The network for 'signal transduction by p53 class mediator' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal transduction by p53 class mediator

An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein.

Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 0.982
TP53 tumor protein p53 0.977
BRCA1 breast cancer 1, early onset 0.968
EP300 E1A binding protein p300 0.951
RB1 retinoblastoma 1 0.926
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.829
XIAP X-linked inhibitor of apoptosis 0.793
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.754
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.750
BAX BCL2-associated X protein 0.647
HIPK2 homeodomain interacting protein kinase 2 0.582
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.575
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.553
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.510
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.475
SIRT1 sirtuin 1 0.403
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.398
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.384
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.356
ESR1 estrogen receptor 1 0.349
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.328
MAPK14 mitogen-activated protein kinase 14 0.315
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.313
NBN nibrin 0.284
MAPK1 mitogen-activated protein kinase 1 0.277
TNIP1 TNFAIP3 interacting protein 1 0.265
WRN Werner syndrome, RecQ helicase-like 0.251
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.251
HDAC1 histone deacetylase 1 0.244
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.226
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.218
ATM ataxia telangiectasia mutated 0.217
PARP1 poly (ADP-ribose) polymerase 1 0.214
SETD7 SET domain containing (lysine methyltransferase) 7 0.210
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.203
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.198
DAXX death-domain associated protein 0.190
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.182
NLRC4 NLR family, CARD domain containing 4 0.182
BCAS2 breast carcinoma amplified sequence 2 0.181
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.177
CCND3 cyclin D3 0.175
TWIST1 twist homolog 1 (Drosophila) 0.173
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.171
CTAG1B cancer/testis antigen 1B 0.171
RPS27 ribosomal protein S27 0.158
CDK2 cyclin-dependent kinase 2 0.157
PML promyelocytic leukemia 0.141
PAX3 paired box 3 0.140
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.138
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.136
POU3F2 POU class 3 homeobox 2 0.135
CREBBP CREB binding protein 0.134
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.130
NAP1L5 nucleosome assembly protein 1-like 5 0.127
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.127
DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0.127
RIN1 Ras and Rab interactor 1 0.126
MAGEA3 melanoma antigen family A, 3 0.124
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.123
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.118
PLK1 polo-like kinase 1 0.114
RUNX1 runt-related transcription factor 1 0.114
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 0.114
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.114
IER3 immediate early response 3 0.111
APAF1 apoptotic peptidase activating factor 1 0.107
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.106
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.105
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.104
STX5 syntaxin 5 0.104
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.098
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.097
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.094
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.093
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.092
CDT1 chromatin licensing and DNA replication factor 1 0.092
GSK3B glycogen synthase kinase 3 beta 0.092
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.090
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.088
FAS Fas (TNF receptor superfamily, member 6) 0.087
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.085
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.085
TEKT4 tektin 4 0.083
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.081
SETD8 SET domain containing (lysine methyltransferase) 8 0.080
MSN moesin 0.080
KAT2B K(lysine) acetyltransferase 2B 0.077
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.076
E2F1 E2F transcription factor 1 0.073
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.073
CFLAR CASP8 and FADD-like apoptosis regulator 0.073
MSH6 mutS homolog 6 (E. coli) 0.070
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.069
LNX1 ligand of numb-protein X 1 0.067
EGR1 early growth response 1 0.066
TNIP2 TNFAIP3 interacting protein 2 0.066
EID2 EP300 interacting inhibitor of differentiation 2 0.065
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.064
LIMD1 LIM domains containing 1 0.064
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
spc24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.094
zgc:65861 zgc:65861 0.089
gins2 GINS complex subunit 2 0.082
tp53 tumor protein p53 0.078
nolc1 nucleolar and coiled-body phosphoprotein 1 0.069
krt4 keratin 4 0.067
nrp2b neuropilin 2b 0.061
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.060
pola2 polymerase (DNA directed), alpha 2 0.056
surf6 surfeit 6 0.050
ccng1 cyclin G1 0.047
prmt1 protein arginine methyltransferase 1 0.044
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.044
LOC100536647 disintegrin and metalloproteinase domain-containing protein 10-like 0.043
ppp4ca protein phosphatase 4 (formerly X), catalytic subunit a 0.043
si:dkeyp-50f5.1 si:dkeyp-50f5.1 0.042
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.042
irf6 interferon regulatory factor 6 0.040
wls wntless homolog (Drosophila) 0.038
zgc:73328 zgc:73328 0.038
smc3 structural maintenance of chromosomes 3 0.038
thoc3 THO complex 3 0.037
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.036
chek1 CHK1 checkpoint homolog (S. pombe) 0.036
fsta follistatin a 0.035
sema3aa semaphorin 3aa 0.034
hug HuG 0.033
rnf7 ring finger protein 7 0.033
bcl2l1 bcl2-like 1 0.033
rp2 retinitis pigmentosa 2 (X-linked recessive) 0.031
eaf2 ELL associated factor 2 0.030
brip1 BRCA1 interacting protein C-terminal helicase 1 0.030
dnajb12 DnaJ (Hsp40) homolog, subfamily B, member 12 0.030
zgc:101661 zgc:101661 0.029
ogt.2 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 2 0.029
card9 caspase recruitment domain family, member 9 0.028
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.028
lin7c lin-7 homolog C (C. elegans) 0.027
mif macrophage migration inhibitory factor 0.026
pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.026
celf1 cugbp, Elav-like family member 1 0.025
znf703 zinc finger protein 703 0.025
rnf144ab ring finger protein 144ab 0.025
cdc45 CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.024
odc1 ornithine decarboxylase 1 0.024
sf3b1 splicing factor 3b, subunit 1 0.024
uspl1 ubiquitin specific peptidase like 1 0.024
vax2 ventral anterior homeobox 2 0.024
gsc goosecoid 0.024
si:dkey-77a20.7 si:dkey-77a20.7 0.023
vsx2 visual system homeobox 2 0.023
ccnl1 cyclin L1 0.022
fanci Fanconi anemia, complementation group I 0.022
hif1an hypoxia-inducible factor 1, alpha subunit inhibitor 0.022
pld1a phospholipase D1a 0.022
foxi2 forkhead box I2 0.021
rps6kal ribosomal protein S6 kinase, like 0.021
rbm39a RNA binding motif protein 39a 0.021
prmt5 protein arginine methyltransferase 5 0.021
timm13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.021
zgc:111944 zgc:111944 0.021
zgc:92321 zgc:92321 0.021
kif14 kinesin family member 14 0.021
cdh1 cadherin 1, epithelial 0.020
ankrd13c ankyrin repeat domain 13C 0.020
chic2 cysteine-rich hydrophobic domain 2 0.020
eif2s1l eukaryotic translation initiation factor 2, subunit 1 alpha, like 0.020
sass6 spindle assembly 6 homolog (C. elegans) 0.019
lsm1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.019
tnfaip1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.019
xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.019
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.019
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.019
orc3 origin recognition complex, subunit 3 0.018
ube2q2 ubiquitin-conjugating enzyme E2Q family member 2 0.018
calm3b calmodulin 3b (phosphorylase kinase, delta) 0.018
nucks1a nuclear casein kinase and cyclin-dependent kinase substrate 1a 0.018
scrt1b scratch homolog 1, zinc finger protein b (Drosophila) 0.018
bbc3 BCL2 binding component 3 0.018
srsf6b serine/arginine-rich splicing factor 6b 0.018
igf2a insulin-like growth factor 2a 0.018
pax8 paired box gene 8 0.017
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.017
rps12 ribosomal protein S12 0.017
zff9 zinc finger protein 9 0.017
esco2 establishment of cohesion 1 homolog 2 0.017
eya2 eyes absent homolog 2 (Drosophila) 0.017
tfe3b transcription factor binding to IGHM enhancer 3b 0.017
maea macrophage erythroblast attacher 0.016
hnrnpa0l heterogeneous nuclear ribonucleoprotein A0, like 0.016
arhgap11a Rho GTPase activating protein 11A 0.016
aida axin interaction partner and dorsalization antagonist 0.016
zgc:114188 zgc:114188 0.016
notch2 notch homolog 2 0.016
ccz1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.016
LOC555279 hypothetical LOC555279 0.016
eif1b eukaryotic translation initiation factor 1B 0.016
acss2 acyl-CoA synthetase short-chain family member 2 0.016
p2rx3b purinergic receptor P2X, ligand-gated ion channel, 3b 0.016
prdm8b PR domain containing 8b 0.016
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Drosophila melanogaster
Name Description Probability Func Analog Organism
yki yorkie 0.311
RASSF8 CG5053 gene product from transcript CG5053-RA 0.111
scyl scylla 0.109
p53 CG33336 gene product from transcript CG33336-RB 0.098
pan pangolin 0.080
Dcp-1 Death caspase-1 0.049
TORC CG6064 gene product from transcript CG6064-RA 0.047
fs(1)h female sterile (1) homeotic 0.036
tefu telomere fusion 0.032
grim CG4345 gene product from transcript CG4345-RA 0.029
Smr Smrter 0.028
wee CG4488 gene product from transcript CG4488-RA 0.024
imd immune deficiency 0.024
klu klumpfuss 0.022
18w 18 wheeler 0.021
heph hephaestus 0.020
lid little imaginal discs 0.020
CG32685 CG32685 gene product from transcript CG32685-RC 0.019
CG33936 CG33936 gene product from transcript CG33936-RB 0.019
crol crooked legs 0.018
Pabp2 CG2163 gene product from transcript CG2163-RA 0.017
CtBP C-terminal Binding Protein 0.017
key kenny 0.017
da daughterless 0.016
CG9821 CG9821 gene product from transcript CG9821-RB 0.016
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.015
babo baboon 0.015
Ten-m Tenascin major 0.014
Gug Grunge 0.013
Hcf Host cell factor 0.013
Sir2 CG5216 gene product from transcript CG5216-RA 0.012
CkIalpha Casein kinase Ialpha 0.012
dup double parked 0.012
Rel Relish 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Mdm2 transformed mouse 3T3 cell double minute 2 1.000
Pten phosphatase and tensin homolog 0.997
Rb1 retinoblastoma 1 0.995
Apc adenomatosis polyposis coli 0.992
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.990
Brca1 breast cancer 1 0.964
Mdm4 transformed mouse 3T3 cell double minute 4 0.958
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.954
Arid1b AT rich interactive domain 1B (SWI-like) 0.932
Ren1 renin 1 structural 0.850
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.841
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.831
Brca2 breast cancer 2 0.829
Bcl2 B-cell leukemia/lymphoma 2 0.823
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.817
Ptgs2 prostaglandin-endoperoxide synthase 2 0.795
Skil SKI-like 0.773
Vasp vasodilator-stimulated phosphoprotein 0.753
E2f1 E2F transcription factor 1 0.691
Hprt hypoxanthine guanine phosphoribosyl transferase 0.688
Bax BCL2-associated X protein 0.679
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.672
Cyld cylindromatosis (turban tumor syndrome) 0.618
Cdk4 cyclin-dependent kinase 4 0.583
Msh2 mutS homolog 2 (E. coli) 0.561
Braf Braf transforming gene 0.558
Kit kit oncogene 0.554
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.526
Smad3 MAD homolog 3 (Drosophila) 0.489
Smad4 MAD homolog 4 (Drosophila) 0.478
H2-Aa histocompatibility 2, class II antigen A, alpha 0.455
Trp73 transformation related protein 73 0.455
Kdm2b lysine (K)-specific demethylase 2B 0.444
Vhl von Hippel-Lindau tumor suppressor 0.419
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.414
Cbx5 chromobox homolog 5 (Drosophila HP1a) 0.414
Lepr leptin receptor 0.407
Ccnd1 cyclin D1 0.404
Agtr1a angiotensin II receptor, type 1a 0.392
Rnf2 ring finger protein 2 0.355
Daxx Fas death domain-associated protein 0.353
Ptch1 patched homolog 1 0.345
Nos2 nitric oxide synthase 2, inducible 0.331
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.328
Ep300 E1A binding protein p300 0.325
Bcl2l1 BCL2-like 1 0.318
Mybl2 myeloblastosis oncogene-like 2 0.316
Tgfb1 transforming growth factor, beta 1 0.316
Thbs1 thrombospondin 1 0.315
Ret ret proto-oncogene 0.314
Atm ataxia telangiectasia mutated homolog (human) 0.313
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.309
Nbn nibrin 0.302
Eda ectodysplasin-A 0.298
Wt1 Wilms tumor 1 homolog 0.293
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.261
Cd40 CD40 antigen 0.243
Edaradd EDAR (ectodysplasin-A receptor)-associated death domain 0.243
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.233
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.223
Kitl kit ligand 0.220
Gtse1 G two S phase expressed protein 1 0.219
Rxra retinoid X receptor alpha 0.206
Smc1a structural maintenance of chromosomes 1A 0.205
Hdac1 histone deacetylase 1 0.203
Evl Ena-vasodilator stimulated phosphoprotein 0.202
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.201
En1 engrailed 1 0.186
Enah enabled homolog (Drosophila) 0.184
Cux1 cut-like homeobox 1 0.168
Icam1 intercellular adhesion molecule 1 0.160
Otx1 orthodenticle homolog 1 (Drosophila) 0.153
Zeb1 zinc finger E-box binding homeobox 1 0.152
Dhx15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 0.148
Prrx1 paired related homeobox 1 0.145
Arid4b AT rich interactive domain 4B (RBP1-like) 0.137
Myc myelocytomatosis oncogene 0.134
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.133
Rybp RING1 and YY1 binding protein 0.126
Ar androgen receptor 0.120
Prmt1 protein arginine N-methyltransferase 1 0.117
Mndal myeloid nuclear differentiation antigen like 0.115
Smn1 survival motor neuron 1 0.114
Dok1 docking protein 1 0.113
Mecp2 methyl CpG binding protein 2 0.109
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.109
Rora RAR-related orphan receptor alpha 0.108
Mmp9 matrix metallopeptidase 9 0.106
Stat3 signal transducer and activator of transcription 3 0.104
S1pr2 sphingosine-1-phosphate receptor 2 0.101
Tfdp2 transcription factor Dp 2 0.100
Huwe1 HECT, UBA and WWE domain containing 1 0.100
Ppard peroxisome proliferator activator receptor delta 0.100
Col1a1 collagen, type I, alpha 1 0.098
S1pr3 sphingosine-1-phosphate receptor 3 0.097
Tgfbr2 transforming growth factor, beta receptor II 0.097
Cct6a chaperonin containing Tcp1, subunit 6a (zeta) 0.096
Ctnnb1 catenin (cadherin associated protein), beta 1 0.095
Wdr5 WD repeat domain 5 0.095
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism