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Process View

Danio rerio

22 genes annotated in zebrafish

lens development in camera type eye

GO:0002088

The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lens development in camera type eye"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lens development in camera type eye" (in gray)

Name	Description	Probability	Func Analog Organism
crygmxl2	crystallin, gamma MX, like 2	0.842
dlc	deltaC	0.715
foxe3	forkhead box E3	0.610
cryba4	crystallin, beta A4	0.583
pax6b	paired box gene 6b	0.552
foxa2	forkhead box A2	0.552	Zebrafish
bmp2b	bone morphogenetic protein 2b	0.473
dnmt4	DNA (cytosine-5-)-methyltransferase 4	0.432
mab21l2	mab-21-like 2	0.423
col4a5	collagen, type IV, alpha 5 (Alport syndrome)	0.400
crygm3	crystallin, gamma M3	0.393
pax6a	paired box gene 6a	0.380	Zebrafish Mouse
cdh2	cadherin 2, neuronal	0.378
crygm6	crystallin, gamma M6	0.314	Mouse
pxn	paxillin	0.303
crygm1	crystallin, gamma M1	0.300	Mouse
otx1b	orthodenticle homolog 1b	0.294
scinla	scinderin like a	0.279
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.274
crygm2f	crystallin, gamma M2f	0.258
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.255
mdka	midkine-related growth factor	0.253
fsta	follistatin a	0.250
myod1	myogenic differentiation 1	0.234
shha	sonic hedgehog a	0.212
tp63	tumor protein p63	0.211
notch1a	notch homolog 1a	0.204
rx2	retinal homeobox gene 2	0.195
crygn1	crystallin, gamma N1	0.193
fgfr2	fibroblast growth factor receptor 2	0.191	Mouse
gdf6a	growth differentiation factor 6a	0.184
crygm2d11	crystallin, gamma M2d11	0.184	Mouse Rat
emx3	empty spiracles homeobox 3	0.183
rx1	retinal homeobox gene 1	0.182
pea3	ETS-domain transcription factor pea3	0.180
lamb1a	laminin, beta 1a	0.173
unc5b	unc-5 homolog B (C. elegans)	0.172
cryaa	crystallin, alpha A	0.163	Mouse
six2a	sine oculis-related homeobox 2a	0.159
pitx2	paired-like homeodomain transcription factor 2	0.158	Zebrafish
crygm2d2	crystallin, gamma M2d2	0.151
otx2	orthodenticle homolog 2	0.141
her6	hairy-related 6	0.137
sox2	SRY-box containing gene 2	0.136	Mouse
dnmt6	DNA (cytosine-5-)-methyltransferase 6	0.135
crygm2a	crystallin, gamma M2a	0.125	Mouse
lama2	laminin, alpha 2	0.123
cryba2a	crystallin, beta A2a	0.122	Mouse
foxi3b	forkhead box I3b	0.122	Zebrafish
crygm4	crystallin, gamma M4	0.121	Mouse
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.120
crygmx	crystallin, gamma MX	0.115
foxi1	forkhead box I1	0.113	Zebrafish
boc	brother of CDO	0.112
vsx2	visual system homeobox 2	0.109
neurog1	neurogenin 1	0.108
fgfr4	fibroblast growth factor receptor 4	0.106
crygm2b	crystallin, gamma M2b	0.106
cryaba	crystallin, alpha B, a	0.103
jag1b	jagged 1b	0.103
aqp10b	aquaporin 10b	0.103
zgc:171792	zgc:171792	0.101
crygm7	crystallin, gamma M7	0.101	Mouse Rat
crygs1	crystallin, gamma S1	0.096	Mouse
crygm2d8	crystallin, gamma M2d8	0.096	Mouse Rat
crestin	crestin	0.093
mipb	major intrinsic protein of lens fiber b	0.092
cx55.5	connexin 55.5	0.089
lama5	laminin, alpha 5	0.088
crygm2d10	crystallin, gamma M2d10	0.088
crabp2a	cellular retinoic acid binding protein 2, a	0.088
extl3	exostoses (multiple)-like 3	0.086
notch3	notch homolog 3	0.085
edn1	endothelin 1	0.083
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.083
crygm2d16	crystallin, gamma M2d16	0.082
gata2a	GATA-binding protein 2a	0.080
crygm2d7	crystallin, gamma M2d7	0.079
sema3aa	semaphorin 3aa	0.077
irx1b	iroquois homeobox protein 1, b	0.077
disp1	dispatched homolog 1 (Drosophila)	0.077
crygmxl1	crystallin, gamma MX, like 1	0.076	Mouse Rat
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.075
crygn2	crystallin, gamma N2	0.074
crygm2d15	crystallin, gamma M2d15	0.073	Mouse Rat
fgf3	fibroblast growth factor 3	0.071
grifin	galectin related inter-fiber protein	0.070
nr2f5	nuclear receptor subfamily 2, group F, member 5	0.070
msxd	muscle segment homeobox D	0.066
coe2	coe2	0.065
nr2f6b	nuclear receptor subfamily 2, group F, member 6b	0.064
ebf3	early B-cell factor 3	0.064
fgfrl1a	fibroblast growth factor receptor-like 1a	0.063
cryba2b	crystallin, beta A2b	0.063	Mouse
fgfr3	fibroblast growth factor receptor 3	0.060	Mouse
dnmt8	DNA (cytosine-5-)-methyltransferase 8	0.059
atp1a1a.2	ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide	0.059
fn1	fibronectin 1	0.059
pitx3	paired-like homeodomain transcription factor 3	0.058
emx2	empty spiracles homeobox 2	0.057
ptch1	patched 1	0.057
pvrl1a	poliovirus receptor-related 1a	0.056	Mouse
cdh23	cadherin-like 23	0.054
znf703	zinc finger protein 703	0.054
LOC799807	novel protein similar to crystallin, gamma family	0.053
chaf1b	chromatin assembly factor 1, subunit B	0.052
crygs4	crystallin, gamma S4	0.052
dct	dopachrome tautomerase	0.051
msxc	muscle segment homeobox C	0.050
crybb1	crystallin, beta B1	0.049
robo3	roundabout homolog 3	0.047
crygm2d13	crystallin, gamma M2d13	0.044	Mouse Rat
mipa	major intrinsic protein of lens fiber a	0.044
plxnb2b	plexin b2b	0.044
zgc:101859	zgc:101859	0.044
rbp4	retinol binding protein 4, plasma	0.043
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.043
atp1a1a.5	ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide	0.041
fgf19	fibroblast growth factor 19	0.040
fgfrl1b	fibroblast growth factor receptor-like 1b	0.039
tcf12	transcription factor 12	0.039
prdm5	PR domain containing 5	0.039
col2a1a	collagen type II, alpha-1a	0.039
crygm2c	crystallin, gamma M2c	0.038	Mouse Rat
igfbp3	insulin-like growth factor binding protein 3	0.038
six4a	sine oculis homeobox homolog 4a	0.038
fgfr1a	fibroblast growth factor receptor 1a	0.037
irx1a	iroquois homeobox protein 1, a	0.037
ptf1a	pancreas specific transcription factor, 1a	0.037
ptgs1	prostaglandin-endoperoxide synthase 1	0.036
igfbp5a	insulin-like growth factor binding protein 5a	0.036
lrp2	low density lipoprotein-related protein 2	0.036
crygm2d6	crystallin, gamma M2d6	0.035
guca1c	guanylate cyclase activator 1C	0.035
vcana	versican a	0.034
crybb1l2	crystallin, beta B1, like 2	0.034
aqp1a.1	aquaporin 1a, tandem duplicate 1	0.034	Zebrafish
crybb2	crystallin, beta B2	0.034
pknox2	pbx/knotted 1 homeobox 2	0.033
pabpc1b	poly A binding protein, cytoplasmic 1 b	0.033
pabpc4	poly(A) binding protein, cytoplasmic 4 (inducible form)	0.033
cldn5a	claudin 5a	0.032
cryba1b	crystallin, beta A1b	0.032
sox9b	SRY-box containing gene 9b	0.032
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.032
bmper	BMP binding endothelial regulator	0.031
fezf2	FEZ family zinc finger 2	0.031
pax4	paired box 4	0.031
dlx5a	distal-less homeobox gene 5a	0.031
neurod4	neurogenic differentiation 4	0.031
irx5a	iroquois homeobox protein 5a	0.031
crygm2d12	crystallin, gamma M2d12	0.030	Mouse Rat
slc4a1b	solute carrier family 4, anion exchanger, member 1b	0.030
zgc:55448	zgc:55448	0.029
foxg1a	forkhead box G1a	0.029	Zebrafish
dmd	dystrophin	0.029
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.029
eya1	eyes absent homolog 1	0.029
stil	TAL1 (SCL) interrupting locus	0.029
cyp1a	cytochrome P450, family 1, subfamily A	0.029
zgc:112285	zgc:112285	0.029
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.028
foxn1	forkhead box N1	0.028
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.028
crygm5	crystallin, gamma M5	0.028	Mouse Rat
zgc:86759	zgc:86759	0.028
ntn1b	netrin 1b	0.028
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.027
her2	hairy-related 2	0.027
sim2	single-minded homolog 2 (Drosophila)	0.027
vax2	ventral anterior homeobox 2	0.027
slc2a11l	solute carrier family 2 (facilitated glucose transporter), member 11-like	0.026
ptch2	patched 2	0.026
sema3gb	semaphorin 3gb	0.026
tfec	transcription factor EC	0.026
id:ibd2573	id:ibd2573	0.026
grhl1	grainyhead-like 1 (Drosophila)	0.026
msxb	muscle segment homeobox B	0.025
kiss1ra	KISS1 receptor a	0.025
sox1a	SRY-box containing gene 1a	0.025
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.024
foxc1a	forkhead box C1a	0.024
gli2a	GLI-Kruppel family member GLI2a	0.024
dctn1a	dynactin 1a	0.024
pax7a	paired box gene 7a	0.024
atoh7	atonal homolog 7	0.023
sfrp5	secreted frizzled-related protein 5	0.023
foxc1b	forkhead box C1b	0.023	Zebrafish
aqp11	aquaporin 11	0.023
ccbe1	collagen and calcium binding EGF domains 1	0.023
evx1	even-skipped homeobox 1	0.023
her1	hairy-related 1	0.023
wdhd1	WD repeat and HMG-box DNA binding protein 1	0.023
zgc:153846	zgc:153846	0.023	Mouse
dmbx1a	diencephalon/mesencephalon homeobox 1a	0.023
skia	nuclear oncoprotein skia	0.022	Mouse
fgf8b	fibroblast growth factor 8 b	0.022
atoh1a	atonal homolog 1a	0.022
tp53	tumor protein p53	0.022
lmx1b.2	LIM homeobox transcription factor 1, beta 2	0.022
lamc3	laminin, gamma 3	0.022
olig1	oligodendrocyte lineage transcription factor 1	0.022
nrl	neural retina leucine zipper	0.021
zgc:194131	zgc:194131	0.021
col12a1	collagen, type XII, alpha 1	0.021
pcdh10a	protocadherin 10a	0.021
lypd6	LY6/PLAUR domain containing 6	0.021
znf503	zinc finger protein 503	0.021
dusp5	dual specificity phosphatase 5	0.021
pax2a	paired box gene 2a	0.021
fzd9b	frizzled homolog 9b	0.021
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.021
LOC567965	rho GTPase-activating protein 7-like	0.021
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.021
zdhhc8b	zinc finger, DHHC-type containing 8b	0.021
myst3	MYST histone acetyltransferase (monocytic leukemia) 3	0.020
spon2a	spondin 2a, extracellular matrix protein	0.020
thrb	thyroid hormone receptor beta	0.020
olig2	oligodendrocyte lineage transcription factor 2	0.020
frem1a	Fras1 related extracellular matrix 1a	0.020
hsp70	heat shock cognate 70-kd protein	0.019
wif1	wnt inhibitory factor 1	0.019
foxi2	forkhead box I2	0.019	Zebrafish
hmcn2	hemicentin 2	0.019
zgc:158345	zgc:158345	0.019
lhx5	LIM homeobox 5	0.019
lctla	lactase-like a	0.019
crybb1l3	crystallin, beta B1, like 3	0.019
igfbp2a	insulin-like growth factor binding protein 2a	0.019
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.019	Mouse
zgc:158643	zgc:158643	0.019
fzd7a	frizzled homolog 7a	0.019
loxl5b	lysyl oxidase-like 5b	0.019
hmx1	H6 homeo box 1	0.019
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.019
and2	actinodin2	0.019
psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.018
axin2	axin 2 (conductin, axil)	0.018
olig4	oligodendrocyte transcription factor 4	0.018
dlg4	discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila)	0.018
lhx1b	LIM homeobox 1b	0.018
emx1	empty spiracles homeobox 1	0.018
pou1f1	POU domain, class 1, transcription factor 1	0.018
il17rd	interleukin 17 receptor D	0.018
rx3	retinal homeobox gene 3	0.018
dla	deltaA	0.018
neu4	sialidase 4	0.018
pou3f3a	POU class 3 homeobox 3a	0.018
epha4b	eph receptor A4b	0.018
rorab	RAR-related orphan receptor A, paralog b	0.017
lamb4	laminin, beta 4	0.017	Zebrafish
hs6st2	heparan sulfate 6-O-sulfotransferase 2	0.017
hsf4	heat shock transcription factor 4	0.017
hand2	heart and neural crest derivatives expressed transcript 2	0.017
her15.1	hairy and enhancer of split-related 15.1	0.017
smoc1	SPARC related modular calcium binding 1	0.017
gbx2	gastrulation brain homeo box 2	0.017
rarga	retinoic acid receptor gamma a	0.017
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.017
itgb3b	integrin beta 3b	0.017
gnrh2	gonadotropin-releasing hormone 2	0.017
prdm16	PR domain containing 16	0.017
hlfb	hepatic leukemia factor b	0.017
wu:fb16h09	wu:fb16h09	0.016
tfeb	transcription factor EB	0.016
snapc4	small nuclear RNA activating complex, polypeptide 4	0.016
c1ql3b	complement component 1, q subcomponent-like 3b	0.016
sox19a	SRY-box containing gene 19a	0.016
twist1a	twist1a	0.016
mxi1	max interacting protein	0.016
efnb2a	ephrin B2a	0.016
hhip	hedgehog interacting protein	0.016
lamb2	laminin, beta 2 (laminin S)	0.016	Zebrafish
hsp90a.1	heat shock protein 90-alpha 1	0.016
vwf	von Willebrand factor	0.016
eya2	eyes absent homolog 2 (Drosophila)	0.016
sulf1	sulfatase 1	0.015
zgc:112329	zgc:112329	0.015
tkt	transketolase	0.015
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.015
sema6e	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E	0.015
pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.015
nova2	neuro-oncological ventral antigen 2	0.015
gucy2f	guanylate cyclase 2F, retinal	0.015
znf395b	zinc finger protein 395b	0.015
dacha	dachshund a	0.015
hesx1	homeo box (expressed in ES cells) 1	0.015
angpt1	angiopoietin 1	0.015
tbr1b	T-box, brain, 1b	0.015
gas1a	growth arrest-specific 1a	0.015
plagl2	pleiomorphic adenoma gene-like 2	0.015
jam3b	junctional adhesion molecule 3b	0.014
zgc:114181	zgc:114181	0.014
foxi3a	forkhead box I3a	0.014	Zebrafish
spry4	sprouty (Drosophila) homolog 4	0.014
rab11fip4a	RAB11 family interacting protein 4 (class II) a	0.014
sfrp1b	secreted frizzled-related protein 1b	0.014
hlxb9la	homeo box HB9 like a	0.014
neu3.5	Neu3.5	0.014
fbn2b	fibrillin 2b	0.014
pdca	phosducin a	0.014
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.014
c10orf11	c10orf11 homolog (H. sapiens)	0.014
sparcl1	SPARC-like 1	0.014
dlx3b	distal-less homeobox gene 3b	0.014
bmpr1ab	bone morphogenetic protein receptor, type 1ab	0.014
crygm2d3	crystallin, gamma M2d3	0.014
or111-10	odorant receptor, family D, subfamily 111, member 10	0.014
rlbp1a	retinaldehyde binding protein 1a	0.014
drd4-rs	dopamine receptor D4 related sequence	0.014
trim71	tripartite motif-containing 71	0.013
tert	telomerase reverse transcriptase	0.013
efna5a	ephrin A5a	0.013
LOC564872	monocarboxylate transporter 7-like	0.013
barhl2	BarH-like 2	0.013
olfm1b	olfactomedin 1b	0.013
psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.013
nkx2.1a	NK2 homeobox 1a	0.013
rxrga	retinoid x receptor, gamma a	0.013
rerea	arginine-glutamic acid dipeptide (RE) repeats a	0.013
rad21	RAD21 homolog (S. pombe)	0.013
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.013
fancb	Fanconi anemia, complementation group B	0.013
lamb2l	laminin, beta 2-like	0.013	Zebrafish
plp1a	proteolipid protein 1a	0.012
zgc:55573	zgc:55573	0.012
gli1	GLI-Kruppel family member 1	0.012
bmp1a	bone morphogenetic protein 1a	0.012
irx4b	iroquois homeobox protein 4b	0.012
actc1a	actin, alpha, cardiac muscle 1a	0.012
dld	deltaD	0.012
aqp8a.1	aquaporin 8a, tandem duplicate 1	0.012	Zebrafish
nt5c2l1	5'-nucleotidase, cytosolic II, like 1	0.012
gadd45aa	growth arrest and DNA-damage-inducible, alpha, a	0.012
ccng1	cyclin G1	0.012
adipoql2	adiponectin, C1Q and collagen domain containing, like 2	0.012
dao.2	D-amino-acid oxidase 2	0.012
ptprub	protein tyrosine phosphatase, receptor type, U, b	0.012
angptl2	angiopoietin-like 2	0.012
fzd6	frizzled homolog 6 (Drosophila)	0.012
flnca	filamin C, gamma a (actin binding protein 280)	0.012
plp1b	proteolipid protein 1b	0.012
usp9	ubiquitin specific peptidase 9	0.012
efna3b	ephrin A3b	0.012
cry1b	cryptochrome 1b	0.012
rtn4b	reticulon 4b	0.012
rnf2	ring finger protein 2	0.012
ctgf	connective tissue growth factor	0.012
fzd8a	frizzled homolog 8a	0.012
crybb3	crystallin, beta B3	0.012
il11ra	interleukin 11 receptor, alpha	0.012
zic4	zic family member 4	0.012
ildr2	immunoglobulin-like domain containing receptor 2	0.011
zgc:113312	zgc:113312	0.011
atoh8	atonal homolog 8	0.011
prkcz	protein kinase C, zeta	0.011
wnt3	wingless-type MMTV integration site family, member 3	0.011
cryba1l	crystallin, beta A1, like	0.011
foxf1	forkhead box F1	0.011
adipor2	adiponectin receptor 2	0.011
rbp1a	retinol binding protein 1a, cellular	0.011
si:dkey-71l1.7	si:dkey-71l1.7	0.011
nkx2.1b	NK2 homeobox 1b	0.011
alpi	alkaline phosphatase, intestinal	0.011
smad3a	MAD homolog 3a (Drosophila)	0.011	Mouse
flncb	filamin C, gamma b (actin binding protein 280)	0.011
msxa	muscle segment homeobox A	0.011
ptpra	protein tyrosine phosphatase, receptor type, A	0.011
wu:fv91b12	wu:fv91b12	0.011
hoxa13a	homeo box A13a	0.011
atp1b1b	ATPase, Na+/K+ transporting, beta 1b polypeptide	0.011
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.011
lama4	laminin, alpha 4	0.011
tlx2	T-cell leukemia, homeobox 2	0.011
slc7a6	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6	0.011
cryba1a	crystallin, beta A1a	0.011
psenen	presenilin enhancer 2 homolog	0.011
sufu	suppressor of fused homolog (Drosophila)	0.011
bnc2	basonuclin 2	0.011
cacnb3b	calcium channel, voltage-dependent, beta 3b	0.011
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.011
mecp2	methyl CpG binding protein 2	0.011
nrf1	nuclear respiratory factor 1	0.011
sema3fa	semaphorin 3fa	0.010
aqp7	aquaporin 7	0.010
cldn5b	claudin 5b	0.010
tie2	endothelium-specific receptor tyrosine kinase 2	0.010
jam2a	junctional adhesion molecule 2a	0.010
pcdh17	protocadherin 17	0.010
lhb	luteinizing hormone, beta polypeptide	0.010
ralgapa1	Ral GTPase activating protein, alpha subunit 1 (catalytic)	0.010
foxp2	forkhead box P2	0.010
si:dkey-49m19.7	si:dkey-49m19.7	0.010
tgfb1a	transforming growth factor, beta 1a	0.010	Mouse
foxa3	forkhead box A3	0.010	Zebrafish
zgc:92139	zgc:92139	0.010
vlk	vertebrate lonesome kinase	0.010
sox9a	SRY-box containing gene 9a	0.010
and4	actinodin4	0.010