IMP

Process View

Mus musculus

14 genes annotated in mouse

endodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endodermal cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endodermal cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	0.999	Fly
Ctnnb1	catenin (cadherin associated protein), beta 1	0.987
Sox2	SRY-box containing gene 2	0.961	Human Mouse
Gli3	GLI-Kruppel family member GLI3	0.952
Bmp4	bone morphogenetic protein 4	0.945	Zebrafish
Otx2	orthodenticle homolog 2 (Drosophila)	0.944
Pitx2	paired-like homeodomain transcription factor 2	0.940
Vangl2	vang-like 2 (van gogh, Drosophila)	0.937
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.924
Fgfr1	fibroblast growth factor receptor 1	0.875	Zebrafish Fly
Shh	sonic hedgehog	0.865
Chd7	chromodomain helicase DNA binding protein 7	0.855
Prrx1	paired related homeobox 1	0.830
Hand1	heart and neural crest derivatives expressed transcript 1	0.822
Pax3	paired box gene 3	0.774
Fgfr3	fibroblast growth factor receptor 3	0.736	Fly
Nodal	nodal	0.728
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.556
Pax2	paired box gene 2	0.518
Alx4	aristaless-like homeobox 4	0.500
Foxg1	forkhead box G1	0.476
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.454
Tbx3	T-box 3	0.453	Mouse
Jag1	jagged 1	0.424
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.409
Foxc1	forkhead box C1	0.397
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.392
Hes1	hairy and enhancer of split 1 (Drosophila)	0.387
Nog	noggin	0.366	Zebrafish
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.348	Human
Isl1	ISL1 transcription factor, LIM/homeodomain	0.307
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.306	Worm
Tcfap2a	transcription factor AP-2, alpha	0.305
Snai1	snail homolog 1 (Drosophila)	0.300
Fgf8	fibroblast growth factor 8	0.300	Zebrafish
Thbs1	thrombospondin 1	0.299
Apc	adenomatosis polyposis coli	0.280	Worm
Pitx1	paired-like homeodomain transcription factor 1	0.279
Lrp6	low density lipoprotein receptor-related protein 6	0.274
Hand2	heart and neural crest derivatives expressed transcript 2	0.250
Eya1	eyes absent 1 homolog (Drosophila)	0.249
Sox11	SRY-box containing gene 11	0.235	Mouse
Smad1	MAD homolog 1 (Drosophila)	0.218	Fly
Gata4	GATA binding protein 4	0.211	Mouse
Hoxa1	homeobox A1	0.211
Col4a1	collagen, type IV, alpha 1	0.208
Gbx2	gastrulation brain homeobox 2	0.191
Dlx5	distal-less homeobox 5	0.184
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.172
Foxc2	forkhead box C2	0.171
Efnb2	ephrin B2	0.153
Sall4	sal-like 4 (Drosophila)	0.149
Tgfb2	transforming growth factor, beta 2	0.137
Wnt3a	wingless-related MMTV integration site 3A	0.122
Hoxa13	homeobox A13	0.122
Eng	endoglin	0.121
Col2a1	collagen, type II, alpha 1	0.115
Meox2	mesenchyme homeobox 2	0.115
En1	engrailed 1	0.114
Pou5f1	POU domain, class 5, transcription factor 1	0.103
Lef1	lymphoid enhancer binding factor 1	0.102
Vangl1	vang-like 1 (van gogh, Drosophila)	0.101
Col11a1	collagen, type XI, alpha 1	0.100	Human
Pou3f3	POU domain, class 3, transcription factor 3	0.099	Mouse
Smad4	MAD homolog 4 (Drosophila)	0.097
Smad6	MAD homolog 6 (Drosophila)	0.094
Col6a2	collagen, type VI, alpha 2	0.093
Smo	smoothened homolog (Drosophila)	0.092
Gata6	GATA binding protein 6	0.090
Ret	ret proto-oncogene	0.088
Bdnf	brain derived neurotrophic factor	0.087
Dll1	delta-like 1 (Drosophila)	0.086
Tbx1	T-box 1	0.085	Mouse
Acvr1	activin A receptor, type 1	0.085
Col5a1	collagen, type V, alpha 1	0.084	Human
Chrd	chordin	0.082
Hoxd13	homeobox D13	0.082
Runx2	runt related transcription factor 2	0.079
Lhx3	LIM homeobox protein 3	0.079
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.079	Worm
Col4a2	collagen, type IV, alpha 2	0.078	Human
Zic3	zinc finger protein of the cerebellum 3	0.077
Foxf1a	forkhead box F1a	0.075
Msx1	homeobox, msh-like 1	0.073
Foxn1	forkhead box N1	0.071
Fgf10	fibroblast growth factor 10	0.071
Tbx2	T-box 2	0.069	Mouse
Col1a1	collagen, type I, alpha 1	0.069
Msx2	homeobox, msh-like 2	0.067
Rnf2	ring finger protein 2	0.065
Foxh1	forkhead box H1	0.063
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.063
Uncx	UNC homeobox	0.063
Hmx3	H6 homeobox 3	0.062
Zeb1	zinc finger E-box binding homeobox 1	0.061
Col3a1	collagen, type III, alpha 1	0.061
Fgf3	fibroblast growth factor 3	0.061
Gli2	GLI-Kruppel family member GLI2	0.060
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.059
Alx3	aristaless-like homeobox 3	0.057
Bmp1	bone morphogenetic protein 1	0.056
Lhx1	LIM homeobox protein 1	0.056
Rarg	retinoic acid receptor, gamma	0.056
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.052	Worm
Sall3	sal-like 3 (Drosophila)	0.052
Wnt6	wingless-related MMTV integration site 6	0.052
Was	Wiskott-Aldrich syndrome homolog (human)	0.050
Lmx1a	LIM homeobox transcription factor 1 alpha	0.050
Emid2	EMI domain containing 2	0.050
Psen1	presenilin 1	0.045
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.044	Worm
Ptch1	patched homolog 1	0.044
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.044
Notch3	Notch gene homolog 3 (Drosophila)	0.043
She	src homology 2 domain-containing transforming protein E	0.043
Sox9	SRY-box containing gene 9	0.042	Mouse
Pax8	paired box gene 8	0.042
Tnc	tenascin C	0.042
Mmp2	matrix metallopeptidase 2	0.042	Human
Plac1	placental specific protein 1	0.041
Tlx3	T-cell leukemia, homeobox 3	0.041
Fbn1	fibrillin 1	0.041
Ptk2	PTK2 protein tyrosine kinase 2	0.039
Tal1	T-cell acute lymphocytic leukemia 1	0.039
Prrx2	paired related homeobox 2	0.039
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.039
En2	engrailed 2	0.038
Ptk7	PTK7 protein tyrosine kinase 7	0.038
Col1a2	collagen, type I, alpha 2	0.038
Efs	embryonal Fyn-associated substrate	0.037
Pax1	paired box gene 1	0.037
Bmp5	bone morphogenetic protein 5	0.036
Efna2	ephrin A2	0.036
Wnt1	wingless-related MMTV integration site 1	0.035
Rag2	recombination activating gene 2	0.035
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.034
Foxb1	forkhead box B1	0.034
Lox	lysyl oxidase	0.034
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.034
Hoxa11	homeobox A11	0.034
Capn6	calpain 6	0.033
Tcfap2c	transcription factor AP-2, gamma	0.033
Alx1	ALX homeobox 1	0.032
Tcfcp2l1	transcription factor CP2-like 1	0.032
Smad3	MAD homolog 3 (Drosophila)	0.031
Bgn	biglycan	0.030
Fst	follistatin	0.030
Apoe	apolipoprotein E	0.030
Itgb3	integrin beta 3	0.030
Emx1	empty spiracles homolog 1 (Drosophila)	0.030
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.029
Nanog	Nanog homeobox	0.028	Human
Hhex	hematopoietically expressed homeobox	0.027
Foxj1	forkhead box J1	0.026
Apaf1	apoptotic peptidase activating factor 1	0.026
Pxn	paxillin	0.026
Htt	huntingtin	0.026
Atoh7	atonal homolog 7 (Drosophila)	0.026
Acan	aggrecan	0.026
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.025
Pax6	paired box gene 6	0.025
Dll4	delta-like 4 (Drosophila)	0.025
Mmp9	matrix metallopeptidase 9	0.025	Human
Sall1	sal-like 1 (Drosophila)	0.024
Hes5	hairy and enhancer of split 5 (Drosophila)	0.024
Bmp2	bone morphogenetic protein 2	0.024	Zebrafish
Hoxa10	homeobox A10	0.023
Tbx5	T-box 5	0.023	Mouse
Sox7	SRY-box containing gene 7	0.023	Mouse
Gja5	gap junction protein, alpha 5	0.023
Cd247	CD247 antigen	0.023
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.023
Hesx1	homeobox gene expressed in ES cells	0.023
Col6a3	collagen, type VI, alpha 3	0.022
Trp63	transformation related protein 63	0.022
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.022
Il10	interleukin 10	0.022
Acvr2b	activin receptor IIB	0.021
Ptch2	patched homolog 2	0.021
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.021
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.021
Gdf3	growth differentiation factor 3	0.021
Gpr50	G-protein-coupled receptor 50	0.021
Pou4f3	POU domain, class 4, transcription factor 3	0.021	Mouse
Smad7	MAD homolog 7 (Drosophila)	0.021
Btbd17	BTB (POZ) domain containing 17	0.021
Evx2	even skipped homeotic gene 2 homolog	0.021
Fgf17	fibroblast growth factor 17	0.020	Zebrafish
Hoxd1	homeobox D1	0.020
Insm1	insulinoma-associated 1	0.020
Sox17	SRY-box containing gene 17	0.020
Lama1	laminin, alpha 1	0.020
Cxadr	coxsackie virus and adenovirus receptor	0.019
Nkx2-1	NK2 homeobox 1	0.019
Tcf15	transcription factor 15	0.019
Smad5	MAD homolog 5 (Drosophila)	0.019	Fly
Mrc2	mannose receptor, C type 2	0.019
Nos3	nitric oxide synthase 3, endothelial cell	0.019
Il11	interleukin 11	0.019
Wnt3	wingless-related MMTV integration site 3	0.019
Fstl1	follistatin-like 1	0.019
Col5a2	collagen, type V, alpha 2	0.019	Human
Hoxb13	homeobox B13	0.019
Tbx6	T-box 6	0.018	Mouse
Atoh1	atonal homolog 1 (Drosophila)	0.018
Has2	hyaluronan synthase 2	0.018
Itgal	integrin alpha L	0.018
Ihh	Indian hedgehog	0.018
Cdh3	cadherin 3	0.018
Npr2	natriuretic peptide receptor 2	0.018
Pax7	paired box gene 7	0.018
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.017
Wnt4	wingless-related MMTV integration site 4	0.017
Dlx1	distal-less homeobox 1	0.017
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.017
Nf1	neurofibromatosis 1	0.017
Foxa1	forkhead box A1	0.017
Tead3	TEA domain family member 3	0.017
Bicc1	bicaudal C homolog 1 (Drosophila)	0.017
Lamc1	laminin, gamma 1	0.017
Gja4	gap junction protein, alpha 4	0.017
Traf6	TNF receptor-associated factor 6	0.017
Hoxd11	homeobox D11	0.017
Sox13	SRY-box containing gene 13	0.016
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.016
Col12a1	collagen, type XII, alpha 1	0.016	Human
Pbx1	pre B-cell leukemia transcription factor 1	0.016
Nid1	nidogen 1	0.015
Creb3l1	cAMP responsive element binding protein 3-like 1	0.015
Bcl6b	B-cell CLL/lymphoma 6, member B	0.015
Eomes	eomesodermin homolog (Xenopus laevis)	0.015
Hoxd4	homeobox D4	0.015
Kif3a	kinesin family member 3A	0.015
Cldn6	claudin 6	0.015
Cd4	CD4 antigen	0.015
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.015
Eda	ectodysplasin-A	0.015
Wnt5a	wingless-related MMTV integration site 5A	0.015
Cdk9	cyclin-dependent kinase 9 (CDC2-related kinase)	0.015
Prop1	paired like homeodomain factor 1	0.015
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.015
Axin2	axin2	0.014
Hoxd9	homeobox D9	0.014
Gata3	GATA binding protein 3	0.014	Mouse
Bptf	bromodomain PHD finger transcription factor	0.014
Foxd3	forkhead box D3	0.014
Neurog2	neurogenin 2	0.014
Matn3	matrilin 3	0.014
Pax9	paired box gene 9	0.014
Nrk	Nik related kinase	0.014
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.014
Tlx2	T-cell leukemia, homeobox 2	0.014
Emx2	empty spiracles homolog 2 (Drosophila)	0.014
Ptpre	protein tyrosine phosphatase, receptor type, E	0.014
Efnb1	ephrin B1	0.014
Pitx3	paired-like homeodomain transcription factor 3	0.014
Wisp1	WNT1 inducible signaling pathway protein 1	0.014
Inhbb	inhibin beta-B	0.014
Nes	nestin	0.014
Foxa2	forkhead box A2	0.014
Gsk3b	glycogen synthase kinase 3 beta	0.014
Des	desmin	0.013
Mapk1	mitogen-activated protein kinase 1	0.013
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.013
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.013
Otx1	orthodenticle homolog 1 (Drosophila)	0.013
Lhx5	LIM homeobox protein 5	0.013
Fgf4	fibroblast growth factor 4	0.013
Tgfbr2	transforming growth factor, beta receptor II	0.013
Sykb	spleen tyrosine kinase	0.013
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.013
Gdnf	glial cell line derived neurotrophic factor	0.013
Efna4	ephrin A4	0.013
Wipf1	WAS/WASL interacting protein family, member 1	0.013
Gpr132	G protein-coupled receptor 132	0.013
Cdh5	cadherin 5	0.013
Fgf5	fibroblast growth factor 5	0.013
1810065E05Rik	RIKEN cDNA 1810065E05 gene	0.013
Cfc1	cripto, FRL-1, cryptic family 1	0.013
Tcf7	transcription factor 7, T-cell specific	0.013
Tspan9	tetraspanin 9	0.013
Col13a1	collagen, type XIII, alpha 1	0.013
Hapln1	hyaluronan and proteoglycan link protein 1	0.013
Prdm1	PR domain containing 1, with ZNF domain	0.013
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.013
Dll3	delta-like 3 (Drosophila)	0.013
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.013
Cdc73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.012
Fbn2	fibrillin 2	0.012
Lrp5	low density lipoprotein receptor-related protein 5	0.012
Kdr	kinase insert domain protein receptor	0.012
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.012
Tcra	T-cell receptor alpha chain	0.012
Col16a1	collagen, type XVI, alpha 1	0.012
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.012
Wnt7b	wingless-related MMTV integration site 7B	0.012
Sept1	septin 1	0.012
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.012
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.012
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	0.012
Smad2	MAD homolog 2 (Drosophila)	0.012
Chrm4	cholinergic receptor, muscarinic 4	0.012
Lhb	luteinizing hormone beta	0.012
Peg10	paternally expressed 10	0.012
Pou4f2	POU domain, class 4, transcription factor 2	0.012	Mouse
Fyb	FYN binding protein	0.012
Sfrp2	secreted frizzled-related protein 2	0.012
Wt1	Wilms tumor 1 homolog	0.012
Ighmbp2	immunoglobulin mu binding protein 2	0.012
Pou3f2	POU domain, class 3, transcription factor 2	0.011	Mouse
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.011
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.011
Ikzf1	IKAROS family zinc finger 1	0.011
Dmrt1	doublesex and mab-3 related transcription factor 1	0.011
Mnx1	motor neuron and pancreas homeobox 1	0.011
T	brachyury	0.011	Mouse
Axin1	axin 1	0.011
Cd5	CD5 antigen	0.011
Shox2	short stature homeobox 2	0.011
Myf5	myogenic factor 5	0.011
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.011
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.011
Gh	growth hormone	0.011
Lama4	laminin, alpha 4	0.011
Neurog3	neurogenin 3	0.011
Plcg2	phospholipase C, gamma 2	0.011
Loxl1	lysyl oxidase-like 1	0.011
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.011
Wnt8b	wingless related MMTV integration site 8b	0.011
Postn	periostin, osteoblast specific factor	0.011
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.011
Gsc	goosecoid homeobox	0.010
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.010
Cd19	CD19 antigen	0.010
Lrp2	low density lipoprotein receptor-related protein 2	0.010
Klf3	Kruppel-like factor 3 (basic)	0.010
Esr1	estrogen receptor 1 (alpha)	0.010
Mixl1	Mix1 homeobox-like 1 (Xenopus laevis)	0.010
Lmx1b	LIM homeobox transcription factor 1 beta	0.010
Myl7	myosin, light polypeptide 7, regulatory	0.010
Ltbp2	latent transforming growth factor beta binding protein 2	0.010
Ceacam10	carcinoembryonic antigen-related cell adhesion molecule 10	0.010
Psg17	pregnancy specific glycoprotein 17	0.010
Snai2	snail homolog 2 (Drosophila)	0.010
Vgf	VGF nerve growth factor inducible	0.010
Smad9	MAD homolog 9 (Drosophila)	0.010	Fly
Ppic	peptidylprolyl isomerase C	0.010
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.010