	RNA binding motif protein, X-linked	0.022
SOD2	superoxide dismutase 2, mitochondrial	0.022
GRB10	growth factor receptor-bound protein 10	0.021
SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	0.020
ESRRG	estrogen-related receptor gamma	0.020
GBP5	guanylate binding protein 5	0.020	Mouse
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.020
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.020
EHD1	EH-domain containing 1	0.019
SLAMF8	SLAM family member 8	0.019
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.019
CTSS	cathepsin S	0.019
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.019
TOP1	topoisomerase (DNA) I	0.019
NRG1	neuregulin 1	0.019
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.019
CCL11	chemokine (C-C motif) ligand 11	0.018	Human
IL10	interleukin 10	0.018
ELF4	E74-like factor 4 (ets domain transcription factor)	0.018
SASH3	SAM and SH3 domain containing 3	0.018
CD163	CD163 molecule	0.018
CCND3	cyclin D3	0.018
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.018
PGR	progesterone receptor	0.018
JAK3	Janus kinase 3	0.018
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.018
FYB	FYN binding protein	0.017
TGS1	trimethylguanosine synthase 1	0.017
IFI16	interferon, gamma-inducible protein 16	0.017
MPEG1	macrophage expressed 1	0.017
FPR3	formyl peptide receptor 3	0.017
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.017
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.017
IRF8	interferon regulatory factor 8	0.017
SNX33	sorting nexin 33	0.016
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.016
IFIH1	interferon induced with helicase C domain 1	0.016
SELE	selectin E	0.015
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.015
MVP	major vault protein	0.015
CCL17	chemokine (C-C motif) ligand 17	0.015	Human
EBI3	Epstein-Barr virus induced 3	0.015
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.015	Mouse
VSIG4	V-set and immunoglobulin domain containing 4	0.015
C1S	complement component 1, s subcomponent	0.015
BCL2A1	BCL2-related protein A1	0.014
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.014
DARC	Duffy blood group, chemokine receptor	0.014
IARS	isoleucyl-tRNA synthetase	0.014
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.014	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.014
ITGA1	integrin, alpha 1	0.013
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.013
CAPN1	calpain 1, (mu/I) large subunit	0.013
IL7R	interleukin 7 receptor	0.013
HIPK2	homeodomain interacting protein kinase 2	0.013
RUNX1	runt-related transcription factor 1	0.013
CXCL5	chemokine (C-X-C motif) ligand 5	0.013
IL1R2	interleukin 1 receptor, type II	0.013
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.013
RUNX3	runt-related transcription factor 3	0.013
PKM2	pyruvate kinase, muscle	0.013
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.013	Human
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.013
ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	0.013
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.012
CD86	CD86 molecule	0.012
HLA-DQB2	major histocompatibility complex, class II, DQ beta 2	0.012
IDO1	indoleamine 2,3-dioxygenase 1	0.012
PPP5C	protein phosphatase 5, catalytic subunit	0.012
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.012
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.012
PARP9	poly (ADP-ribose) polymerase family, member 9	0.012
RGS1	regulator of G-protein signaling 1	0.012
NBN	nibrin	0.012
B2M	beta-2-microglobulin	0.012
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.012
MTDH	metadherin	0.012
TNS3	tensin 3	0.012
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.011
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.011
VAV1	vav 1 guanine nucleotide exchange factor	0.011
PPARG	peroxisome proliferator-activated receptor gamma	0.011
LRP6	low density lipoprotein receptor-related protein 6	0.011
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.011
KYNU	kynureninase	0.011
CD40	CD40 molecule, TNF receptor superfamily member 5	0.011
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.011
LMO2	LIM domain only 2 (rhombotin-like 1)	0.011
STAT4	signal transducer and activator of transcription 4	0.011	Human
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.011
LITAF	lipopolysaccharide-induced TNF factor	0.011
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.011
IL18BP	interleukin 18 binding protein	0.011
HDAC3	histone deacetylase 3	0.011
EEF1G	eukaryotic translation elongation factor 1 gamma	0.011
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.011
CH25H	cholesterol 25-hydroxylase	0.011
SP1	Sp1 transcription factor	0.011
APOL6	apolipoprotein L, 6	0.011
CXCR5	chemokine (C-X-C motif) receptor 5	0.011
CCL23	chemokine (C-C motif) ligand 23	0.011	Human
MUC1	mucin 1, cell surface associated	0.011
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.011
SRCIN1	SRC kinase signaling inhibitor 1	0.011
IL21R	interleukin 21 receptor	0.011
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.010
APOL1	apolipoprotein L, 1	0.010
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.010
RPL3	ribosomal protein L3	0.010
NCOR1	nuclear receptor corepressor 1	0.010
LARS	leucyl-tRNA synthetase	0.010
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.010	Human
HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	0.010
ZNFX1	zinc finger, NFX1-type containing 1	0.010
APOC1	apolipoprotein C-I	0.010
IRF2	interferon regulatory factor 2	0.010