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Mus musculus

4 genes annotated in mouse

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lymphocyte anergy

GO:0002249

Any process contributing to lymphocyte anergy, a state of functional inactivation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lymphocyte anergy"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lymphocyte anergy" (in gray)

Name	Description	Probability	Func Analog Organism
Stat3	signal transducer and activator of transcription 3	0.613
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.611
Rac1	RAS-related C3 botulinum substrate 1	0.474
Cd19	CD19 antigen	0.471
Lat	linker for activation of T cells	0.363
Myd88	myeloid differentiation primary response gene 88	0.321
Trp53	transformation related protein 53	0.312
Cd3d	CD3 antigen, delta polypeptide	0.301	Mouse
Itk	IL2-inducible T-cell kinase	0.280
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.274
Lck	lymphocyte protein tyrosine kinase	0.271
Cd28	CD28 antigen	0.266
Cyld	cylindromatosis (turban tumor syndrome)	0.257
Traf6	TNF receptor-associated factor 6	0.243
Sh2d1a	SH2 domain protein 1A	0.200
Rnf11	ring finger protein 11	0.194
Zap70	zeta-chain (TCR) associated protein kinase	0.188
Ikzf1	IKAROS family zinc finger 1	0.182
Cd3g	CD3 antigen, gamma polypeptide	0.182	Mouse
Cd6	CD6 antigen	0.168
Card11	caspase recruitment domain family, member 11	0.160
Inpp5d	inositol polyphosphate-5-phosphatase D	0.151
Cd8b1	CD8 antigen, beta chain 1	0.131
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.128
Tcra	T-cell receptor alpha chain	0.124
Grb2	growth factor receptor bound protein 2	0.123
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.115
Cd8a	CD8 antigen, alpha chain	0.115
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.108
Ttc7	tetratricopeptide repeat domain 7	0.101
Cd5	CD5 antigen	0.097
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.093
Cd27	CD27 antigen	0.090
Smad7	MAD homolog 7 (Drosophila)	0.084
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.084
Grb10	growth factor receptor bound protein 10	0.084
Smad6	MAD homolog 6 (Drosophila)	0.079
Cd2	CD2 antigen	0.079
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.076
Il27ra	interleukin 27 receptor, alpha	0.075
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.072
Tmem64	transmembrane protein 64	0.069
Tbl1x	transducin (beta)-like 1 X-linked	0.066
Nkd2	naked cuticle 2 homolog (Drosophila)	0.063
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.062
Cd247	CD247 antigen	0.061
Nkg7	natural killer cell group 7 sequence	0.061
Shc1	src homology 2 domain-containing transforming protein C1	0.060
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.058
Gimap7	GTPase, IMAP family member 7	0.057
Icos	inducible T-cell co-stimulator	0.056
Ticam1	toll-like receptor adaptor molecule 1	0.055
Smad1	MAD homolog 1 (Drosophila)	0.054
Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein	0.050
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.048
Pcmtd1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	0.046
Cd96	CD96 antigen	0.046
Gli2	GLI-Kruppel family member GLI2	0.045
Prkcq	protein kinase C, theta	0.044
Ctsw	cathepsin W	0.044
Cbl	Casitas B-lineage lymphoma	0.043	Mouse
Gimap3	GTPase, IMAP family member 3	0.043
Cxcr6	chemokine (C-X-C motif) receptor 6	0.041
Smad4	MAD homolog 4 (Drosophila)	0.041
Stat5a	signal transducer and activator of transcription 5A	0.040
Sh2b2	SH2B adaptor protein 2	0.039
Rhoh	ras homolog gene family, member H	0.037
Cflar	CASP8 and FADD-like apoptosis regulator	0.037
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.036
Il2rb	interleukin 2 receptor, beta chain	0.036
Sept1	septin 1	0.035
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.034
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.033
Ikzf3	IKAROS family zinc finger 3	0.032
Cxcr3	chemokine (C-X-C motif) receptor 3	0.032
Fas	Fas (TNF receptor superfamily member 6)	0.032
Trp53bp1	transformation related protein 53 binding protein 1	0.031
Prdx6	peroxiredoxin 6	0.031
Il6st	interleukin 6 signal transducer	0.030
Vav1	vav 1 oncogene	0.029
Phf2	PHD finger protein 2	0.029
Ikbkg	inhibitor of kappaB kinase gamma	0.029
Gtf2i	general transcription factor II I	0.028
Ubc	ubiquitin C	0.028
Smad5	MAD homolog 5 (Drosophila)	0.028
Kit	kit oncogene	0.027
Ralbp1	ralA binding protein 1	0.027
Pmepa1	prostate transmembrane protein, androgen induced 1	0.027
Cd7	CD7 antigen	0.027
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.026
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.026
Slamf6	SLAM family member 6	0.026
Notch1	Notch gene homolog 1 (Drosophila)	0.026
Sit1	suppression inducing transmembrane adaptor 1	0.025
Atp11c	ATPase, class VI, type 11C	0.025
BC021614	cDNA sequence BC021614	0.025
Cd3e	CD3 antigen, epsilon polypeptide	0.025
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.025
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.024
Tspan32	tetraspanin 32	0.024
Skap1	src family associated phosphoprotein 1	0.024
Stat5b	signal transducer and activator of transcription 5B	0.024
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.024
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.023	Mouse
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.023
Ahr	aryl-hydrocarbon receptor	0.023
Rag1	recombination activating gene 1	0.023
Stat4	signal transducer and activator of transcription 4	0.022
Bach2	BTB and CNC homology 2	0.022
Cldn3	claudin 3	0.022
Stim1	stromal interaction molecule 1	0.022
Sp1	trans-acting transcription factor 1	0.022
Ly6d	lymphocyte antigen 6 complex, locus D	0.022
Wbp1	WW domain binding protein 1	0.021
Prrg2	proline-rich Gla (G-carboxyglutamic acid) polypeptide 2	0.021
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.021	Mouse
Zcchc14	zinc finger, CCHC domain containing 14	0.021
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.021
Fmnl1	formin-like 1	0.021
Git2	G protein-coupled receptor kinase-interactor 2	0.020
Pglyrp2	peptidoglycan recognition protein 2	0.020
Gzma	granzyme A	0.020
Arid1b	AT rich interactive domain 1B (SWI-like)	0.020
Pum1	pumilio 1 (Drosophila)	0.020
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.020
Ccr7	chemokine (C-C motif) receptor 7	0.020
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.019	Mouse
Pak1	p21 protein (Cdc42/Rac)-activated kinase 1	0.019
Skil	SKI-like	0.019
Rictor	RPTOR independent companion of MTOR, complex 2	0.018
Itgb7	integrin beta 7	0.018
Sh2d2a	SH2 domain protein 2A	0.018
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.018
Gab1	growth factor receptor bound protein 2-associated protein 1	0.018
Txk	TXK tyrosine kinase	0.018
Sorbs1	sorbin and SH3 domain containing 1	0.018
Kitl	kit ligand	0.018
Fam160b1	family with sequence similarity 160, member B1	0.017
Sos1	son of sevenless homolog 1 (Drosophila)	0.017
Smc1a	structural maintenance of chromosomes 1A	0.017
Dgcr2	DiGeorge syndrome critical region gene 2	0.017
Add1	adducin 1 (alpha)	0.017
Cd4	CD4 antigen	0.017
Snx20	sorting nexin 20	0.017
Hmbox1	homeobox containing 1	0.016
Pkp3	plakophilin 3	0.016
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.016
Igf1r	insulin-like growth factor I receptor	0.016
Tbc1d10c	TBC1 domain family, member 10c	0.016
Hdlbp	high density lipoprotein (HDL) binding protein	0.016
Chd4	chromodomain helicase DNA binding protein 4	0.016
Eif4ebp2	eukaryotic translation initiation factor 4E binding protein 2	0.015
Pla2g2d	phospholipase A2, group IID	0.015
Ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.015
Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.015
Cblb	Casitas B-lineage lymphoma b	0.015
Hook3	hook homolog 3 (Drosophila)	0.015
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.015
C230081A13Rik	RIKEN cDNA C230081A13 gene	0.015
Il2	interleukin 2	0.015
Ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.015
Arrdc1	arrestin domain containing 1	0.015
Jak3	Janus kinase 3	0.015
Sla2	Src-like-adaptor 2	0.015
Il2rg	interleukin 2 receptor, gamma chain	0.015
Folr4	folate receptor 4 (delta)	0.015
Gcn1l1	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	0.015
Fam168a	family with sequence similarity 168, member A	0.015
Scnn1a	sodium channel, nonvoltage-gated 1 alpha	0.015
Flt1	FMS-like tyrosine kinase 1	0.014
Atxn2l	ataxin 2-like	0.014
Tbc1d4	TBC1 domain family, member 4	0.014
Ebf1	early B-cell factor 1	0.014
Huwe1	HECT, UBA and WWE domain containing 1	0.014
Sipa1l1	signal-induced proliferation-associated 1 like 1	0.014
Zfp362	zinc finger protein 362	0.014
Faah	fatty acid amide hydrolase	0.014
4921513D23Rik	RIKEN cDNA 4921513D23 gene	0.014
Pknox1	Pbx/knotted 1 homeobox	0.014
Pard6a	par-6 (partitioning defective 6,) homolog alpha (C. elegans)	0.014
Cdk6	cyclin-dependent kinase 6	0.014
Lad1	ladinin	0.013
Traf3ip3	TRAF3 interacting protein 3	0.013
Lax1	lymphocyte transmembrane adaptor 1	0.013
Tbx21	T-box 21	0.013
Tmem79	transmembrane protein 79	0.013
Slc44a3	solute carrier family 44, member 3	0.013
Stat6	signal transducer and activator of transcription 6	0.013
Bcl11b	B-cell leukemia/lymphoma 11B	0.013
Muc20	mucin 20	0.013
Tmc4	transmembrane channel-like gene family 4	0.013
Eps8l2	EPS8-like 2	0.013
Fign	fidgetin	0.013
Pstpip2	proline-serine-threonine phosphatase-interacting protein 2	0.013
Lcor	ligand dependent nuclear receptor corepressor	0.013
Hhex	hematopoietically expressed homeobox	0.013
Farp1	FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)	0.013
St14	suppression of tumorigenicity 14 (colon carcinoma)	0.013
Btbd7	BTB (POZ) domain containing 7	0.012
Meox2	mesenchyme homeobox 2	0.012
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.012
Eif4b	eukaryotic translation initiation factor 4B	0.012
Zfc3h1	zinc finger, C3H1-type containing	0.012
Pkn2	protein kinase N2	0.012
Acly	ATP citrate lyase	0.012
Erbb2ip	Erbb2 interacting protein	0.012
Scnn1g	sodium channel, nonvoltage-gated 1 gamma	0.012
Blk	B lymphoid kinase	0.012
L3mbtl3	l(3)mbt-like 3 (Drosophila)	0.012
Secisbp2l	SECIS binding protein 2-like	0.012
Tbc1d22b	TBC1 domain family, member 22B	0.012
H2-Ob	histocompatibility 2, O region beta locus	0.012
Zcchc11	zinc finger, CCHC domain containing 11	0.012
Bcr	breakpoint cluster region	0.012
Aplp2	amyloid beta (A4) precursor-like protein 2	0.012
Baz2a	bromodomain adjacent to zinc finger domain, 2A	0.012
Snx13	sorting nexin 13	0.012
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.012
Cald1	caldesmon 1	0.011
C1galt1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	0.011
Ccr6	chemokine (C-C motif) receptor 6	0.011
Cxcr5	chemokine (C-X-C motif) receptor 5	0.011
Kif1b	kinesin family member 1B	0.011
Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase	0.011
Krt8	keratin 8	0.011
Csnk1d	casein kinase 1, delta	0.011
Prkce	protein kinase C, epsilon	0.011
Tcf7	transcription factor 7, T-cell specific	0.011
Irf2bp2	interferon regulatory factor 2 binding protein 2	0.011
Trat1	T cell receptor associated transmembrane adaptor 1	0.011
Itgae	integrin alpha E, epithelial-associated	0.011
Chd9	chromodomain helicase DNA binding protein 9	0.011
Ptprk	protein tyrosine phosphatase, receptor type, K	0.011
Cdc42bpb	CDC42 binding protein kinase beta	0.011
Gatad2b	GATA zinc finger domain containing 2B	0.011
Prnp	prion protein	0.011
Tlr4	toll-like receptor 4	0.011
Med15	mediator complex subunit 15	0.011
Phf21a	PHD finger protein 21A	0.011
Tgfbr1	transforming growth factor, beta receptor I	0.011
Trp53bp2	transformation related protein 53 binding protein 2	0.011
Ap1m2	adaptor protein complex AP-1, mu 2 subunit	0.011
Zfp945	zinc finger protein 945	0.011
Gpc4	glypican 4	0.011
Ptprg	protein tyrosine phosphatase, receptor type, G	0.011
5830427D02Rik	RIKEN cDNA 5830427D02 gene	0.011
Robo2	roundabout homolog 2 (Drosophila)	0.011
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.010
Ssh2	slingshot homolog 2 (Drosophila)	0.010
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.010
Hnrnpul1	heterogeneous nuclear ribonucleoprotein U-like 1	0.010
Arhgef16	Rho guanine nucleotide exchange factor (GEF) 16	0.010
Pdcd6ip	programmed cell death 6 interacting protein	0.010
Usp22	ubiquitin specific peptidase 22	0.010
Dlg3	discs, large homolog 3 (Drosophila)	0.010
S1pr4	sphingosine-1-phosphate receptor 4	0.010
Dclk1	doublecortin-like kinase 1	0.010
Ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	0.010
Fermt2	fermitin family homolog 2 (Drosophila)	0.010