The network for 'morphogenesis of a polarized epithelium' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

morphogenesis of a polarized epithelium

The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.

Mus musculus
Name Description Probability Func Analog Organism
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Ptk7 PTK7 protein tyrosine kinase 7 0.999
Fgfr2 fibroblast growth factor receptor 2 0.998
Shh sonic hedgehog 0.998
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.997
Pax6 paired box gene 6 0.995
Dlg4 discs, large homolog 4 (Drosophila) 0.994
Gli3 GLI-Kruppel family member GLI3 0.994
Pitx2 paired-like homeodomain transcription factor 2 0.985
App amyloid beta (A4) precursor protein 0.981
Sox11 SRY-box containing gene 11 0.977
Wnt3a wingless-related MMTV integration site 3A 0.975
Foxc1 forkhead box C1 0.967
Itga3 integrin alpha 3 0.961
Bmp4 bone morphogenetic protein 4 0.959
Fzd1 frizzled homolog 1 (Drosophila) 0.954
Gli2 GLI-Kruppel family member GLI2 0.950
Dlg1 discs, large homolog 1 (Drosophila) 0.950
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.948
Vangl1 vang-like 1 (van gogh, Drosophila) 0.939
Egfr epidermal growth factor receptor 0.939
Sfrp2 secreted frizzled-related protein 2 0.931
Otx2 orthodenticle homolog 2 (Drosophila) 0.929
Fgf8 fibroblast growth factor 8 0.929
Sox2 SRY-box containing gene 2 0.929
Lrp6 low density lipoprotein receptor-related protein 6 0.909
Ptk2 PTK2 protein tyrosine kinase 2 0.908
Vegfa vascular endothelial growth factor A 0.883
Emx1 empty spiracles homolog 1 (Drosophila) 0.878
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.878
Gpc3 glypican 3 0.847
Lama5 laminin, alpha 5 0.844
Lmx1b LIM homeobox transcription factor 1 beta 0.828
Tbx2 T-box 2 0.818
Wnt4 wingless-related MMTV integration site 4 0.817
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.813
Axin1 axin 1 0.794
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.788
Wnt5a wingless-related MMTV integration site 5A 0.776
T brachyury 0.773
Pten phosphatase and tensin homolog 0.747
Mecom MDS1 and EVI1 complex locus 0.746
Mks1 Meckel syndrome, type 1 0.744
Gdnf glial cell line derived neurotrophic factor 0.743
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.726
Fgfr1 fibroblast growth factor receptor 1 0.722
Sall4 sal-like 4 (Drosophila) 0.706
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.699
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.680
En1 engrailed 1 0.678
Pou4f3 POU domain, class 4, transcription factor 3 0.663
Pax3 paired box gene 3 0.646
Grb2 growth factor receptor bound protein 2 0.646
Pax2 paired box gene 2 0.643
Foxc2 forkhead box C2 0.622
Hoxd11 homeobox D11 0.605
Neurod1 neurogenic differentiation 1 0.600
Tbx3 T-box 3 0.574
Foxf1a forkhead box F1a 0.572
Bmp7 bone morphogenetic protein 7 0.554
Hoxa1 homeobox A1 0.551
Lef1 lymphoid enhancer binding factor 1 0.549
Sfrp1 secreted frizzled-related protein 1 0.548
Ntf3 neurotrophin 3 0.544
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.530
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.529
Meox2 mesenchyme homeobox 2 0.521
Apc adenomatosis polyposis coli 0.501
Psen1 presenilin 1 0.499
Msx2 homeobox, msh-like 2 0.495
Neurog2 neurogenin 2 0.495
Zfp185 zinc finger protein 185 0.488
Twist2 twist homolog 2 (Drosophila) 0.486
Wnt6 wingless-related MMTV integration site 6 0.484
Fjx1 four jointed box 1 (Drosophila) 0.476
Tgfb2 transforming growth factor, beta 2 0.473
Foxg1 forkhead box G1 0.473
Trp63 transformation related protein 63 0.465
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.457
Tcfap2a transcription factor AP-2, alpha 0.452
Hoxd9 homeobox D9 0.452
Msx1 homeobox, msh-like 1 0.428
Bcl2 B-cell leukemia/lymphoma 2 0.427
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.424
Fzd7 frizzled homolog 7 (Drosophila) 0.419
Fgfr3 fibroblast growth factor receptor 3 0.418
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.416
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.396
Tcfap2c transcription factor AP-2, gamma 0.393
Efs embryonal Fyn-associated substrate 0.391
Lrp2 low density lipoprotein receptor-related protein 2 0.384
Pou3f3 POU domain, class 3, transcription factor 3 0.377
Zic3 zinc finger protein of the cerebellum 3 0.372
Notch2 Notch gene homolog 2 (Drosophila) 0.371
Tcfcp2l1 transcription factor CP2-like 1 0.369
Bdnf brain derived neurotrophic factor 0.367
Lhx1 LIM homeobox protein 1 0.364
Trp73 transformation related protein 73 0.364
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
fz frizzled 1.000
dsh dishevelled 0.999
pk prickle 0.998
ed echinoid 0.997
N Notch 0.997
rok Rho-kinase 0.996
rin rasputin 0.990
hbs hibris 0.980
in inturned 0.978
Vang Van Gogh 0.977
ttk tramtrack 0.976
msn misshapen 0.974
sano serrano 0.961
stan starry night 0.957
cindr CIN85 and CD2AP orthologue 0.954
gish gilgamesh 0.944
Cdc42 CG12530 gene product from transcript CG12530-RA 0.940
fw furrowed 0.938
wdb widerborst 0.935
mwh multiple wing hairs 0.933
Wnt4 Wnt oncogene analog 4 0.928
wg wingless 0.917
frtz fritz 0.906
Rho1 CG8416 gene product from transcript CG8416-RB 0.904
CG32556 CG32556 gene product from transcript CG32556-RB 0.898
scrib scribbled 0.894
Rac1 CG2248 gene product from transcript CG2248-RA 0.883
ft fat 0.880
CG42251 CG42251 gene product from transcript CG42251-RC 0.857
crb crumbs 0.855
argos CG4531 gene product from transcript CG4531-RA 0.847
sca scabrous 0.822
frc fringe connection 0.819
Tom Twin of m4 0.814
Peb Protein ejaculatory bulb 0.810
POSH Plenty of SH3s 0.807
par-1 CG8201 gene product from transcript CG8201-RA 0.781
Pkn Protein kinase related to protein kinase N 0.771
SoxN SoxNeuro 0.757
ru roughoid 0.741
neur neuralized 0.697
fz2 frizzled 2 0.688
G-oalpha47A G protein oalpha 47A 0.684
rst roughest 0.679
fng fringe 0.672
arm armadillo 0.651
Mob2 CG11711 gene product from transcript CG11711-RC 0.651
mirr mirror 0.651
Akt1 CG4006 gene product from transcript CG4006-RA 0.619
nmo nemo 0.600
raps rapsynoid 0.542
aop anterior open 0.535
dgo diego 0.526
csw corkscrew 0.489
bdg bedraggled 0.468
fj four-jointed 0.466
Jra Jun-related antigen 0.447
baz bazooka 0.446
rdgA retinal degeneration A 0.442
Mtl Mig-2-like 0.438
sina seven in absentia 0.431
hep hemipterous 0.426
pyd polychaetoid 0.400
CG15730 CG15730 gene product from transcript CG15730-RA 0.394
edl ETS-domain lacking 0.393
norpA no receptor potential A 0.390
Parp Poly-(ADP-ribose) polymerase 0.375
CG31687 CG31687 gene product from transcript CG31687-RA 0.375
slou slouch 0.372
nej nejire 0.369
Nrt Neurotactin 0.352
R Roughened 0.335
Traf4 TNF-receptor-associated factor 4 0.323
eyg eyegone 0.322
sty sprouty 0.320
Rala Ras-related protein 0.317
kay kayak 0.300
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.295
Ten-m Tenascin major 0.288
ds dachsous 0.287
ase asense 0.285
stumps CG31317 gene product from transcript CG31317-RC 0.285
sdk sidekick 0.281
sev sevenless 0.280
spen split ends 0.280
S6k RPS6-p70-protein kinase 0.276
hipk homeodomain interacting protein kinase 0.270
sktl skittles 0.268
tinc tincar 0.268
ovo CG6824 gene product from transcript CG6824-RE 0.268
kermit CG11546 gene product from transcript CG11546-RB 0.258
gbb glass bottom boat 0.257
svp seven up 0.256
Gug Grunge 0.254
CG11347 CG11347 gene product from transcript CG11347-RE 0.248
E(spl) Enhancer of split 0.246
Tollo CG6890 gene product from transcript CG6890-RA 0.244
CG34449 CG34449 gene product from transcript CG34449-RB 0.243
shg shotgun 0.241
mbl muscleblind 0.235
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
PRKCZ protein kinase C, zeta 0.970
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.963
ARHGAP1 Rho GTPase activating protein 1 0.951
APC adenomatous polyposis coli 0.918
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.918
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.876
AFF4 AF4/FMR2 family, member 4 0.806
GDA guanine deaminase 0.788
SORBS3 sorbin and SH3 domain containing 3 0.774
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.768
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.731
LRRK2 leucine-rich repeat kinase 2 0.716
CFL1 cofilin 1 (non-muscle) 0.648
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.614
TPBG trophoblast glycoprotein 0.598
SEC23A Sec23 homolog A (S. cerevisiae) 0.514
EGFR epidermal growth factor receptor 0.422
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.416
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.363
AMPH amphiphysin 0.361
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.358
CABLES1 Cdk5 and Abl enzyme substrate 1 0.342
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.331
DNM2 dynamin 2 0.303
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.298
PTN pleiotrophin 0.298
F11R F11 receptor 0.279
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.277
WNT3A wingless-type MMTV integration site family, member 3A 0.265
MED24 mediator complex subunit 24 0.259
TTC30B tetratricopeptide repeat domain 30B 0.232
LRP6 low density lipoprotein receptor-related protein 6 0.230
TNS4 tensin 4 0.228
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.228
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.221
PTPRJ protein tyrosine phosphatase, receptor type, J 0.215
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.213
ACTA2 actin, alpha 2, smooth muscle, aorta 0.207
DNM1 dynamin 1 0.207
RTKN rhotekin 0.202
JUP junction plakoglobin 0.199
AXIN1 axin 1 0.194
RIN1 Ras and Rab interactor 1 0.193
FZD1 frizzled homolog 1 (Drosophila) 0.184
WNT5A wingless-type MMTV integration site family, member 5A 0.182
JAM2 junctional adhesion molecule 2 0.175
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.169
JAM3 junctional adhesion molecule 3 0.158
FRMD5 FERM domain containing 5 0.154
GRB7 growth factor receptor-bound protein 7 0.154
SATB2 SATB homeobox 2 0.152
SIAH1 seven in absentia homolog 1 (Drosophila) 0.143
CSNK1E casein kinase 1, epsilon 0.135
SMAD2 SMAD family member 2 0.134
SOX4 SRY (sex determining region Y)-box 4 0.131
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.128
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.128
CEP164 centrosomal protein 164kDa 0.128
SDC2 syndecan 2 0.128
YAP1 Yes-associated protein 1 0.127
AFF1 AF4/FMR2 family, member 1 0.127
EZR ezrin 0.127
PRKCI protein kinase C, iota 0.124
RHOA ras homolog gene family, member A 0.122
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.122
FASLG Fas ligand (TNF superfamily, member 6) 0.119
MAPT microtubule-associated protein tau 0.113
TYRP1 tyrosinase-related protein 1 0.112
COL7A1 collagen, type VII, alpha 1 0.110
INVS inversin 0.109
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.106
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.098
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.097
SYNJ1 synaptojanin 1 0.097
FBLN2 fibulin 2 0.097
MCC mutated in colorectal cancers 0.096
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.095
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.095
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.094
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.090
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.089
SMAD3 SMAD family member 3 0.088
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.088
SFN stratifin 0.084
GSK3B glycogen synthase kinase 3 beta 0.083
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.083
BCR breakpoint cluster region 0.080
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.080
PTPRF protein tyrosine phosphatase, receptor type, F 0.080
JUB jub, ajuba homolog (Xenopus laevis) 0.079
VCL vinculin 0.078
FGFR1 fibroblast growth factor receptor 1 0.078
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.076
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.076
HIPK3 homeodomain interacting protein kinase 3 0.075
TNS3 tensin 3 0.075
STON2 stonin 2 0.075
ZEB2 zinc finger E-box binding homeobox 2 0.073
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.072
FERMT2 fermitin family member 2 0.071
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
C1r complement component 1, r subcomponent 0.167
Ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.051
Spon1 spondin 1, extracellular matrix protein 0.045
Cd82 Cd82 molecule 0.039
Ifitm3 interferon induced transmembrane protein 3 0.038
Baiap2 BAI1-associated protein 2 0.036
Cdc2l5 cell division cycle 2-like 5 (cholinesterase-related cell division controller) 0.036
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.036
C1s complement component 1, s subcomponent 0.031
Ednrb endothelin receptor type B 0.030
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.030
Col5a2 collagen, type V, alpha 2 0.029
Lox lysyl oxidase 0.028
Fgfr1 Fibroblast growth factor receptor 1 0.025
Col12a1 collagen, type XII, alpha 1 0.025
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.024
Igfbp5 insulin-like growth factor binding protein 5 0.024
Nfia nuclear factor I/A 0.024
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.023
Dbn1 drebrin 1 0.023
Fzd2 frizzled homolog 2 (Drosophila) 0.023
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.023
Paqr5 progestin and adipoQ receptor family member V 0.023
Lrfn2 leucine rich repeat and fibronectin type III domain containing 2 0.023
Myoz2 myozenin 2 0.023
Ranbp1 RAN binding protein 1 0.022
Aebp1 AE binding protein 1 0.022
Tagln transgelin 0.022
Sorbs2 sorbin and SH3 domain containing 2 0.021
Ptbp1 polypyrimidine tract binding protein 1 0.021
Sostdc1 sclerostin domain containing 1 0.020
Hbz hemoglobin, zeta 0.020
Fam129b family with sequence similarity 129, member B 0.020
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.019
Anxa2 annexin A2 0.019
Cald1 caldesmon 1 0.019
Il6st interleukin 6 signal transducer 0.019
Acvr1 activin A receptor, type I 0.018
Plagl1 pleiomorphic adenoma gene-like 1 0.018
Ece1 endothelin converting enzyme 1 0.018
Fzd1 frizzled homolog 1 (Drosophila) 0.018
Slc39a14 solute carrier family 39 (zinc transporter), member 14 0.018
Bnc1 basonuclin 1 0.018
Plac1 placenta-specific 1 0.018
Stard8 StAR-related lipid transfer (START) domain containing 8 0.017
Acta2 smooth muscle alpha-actin 0.017
LOC313672 kazrin 0.017
Lphn2 latrophilin 2 0.017
Ppapdc1a phosphatidic acid phosphatase type 2 domain containing 1A 0.017
Fam189a2 family with sequence similarity 189, member A2 0.017
Prx periaxin 0.017
Bmp4 bone morphogenetic protein 4 0.017
Cxxc4 CXXC finger 4 0.016
Vcam1 vascular cell adhesion molecule 1 0.016
Glud1 glutamate dehydrogenase 1 0.016
Ptk7 PTK7 protein tyrosine kinase 7 0.016
Gja1 gap junction protein, alpha 1 0.016
Prph peripherin 0.016
Loxl1 lysyl oxidase-like 1 0.016
Arvcf armadillo repeat gene deleted in velo-cardio-facial syndrome 0.016
Anxa9 annexin A9 0.016
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.016
Nrp1 neuropilin 1 0.016
Tcfe2a transcription factor E2a 0.016
Lgals7 lectin, galactoside-binding, soluble, 7 0.016
Actg2 actin, gamma 2, smooth muscle, enteric 0.016
Zfp278 zinc finger protein 278 0.016
Id3 inhibitor of DNA binding 3 0.016
Wiz widely-interspaced zinc finger motifs 0.015
Fmod fibromodulin 0.015
Ptprk protein tyrosine phosphatase, receptor type, K, extracellular region 0.015
Sorbs1 sorbin and SH3 domain containing 1 0.015
Mapt microtubule-associated protein tau 0.015
Efemp1 EGF-containing fibulin-like extracellular matrix protein 1 0.015
Irx4 iroquois homeobox 4 0.015
Litaf lipopolysaccharide-induced TNF factor 0.015
Tead2 TEA domain family member 2 0.015
Sorcs2 sortilin-related VPS10 domain containing receptor 2 0.015
Ddah1 dimethylarginine dimethylaminohydrolase 1 0.015
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.015
Nradd neurotrophin receptor associated death domain 0.015
Ppp1r10 protein phosphatase 1, regulatory subunit 10 0.015
Fam46b family with sequence similarity 46, member B 0.015
Col2a1 collagen, type II, alpha 1 0.015
Gak cyclin G associated kinase 0.015
Bdkrb2 bradykinin receptor B2 0.015
Lce1f late cornified envelope 1F 0.015
A2m alpha-2-macroglobulin 0.015
Cp ceruloplasmin 0.014
Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 0.014
Speg SPEG complex locus 0.014
Krt7 keratin 7 0.014
RGD1560271 similar to inhibitor of MyoD family-a 0.014
Hdac6 histone deacetylase 6 0.014
Ccdc8 coiled-coil domain containing 8 0.014
Aard alanine and arginine rich domain containing protein 0.014
Tgfa transforming growth factor alpha 0.014
Pax9 paired box 9 0.014
Dcdc2 doublecortin domain containing 2 0.014
Rdh10 retinol dehydrogenase 10 (all-trans) 0.014
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism