IMP

Process View

Mus musculus

10 genes annotated in mouse

negative regulation of inflammatory response to antigenic stimulus

Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of inflammatory response to antigenic stimulus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of inflammatory response to antigenic stimulus" (in gray)

Name	Description	Probability	Func Analog Organism
Lyz2	lysozyme 2	1.000
Tnf	tumor necrosis factor	1.000
Tlr4	toll-like receptor 4	1.000
Ifng	interferon gamma	0.999
Rag1	recombination activating gene 1	0.999
Cd44	CD44 antigen	0.998
Foxp3	forkhead box P3	0.998
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.997
Fas	Fas (TNF receptor superfamily member 6)	0.996
Prf1	perforin 1 (pore forming protein)	0.993
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.993
Mmp9	matrix metallopeptidase 9	0.984
Ccr1	chemokine (C-C motif) receptor 1	0.981
Ptprc	protein tyrosine phosphatase, receptor type, C	0.981
Il10	interleukin 10	0.973
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.962
Il6	interleukin 6	0.931
Tcra	T-cell receptor alpha chain	0.926
Myd88	myeloid differentiation primary response gene 88	0.907
Ccr2	chemokine (C-C motif) receptor 2	0.906
Nos2	nitric oxide synthase 2, inducible	0.878
Il4	interleukin 4	0.863
Itgb2	integrin beta 2	0.854
Cd19	CD19 antigen	0.852
Inpp5d	inositol polyphosphate-5-phosphatase D	0.851
Ifngr1	interferon gamma receptor 1	0.801
Nlrp3	NLR family, pyrin domain containing 3	0.794	Mouse
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.776
Il1r1	interleukin 1 receptor, type I	0.732
Apoe	apolipoprotein E	0.710
Il2	interleukin 2	0.709
Ccl2	chemokine (C-C motif) ligand 2	0.706
Il6st	interleukin 6 signal transducer	0.659
Stat3	signal transducer and activator of transcription 3	0.658
Fasl	Fas ligand (TNF superfamily, member 6)	0.647
Tyrobp	TYRO protein tyrosine kinase binding protein	0.642
Casp1	caspase 1	0.628
Mefv	Mediterranean fever	0.570
C1qb	complement component 1, q subcomponent, beta polypeptide	0.500
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.499
Il1b	interleukin 1 beta	0.477
Pycard	PYD and CARD domain containing	0.413
C3ar1	complement component 3a receptor 1	0.368
Unc93b1	unc-93 homolog B1 (C. elegans)	0.368
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.353
Tlr2	toll-like receptor 2	0.347
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.334
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.333
Tgfb1	transforming growth factor, beta 1	0.323
Il2rg	interleukin 2 receptor, gamma chain	0.323
Rag2	recombination activating gene 2	0.306
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.305
Iqcb1	IQ calmodulin-binding motif containing 1	0.269
C1qc	complement component 1, q subcomponent, C chain	0.266
Clec4n	C-type lectin domain family 4, member n	0.238
Cxcr2	chemokine (C-X-C motif) receptor 2	0.232
Foxn1	forkhead box N1	0.227
Gpx1	glutathione peroxidase 1	0.227
Csf1r	colony stimulating factor 1 receptor	0.218
Ikzf1	IKAROS family zinc finger 1	0.217
Col1a1	collagen, type I, alpha 1	0.209
Hmox1	heme oxygenase (decycling) 1	0.208
Psma3	proteasome (prosome, macropain) subunit, alpha type 3	0.192
Spp1	secreted phosphoprotein 1	0.165
Cd28	CD28 antigen	0.156
Ooep	oocyte expressed protein homolog (dog)	0.146
Tnip1	TNFAIP3 interacting protein 1	0.137
Trem3	triggering receptor expressed on myeloid cells 3	0.125
Pilrb1	paired immunoglobin-like type 2 receptor beta 1	0.124
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.116
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.110
Selp	selectin, platelet	0.100
Psma6	proteasome (prosome, macropain) subunit, alpha type 6	0.099
Trp53	transformation related protein 53	0.099
Msr1	macrophage scavenger receptor 1	0.095
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.094
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.091
Il22	interleukin 22	0.089	Mouse
Cd14	CD14 antigen	0.086
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.085
Il10ra	interleukin 10 receptor, alpha	0.085
Il27ra	interleukin 27 receptor, alpha	0.084
Stat6	signal transducer and activator of transcription 6	0.084
Vdr	vitamin D receptor	0.084
Csf1	colony stimulating factor 1 (macrophage)	0.084
Cd68	CD68 antigen	0.082
Ccl9	chemokine (C-C motif) ligand 9	0.079
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.076
Ptgs2	prostaglandin-endoperoxide synthase 2	0.074
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.074
Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	0.068
Lyz1	lysozyme 1	0.068
Aif1	allograft inflammatory factor 1	0.066
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.066
Sfpi1	SFFV proviral integration 1	0.065
Cd40	CD40 antigen	0.065
Mrc1	mannose receptor, C type 1	0.065
Ctss	cathepsin S	0.064
Il23a	interleukin 23, alpha subunit p19	0.063
Irf1	interferon regulatory factor 1	0.063
Gba	glucosidase, beta, acid	0.061
Pdcd1	programmed cell death 1	0.057
AF251705	cDNA sequence AF251705	0.054
Fpr1	formyl peptide receptor 1	0.051
Card11	caspase recruitment domain family, member 11	0.050
C3	complement component 3	0.049
Ly86	lymphocyte antigen 86	0.049
Ikbkg	inhibitor of kappaB kinase gamma	0.049
Lif	leukemia inhibitory factor	0.047
Il1f9	interleukin 1 family, member 9	0.045
Mpeg1	macrophage expressed gene 1	0.044
Ccl6	chemokine (C-C motif) ligand 6	0.042
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.042
2410004A20Rik	RIKEN cDNA 2410004A20 gene	0.042
Stat5a	signal transducer and activator of transcription 5A	0.041
Ticam1	toll-like receptor adaptor molecule 1	0.037
Ccr5	chemokine (C-C motif) receptor 5	0.037
Ccl12	chemokine (C-C motif) ligand 12	0.037
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.036
Cd4	CD4 antigen	0.035
Igh	immunoglobulin heavy chain complex	0.035
Smad3	MAD homolog 3 (Drosophila)	0.034
Hck	hemopoietic cell kinase	0.033
Clec4d	C-type lectin domain family 4, member d	0.033
Kit	kit oncogene	0.033
Gm11428	predicted gene 11428	0.033
Lepr	leptin receptor	0.033
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.031
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.031
Psma7	proteasome (prosome, macropain) subunit, alpha type 7	0.030
Socs1	suppressor of cytokine signaling 1	0.030
Gcet2	germinal center expressed transcript 2	0.028
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.028
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.027
Esr1	estrogen receptor 1 (alpha)	0.027
Plg	plasminogen	0.027
Ifitm6	interferon induced transmembrane protein 6	0.027
Il18	interleukin 18	0.027
Mmp8	matrix metallopeptidase 8	0.027
Psma5	proteasome (prosome, macropain) subunit, alpha type 5	0.026
Ccr7	chemokine (C-C motif) receptor 7	0.026
Pf4	platelet factor 4	0.025
Fcgr4	Fc receptor, IgG, low affinity IV	0.025
Il17a	interleukin 17A	0.024
Flt3	FMS-like tyrosine kinase 3	0.024
Fpr2	formyl peptide receptor 2	0.024
Il4ra	interleukin 4 receptor, alpha	0.022
Cxcl13	chemokine (C-X-C motif) ligand 13	0.022
Gp5	glycoprotein 5 (platelet)	0.022
Runx1	runt related transcription factor 1	0.021
Cd86	CD86 antigen	0.020
Cd180	CD180 antigen	0.020
Slamf1	signaling lymphocytic activation molecule family member 1	0.020
Btk	Bruton agammaglobulinemia tyrosine kinase	0.020
Psmc4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.020
Ccl3	chemokine (C-C motif) ligand 3	0.019
Fcgr3	Fc receptor, IgG, low affinity III	0.019	Mouse
Irg1	immunoresponsive gene 1	0.019
Cd80	CD80 antigen	0.019
Siglece	sialic acid binding Ig-like lectin E	0.019
Folr2	folate receptor 2 (fetal)	0.018
Cybb	cytochrome b-245, beta polypeptide	0.018
Cd247	CD247 antigen	0.018
Slpi	secretory leukocyte peptidase inhibitor	0.018
Nos1	nitric oxide synthase 1, neuronal	0.017
Gdf3	growth differentiation factor 3	0.017
Lyst	lysosomal trafficking regulator	0.017
Traf3ip2	TRAF3 interacting protein 2	0.017
Tlr9	toll-like receptor 9	0.017
Adam17	a disintegrin and metallopeptidase domain 17	0.017
Tbx21	T-box 21	0.016
Clec7a	C-type lectin domain family 7, member a	0.016
Stat5b	signal transducer and activator of transcription 5B	0.016
Cr2	complement receptor 2	0.015
Itgam	integrin alpha M	0.015
Pcsk1	proprotein convertase subtilisin/kexin type 1	0.015
Pla2g2a	phospholipase A2, group IIA (platelets, synovial fluid)	0.015
Clec4a3	C-type lectin domain family 4, member a3	0.015
Olfr65	olfactory receptor 65	0.014
Dub1	deubiquitinating enzyme 1	0.014
Fcna	ficolin A	0.014
Mcpt8	mast cell protease 8	0.014
Ccl8	chemokine (C-C motif) ligand 8	0.014
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.014
Il12a	interleukin 12a	0.014
Tcrd	T-cell receptor delta chain	0.014
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.014
Il13ra2	interleukin 13 receptor, alpha 2	0.013
Gp1ba	glycoprotein 1b, alpha polypeptide	0.013
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.013
Clec4a2	C-type lectin domain family 4, member a2	0.013
Cd5l	CD5 antigen-like	0.013
Rc3h1	RING CCCH (C3H) domains 1	0.013
Fcgr1	Fc receptor, IgG, high affinity I	0.013	Mouse
Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	0.013
Lat	linker for activation of T cells	0.013
Cd33	CD33 antigen	0.013
Alox5ap	arachidonate 5-lipoxygenase activating protein	0.013
Ccl4	chemokine (C-C motif) ligand 4	0.012
Folr4	folate receptor 4 (delta)	0.012
Psmb1	proteasome (prosome, macropain) subunit, beta type 1	0.012
Oosp1	oocyte secreted protein 1	0.012
Tcrb	T-cell receptor beta chain	0.012
Vcam1	vascular cell adhesion molecule 1	0.012
Ccr6	chemokine (C-C motif) receptor 6	0.012
Il1a	interleukin 1 alpha	0.012
Cdca3	cell division cycle associated 3	0.012
Ccr3	chemokine (C-C motif) receptor 3	0.012
Plek	pleckstrin	0.012
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2	0.011
Lrp2	low density lipoprotein receptor-related protein 2	0.011
Il13	interleukin 13	0.011
Birc3	baculoviral IAP repeat-containing 3	0.011
Expi	extracellular proteinase inhibitor	0.011
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.011
Treml1	triggering receptor expressed on myeloid cells-like 1	0.011
Ms4a3	membrane-spanning 4-domains, subfamily A, member 3	0.011
Vpreb3	pre-B lymphocyte gene 3	0.011
Ms4a6b	membrane-spanning 4-domains, subfamily A, member 6B	0.011
Tlr8	toll-like receptor 8	0.010
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.010
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.010
F13a1	coagulation factor XIII, A1 subunit	0.010
Eps8l3	EPS8-like 3	0.010
Icam1	intercellular adhesion molecule 1	0.010
Dok2	docking protein 2	0.010
Aifm1	apoptosis-inducing factor, mitochondrion-associated 1	0.010
Gzmk	granzyme K	0.010
Il18rap	interleukin 18 receptor accessory protein	0.010