The network for 'positive regulation of phosphatidylinositol 3 kinase signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of phosphatidylinositol 3 kinase signaling

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.

Homo sapiens
Name Description Probability Func Analog Organism
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
GRB2 growth factor receptor-bound protein 2 1.000
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
EGFR epidermal growth factor receptor 1.000
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.000
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.000
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 1.000
FYN FYN oncogene related to SRC, FGR, YES 1.000
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 1.000
SH3KBP1 SH3-domain kinase binding protein 1 0.998
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.997
LAT linker for activation of T cells 0.993
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.992
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.991
GAB1 GRB2-associated binding protein 1 0.990
PLCG1 phospholipase C, gamma 1 0.987
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.985
MET met proto-oncogene (hepatocyte growth factor receptor) 0.985
SYK spleen tyrosine kinase 0.982
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.979
TEK TEK tyrosine kinase, endothelial 0.972
WIPF1 WAS/WASL interacting protein family, member 1 0.964
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.961
VEGFA vascular endothelial growth factor A 0.949
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.947
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.944
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.936
CCR5 chemokine (C-C motif) receptor 5 0.930
VAV1 vav 1 guanine nucleotide exchange factor 0.918
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.915
LCK lymphocyte-specific protein tyrosine kinase 0.909
SH3BP2 SH3-domain binding protein 2 0.907
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.899
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.895
CCL4 chemokine (C-C motif) ligand 4 0.885
GH1 growth hormone 1 0.879
NRP1 neuropilin 1 0.837
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.832
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.826
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.817
PDCD6IP programmed cell death 6 interacting protein 0.690
SH2D4A SH2 domain containing 4A 0.669
PTPRC protein tyrosine phosphatase, receptor type, C 0.661
RND1 Rho family GTPase 1 0.653
BLNK B-cell linker 0.646
HCK hemopoietic cell kinase 0.640
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.629
CCL8 chemokine (C-C motif) ligand 8 0.594
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.570
CAV1 caveolin 1, caveolae protein, 22kDa 0.537
PECAM1 platelet/endothelial cell adhesion molecule 0.510
IGF1R insulin-like growth factor 1 receptor 0.506
IRS1 insulin receptor substrate 1 0.490
CXCL9 chemokine (C-X-C motif) ligand 9 0.471
IL1B interleukin 1, beta 0.450
RNF11 ring finger protein 11 0.444
ANGPT2 angiopoietin 2 0.417
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.410
TGFB3 transforming growth factor, beta 3 0.395
PTPRB protein tyrosine phosphatase, receptor type, B 0.391
RXRA retinoid X receptor, alpha 0.388
MED28 mediator complex subunit 28 0.376
CSH2 chorionic somatomammotropin hormone 2 0.373
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.338
HCLS1 hematopoietic cell-specific Lyn substrate 1 0.327
CD2AP CD2-associated protein 0.324
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.316
SOS1 son of sevenless homolog 1 (Drosophila) 0.313
DARC Duffy blood group, chemokine receptor 0.311
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.303
CXCL3 chemokine (C-X-C motif) ligand 3 0.298
SNX9 sorting nexin 9 0.273
IL6 interleukin 6 (interferon, beta 2) 0.268
INSR insulin receptor 0.265
CCR1 chemokine (C-C motif) receptor 1 0.261
FGFR1 fibroblast growth factor receptor 1 0.250
GRAP2 GRB2-related adaptor protein 2 0.249
CXCL2 chemokine (C-X-C motif) ligand 2 0.220
ANGPT1 angiopoietin 1 0.219
CSHL1 chorionic somatomammotropin hormone-like 1 0.218
IL8 interleukin 8 0.207
GAB2 GRB2-associated binding protein 2 0.202
TGFBR1 transforming growth factor, beta receptor 1 0.202
RICTOR RPTOR independent companion of MTOR, complex 2 0.199
PGF placental growth factor 0.196
PLAUR plasminogen activator, urokinase receptor 0.195
SOCS3 suppressor of cytokine signaling 3 0.194
PTPRJ protein tyrosine phosphatase, receptor type, J 0.194
CCL2 chemokine (C-C motif) ligand 2 0.187
BTK Bruton agammaglobulinemia tyrosine kinase 0.175
CCL5 chemokine (C-C motif) ligand 5 0.163
ZFYVE9 zinc finger, FYVE domain containing 9 0.151
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.147
GRB7 growth factor receptor-bound protein 7 0.146
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.146
CCR7 chemokine (C-C motif) receptor 7 0.144
IDE insulin-degrading enzyme 0.144
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.140
STAT5A signal transducer and activator of transcription 5A 0.134
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Nos3 nitric oxide synthase 3, endothelial cell 0.966
Kdr kinase insert domain protein receptor 0.737
Tgfb1 transforming growth factor, beta 1 0.716
Egfr epidermal growth factor receptor 0.648
Grb2 growth factor receptor bound protein 2 0.556
Rxra retinoid X receptor alpha 0.517
Flt4 FMS-like tyrosine kinase 4 0.448
Flt1 FMS-like tyrosine kinase 1 0.433
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.418
Vegfa vascular endothelial growth factor A 0.405
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.401
Nrp1 neuropilin 1 0.395
Lepr leptin receptor 0.382
Nf1 neurofibromatosis 1 0.320
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.309
Grb10 growth factor receptor bound protein 10 0.306
Plcg1 phospholipase C, gamma 1 0.294
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.290
Insr insulin receptor 0.274
Csf1 colony stimulating factor 1 (macrophage) 0.271
Ntf3 neurotrophin 3 0.262
Ret ret proto-oncogene 0.262
Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.257
Fyn Fyn proto-oncogene 0.254
Pten phosphatase and tensin homolog 0.252
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.236
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.229
Inpp5d inositol polyphosphate-5-phosphatase D 0.220
Fgfr2 fibroblast growth factor receptor 2 0.211
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.204
Lep leptin 0.199
Il6st interleukin 6 signal transducer 0.194
Pdgfb platelet derived growth factor, B polypeptide 0.192
Esr1 estrogen receptor 1 (alpha) 0.190
Stat3 signal transducer and activator of transcription 3 0.180
Zeb1 zinc finger E-box binding homeobox 1 0.179
Trp53 transformation related protein 53 0.174
Ephb2 Eph receptor B2 0.165
Meox2 mesenchyme homeobox 2 0.164
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.157
Gata4 GATA binding protein 4 0.140
Nos1 nitric oxide synthase 1, neuronal 0.138
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.131
Lrg1 leucine-rich alpha-2-glycoprotein 1 0.127
Efnb2 ephrin B2 0.126
Cxcl12 chemokine (C-X-C motif) ligand 12 0.118
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.113
Plxna1 plexin A1 0.111
Gata6 GATA binding protein 6 0.110
Hs1bp3 HCLS1 binding protein 3 0.103
Socs1 suppressor of cytokine signaling 1 0.102
Ptprc protein tyrosine phosphatase, receptor type, C 0.100
Fga fibrinogen alpha chain 0.100
Onecut1 one cut domain, family member 1 0.099
Edar ectodysplasin-A receptor 0.096
Vegfc vascular endothelial growth factor C 0.096
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.095
Epas1 endothelial PAS domain protein 1 0.085
Ikzf1 IKAROS family zinc finger 1 0.082
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.080
Cd22 CD22 antigen 0.077
Slamf1 signaling lymphocytic activation molecule family member 1 0.073
Ptprb protein tyrosine phosphatase, receptor type, B 0.071
Fzd4 frizzled homolog 4 (Drosophila) 0.070
Zap70 zeta-chain (TCR) associated protein kinase 0.070
Epha4 Eph receptor A4 0.070
Foxp3 forkhead box P3 0.067
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.065
Fzd8 frizzled homolog 8 (Drosophila) 0.065
Plg plasminogen 0.064
Tcf21 transcription factor 21 0.063
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.062
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.062
Smad3 MAD homolog 3 (Drosophila) 0.061
Bcar1 breast cancer anti-estrogen resistance 1 0.060
Prlr prolactin receptor 0.059
Ednrb endothelin receptor type B 0.059
Ednra endothelin receptor type A 0.058
Pzp pregnancy zone protein 0.058
Hes1 hairy and enhancer of split 1 (Drosophila) 0.057
Cd4 CD4 antigen 0.056
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.055
Adam17 a disintegrin and metallopeptidase domain 17 0.054
Kng1 kininogen 1 0.054
Nos2 nitric oxide synthase 2, inducible 0.053
Stat5a signal transducer and activator of transcription 5A 0.052
Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.051
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.051
Saa3 serum amyloid A 3 0.049
Src Rous sarcoma oncogene 0.049
Ikbkap inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein 0.048
Fgg fibrinogen gamma chain 0.047
Serpina1b serine (or cysteine) preptidase inhibitor, clade A, member 1B 0.046
Irs2 insulin receptor substrate 2 0.045
Bmp4 bone morphogenetic protein 4 0.045
Cbl Casitas B-lineage lymphoma 0.045
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.044
F11 coagulation factor XI 0.044
Hnf4a hepatic nuclear factor 4, alpha 0.043
Itih1 inter-alpha trypsin inhibitor, heavy chain 1 0.043
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Rattus norvegicus
Name Description Probability Func Analog Organism
Il1b interleukin 1 beta 0.057
Cfp complement factor properdin 0.036
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.034
Ralgds ral guanine nucleotide dissociation stimulator 0.032
Fgfr2 fibroblast growth factor receptor 2 0.031
Cd86 CD86 molecule 0.031
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.027
Il2rb interleukin 2 receptor, beta 0.026
Ccl3 chemokine (C-C motif) ligand 3 0.023
Ptafr platelet-activating factor receptor 0.021
Prf1 perforin 1 (pore forming protein) 0.020
Pou2f2 POU class 2 homeobox 2 0.018
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.016
Ddr1 discoidin domain receptor tyrosine kinase 1 0.013
Cd4 Cd4 molecule 0.013
Dbp D site of albumin promoter (albumin D-box) binding protein 0.013
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.013
Prdm2 PR domain containing 2, with ZNF domain 0.013
Ccl2 chemokine (C-C motif) ligand 2 0.013
Ptprc protein tyrosine phosphatase, receptor type, C 0.012
Gria1 glutamate receptor, ionotropic, AMPA 1 0.012
Gfra2 GDNF family receptor alpha 2 0.012
Ifng interferon gamma 0.012
Cd8a CD8a molecule 0.012
Dock8 dedicator of cytokinesis 8 0.011
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.011
Csf1 colony stimulating factor 1 (macrophage) 0.011
Fgf7 fibroblast growth factor 7 0.011
Itpr3 inositol 1,4,5-triphosphate receptor, type 3 0.010
Ccl4 chemokine (C-C motif) ligand 4 0.010
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism