The network for 'positive regulation of interferon gamma production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of interferon gamma production

Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
IL1R1 interleukin 1 receptor, type I 0.918
HLA-B major histocompatibility complex, class I, B 0.909
HLA-F major histocompatibility complex, class I, F 0.873
B2M beta-2-microglobulin 0.866
HLA-G major histocompatibility complex, class I, G 0.858
BTN3A2 butyrophilin, subfamily 3, member A2 0.847
BTN3A3 butyrophilin, subfamily 3, member A3 0.836
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.791
HLA-A major histocompatibility complex, class I, A 0.771
SYK spleen tyrosine kinase 0.756
HLA-C major histocompatibility complex, class I, C 0.742
BTN3A1 butyrophilin, subfamily 3, member A1 0.711
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.692
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.681
HCK hemopoietic cell kinase 0.632
LCK lymphocyte-specific protein tyrosine kinase 0.595
HLA-E major histocompatibility complex, class I, E 0.592
MYD88 myeloid differentiation primary response gene (88) 0.497
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.421
IL23A interleukin 23, alpha subunit p19 0.415
NLRC4 NLR family, CARD domain containing 4 0.329
BLNK B-cell linker 0.306
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.293
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.293
TRAF1 TNF receptor-associated factor 1 0.292
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.270
CD80 CD80 molecule 0.267
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.252
SPRR2A small proline-rich protein 2A 0.252
DDIT3 DNA-damage-inducible transcript 3 0.248
CD247 CD247 molecule 0.248
SOCS3 suppressor of cytokine signaling 3 0.231
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.228
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.204
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.201
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.199
SH3KBP1 SH3-domain kinase binding protein 1 0.167
PTPRC protein tyrosine phosphatase, receptor type, C 0.161
IL1RAP interleukin 1 receptor accessory protein 0.153
PRKCQ protein kinase C, theta 0.149
BTN2A2 butyrophilin, subfamily 2, member A2 0.139
TLR2 toll-like receptor 2 0.135
MEFV Mediterranean fever 0.130
STAT4 signal transducer and activator of transcription 4 0.116
ICAM1 intercellular adhesion molecule 1 0.108
RIN1 Ras and Rab interactor 1 0.103
GRB2 growth factor receptor-bound protein 2 0.102
TICAM2 toll-like receptor adaptor molecule 2 0.101
CD48 CD48 molecule 0.096
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.090
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.087
FYN FYN oncogene related to SRC, FGR, YES 0.083
ITK IL2-inducible T-cell kinase 0.078
NCK1 NCK adaptor protein 1 0.077
VAV1 vav 1 guanine nucleotide exchange factor 0.076
TRADD TNFRSF1A-associated via death domain 0.074
SLA Src-like-adaptor 0.073
LY86 lymphocyte antigen 86 0.072
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.068
IL1RN interleukin 1 receptor antagonist 0.067
HCP5 HLA complex P5 0.066
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.063
BTK Bruton agammaglobulinemia tyrosine kinase 0.063
IL1R2 interleukin 1 receptor, type II 0.061
BIRC3 baculoviral IAP repeat containing 3 0.060
BTN2A1 butyrophilin, subfamily 2, member A1 0.058
TRAF3IP3 TRAF3 interacting protein 3 0.058
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.058
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.056
STAT1 signal transducer and activator of transcription 1, 91kDa 0.055
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.051
IL1B interleukin 1, beta 0.050
LAT linker for activation of T cells 0.047
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.046
JAK1 Janus kinase 1 0.046
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.045
HLA-DRA major histocompatibility complex, class II, DR alpha 0.045
LY96 lymphocyte antigen 96 0.044
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.041
PLCG1 phospholipase C, gamma 1 0.040
IRF1 interferon regulatory factor 1 0.040
CD86 CD86 molecule 0.040
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.038
LIF leukemia inhibitory factor (cholinergic differentiation factor) 0.038
FGL2 fibrinogen-like 2 0.037
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.035
IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) 0.034
NDP Norrie disease (pseudoglioma) 0.034
TLR1 toll-like receptor 1 0.034
JAK2 Janus kinase 2 0.033
WNT5A wingless-type MMTV integration site family, member 5A 0.033
CXCR4 chemokine (C-X-C motif) receptor 4 0.033
PDCD6IP programmed cell death 6 interacting protein 0.033
WIPF1 WAS/WASL interacting protein family, member 1 0.032
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.032
HLA-DMA major histocompatibility complex, class II, DM alpha 0.031
GARS glycyl-tRNA synthetase 0.031
IL10RA interleukin 10 receptor, alpha 0.031
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.030
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.983
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.954
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.934
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.906
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.892
Myd88 myeloid differentiation primary response gene 88 0.886
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.843
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.784
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.778
Icos inducible T-cell co-stimulator 0.776
Ccr2 chemokine (C-C motif) receptor 2 0.753
Lta lymphotoxin A 0.707
Fasl Fas ligand (TNF superfamily, member 6) 0.694
Ifng interferon gamma 0.683
Tlr4 toll-like receptor 4 0.560
Il18rap interleukin 18 receptor accessory protein 0.557
Cd40 CD40 antigen 0.533
Socs1 suppressor of cytokine signaling 1 0.526
Gzma granzyme A 0.523
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.488
Pax2 paired box gene 2 0.455
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.443
Ltb lymphotoxin B 0.436
Stat3 signal transducer and activator of transcription 3 0.423
Prf1 perforin 1 (pore forming protein) 0.421
Cxcr3 chemokine (C-X-C motif) receptor 3 0.419
Xcl1 chemokine (C motif) ligand 1 0.415
Ncr1 natural cytotoxicity triggering receptor 1 0.414
Ikzf1 IKAROS family zinc finger 1 0.412
Il2ra interleukin 2 receptor, alpha chain 0.412
Il10 interleukin 10 0.412
Gli3 GLI-Kruppel family member GLI3 0.403
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.400
Cxcr5 chemokine (C-X-C motif) receptor 5 0.391
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.389
Casp1 caspase 1 0.381
Nlrp3 NLR family, pyrin domain containing 3 0.381
Ccl4 chemokine (C-C motif) ligand 4 0.380
Il18r1 interleukin 18 receptor 1 0.368
Ccl2 chemokine (C-C motif) ligand 2 0.361
Gzmk granzyme K 0.360
Il6 interleukin 6 0.358
Emx2 empty spiracles homolog 2 (Drosophila) 0.352
Gzmb granzyme B 0.341
Gpr132 G protein-coupled receptor 132 0.338
Il4 interleukin 4 0.333
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.322
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.316
Ccr7 chemokine (C-C motif) receptor 7 0.307
Fas Fas (TNF receptor superfamily member 6) 0.296
Il2rb interleukin 2 receptor, beta chain 0.294
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.284
Sh2d2a SH2 domain protein 2A 0.270
Lhx1 LIM homeobox protein 1 0.266
Rel reticuloendotheliosis oncogene 0.264
Il27ra interleukin 27 receptor, alpha 0.263
Irf1 interferon regulatory factor 1 0.256
Casp8 caspase 8 0.252
Itk IL2-inducible T-cell kinase 0.250
Otx2 orthodenticle homolog 2 (Drosophila) 0.240
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.236
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.235
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.232
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.230
Cd44 CD44 antigen 0.230
Ctsw cathepsin W 0.224
Ccr6 chemokine (C-C motif) receptor 6 0.224
Il10ra interleukin 10 receptor, alpha 0.218
Pou2af1 POU domain, class 2, associating factor 1 0.204
Ccl3 chemokine (C-C motif) ligand 3 0.194
Bcl3 B-cell leukemia/lymphoma 3 0.189
Il1b interleukin 1 beta 0.185
Pyhin1 pyrin and HIN domain family, member 1 0.182
Cd160 CD160 antigen 0.180
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.179
Xcr1 chemokine (C motif) receptor 1 0.174
Cd7 CD7 antigen 0.159
H2-Q7 histocompatibility 2, Q region locus 7 0.158
Cd96 CD96 antigen 0.157
Cd19 CD19 antigen 0.157
Il1a interleukin 1 alpha 0.156
Il1r1 interleukin 1 receptor, type I 0.155
Ccr5 chemokine (C-C motif) receptor 5 0.154
Il12b interleukin 12b 0.153
Rhoh ras homolog gene family, member H 0.142
Cxcl13 chemokine (C-X-C motif) ligand 13 0.140
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.140
Itgal integrin alpha L 0.139
Nos2 nitric oxide synthase 2, inducible 0.135
B2m beta-2 microglobulin 0.132
Cd180 CD180 antigen 0.131
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.127
En1 engrailed 1 0.125
Ifnar1 interferon (alpha and beta) receptor 1 0.122
H2-M9 histocompatibility 2, M region locus 9 0.121
Cd6 CD6 antigen 0.120
Flt3 FMS-like tyrosine kinase 3 0.118
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.118
Blk B lymphoid kinase 0.116
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hspa8 heat shock protein 8 0.105
Il1a interleukin 1 alpha 0.061
Igsf6 immunoglobulin superfamily, member 6 0.060
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.052
Hsph1 heat shock 105/110 protein 1 0.048
Il6 interleukin 6 0.046
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.045
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.044
Ccl4 chemokine (C-C motif) ligand 4 0.042
Hspe1 heat shock protein 1 (chaperonin 10) 0.035
Cxcl10 chemokine (C-X-C motif) ligand 10 0.034
Ccl3 chemokine (C-C motif) ligand 3 0.031
Slc25a5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.030
Cycs cytochrome c, somatic 0.028
Cd86 CD86 molecule 0.028
Sell selectin L 0.028
RT1-A3 RT1 class I, locus A3 0.026
LOC100364500 RT1 class I, locus CE11-like 0.026
Cd247 Cd247 molecule 0.026
C5ar1 complement component 5a receptor 1 0.026
LOC687856 similar to Myeloid cell surface antigen CD33 precursor (Siglec-3) 0.025
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.025
Ccr1 chemokine (C-C motif) receptor 1 0.024
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.023
Pgk1 phosphoglycerate kinase 1 0.022
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.022
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.021
Epor erythropoietin receptor 0.019
Ccl5 chemokine (C-C motif) ligand 5 0.019
Jak1 Janus kinase 1 0.019
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.018
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.018
Vegfa vascular endothelial growth factor A 0.017
Clec9a C-type lectin domain family 9, member a 0.017
Cxcl2 chemokine (C-X-C motif) ligand 2 0.017
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.016
C1qbp complement component 1, q subcomponent binding protein 0.016
RT1-EC2 RT1 class Ib, locus EC2 0.016
Mmp8 matrix metallopeptidase 8 0.015
Casp12 caspase 12 0.015
Hoxb7 homeo box B7 0.015
Vcan versican 0.015
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.015
Il1rl1 interleukin 1 receptor-like 1 0.015
LOC300024 similar to Ly6-B antigen gene 0.014
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.014
Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 0.014
Cd22 CD22 molecule 0.014
Tcrb T-cell receptor beta chain 0.013
Ybx1 Y box binding protein 1 0.013
Il1b interleukin 1 beta 0.013
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.013
Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.013
Vom1r90 vomeronasal 1 receptor 90 0.013
Hspa9 heat shock protein 9 0.013
Tlr4 toll-like receptor 4 0.013
Ccr5 chemokine (C-C motif) receptor 5 0.013
Trhr thyrotropin releasing hormone receptor 0.013
Casp1 caspase 1 0.013
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.012
Prl8a7 prolactin family 8, subfamily a, member 7 0.012
Ccl7 chemokine (C-C motif) ligand 7 0.012
St13 suppression of tumorigenicity 13 0.012
Mmp12 matrix metallopeptidase 12 0.012
Nkg7 natural killer cell group 7 sequence 0.012
Trh thyrotropin releasing hormone 0.012
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.012
Ccl2 chemokine (C-C motif) ligand 2 0.012
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.012
Hoxa2 homeo box A2 0.011
RGD1559588 similar to cell surface receptor FDFACT 0.011
Cd2 Cd2 molecule 0.011
Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 0.011
Cysltr1 cysteinyl leukotriene receptor 1 0.011
Il7 interleukin 7 0.011
Prl8a9 prolactin family 8, subfamily a, member 9 0.011
Kcnk13 potassium channel, subfamily K, member 13 0.011
Retnla resistin like alpha 0.011
P2ry14 purinergic receptor P2Y, G-protein coupled, 14 0.011
Ifng interferon gamma 0.011
Pate4 prostate and testis expressed 4 0.011
Cxcl9 chemokine (C-X-C motif) ligand 9 0.011
Arl5c ADP-ribosylation factor-like 5C 0.011
Dok2 docking protein 2 0.010
Spam1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 0.010
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.010
Il2rg interleukin 2 receptor, gamma 0.010
Sod2 superoxide dismutase 2, mitochondrial 0.010
Ciita class II, major histocompatibility complex, transactivator 0.010
Il1r1 interleukin 1 receptor, type I 0.010
Psbpc2 prostatic steroid-binding protein C2 0.010
Gpr114 G protein-coupled receptor 114 0.010
Etf1 eukaryotic translation termination factor 1 0.010
Olr1082 olfactory receptor 1082 0.010
Otp orthopedia homeobox 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism