The network for 'necroptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

necroptotic process

A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.999
Casp8 caspase 8 0.999
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.991
Ikbkg inhibitor of kappaB kinase gamma 0.969
Tlr4 toll-like receptor 4 0.952
Traf2 TNF receptor-associated factor 2 0.928
Il10 interleukin 10 0.913
Itch itchy, E3 ubiquitin protein ligase 0.901
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.886
Myd88 myeloid differentiation primary response gene 88 0.835
Ikbkb inhibitor of kappaB kinase beta 0.811
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.771
Fadd Fas (TNFRSF6)-associated via death domain 0.765
Cd40 CD40 antigen 0.754
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.694
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.631
Lta lymphotoxin A 0.609
Traf6 TNF receptor-associated factor 6 0.604
Bcl3 B-cell leukemia/lymphoma 3 0.577
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.554
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.544
Casp1 caspase 1 0.448
Gbp5 guanylate binding protein 5 0.438
Nlrp3 NLR family, pyrin domain containing 3 0.435
Ripk3 receptor-interacting serine-threonine kinase 3 0.418
Sharpin SHANK-associated RH domain interacting protein 0.392
Rnf31 ring finger protein 31 0.353
Hccs holocytochrome c synthetase 0.351
Fas Fas (TNF receptor superfamily member 6) 0.347
Cd19 CD19 antigen 0.326
Pten phosphatase and tensin homolog 0.317
Pycard PYD and CARD domain containing 0.314
Il7 interleukin 7 0.295
Trp53 transformation related protein 53 0.260
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.259
Tox thymocyte selection-associated high mobility group box 0.247
Ifng interferon gamma 0.247
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.237
Il6st interleukin 6 signal transducer 0.230
Il1r1 interleukin 1 receptor, type I 0.227
Aim2 absent in melanoma 2 0.225
Hif1a hypoxia inducible factor 1, alpha subunit 0.218
C1qbp complement component 1, q subcomponent binding protein 0.203
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.179
Stim2 stromal interaction molecule 2 0.159
Casp7 caspase 7 0.154
Igh immunoglobulin heavy chain complex 0.147
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.146
Cyld cylindromatosis (turban tumor syndrome) 0.145
Lrrk2 leucine-rich repeat kinase 2 0.137
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.119
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.106
Tlr2 toll-like receptor 2 0.098
Casp3 caspase 3 0.096
Ahr aryl-hydrocarbon receptor 0.093
Cxcl13 chemokine (C-X-C motif) ligand 13 0.091
Ptgs2 prostaglandin-endoperoxide synthase 2 0.087
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.083
Il6 interleukin 6 0.079
Card11 caspase recruitment domain family, member 11 0.078
Stat3 signal transducer and activator of transcription 3 0.076
2310061I04Rik RIKEN cDNA 2310061I04 gene 0.071
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.070
Sfn stratifin 0.070
Prkcd protein kinase C, delta 0.065
Mlkl mixed lineage kinase domain-like 0.060
Il18 interleukin 18 0.059
Cd44 CD44 antigen 0.059
Emx1 empty spiracles homolog 1 (Drosophila) 0.057
Bcl6 B-cell leukemia/lymphoma 6 0.051
Ly96 lymphocyte antigen 96 0.049
Il15 interleukin 15 0.049
Ticam1 toll-like receptor adaptor molecule 1 0.048
Ctnnb1 catenin (cadherin associated protein), beta 1 0.047
Socs1 suppressor of cytokine signaling 1 0.045
Il1b interleukin 1 beta 0.044
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.044
Rel reticuloendotheliosis oncogene 0.043
Naip2 NLR family, apoptosis inhibitory protein 2 0.042
Icos inducible T-cell co-stimulator 0.041
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.039
Rb1 retinoblastoma 1 0.038
Aldh2 aldehyde dehydrogenase 2, mitochondrial 0.036
Il2ra interleukin 2 receptor, alpha chain 0.036
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.035
Csf1 colony stimulating factor 1 (macrophage) 0.034
Apoe apolipoprotein E 0.034
Ccl2 chemokine (C-C motif) ligand 2 0.033
Ltb lymphotoxin B 0.031
Batf2 basic leucine zipper transcription factor, ATF-like 2 0.030
Irf6 interferon regulatory factor 6 0.030
Pdcd1lg2 programmed cell death 1 ligand 2 0.029
Psen1 presenilin 1 0.028
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.028
Eya2 eyes absent 2 homolog (Drosophila) 0.027
Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.026
Naip6 NLR family, apoptosis inhibitory protein 6 0.025
Gja1 gap junction protein, alpha 1 0.023
Smad5 MAD homolog 5 (Drosophila) 0.022
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.000
BIRC3 baculoviral IAP repeat containing 3 0.998
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.977
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.887
FAS Fas (TNF receptor superfamily, member 6) 0.871
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.869
CFLAR CASP8 and FADD-like apoptosis regulator 0.860
TRAF1 TNF receptor-associated factor 1 0.852
FADD Fas (TNFRSF6)-associated via death domain 0.842
BIRC2 baculoviral IAP repeat containing 2 0.841
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.766
RIPK3 receptor-interacting serine-threonine kinase 3 0.342
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.315
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.272
TRADD TNFRSF1A-associated via death domain 0.187
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.171
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.170
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.121
RNF31 ring finger protein 31 0.115
XIAP X-linked inhibitor of apoptosis 0.114
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.098
SMCR7 Smith-Magenis syndrome chromosome region, candidate 7 0.088
HDAC6 histone deacetylase 6 0.067
FASLG Fas ligand (TNF superfamily, member 6) 0.064
BBS10 Bardet-Biedl syndrome 10 0.063
TRAF3 TNF receptor-associated factor 3 0.056
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.049
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.040
TNIP1 TNFAIP3 interacting protein 1 0.036
SQSTM1 sequestosome 1 0.035
TANK TRAF family member-associated NFKB activator 0.033
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.029
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.028
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.025
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.025
RIPK2 receptor-interacting serine-threonine kinase 2 0.025
BID BH3 interacting domain death agonist 0.024
C1orf93 chromosome 1 open reading frame 93 0.021
TRIM39 tripartite motif containing 39 0.018
NOD2 nucleotide-binding oligomerization domain containing 2 0.018
NOD1 nucleotide-binding oligomerization domain containing 1 0.018
FBXO33 F-box protein 33 0.017
TNF tumor necrosis factor 0.016
EIF4A1 eukaryotic translation initiation factor 4A1 0.016
RIPK4 receptor-interacting serine-threonine kinase 4 0.015
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.014
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.014
USP15 ubiquitin specific peptidase 15 0.014
ZBTB16 zinc finger and BTB domain containing 16 0.013
TRIM25 tripartite motif containing 25 0.012
RPL8 ribosomal protein L8 0.012
THOC3 THO complex 3 0.012
SHARPIN SHANK-associated RH domain interactor 0.012
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.011
BCL10 B-cell CLL/lymphoma 10 0.011
TRIM21 tripartite motif containing 21 0.011
MYH14 myosin, heavy chain 14, non-muscle 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Mcpt8 mast cell protease 8 0.844
Cma1 chymase 1, mast cell 0.319
Cpa3 carboxypeptidase A3, mast cell 0.213
Prf1 perforin 1 (pore forming protein) 0.205
Il1b interleukin 1 beta 0.191
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.180
Ccl5 chemokine (C-C motif) ligand 5 0.158
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.118
Nkg7 natural killer cell group 7 sequence 0.105
Mcpt10 mast cell protease 10 0.092
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.088
Xcl1 chemokine (C motif) ligand 1 0.083
Clca4 chloride channel accessory 4 0.073
LOC100361261 rCG23560-like 0.071
Tmigd1 transmembrane and immunoglobulin domain containing 1 0.066
Mdh1 malate dehydrogenase 1, NAD (soluble) 0.066
Tcrb T-cell receptor beta chain 0.063
Rabac1 Rab acceptor 1 (prenylated) 0.059
Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 0.053
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.051
Mcpt2 mast cell protease 2 0.051
Slfn2 schlafen 2 0.050
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.050
Prm2 protamine 2 0.047
LOC100361706 lambda-chain C1-region-like 0.046
Art2 ADP-ribosyltransferase 2 0.045
Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 0.044
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.042
Aldoa aldolase A, fructose-bisphosphate 0.041
Klrb1a killer cell lectin-like receptor subfamily B, member 1A 0.041
Dnase1l3 deoxyribonuclease 1-like 3 0.041
Spam1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 0.040
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.040
Cd2 Cd2 molecule 0.038
Cd3g CD3 molecule, gamma 0.035
Neurl3 neuralized homolog 3 (Drosophila) 0.035
Oas1b 2-5 oligoadenylate synthetase 1B 0.034
Mcpt9 mast cell protease 9 0.033
Zcchc6 zinc finger, CCHC domain containing 6 0.033
Cd247 Cd247 molecule 0.031
Myd88 myeloid differentiation primary response gene 88 0.029
LOC24906 RoBo-1 0.028
Il6 interleukin 6 0.028
Ubd ubiquitin D 0.028
RGD1564878 similar to natural killer cell protease 7 0.028
RGD1309621 similar to hypothetical protein FLJ10652 0.026
Il2rb interleukin 2 receptor, beta 0.026
Cd52 CD52 antigen 0.026
Cd8a CD8a molecule 0.026
Tmf1 TATA element modulatory factor 1 0.025
Gzma granzyme A 0.025
Lilrb3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.025
Cxcl10 chemokine (C-X-C motif) ligand 10 0.024
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.024
Hck hemopoietic cell kinase 0.024
Bcl10 B-cell CLL/lymphoma 10 0.024
Cela1 chymotrypsin-like elastase family, member 1 0.023
Klrc2 killer cell lectin-like receptor subfamily C, member 2 0.023
Igh-6 immunoglobulin heavy chain 6 0.023
Atp5b ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.022
Hist1h2ba histone cluster 1, H2ba 0.022
Spink1 serine peptidase inhibitor, Kazal type 1 0.022
Tsx testis specific X-linked gene 0.022
Cdh17 cadherin 17 0.022
Lgals4 lectin, galactoside-binding, soluble, 4 0.022
Got1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 0.022
Lmna lamin A 0.022
Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.021
RatNP-3b defensin RatNP-3 precursor 0.021
Nr1h3 nuclear receptor subfamily 1, group H, member 3 0.021
Cox4i1 cytochrome c oxidase subunit IV isoform 1 0.021
Stip1 stress-induced phosphoprotein 1 0.021
Hnf1a HNF1 homeobox A 0.021
Clec9a C-type lectin domain family 9, member a 0.020
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.020
Stat4 signal transducer and activator of transcription 4 0.020
Gzmb granzyme B 0.020
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.020
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.020
Ton tonin 0.020
Pttg1ip pituitary tumor-transforming 1 interacting protein 0.020
Fcnb ficolin B 0.020
Tgm1 transglutaminase 1, K polypeptide 0.019
Tpsab1 tryptase alpha/beta 1 0.019
Klre1 killer cell lectin-like receptor, family E, member 1 0.019
Ear11 eosinophil-associated, ribonuclease A family, member 11 0.019
PVR poliovirus receptor 0.019
Irgm immunity-related GTPase family, M 0.018
Zap70 zeta-chain (TCR) associated protein kinase 0.018
Semg1 semenogelin I 0.018
Gzmm granzyme M (lymphocyte met-ase 1) 0.018
Fabp4 fatty acid binding protein 4, adipocyte 0.018
Trim23 tripartite motif-containing 23 0.018
Gzmc granzyme C 0.018
Arhgef5 Rho guanine nucleotide exchange factor (GEF) 5 0.018
Rnf10 ring finger protein 10 0.018
Gfi1 growth factor independent 1 transcription repressor 0.018
Sh2d2a SH2 domain protein 2A 0.018
Adora2a adenosine A2a receptor 0.018
Tbc1d15 TBC1 domain family, member 15 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism