The network for 'regulation of monooxygenase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of monooxygenase activity

Any process that modulates the activity of a monooxygenase.

Homo sapiens
Name Description Probability Func Analog Organism
ESR1 estrogen receptor 1 0.418
BCL3 B-cell CLL/lymphoma 3 0.408
MAPT microtubule-associated protein tau 0.395
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.337
IL1R1 interleukin 1 receptor, type I 0.332
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.310
MPDZ multiple PDZ domain protein 0.235
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.230
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.182
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.179
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.146
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.128
EGFR epidermal growth factor receptor 0.127
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.123
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.106
NCF1 neutrophil cytosolic factor 1 0.089
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.083
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.075
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.073
HP haptoglobin 0.073
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.073
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.072
NOXA1 NADPH oxidase activator 1 0.060
IL1RAP interleukin 1 receptor accessory protein 0.058
IL1B interleukin 1, beta 0.056
DSG2 desmoglein 2 0.054
IL1R2 interleukin 1 receptor, type II 0.054
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.052
DLG2 discs, large homolog 2 (Drosophila) 0.051
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.051
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.042
TNIP2 TNFAIP3 interacting protein 2 0.038
CDCP1 CUB domain containing protein 1 0.038
HR hairless homolog (mouse) 0.038
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.037
APOC1 apolipoprotein C-I 0.037
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.036
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.036
TRAF1 TNF receptor-associated factor 1 0.034
PRKCD protein kinase C, delta 0.031
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.031
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.029
MYLK2 myosin light chain kinase 2 0.029
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.029
CALCA calcitonin-related polypeptide alpha 0.028
CAV2 caveolin 2 0.028
IL1RN interleukin 1 receptor antagonist 0.026
APOC3 apolipoprotein C-III 0.026
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.026
TGFB1 transforming growth factor, beta 1 0.026
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.026
BTRC beta-transducin repeat containing 0.025
CHUK conserved helix-loop-helix ubiquitous kinase 0.024
MATK megakaryocyte-associated tyrosine kinase 0.022
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.021
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.021
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.021
PRKCB protein kinase C, beta 0.021
APP amyloid beta (A4) precursor protein 0.020
LCAT lecithin-cholesterol acyltransferase 0.020
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.020
IL8 interleukin 8 0.020
BIRC3 baculoviral IAP repeat containing 3 0.019
PRKCA protein kinase C, alpha 0.019
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.019
CD83 CD83 molecule 0.018
MUC1 mucin 1, cell surface associated 0.018
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.017
SH3RF1 SH3 domain containing ring finger 1 0.017
JUP junction plakoglobin 0.016
PRKCZ protein kinase C, zeta 0.016
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.015
PTPRA protein tyrosine phosphatase, receptor type, A 0.015
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.015
ARRDC3 arrestin domain containing 3 0.014
DSP desmoplakin 0.014
PKP3 plakophilin 3 0.014
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.014
OSBPL8 oxysterol binding protein-like 8 0.014
IL1A interleukin 1, alpha 0.014
PTPRF protein tyrosine phosphatase, receptor type, F 0.014
SOCS3 suppressor of cytokine signaling 3 0.014
FRS2 fibroblast growth factor receptor substrate 2 0.014
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 0.013
NRG1 neuregulin 1 0.013
TGFA transforming growth factor, alpha 0.013
APOA1 apolipoprotein A-I 0.013
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.013
HNF4A hepatocyte nuclear factor 4, alpha 0.013
SNCAIP synuclein, alpha interacting protein 0.013
A2M alpha-2-macroglobulin 0.013
FABP4 fatty acid binding protein 4, adipocyte 0.013
ADAM15 ADAM metallopeptidase domain 15 0.013
CCL20 chemokine (C-C motif) ligand 20 0.013
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.012
PTEN phosphatase and tensin homolog 0.012
APC adenomatous polyposis coli 0.012
CLEC4E C-type lectin domain family 4, member E 0.012
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 0.012
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.876
Pparg peroxisome proliferator activated receptor gamma 0.615
Nos3 nitric oxide synthase 3, endothelial cell 0.614
Lep leptin 0.556
Fbn1 fibrillin 1 0.540
Esr1 estrogen receptor 1 (alpha) 0.515
Nos1 nitric oxide synthase 1, neuronal 0.448
Tgfb1 transforming growth factor, beta 1 0.317
Cav1 caveolin 1, caveolae protein 0.294
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.268
Acvrl1 activin A receptor, type II-like 1 0.180
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.168
Insr insulin receptor 0.157
Rxra retinoid X receptor alpha 0.156
Wt1 Wilms tumor 1 homolog 0.142
Ren1 renin 1 structural 0.113
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.113
Ptgs2 prostaglandin-endoperoxide synthase 2 0.109
Ldlr low density lipoprotein receptor 0.097
Fas Fas (TNF receptor superfamily member 6) 0.096
Mstn myostatin 0.096
Nos2 nitric oxide synthase 2, inducible 0.095
Vegfa vascular endothelial growth factor A 0.089
Agtr1a angiotensin II receptor, type 1a 0.088
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.085
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.085
Ptrf polymerase I and transcript release factor 0.078
Bcar1 breast cancer anti-estrogen resistance 1 0.074
Tgfbr2 transforming growth factor, beta receptor II 0.071
Col1a1 collagen, type I, alpha 1 0.062
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.058
Esr2 estrogen receptor 2 (beta) 0.054
Plat plasminogen activator, tissue 0.053
Ptprb protein tyrosine phosphatase, receptor type, B 0.051
Stat3 signal transducer and activator of transcription 3 0.050
Vdr vitamin D receptor 0.050
Il1a interleukin 1 alpha 0.047
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.045
Agtr2 angiotensin II receptor, type 2 0.043
Pten phosphatase and tensin homolog 0.042
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.040
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.039
Lrp1 low density lipoprotein receptor-related protein 1 0.036
Notch2 Notch gene homolog 2 (Drosophila) 0.031
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.031
Npy1r neuropeptide Y receptor Y1 0.029
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.028
Clcn5 chloride channel 5 0.028
Pcdh12 protocadherin 12 0.027
Vhl von Hippel-Lindau tumor suppressor 0.026
Csf1 colony stimulating factor 1 (macrophage) 0.026
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.025
Sik3 SIK family kinase 3 0.025
Dmd dystrophin, muscular dystrophy 0.025
Plin1 perilipin 1 0.023
Nodal nodal 0.023
Tlr2 toll-like receptor 2 0.022
Ret ret proto-oncogene 0.022
Plau plasminogen activator, urokinase 0.021
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.021
Tlr4 toll-like receptor 4 0.021
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.020
Oprm1 opioid receptor, mu 1 0.019
Dll4 delta-like 4 (Drosophila) 0.018
Rdh16 retinol dehydrogenase 16 0.017
Megf8 multiple EGF-like-domains 8 0.017
Klf15 Kruppel-like factor 15 0.017
Apoa1 apolipoprotein A-I 0.017
Lmna lamin A 0.016
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.016
Idua iduronidase, alpha-L- 0.015
Spry4 sprouty homolog 4 (Drosophila) 0.015
Kit kit oncogene 0.015
Phox2b paired-like homeobox 2b 0.014
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.014
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.014
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.014
2900010M23Rik RIKEN cDNA 2900010M23 gene 0.013
Itga5 integrin alpha 5 (fibronectin receptor alpha) 0.013
Bcl2 B-cell leukemia/lymphoma 2 0.013
Nr3c2 nuclear receptor subfamily 3, group C, member 2 0.012
Smad3 MAD homolog 3 (Drosophila) 0.012
Lrrk2 leucine-rich repeat kinase 2 0.012
Lyz2 lysozyme 2 0.012
Src Rous sarcoma oncogene 0.011
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.011
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.011
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.011
Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 0.011
Scd1 stearoyl-Coenzyme A desaturase 1 0.011
Smad2 MAD homolog 2 (Drosophila) 0.011
Cd36 CD36 antigen 0.011
P2ry2 purinergic receptor P2Y, G-protein coupled 2 0.011
Egfr epidermal growth factor receptor 0.011
Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ppia peptidylprolyl isomerase A (cyclophilin A) 0.395
Sub1 SUB1 homolog (S. cerevisiae) 0.178
Ptp4a2 protein tyrosine phosphatase 4a2 0.143
Arf5 ADP-ribosylation factor 5 0.109
Fkbp1a FK506 binding protein 1a 0.108
Smad3 SMAD family member 3 0.069
Dynll1 dynein light chain LC8-type 1 0.069
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.069
Actr2 ARP2 actin-related protein 2 homolog (yeast) 0.063
Clcn3 chloride channel 3 0.060
Uhmk1 U2AF homology motif (UHM) kinase 1 0.058
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.039
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.036
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.036
Calm1 calmodulin 1 0.032
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.032
Ccl4 chemokine (C-C motif) ligand 4 0.032
Pde5a phosphodiesterase 5A, cGMP-specific 0.031
Ube2m ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 0.031
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.031
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.030
Mlf2 myeloid leukemia factor 2 0.026
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.025
Mapk3 mitogen activated protein kinase 3 0.025
Cdon Cdon homolog (mouse) 0.025
Tlr4 toll-like receptor 4 0.025
Calm2 calmodulin 2 0.024
Gtf2a1 general transcription factor IIA, 1 0.023
Kitlg KIT ligand 0.023
Nrp2 neuropilin 2 0.022
Ptms parathymosin 0.022
Tuba4a tubulin, alpha 4A 0.021
Prrx1 paired related homeobox 1 0.020
Fgfr1 Fibroblast growth factor receptor 1 0.019
Atp6v1d ATPase, H+ transporting, lysosomal V1 subunit D 0.019
Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.019
Elf1 E74-like factor 1 0.019
Actn4 actinin alpha 4 0.019
Efhd2 EF-hand domain family, member D2 0.019
Cd28 Cd28 molecule 0.017
Lst1 leukocyte specific transcript 1 0.017
Foxe3 forkhead box E3 0.017
Atxn3 ataxin 3 0.017
Met met proto-oncogene 0.017
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.017
Il8ra interleukin 8 receptor, alpha 0.017
Mmd monocyte to macrophage differentiation-associated 0.017
Tmed5 transmembrane emp24 protein transport domain containing 5 0.016
Insr insulin receptor 0.016
Mcpt1 mast cell protease 1 0.016
Kcnk1 potassium channel, subfamily K, member 1 0.016
Map2k2 mitogen activated protein kinase kinase 2 0.016
Eef2 eukaryotic translation elongation factor 2 0.016
Ccnd3 cyclin D3 0.015
Acvr1c activin A receptor, type IC 0.015
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.015
Ivl involucrin 0.015
Klf6 Kruppel-like factor 6 0.015
Ube2d4 ubiquitin-conjugating enzyme E2D 4 0.015
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.014
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.014
Myo9a myosin IXA 0.014
Plcg2 phospholipase C, gamma 2 0.014
Ccl3 chemokine (C-C motif) ligand 3 0.013
Cd55 Cd55 molecule 0.013
Nlrp6 NLR family, pyrin domain containing 6 0.013
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.013
Cma1 chymase 1, mast cell 0.013
Stc1 stanniocalcin 1 0.013
Hapln1 hyaluronan and proteoglycan link protein 1 0.013
Wsb2 WD repeat and SOCS box-containing 2 0.013
Cntn1 contactin 1 0.013
Strn3 striatin, calmodulin binding protein 3 0.012
Clcn7 chloride channel 7 0.012
Rin1 Ras and Rab interactor 1 0.012
LOC100360174 lysM and putative peptidoglycan-binding domain-containing protein 3-like 0.012
Nmu neuromedin U 0.012
Mertk c-mer proto-oncogene tyrosine kinase 0.012
Rab4a RAB4A, member RAS oncogene family 0.012
Itgad integrin, alpha D 0.011
Irf1 interferon regulatory factor 1 0.011
Ccnd2 cyclin D2 0.011
Slc22a2 solute carrier family 22 (organic cation transporter), member 2 0.011
Ergic2 ERGIC and golgi 2 0.011
Maoa monoamine oxidase A 0.011
Rab1b RAB1B, member RAS oncogene family 0.011
Rassf9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 0.011
Stmn1 stathmin 1 0.011
Stat3 signal transducer and activator of transcription 3 0.011
Akt3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) 0.011
Prss35 protease, serine, 35 0.011
Wdr7 WD repeat domain 7 0.011
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.011
Aqp3 aquaporin 3 0.011
Tec tec protein tyrosine kinase 0.011
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.011
Sirpa signal-regulatory protein alpha 0.011
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.011
Tsc22d1 TSC22 domain family, member 1 0.011
Hist1h2ba histone cluster 1, H2ba 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism