IMP

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Danio rerio

22 genes annotated in zebrafish

negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway

Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
bmp2b	bone morphogenetic protein 2b	0.948
hdac4	histone deacetylase 4	0.445
flh	floating head	0.262
raraa	retinoic acid receptor, alpha a	0.254	Zebrafish
rasl11b	RAS-like, family 11, member B	0.253
nanos3	nanos homolog 3	0.229
tbx1	T-box 1	0.215
si:ch211-173o4.2	si:ch211-173o4.2	0.182
nkx2.5	NK2 transcription factor related 5	0.181
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.170
kif5bb	kinesin family member 5B, b	0.162
brd2b	bromodomain containing 2b	0.150
bmp4	bone morphogenetic protein 4	0.147
rarga	retinoic acid receptor gamma a	0.141	Zebrafish
LOC100000687	signal peptide, CUB and EGF-like domain-containing protein 3-like	0.114
mib	mind bomb	0.111
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.108
col11a1a	collagen, type XI, alpha 1a	0.094
ctsl1b	cathepsin L, 1 b	0.087
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.086
gpia	glucose phosphate isomerase a	0.085
wnt9a	wingless-type MMTV integration site family, member 9A	0.084
efnb2a	ephrin B2a	0.084
rxrga	retinoid x receptor, gamma a	0.083
gng2	guanine nucleotide binding protein (G protein), gamma 2	0.081
pcdh18b	protocadherin 18b	0.081
cacnb4b	calcium channel, voltage-dependent, beta 4b subunit	0.076
rxraa	retinoid X receptor, alpha a	0.073
smad1	MAD homolog 1 (Drosophila)	0.070
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.069
gbx2	gastrulation brain homeo box 2	0.069
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.067	Zebrafish
lft1	lefty1	0.064	Mouse
elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.063
grnb	granulin b	0.062
nog1	noggin 1	0.060
twist3	twist3	0.060
cdx1b	caudal type homeobox 1 b	0.060
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.059
foxo3b	forkhead box O3b	0.059
frzb	frizzled-related protein	0.056
tp53bp2	tumor protein p53 binding protein, 2	0.055
vasa	vasa homolog	0.055
nog2	noggin 2	0.053
col7a1l	collagen type VII alpha 1-like	0.052
wnt5b	wingless-type MMTV integration site family, member 5b	0.051	Mouse
gng7	guanine nucleotide binding protein (G protein), gamma 7	0.050
foxa3	forkhead box A3	0.049
gng12a	guanine nucleotide binding protein (G protein), gamma 12a	0.049
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.048
mbnl2	muscleblind-like 2 (Drosophila)	0.048
e2f5	E2F transcription factor 5	0.048
LOC568379	von Willebrand factor A domain-containing protein 1-like	0.045
spon2b	spondin 2b, extracellular matrix protein	0.045
btg1	B-cell translocation gene 1	0.045
tbx2b	T-box 2b	0.044
has2	hyaluronan synthase 2	0.044
smoc1	SPARC related modular calcium binding 1	0.044
bmp7b	bone morphogenetic protein 7b	0.044
satb2	SATB homeobox 2	0.044
cdx4	caudal type homeo box transcription factor 4	0.043
thbs1	thrombospondin 1	0.043
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.043	Human Mouse Fly
camk2n2	calcium/calmodulin-dependent protein kinase II inhibitor 2	0.042
rarab	retinoic acid receptor, alpha b	0.042	Zebrafish
wnt11	wingless-type MMTV integration site family, member 11	0.041
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.041
ncl1	nicalin	0.041
si:ch211-173b8.2	si:ch211-173b8.2	0.040	Zebrafish
matn4	matrilin 4	0.040
col5a2l	collagen, type V, alpha 2-like	0.039
plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.039
col2a1a	collagen type II, alpha-1a	0.039
bmp2a	bone morphogenetic protein 2a	0.038
zbtb4	zinc finger and BTB domain containing 4	0.038
igfbp1a	insulin-like growth factor binding protein 1a	0.038	Zebrafish
gng8	guanine nucleotide binding protein (G protein), gamma 8	0.037
sox17	SRY-box containing gene 17	0.037
bhlhe41	basic helix-loop-helix family, member e41	0.037
fgfr3	fibroblast growth factor receptor 3	0.037
zgc:136773	zgc:136773	0.037
nav3	neuron navigator 3	0.036
igfbp6b	insulin-like growth factor binding protein 6b	0.036
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.036
loxl2b	lysyl oxidase-like 2b	0.036
wnt8a	wingless-type MMTV integration site family, member 8a	0.036
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.035
cftr	cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)	0.035
LOC100000500	sclerostin-like	0.035
fgf17	fibroblast growth factor 17	0.035
oep	one-eyed pinhead	0.035	Mouse
arg2	arginase, type II	0.035
si:dkeyp-34c12.2	si:dkeyp-34c12.2	0.035
mef2a	myocyte enhancer factor 2a	0.034
gli2a	GLI-Kruppel family member GLI2a	0.034
dusp6	dual specificity phosphatase 6	0.033
gata4	GATA-binding protein 4	0.033
epb4.1l4	erythrocyte protein band 4.1-like 4	0.033
szl	sizzled	0.033
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.032
clptm1	cleft lip and palate associated transmembrane protein 1	0.032
fli1a	friend leukemia integration 1a	0.031
pax7a	paired box gene 7a	0.031
ecrg4a	esophageal cancer related gene 4a	0.031
ulk2	unc-51-like kinase 2 (C. elegans)	0.031
tgfb1a	transforming growth factor, beta 1a	0.030
sox9a	SRY-box containing gene 9a	0.030
per2	period homolog 2 (Drosophila)	0.029
wnt2	wingless-type MMTV integration site family member 2	0.029
rxrba	retinoid x receptor, beta a	0.029
twist2	twist2	0.029
nr1d2b	nuclear receptor subfamily 1, group D, member 2b	0.028	Zebrafish
gata5	GATA-binding protein 5	0.028
myhc4	myosin heavy chain 4	0.028
cbfb	core-binding factor, beta subunit	0.028
col27a1a	collagen, type XXVII, alpha 1a	0.028
tcf12	transcription factor 12	0.027
ntla	no tail a	0.027
wnt11r	wingless-type MMTV integration site family, member 11, related	0.027
igfbp3	insulin-like growth factor binding protein 3	0.027
tbx22	T-box 22	0.027
slit3	slit (Drosophila) homolog 3	0.026
ptpn21	protein tyrosine phosphatase, non-receptor type 21	0.026
esr1	estrogen receptor 1	0.026
ext1a	exostoses (multiple) 1a	0.026
tp53inp1	tumor protein p53 inducible nuclear protein 1	0.025
ldb2b	LIM-domain binding factor 2b	0.025
cldn15lb	claudin 15-like b	0.025
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.025
zgc:114095	zgc:114095	0.025
lmna	lamin A	0.025
lhx1b	LIM homeobox 1b	0.024
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.024
ralgapa1	Ral GTPase activating protein, alpha subunit 1 (catalytic)	0.023
col10a1	collagen, type X, alpha 1	0.023
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.023
vsx2	visual system homeobox 2	0.023
tbx16	T-box gene 16	0.023
spns2	spinster homolog 2 (Drosophila)	0.023	Fly
col11a2	collagen type XI alpha-2	0.023
fzd8b	frizzled homolog 8b	0.023
hlxb9la	homeo box HB9 like a	0.023
efnb3b	ephrin B3b	0.022
nkd1	naked cuticle homolog 1 (Drosophila)	0.022
crabp2a	cellular retinoic acid binding protein 2, a	0.022
spata2	spermatogenesis associated 2	0.022
sass6	spindle assembly 6 homolog (C. elegans)	0.022
LOC562316	klotho-like	0.022
mapk4	mitogen-activated protein kinase 4	0.022
isl2b	islet2b	0.021
si:dkey-7c22.1	si:dkey-7c22.1	0.021
wnt4b	wingless-type MMTV integration site family, member 4b	0.021
twist1a	twist1a	0.021
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.021
tob1a	transducer of ERBB2, 1a	0.020	Mouse
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.020
olfm2	olfactomedin 2	0.020
tll1	tolloid-like 1	0.020
uba1	ubiquitin-like modifier activating enzyme 1	0.020
nr1d2a	nuclear receptor subfamily 1, group D, member 2a	0.020	Zebrafish
hspb12	heat shock protein, alpha-crystallin-related, b12	0.020
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.020
flnca	filamin C, gamma a (actin binding protein 280)	0.020
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.020
vhl	von Hippel-Lindau tumor suppressor	0.019
c8a	complement component 8, alpha polypeptide	0.019
bnip3lb	BCL2/adenovirus E1B interacting protein 3-like b	0.019
ocrl	oculocerebrorenal syndrome of Lowe	0.019
osr1	odd-skipped related 1 (Drosophila)	0.019
chd	chordin	0.019
baxa	bcl2-associated X protein, a	0.019
mknk2b	MAP kinase-interacting serine/threonine kinase 2b	0.019
tsga14	testis specific, 14	0.019
stat1a	signal transduction and activation of transcription 1a	0.019
igf1	insulin-like growth factor 1	0.019
fanci	Fanconi anemia, complementation group I	0.019
igf2b	insulin-like growth factor 2b	0.018
plxnb2a	plexin b2a	0.018
skia	nuclear oncoprotein skia	0.018	Human Mouse
si:ch211-212m21.5	si:ch211-212m21.5	0.018
cry3	cryptochrome 3	0.018
mtor	mechanistic target of rapamycin (serine/threonine kinase)	0.018
ptprsa	protein tyrosine phosphatase, receptor type, s, a	0.018
wnt9b	wingless-type MMTV integration site family, member 9B	0.018
hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.018
plod1a	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a	0.018
fgf18a	fibroblast growth factor 18a	0.018
runx3	runt-related transcription factor 3	0.018
si:dkey-177p2.6	si:dkey-177p2.6	0.018
scn4ab	sodium channel, voltage-gated, type IV, alpha, b	0.018
popdc1	popeye domain containing 1	0.018
smyd3	SET and MYND domain containing 3	0.018
ntn4	netrin 4	0.017
mych	myelocytomatosis oncogene homolog	0.017
zgc:111821	zgc:111821	0.017
ntn2	netrin 2	0.017
epyc	epiphycan	0.017
dkk1b	dickkopf 1b	0.017	Mouse
pacsin3	protein kinase C and casein kinase substrate in neurons 3	0.017
ap2a1	adaptor-related protein complex 2, alpha 1 subunit	0.017
gnrh2	gonadotropin-releasing hormone 2	0.017
nog3	noggin 3	0.017
loxl3a	lysyl oxidase-like 3a	0.017
pabpc1b	poly A binding protein, cytoplasmic 1 b	0.017
foxl1	forkhead box L1	0.017
nhsl1b	NHS-like 1b	0.017
rxrgb	retinoid X receptor, gamma b	0.017
surf4l	surfeit gene 4, like	0.017
pcdh15b	protocadherin 15b	0.016
eprs	glutamyl-prolyl-tRNA synthetase	0.016
brd2a	bromodomain-containing 2a	0.016
dcn	decorin	0.016
prdm4	PR domain containing 4	0.016
pcdh8	protocadherin 8	0.016
ppargc1b	peroxisome proliferative activated receptor, gamma, coactivator 1, beta	0.016
prkcbp1l	protein kinase C binding protein 1, like	0.016
mapk1	mitogen-activated protein kinase 1	0.016
hsf2	heat shock factor 2	0.016
rrm2b	ribonucleotide reductase M2 b	0.016
tfpi2	tissue factor pathway inhibitor 2	0.016
acta2	actin, alpha 2, smooth muscle, aorta	0.016
igf1rb	insulin-like growth factor 1b receptor	0.016
smad3a	MAD homolog 3a (Drosophila)	0.016
mef2d	myocyte enhancer factor 2d	0.016
zgc:171802	zgc:171802	0.016
cdh5	cadherin 5	0.016
lama5	laminin, alpha 5	0.015
plekhg5a	pleckstrin homology domain containing, family G (with RhoGef domain) member 5a	0.015
sbf1	SET binding factor 1	0.015
rorca	RAR-related orphan receptor C a	0.015
rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.015
smap1	stromal membrane-associated protein 1	0.015
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.015
rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.015
hlxb9lb	homeo box HB9 like b	0.015
postn	periostin, osteoblast specific factor	0.015
btbd6a	BTB (POZ) domain containing 6a	0.015
rspo1	R-spondin homolog (Xenopus laevis)	0.015
il1b	interleukin 1, beta and interleukin 1, beta	0.015
sf3b1	splicing factor 3b, subunit 1	0.015
sema3aa	semaphorin 3aa	0.015
ptrfb	polymerase I and transcript release factor b	0.015
bbc3	BCL2 binding component 3	0.015
cacna1da	calcium channel, voltage-dependent, L type, alpha 1D subunit, a	0.014
csnk1g2a	casein kinase 1, gamma 2a	0.014
im:7153552	im:7153552	0.014
cdk10	cyclin-dependent kinase 10	0.014
mapk7	mitogen-activated protein kinase 7	0.014
rtn4rl2b	reticulon 4 receptor-like 2b	0.014
tbx20	T-box 20	0.014	Mouse
twist1b	twist1b	0.014
irx5b	iroquois homeobox protein 5b	0.014
appl2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.014
pax2b	paired box gene 2b	0.014
map2k7	mitogen-activated protein kinase kinase 7	0.014
fn1	fibronectin 1	0.014
uncx4.1	Unc4.1 homeobox (C. elegans)	0.014
ghra	growth hormone receptor a	0.014
zgc:171495	zgc:171495	0.014
e4f1	E4F transcription factor 1	0.014
boc	brother of CDO	0.014
ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.014
slc3a2	solute carrier family 3, member 2	0.014
zfand5a	zinc finger, AN1-type domain 5a	0.014
sh2d3cb	SH2 domain containing 3Cb	0.014
frem1a	Fras1 related extracellular matrix 1a	0.014
tbx18	T-box 18	0.014
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.013
si:ch1073-351m12.1	si:ch1073-351m12.1	0.013
ca15b	carbonic anhydrase XV b	0.013
slc25a37	solute carrier family 25, member 37	0.013
tjp2b	tight junction protein 2b (zona occludens 2)	0.013
rictor	RPTOR independent companion of MTOR, complex 2	0.013
spry4	sprouty (Drosophila) homolog 4	0.013
crygn2	crystallin, gamma N2	0.013
stat3	signal transduction and activation of transcription 3	0.013
copb1	coatomer protein complex, subunit beta 1	0.013
rasgef1ba	RasGEF domain family, member 1Ba	0.013
plod2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.013
vox	ventral homeobox	0.013
aanat2	arylalkylamine N-acetyltransferase	0.013
zgc:77060	zgc:77060	0.013
zgc:73324	zgc:73324	0.013
dlc	deltaC	0.013
pcdh18a	protocadherin 18a	0.013
rbp4	retinol binding protein 4, plasma	0.013
pax9	paired box gene 9	0.013
tfe3a	transcription factor binding to IGHM enhancer 3a	0.013
msxc	muscle segment homeobox C	0.013
foxi3b	forkhead box I3b	0.013
hmx1	H6 homeo box 1	0.013
msgn1	mesogenin 1	0.013
olfm1a	olfactomedin 1a	0.013
zic6	zic family member 6	0.013
sh3gl1b	SH3-domain GRB2-like 1b	0.012
lmo7a	LIM domain only 7a	0.012
maf	v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog	0.012
meox1	mesenchyme homeobox 1	0.012
ltbp3	latent transforming growth factor beta binding protein 3	0.012
gdf11	growth differentiation factor 11	0.012
dlg1	discs, large (Drosophila) homolog 1	0.012
atoh8	atonal homolog 8	0.012
dip2c	DIP2 disco-interacting protein 2 homolog C (Drosophila)	0.012
raf1a	v-raf-1 murine leukemia viral oncogene homolog 1a	0.012
pbx1a	pre-B-cell leukemia transcription factor 1a	0.012
dsg2	desmoglein 2	0.012
bmp3	bone morphogenetic protein 3	0.012
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.012
mcoln1	mucolipin 1	0.012
tbx6	T-box gene 6	0.012
chac1	ChaC, cation transport regulator-like 1	0.012
stam	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.012
rasgrp3	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	0.012
bmp1a	bone morphogenetic protein 1a	0.012
dscam	Down syndrome cell adhesion molecule	0.012
id:ibd1125	id:ibd1125	0.012
baxb	bcl2-associated X protein, b	0.012
dedd1	death effector domain-containing 1	0.012
pnp4a	purine nucleoside phosphorylase 4a	0.012
sox21b	SRY-box containing gene 21 b	0.012
znf395b	zinc finger protein 395b	0.012
eng1a	engrailed 1a	0.012
grin2da	glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a	0.012
sema3e	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	0.012
nkx2.2b	NK2 transcription factor related 2b	0.012
LOC100005295	acetylcholine receptor subunit beta-like	0.012
thbs3a	thrombospondin 3a	0.012
efnb2b	ephrin B2b	0.012
wu:fb80a07	wu:fb80a07	0.011
ntrk2b	neurotrophic tyrosine kinase, receptor, type 2b	0.011
zgc:92765	zgc:92765	0.011
tfr1a	transferrin receptor 1a	0.011
gng13a	guanine nucleotide binding protein (G protein), gamma 13a	0.011
col11a1b	collagen type XI alpha-1b and collagen, type XI, alpha 1b	0.011
eve1	even-skipped-like1	0.011
fstl1a	follistatin-like 1a	0.011
ggct	gamma-glutamyl cyclotransferase	0.011
dnmt8	DNA (cytosine-5-)-methyltransferase 8	0.011
xrn1	5'-3' exoribonuclease 1	0.011
il1rapl1a	interleukin 1 receptor accessory protein-like 1a	0.011
sbno2a	strawberry notch homolog 2a	0.011
dkk1a	dickkopf 1a	0.011
slc5a12	solute carrier family 5 (sodium/glucose cotransporter), member 12	0.011
hs3st1l1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like1	0.011
als2cr4b	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4b	0.011
dmrt2a	doublesex and mab-3 related transcription factor 2a	0.011
sb:cb648	sb:cb648	0.011
zgc:77051	zgc:77051	0.011
slc30a7	solute carrier family 30 (zinc transporter), member 7	0.011
calb2a	calbindin 2a	0.011
and2	actinodin2	0.011
c20orf11	c20orf11 homolog (H. sapiens)	0.011
gclm	glutamate-cysteine ligase, modifier subunit	0.011
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.011
c11orf2	c11orf2 homolog (H. sapiens)	0.011
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.011
LOC562331	transmembrane protein 136-like	0.011
fgf3	fibroblast growth factor 3	0.011
dbx2	developing brain homeobox 2	0.011
smtnl	smoothelin, like	0.011
nr5a2	nuclear receptor subfamily 5, group A, member 2	0.011
itga7	integrin, alpha 7	0.011
her12	hairy-related 12	0.011
duox	dual oxidase	0.011
edn1	endothelin 1	0.011
cyp1b1	cytochrome P450, family 1, subfamily B, polypeptide 1	0.011
h2afy2	H2A histone family, member Y2	0.010
brd4	bromodomain containing 4	0.010
per3	period homolog 3 (Drosophila)	0.010
diaph2	diaphanous homolog 2 (Drosophila)	0.010
lrrc6	leucine rich repeat containing 6	0.010
dnmt6	DNA (cytosine-5-)-methyltransferase 6	0.010
relt	RELT tumor necrosis factor receptor	0.010
col5a1	procollagen, type V, alpha 1	0.010
camk2g1	calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1	0.010
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.010
foxd1l	forkhead box D1 like	0.010
cacnb4a	calcium channel, voltage-dependent, beta 4a subunit	0.010
ambra1	autophagy/beclin-1 regulator 1	0.010
tsku	tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)	0.010
rbp1b	retinol binding protein 1b, cellular	0.010
cp	ceruloplasmin	0.010
clu	clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)	0.010
prdm1a	PR domain containing 1a, with ZNF domain	0.010
tsc22d3	TSC22 domain family, member 3	0.010
id:ibd2573	id:ibd2573	0.010
cap1	Cap1 CAP, adenylate cyclase-associated protein 1	0.010
pck1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.010
gcm2	glial cells missing homolog 2 (Drosophila)	0.010