The network for 'activation of jun kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of jun kinase activity

The initiation of the activity of the inactive enzyme JUN kinase (JNK).

Mus musculus
Name Description Probability Func Analog Organism
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.908
Tnf tumor necrosis factor 0.883
Ifng interferon gamma 0.771
Cd40 CD40 antigen 0.755
C3ar1 complement component 3a receptor 1 0.721
Cxcl13 chemokine (C-X-C motif) ligand 13 0.692
Ccr1 chemokine (C-C motif) receptor 1 0.625
Klc1 kinesin light chain 1 0.590
Msr1 macrophage scavenger receptor 1 0.580
Lta lymphotoxin A 0.555
Ccl12 chemokine (C-C motif) ligand 12 0.537
Grb2 growth factor receptor bound protein 2 0.535
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.430
Ccl8 chemokine (C-C motif) ligand 8 0.351
Ccl2 chemokine (C-C motif) ligand 2 0.322
Il1b interleukin 1 beta 0.284
Ltb lymphotoxin B 0.253
Fcgr1 Fc receptor, IgG, high affinity I 0.239
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.234
Pdcd1 programmed cell death 1 0.212
Mapk8 mitogen-activated protein kinase 8 0.195
Cxcr5 chemokine (C-X-C motif) receptor 5 0.186
Clec4d C-type lectin domain family 4, member d 0.180
Gzma granzyme A 0.168
Folr2 folate receptor 2 (fetal) 0.167
Shc1 src homology 2 domain-containing transforming protein C1 0.155
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.151
Ccl4 chemokine (C-C motif) ligand 4 0.149
Ccl3 chemokine (C-C motif) ligand 3 0.142
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.125
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.119
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.115
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.114
Il4 interleukin 4 0.112
C1qb complement component 1, q subcomponent, beta polypeptide 0.104
Cxcl2 chemokine (C-X-C motif) ligand 2 0.103
Prkce protein kinase C, epsilon 0.103
Tyrobp TYRO protein tyrosine kinase binding protein 0.099
Cd19 CD19 antigen 0.097
Icos inducible T-cell co-stimulator 0.097
Il7 interleukin 7 0.096
Crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.093
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.092
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.090
Mmp12 matrix metallopeptidase 12 0.087
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.085
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.084
Aoah acyloxyacyl hydrolase 0.084
Irg1 immunoresponsive gene 1 0.083
Cd28 CD28 antigen 0.078
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.077
Btk Bruton agammaglobulinemia tyrosine kinase 0.076
Csf1r colony stimulating factor 1 receptor 0.074
Ch25h cholesterol 25-hydroxylase 0.074
Igh immunoglobulin heavy chain complex 0.073
Mrc1 mannose receptor, C type 1 0.073
Cbl Casitas B-lineage lymphoma 0.073
Cd5l CD5 antigen-like 0.071
Cd14 CD14 antigen 0.071
Tbxas1 thromboxane A synthase 1, platelet 0.070
Il6 interleukin 6 0.068
Inpp5d inositol polyphosphate-5-phosphatase D 0.064
Met met proto-oncogene 0.062
Ccl22 chemokine (C-C motif) ligand 22 0.061
Tox thymocyte selection-associated high mobility group box 0.060
Csf1 colony stimulating factor 1 (macrophage) 0.059
Cd22 CD22 antigen 0.057
C5ar1 complement component 5a receptor 1 0.056
Aif1 allograft inflammatory factor 1 0.056
Cd86 CD86 antigen 0.056
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.051
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.049
Clec4n C-type lectin domain family 4, member n 0.046
Slpi secretory leukocyte peptidase inhibitor 0.045
Ikzf1 IKAROS family zinc finger 1 0.045
Ccl17 chemokine (C-C motif) ligand 17 0.044
Batf basic leucine zipper transcription factor, ATF-like 0.041
Ccr5 chemokine (C-C motif) receptor 5 0.039
Ccl7 chemokine (C-C motif) ligand 7 0.039
Itgax integrin alpha X 0.039
Mmp8 matrix metallopeptidase 8 0.038
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.038
Lyz2 lysozyme 2 0.038
AF251705 cDNA sequence AF251705 0.038
Socs1 suppressor of cytokine signaling 1 0.038
Clec4a2 C-type lectin domain family 4, member a2 0.037
Clec4e C-type lectin domain family 4, member e 0.037
Traf6 TNF receptor-associated factor 6 0.037
C1qc complement component 1, q subcomponent, C chain 0.036
Il10ra interleukin 10 receptor, alpha 0.035
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.035
Map2k4 mitogen-activated protein kinase kinase 4 0.035
Il1rn interleukin 1 receptor antagonist 0.034
Batf2 basic leucine zipper transcription factor, ATF-like 2 0.034
Pf4 platelet factor 4 0.033
Slfn4 schlafen 4 0.032
Gripap1 GRIP1 associated protein 1 0.032
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.032
Fpr2 formyl peptide receptor 2 0.031
Alox15 arachidonate 15-lipoxygenase 0.031
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
meg-2 Protein MEG-2 0.127
daf-19 Protein DAF-19 0.054
sax-3 Protein SAX-3 0.051
pqn-82 Protein PQN-82 0.050
F21A10.2 Protein F21A10.2 0.046
oga-1 Protein OGA-1 0.042
nhr-34 Protein NHR-34 0.036
sym-4 Protein SYM-4 0.035
K10D6.4 Protein K10D6.4 0.033
gap-2 Protein GAP-2 0.033
T14G11.1 Protein T14G11.1 0.031
lin-36 Protein LIN-36 0.030
pup-2 Protein PUP-2 0.030
glit-1 Protein GLIT-1 0.029
let-19 Protein LET-19 0.028
alg-1 Protein ALG-1 0.027
C36B7.6 Protein C36B7.6 0.027
vav-1 Protein VAV-1 0.025
sor-1 Protein SOR-1 0.025
unc-18 Protein UNC-18 0.023
dpy-22 Protein DPY-22 0.023
T04F8.6 Protein T04F8.6 0.022
obr-3 Protein OBR-3 0.021
cec-1 Protein CEC-1 0.021
syd-2 Protein SYD-2 0.020
K05B2.2 Protein K05B2.2 0.020
dpy-23 Protein DPY-23 0.019
sax-7 Protein SAX-7 0.019
mig-10 Protein MIG-10 0.018
cdf-1 Protein CDF-1 0.018
dsh-1 Protein DSH-1 0.017
hpo-22 Protein HPO-22 0.017
sec-15 Protein SEC-15 0.017
zoo-1 Protein ZOO-1 0.017
cgef-1 Protein CGEF-1 0.017
agr-1 Protein AGR-1 0.016
F59F4.3 Protein F59F4.3 0.016
ksr-1 Protein KSR-1 0.014
csnk-1 Protein CSNK-1 0.014
scd-1 Protein SCD-1 0.014
unc-129 Protein UNC-129 0.014
F48F7.6 Protein F48F7.6 0.014
ZC53.1 Protein ZC53.1 0.014
F28B3.1 Protein F28B3.1 0.014
pop-1 Protein POP-1 0.014
F47A4.5 Protein F47A4.5 0.013
F17E5.2 Protein F17E5.2 0.013
T09B9.4 Protein T09B9.4 0.013
rme-6 Protein RME-6 0.013
B0416.5 Protein B0416.5 0.013
bar-1 Protein BAR-1 0.013
saeg-2 Protein SAEG-2 0.012
eor-2 Protein EOR-2 0.012
axl-1 Protein AXL-1 0.011
K09F5.6 Protein K09F5.6 0.011
unc-10 Protein UNC-10 0.011
plx-1 Protein PLX-1 0.011
chd-7 Protein CHD-7 0.011
tps-1 Protein TPS-1 0.010
lip-1 Protein LIP-1 0.010
cst-1 Protein CST-1 0.010
sto-4 Protein STO-4 0.010
CELE_H28G03.2 Protein H28G03.2 0.010
F38B6.6 Protein F38B6.6 0.010
tir-1 Protein TIR-1 0.010
C24H10.2 Protein C24H10.2 0.010
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Danio rerio
Name Description Probability Func Analog Organism
dzip1 DAZ interacting protein 1 0.247
lef1 lymphocyte enhancer binding factor 1 0.153
gata1a GATA binding protein 1a 0.106
gro2 groucho 2 0.100
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.095
etv2 ets variant gene 2 0.082
wnt7bb wingless-type MMTV integration site family, member 7Bb 0.077
zbtb4 zinc finger and BTB domain containing 4 0.074
dusp6 dual specificity phosphatase 6 0.066
gro1 groucho 1 0.064
csnk1g2a casein kinase 1, gamma 2a 0.063
gli3 GLI-Kruppel family member GLI3 0.062
wnt3 wingless-type MMTV integration site family, member 3 0.061
mrc1a mannose receptor, C type 1a 0.059
map2k4b mitogen-activated protein kinase kinase 4b 0.058
itih2 inter-alpha (globulin) inhibitor H2 0.057
pbx4 pre-B-cell leukemia transcription factor 4 0.053
nort notch-regulated transcript 0.052
zgc:193613 zgc:193613 0.051
apoc2 apolipoprotein C-II 0.051
mtmr8 myotubularin related protein 8 0.046
robo1 roundabout homolog 1 0.046
LOC100151531 zinc finger protein Gfi-1b-like 0.044
axin1 axin 1 0.042
LOC566708 FL cytokine receptor-like 0.037
wnt5a wingless-type MMTV integration site family, member 5a 0.037
wnt7aa wingless-type MMTV integration site family, member 7Aa 0.036
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.036
wnt11 wingless-type MMTV integration site family, member 11 0.036
tie1 endothelium-specific receptor tyrosine kinase 1 0.035
twist1a twist1a 0.035
mkks McKusick-Kaufman syndrome 0.034
ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 0.034
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.032
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.031
spsb4a splA/ryanodine receptor domain and SOCS box containing 4a 0.031
tie2 endothelium-specific receptor tyrosine kinase 2 0.030
bhmt betaine-homocysteine methyltransferase 0.030
oep one-eyed pinhead 0.029
wnt16 wingless-type MMTV integration site family, member 16 0.029
nrarpa notch-regulated ankyrin repeat protein a 0.029
sult3st1 sulfotransferase family 3, cytosolic sulfotransferase 1 0.028
celf1 cugbp, Elav-like family member 1 0.026
ctnnb1 catenin (cadherin-associated protein), beta 1 0.026
wwp1 WW domain containing E3 ubiquitin protein ligase 1 0.026
gip gastric inhibitory polypeptide 0.026
rbl1 retinoblastoma-like 1 (p107) 0.025
dkk3 dickkopf homolog 3 (Xenopus laevis) 0.025
fbn2b fibrillin 2b 0.025
glceb glucuronyl C5-epimerase b 0.024
map2k7 mitogen-activated protein kinase kinase 7 0.024
si:dkey-273o13.1 si:dkey-273o13.1 0.024
ptprb protein tyrosine phosphatase, receptor type, b 0.024
hspa12b heat shock protein 12B 0.023
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.023
si:dkey-261h17.1 si:dkey-261h17.1 0.023
sulf1 sulfatase 1 0.022
ahctf1 AT hook containing transcription factor 1 0.021
stac3 SH3 and cysteine rich domain 3 0.021
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.021
zgc:161979 zgc:161979 0.021
notch3 notch homolog 3 0.021
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.021
atoh8 atonal homolog 8 0.020
zgc:101761 zgc:101761 0.020
cbx2 chromobox homolog 2 (Drosophila Pc class) 0.020
tmpoa thymopoietin a 0.019
kop askopos 0.019
hdr hematopoietic death receptor 0.019
zgc:111944 zgc:111944 0.019
ddr2b discoidin domain receptor family, member 2b 0.018
dkk1b dickkopf 1b 0.018
lamb1a laminin, beta 1a 0.018
greb1 growth regulation by estrogen in breast cancer 1 0.018
ogt.1 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1 0.017
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.017
stk36 serine/threonine kinase 36 (fused homolog, Drosophila) 0.017
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.016
stat1b signal transducer and activator of transcription 1b 0.016
flt4 fms-related tyrosine kinase 4 0.016
skia nuclear oncoprotein skia 0.016
scube2 signal peptide, CUB domain, EGF-like 2 0.016
dvl2 dishevelled, dsh homolog 2 (Drosophila) 0.016
fgg fibrinogen, gamma polypeptide 0.016
kdm4b lysine (K)-specific demethylase 4B 0.015
fcho2 FCH domain only 2 0.015
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.014
igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 0.014
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.014
twist3 twist3 0.014
mbnl2 muscleblind-like 2 (Drosophila) 0.014
iba57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 0.014
anxa4 annexin A4 0.014
zgc:66100 zgc:66100 0.014
ckap5 cytoskeleton associated protein 5 0.014
zgc:194131 zgc:194131 0.014
apaf1 apoptotic protease activating factor 1 0.014
lamc1 laminin, gamma 1 0.014
mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.014
ptk2.1 protein tyrosine kinase 2a 0.013
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Drosophila melanogaster
Name Description Probability Func Analog Organism
yki yorkie 0.232
hep hemipterous 0.213
puc puckered 0.180
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.164
Sema-1a CG18405 gene product from transcript CG18405-RD 0.117
Pkn Protein kinase related to protein kinase N 0.103
bsk basket 0.088
Gug Grunge 0.080
CG5794 CG5794 gene product from transcript CG5794-RB 0.079
kay kayak 0.062
msn misshapen 0.051
Atg1 Autophagy-specific gene 1 0.047
dia diaphanous 0.039
cnk connector enhancer of ksr 0.037
rap retina aberrant in pattern 0.037
Tak1 TGF-beta activated kinase 1 0.033
rok Rho-kinase 0.032
Sra-1 specifically Rac1-associated protein 1 0.032
gro groucho 0.029
Jra Jun-related antigen 0.029
Abl Abl tyrosine kinase 0.028
mask multiple ankyrin repeats single KH domain 0.028
spas spastin 0.026
slik Sterile20-like kinase 0.026
arr arrow 0.026
phl pole hole 0.024
skd skuld 0.024
chico CG5686 gene product from transcript CG5686-RB 0.024
Lnk CG17367 gene product from transcript CG17367-RC 0.024
krz kurtz 0.023
pyd polychaetoid 0.021
kibra kibra ortholog 0.021
CG14614 CG14614 gene product from transcript CG14614-RA 0.020
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.020
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.020
fu fused 0.019
S6k RPS6-p70-protein kinase 0.019
milt milton 0.018
Smg1 CG32743 gene product from transcript CG32743-RA 0.018
ci cubitus interruptus 0.018
Ten-m Tenascin major 0.017
Sos Son of sevenless 0.017
RYBP Ring and YY1 Binding Protein 0.017
Rala Ras-related protein 0.016
dlt discs lost 0.016
Src42A Src oncogene at 42A 0.016
synj synaptojanin 0.015
gek genghis khan 0.015
yrt yurt 0.014
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.014
POSH Plenty of SH3s 0.014
R Roughened 0.014
ari-2 ariadne 2 0.013
Sara Smad anchor for receptor activation 0.013
pnt pointed 0.013
Apc2 Adenomatous polyposis coli tumor suppressor homolog 2 0.013
lig lingerer 0.012
CG1347 CG1347 gene product from transcript CG1347-RB 0.012
Dcr-1 Dicer-1 0.012
Rab5 Rab-protein 5 0.012
sgl sugarless 0.012
Rab30 CG9100 gene product from transcript CG9100-RB 0.012
pUf68 poly U binding factor 68kD 0.012
rl rolled 0.012
p53 CG33336 gene product from transcript CG33336-RB 0.012
rictor rapamycin-insensitive companion of Tor 0.011
CG6194 CG6194 gene product from transcript CG6194-RA 0.011
Patj CG12021 gene product from transcript CG12021-RC 0.011
por porcupine 0.011
Zyx102EF CG32018 gene product from transcript CG32018-RA 0.011
lap like-AP180 0.011
unk unkempt 0.010
lok loki 0.010
flfl falafel 0.010
InR Insulin-like receptor 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
MAPK8 mitogen-activated protein kinase 8 0.942
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.638
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.593
EGFR epidermal growth factor receptor 0.547
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.425
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.404
DCAF7 DDB1 and CUL4 associated factor 7 0.241
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.213
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.141
LAT linker for activation of T cells 0.138
MAPK9 mitogen-activated protein kinase 9 0.128
MAP2K7 mitogen-activated protein kinase kinase 7 0.112
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.098
GRB2 growth factor receptor-bound protein 2 0.096
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.093
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.081
BBS10 Bardet-Biedl syndrome 10 0.072
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.051
BLNK B-cell linker 0.045
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.042
MAP2K4 mitogen-activated protein kinase kinase 4 0.034
SOS1 son of sevenless homolog 1 (Drosophila) 0.032
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.030
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.026
UBASH3B ubiquitin associated and SH3 domain containing B 0.026
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.025
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.024
LRP6 low density lipoprotein receptor-related protein 6 0.023
ARHGAP5 Rho GTPase activating protein 5 0.022
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.022
ARRB1 arrestin, beta 1 0.021
VAV3 vav 3 guanine nucleotide exchange factor 0.021
SMAD7 SMAD family member 7 0.020
IRS1 insulin receptor substrate 1 0.019
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.018
CSNK1E casein kinase 1, epsilon 0.018
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.018
SH3KBP1 SH3-domain kinase binding protein 1 0.016
GAB2 GRB2-associated binding protein 2 0.013
ARL4D ADP-ribosylation factor-like 4D 0.013
GSK3A glycogen synthase kinase 3 alpha 0.012
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.012
FZD1 frizzled homolog 1 (Drosophila) 0.012
IGF1R insulin-like growth factor 1 receptor 0.011
EXOC5 exocyst complex component 5 0.011
PXN paxillin 0.011
C1orf93 chromosome 1 open reading frame 93 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism