IMP

Process View

Mus musculus

10 genes annotated in mouse

regulation of tumor necrosis factor biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of tumor necrosis factor biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of tumor necrosis factor biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.999
Cd19	CD19 antigen	0.983
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.975
Lyz2	lysozyme 2	0.946
Igh	immunoglobulin heavy chain complex	0.924
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.908
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.885
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.859
Tnf	tumor necrosis factor	0.811
Ccr1	chemokine (C-C motif) receptor 1	0.810	Mouse
Btk	Bruton agammaglobulinemia tyrosine kinase	0.737
Ccr2	chemokine (C-C motif) receptor 2	0.722
Ikzf1	IKAROS family zinc finger 1	0.716
Ifng	interferon gamma	0.710
Ccl2	chemokine (C-C motif) ligand 2	0.676
Cd40	CD40 antigen	0.674
Myd88	myeloid differentiation primary response gene 88	0.668
Fas	Fas (TNF receptor superfamily member 6)	0.665
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.660
Cd44	CD44 antigen	0.532
Tlr4	toll-like receptor 4	0.476	Human Mouse
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.473
Sfpi1	SFFV proviral integration 1	0.462
Il10	interleukin 10	0.440
Clec4n	C-type lectin domain family 4, member n	0.397	Mouse
Cd180	CD180 antigen	0.390	Mouse
Ccr6	chemokine (C-C motif) receptor 6	0.372	Mouse
Tlr2	toll-like receptor 2	0.348
Clec4d	C-type lectin domain family 4, member d	0.289	Mouse
Ptprc	protein tyrosine phosphatase, receptor type, C	0.269
Mmp9	matrix metallopeptidase 9	0.255
Blk	B lymphoid kinase	0.237
Foxp3	forkhead box P3	0.228
Cd22	CD22 antigen	0.216
Fasl	Fas ligand (TNF superfamily, member 6)	0.211
Xcr1	chemokine (C motif) receptor 1	0.188	Mouse
Stat3	signal transducer and activator of transcription 3	0.151
Cd14	CD14 antigen	0.144
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.141
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.140
Ccl3	chemokine (C-C motif) ligand 3	0.139
Clec4e	C-type lectin domain family 4, member e	0.137	Mouse
Tnip1	TNFAIP3 interacting protein 1	0.135
C3ar1	complement component 3a receptor 1	0.127
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.118
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.118
Tgfb1	transforming growth factor, beta 1	0.104
Csf1	colony stimulating factor 1 (macrophage)	0.097
Cd209b	CD209b antigen	0.096
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.095
Inpp5d	inositol polyphosphate-5-phosphatase D	0.095
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.093
Lta	lymphotoxin A	0.093
Il4	interleukin 4	0.087
Icos	inducible T-cell co-stimulator	0.084
Cd96	CD96 antigen	0.084
Pou2af1	POU domain, class 2, associating factor 1	0.083
Cd7	CD7 antigen	0.082
Ccr5	chemokine (C-C motif) receptor 5	0.080	Mouse
Folr2	folate receptor 2 (fetal)	0.080
Cxcr2	chemokine (C-X-C motif) receptor 2	0.079	Mouse
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.074
Irf4	interferon regulatory factor 4	0.072
Nos2	nitric oxide synthase 2, inducible	0.071
Tcra	T-cell receptor alpha chain	0.069
H2-Ob	histocompatibility 2, O region beta locus	0.069
Vpreb3	pre-B lymphocyte gene 3	0.067
Il1b	interleukin 1 beta	0.064
Runx1	runt related transcription factor 1	0.064
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.062
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.060
Ciita	class II transactivator	0.059
Tlr5	toll-like receptor 5	0.058	Mouse
Itgam	integrin alpha M	0.057
Itgal	integrin alpha L	0.057
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.056	Mouse
Sykb	spleen tyrosine kinase	0.055
Cr2	complement receptor 2	0.053
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.052
Ccr3	chemokine (C-C motif) receptor 3	0.052	Mouse
Tlr7	toll-like receptor 7	0.051
Cd300ld	CD300 molecule-like family member d	0.050
Cxcr5	chemokine (C-X-C motif) receptor 5	0.049	Mouse
Fgd3	FYVE, RhoGEF and PH domain containing 3	0.049
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.049
Msr1	macrophage scavenger receptor 1	0.047
Prkcd	protein kinase C, delta	0.047
Ccr7	chemokine (C-C motif) receptor 7	0.047	Mouse
AF251705	cDNA sequence AF251705	0.045
Cryab	crystallin, alpha B	0.045	Mouse
Fcrla	Fc receptor-like A	0.045	Mouse
Lair1	leukocyte-associated Ig-like receptor 1	0.045
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.045
Ifngr1	interferon gamma receptor 1	0.043
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.042	Mouse
Spp1	secreted phosphoprotein 1	0.041
Sit1	suppression inducing transmembrane adaptor 1	0.039
Ncr1	natural cytotoxicity triggering receptor 1	0.039
Bcl6	B-cell leukemia/lymphoma 6	0.038
Cd33	CD33 antigen	0.038
Igk	immunoglobulin kappa chain complex	0.037
Ikzf3	IKAROS family zinc finger 3	0.037
Itgax	integrin alpha X	0.037
Selp	selectin, platelet	0.035
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.034
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.034
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.034
Cybb	cytochrome b-245, beta polypeptide	0.034
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.034
Prg3	proteoglycan 3	0.034
Jak3	Janus kinase 3	0.033
Apoe	apolipoprotein E	0.032
Cx3cr1	chemokine (C-X3-C) receptor 1	0.032	Mouse
Cyld	cylindromatosis (turban tumor syndrome)	0.032
Cmklr1	chemokine-like receptor 1	0.031
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.031
Ear2	eosinophil-associated, ribonuclease A family, member 2	0.031
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.030
Gpr132	G protein-coupled receptor 132	0.029
Prdm1	PR domain containing 1, with ZNF domain	0.029
Ccl24	chemokine (C-C motif) ligand 24	0.028
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.027
Il12a	interleukin 12a	0.027
Il10ra	interleukin 10 receptor, alpha	0.026
Il2rg	interleukin 2 receptor, gamma chain	0.026
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.025
Grap2	GRB2-related adaptor protein 2	0.025
Cd79b	CD79B antigen	0.025
Art2a-ps	ADP-ribosyltransferase 2a, pseudogene	0.025
Flt3	FMS-like tyrosine kinase 3	0.024
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.024
S1pr4	sphingosine-1-phosphate receptor 4	0.024
Birc3	baculoviral IAP repeat-containing 3	0.024
Cxcr3	chemokine (C-X-C motif) receptor 3	0.024	Mouse
Tlr8	toll-like receptor 8	0.023	Mouse
Siglecg	sialic acid binding Ig-like lectin G	0.023
Plcg2	phospholipase C, gamma 2	0.022
Ms4a7	membrane-spanning 4-domains, subfamily A, member 7	0.022
Slamf6	SLAM family member 6	0.022
Mgl2	macrophage galactose N-acetyl-galactosamine specific lectin 2	0.022
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.021
Cd209a	CD209a antigen	0.021	Mouse
Trp53	transformation related protein 53	0.021
Pla2g2d	phospholipase A2, group IID	0.021
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.020
Ptgs2	prostaglandin-endoperoxide synthase 2	0.020
Smad3	MAD homolog 3 (Drosophila)	0.020
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.020
Cxcl13	chemokine (C-X-C motif) ligand 13	0.020
Cd209g	CD209g antigen	0.020
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.019
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.019
Icam1	intercellular adhesion molecule 1	0.019
Slamf1	signaling lymphocytic activation molecule family member 1	0.018
Lepr	leptin receptor	0.018
Il1r1	interleukin 1 receptor, type I	0.018
Mmp8	matrix metallopeptidase 8	0.018
Tbxas1	thromboxane A synthase 1, platelet	0.018
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.018
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.018
Bag3	BCL2-associated athanogene 3	0.017
Il6	interleukin 6	0.017
Clec5a	C-type lectin domain family 5, member a	0.017
Il12rb2	interleukin 12 receptor, beta 2	0.017
Ptgir	prostaglandin I receptor (IP)	0.017
Pax5	paired box gene 5	0.017
Cd207	CD207 antigen	0.017	Mouse
Il4ra	interleukin 4 receptor, alpha	0.016
Pdcd1	programmed cell death 1	0.016
Inhbe	inhibin beta E	0.016
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.016
Cd209e	CD209e antigen	0.015
Ticam1	toll-like receptor adaptor molecule 1	0.015
Card9	caspase recruitment domain family, member 9	0.015
Cd4	CD4 antigen	0.015
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.015
Gpr182	G protein-coupled receptor 182	0.015
Cd8a	CD8 antigen, alpha chain	0.015
Nckap1l	NCK associated protein 1 like	0.015
Traf3ip2	TRAF3 interacting protein 2	0.015
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.014
Clec7a	C-type lectin domain family 7, member a	0.014
Myo1f	myosin IF	0.014
Cysltr1	cysteinyl leukotriene receptor 1	0.014
Cd86	CD86 antigen	0.014
Il27ra	interleukin 27 receptor, alpha	0.014
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.014
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.014
Serpinb7	serine (or cysteine) peptidase inhibitor, clade B, member 7	0.014
Pilra	paired immunoglobin-like type 2 receptor alpha	0.014
Ccr8	chemokine (C-C motif) receptor 8	0.014	Mouse
Ticam2	toll-like receptor adaptor molecule 2	0.013
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.013
Tnfaip2	tumor necrosis factor, alpha-induced protein 2	0.013
Junb	Jun-B oncogene	0.013
Clec4b1	C-type lectin domain family 4, member b1	0.013	Mouse
Clec4a2	C-type lectin domain family 4, member a2	0.013	Mouse
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.013
Opn4	opsin 4 (melanopsin)	0.013
Sell	selectin, lymphocyte	0.013
C5ar1	complement component 5a receptor 1	0.012
Ccl4	chemokine (C-C motif) ligand 4	0.012
Batf	basic leucine zipper transcription factor, ATF-like	0.012
Chst3	carbohydrate (chondroitin 6/keratan) sulfotransferase 3	0.012
Fpr2	formyl peptide receptor 2	0.012
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.012
Il9r	interleukin 9 receptor	0.012
Efna1	ephrin A1	0.012
Cd40lg	CD40 ligand	0.012
Ccl6	chemokine (C-C motif) ligand 6	0.012
Ltb	lymphotoxin B	0.012
H2-Eb2	histocompatibility 2, class II antigen E beta2	0.012
Vim	vimentin	0.012
Gadd45b	growth arrest and DNA-damage-inducible 45 beta	0.011
Plau	plasminogen activator, urokinase	0.011
Hspb1	heat shock protein 1	0.011
Prf1	perforin 1 (pore forming protein)	0.011
Pparg	peroxisome proliferator activated receptor gamma	0.011
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.011
Tgm2	transglutaminase 2, C polypeptide	0.011
Pou2f2	POU domain, class 2, transcription factor 2	0.011
Lat2	linker for activation of T cells family, member 2	0.011
Gcet2	germinal center expressed transcript 2	0.011
Gimap7	GTPase, IMAP family member 7	0.011
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.011
Fcrl1	Fc receptor-like 1	0.010
Pdcd1lg2	programmed cell death 1 ligand 2	0.010
Cd84	CD84 antigen	0.010
Fpr3	formyl peptide receptor 3	0.010
Clec4g	C-type lectin domain family 4, member g	0.010	Mouse
Tspan10	tetraspanin 10	0.010
Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase	0.010