The network for 'cytokine production involved in immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cytokine production involved in immune response

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Traf6 TNF receptor-associated factor 6 0.999
Cd40 CD40 antigen 0.998
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.976
Ifng interferon gamma 0.964
Kdr kinase insert domain protein receptor 0.942
Ccl2 chemokine (C-C motif) ligand 2 0.926
Igh immunoglobulin heavy chain complex 0.916
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.914
Lta lymphotoxin A 0.870
Ccl4 chemokine (C-C motif) ligand 4 0.866
Cdh5 cadherin 5 0.851
Il10 interleukin 10 0.847
B2m beta-2 microglobulin 0.823
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.804
Myd88 myeloid differentiation primary response gene 88 0.795
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.791
Lyz2 lysozyme 2 0.765
Csf1 colony stimulating factor 1 (macrophage) 0.695
H2-Aa histocompatibility 2, class II antigen A, alpha 0.693
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.680
Ubd ubiquitin D 0.674
Tlr2 toll-like receptor 2 0.637
Il2rg interleukin 2 receptor, gamma chain 0.631
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.560
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.551
Btk Bruton agammaglobulinemia tyrosine kinase 0.527
Tgfbr2 transforming growth factor, beta receptor II 0.524
Socs1 suppressor of cytokine signaling 1 0.516
Irg1 immunoresponsive gene 1 0.515
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.486
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.483
H2-K1 histocompatibility 2, K1, K region 0.460
Zeb1 zinc finger E-box binding homeobox 1 0.455
Apoe apolipoprotein E 0.448
Ccr2 chemokine (C-C motif) receptor 2 0.430
Ikzf1 IKAROS family zinc finger 1 0.420
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.410
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.410
Card11 caspase recruitment domain family, member 11 0.390
Cd40lg CD40 ligand 0.386
H2-Eb1 histocompatibility 2, class II antigen E beta 0.381
Stat3 signal transducer and activator of transcription 3 0.377
Pdcd1lg2 programmed cell death 1 ligand 2 0.365
Muc13 mucin 13, epithelial transmembrane 0.365
C3ar1 complement component 3a receptor 1 0.359
Ldlr low density lipoprotein receptor 0.355
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.348
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.335
Siglece sialic acid binding Ig-like lectin E 0.327
Tcra T-cell receptor alpha chain 0.323
Ccl8 chemokine (C-C motif) ligand 8 0.316
Cd19 CD19 antigen 0.312
Nos2 nitric oxide synthase 2, inducible 0.310
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.295
Dab2 disabled homolog 2 (Drosophila) 0.293
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.272
Pdgfb platelet derived growth factor, B polypeptide 0.269
Ccl22 chemokine (C-C motif) ligand 22 0.264
Ptprb protein tyrosine phosphatase, receptor type, B 0.257
Meox2 mesenchyme homeobox 2 0.249
Sh2d2a SH2 domain protein 2A 0.247
Vegfa vascular endothelial growth factor A 0.244
Il1b interleukin 1 beta 0.244
Il1r1 interleukin 1 receptor, type I 0.243
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.242
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.237
Emcn endomucin 0.232
Ccl3 chemokine (C-C motif) ligand 3 0.227
Cd14 CD14 antigen 0.224
Nf1 neurofibromatosis 1 0.222
Fcgr3 Fc receptor, IgG, low affinity III 0.222
H2-DMa histocompatibility 2, class II, locus DMa 0.217
Fzd4 frizzled homolog 4 (Drosophila) 0.208
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.203
Ikbkg inhibitor of kappaB kinase gamma 0.202
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.202
Dlg4 discs, large homolog 4 (Drosophila) 0.200
Prf1 perforin 1 (pore forming protein) 0.198
Mx2 myxovirus (influenza virus) resistance 2 0.197
Il2rb interleukin 2 receptor, beta chain 0.195
Acvrl1 activin A receptor, type II-like 1 0.193
Cxcl10 chemokine (C-X-C motif) ligand 10 0.193
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.185
Tlr4 toll-like receptor 4 0.183
Clec4d C-type lectin domain family 4, member d 0.182
F10 coagulation factor X 0.171
Cp ceruloplasmin 0.171
Tifa TRAF-interacting protein with forkhead-associated domain 0.170
Mmp12 matrix metallopeptidase 12 0.167
Cxcl9 chemokine (C-X-C motif) ligand 9 0.167
Birc3 baculoviral IAP repeat-containing 3 0.164
Fcgr1 Fc receptor, IgG, high affinity I 0.159
C1qb complement component 1, q subcomponent, beta polypeptide 0.155
Ccr7 chemokine (C-C motif) receptor 7 0.155
Il1rn interleukin 1 receptor antagonist 0.152
C1qa complement component 1, q subcomponent, alpha polypeptide 0.151
H2-Q7 histocompatibility 2, Q region locus 7 0.151
Ikbkb inhibitor of kappaB kinase beta 0.151
Ptgs2 prostaglandin-endoperoxide synthase 2 0.151
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
dlg2 discs, large (Drosophila) homolog 2 0.033
dlg4 discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila) 0.032
twist1a twist1a 0.029
rpe65b retinal pigment epithelium-specific protein 65b 0.028
tie1 endothelium-specific receptor tyrosine kinase 1 0.018
sh3gl1b SH3-domain GRB2-like 1b 0.017
eya2 eyes absent homolog 2 (Drosophila) 0.017
per2 period homolog 2 (Drosophila) 0.016
irak4 interleukin-1 receptor-associated kinase 4 0.016
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.015
myca myelocytomatosis oncogene a 0.015
tgfb3 transforming growth factor, beta 3 0.015
il7r interleukin 7 receptor 0.015
aldocb aldolase C, fructose-bisphosphate, b 0.014
ednra endothelin receptor type A 0.014
sc:d812 sc:d812 0.014
tirap toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.014
frzb frizzled-related protein 0.013
bmp7b bone morphogenetic protein 7b 0.013
fgf20a fibroblast growth factor 20a 0.013
tbx5b T-box 5b 0.013
pnp4a purine nucleoside phosphorylase 4a 0.013
ptpn21 protein tyrosine phosphatase, non-receptor type 21 0.013
jak1 Janus kinase 1 0.013
gpr126 G protein-coupled receptor 126 0.012
tlr18 toll-like receptor 18 0.012
prkcz protein kinase C, zeta 0.012
pax9 paired box gene 9 0.012
spon2a spondin 2a, extracellular matrix protein 0.012
crip2 cysteine-rich protein 2 0.012
tlr3 toll-like receptor 3 0.012
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.012
c1qc complement component 1, q subcomponent, C chain 0.011
lox lysyl oxidase 0.011
mych myelocytomatosis oncogene homolog 0.011
mitfa microphthalmia-associated transcription factor a 0.011
scn8ab sodium channel, voltage-gated, type VIII, alpha b 0.010
cmyb transcription factor cmyb 0.010
hspa5 heat shock protein 5 0.010
mmp2 matrix metalloproteinase 2 0.010
osr1 odd-skipped related 1 (Drosophila) 0.010
avpr1b arginine vasopressin receptor 1B 0.010
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.979
TRAF1 TNF receptor-associated factor 1 0.960
TRAF6 TNF receptor-associated factor 6 0.943
CCR5 chemokine (C-C motif) receptor 5 0.813
CD40 CD40 molecule, TNF receptor superfamily member 5 0.803
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.799
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.763
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.744
TRAF2 TNF receptor-associated factor 2 0.578
NRP1 neuropilin 1 0.545
IL10RA interleukin 10 receptor, alpha 0.540
CCR1 chemokine (C-C motif) receptor 1 0.533
CCL4 chemokine (C-C motif) ligand 4 0.526
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.481
SIGLEC7 sialic acid binding Ig-like lectin 7 0.479
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.446
BIRC3 baculoviral IAP repeat containing 3 0.438
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.372
RIPK2 receptor-interacting serine-threonine kinase 2 0.370
ANGPT2 angiopoietin 2 0.367
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.362
CD14 CD14 molecule 0.359
TGIF1 TGFB-induced factor homeobox 1 0.353
TRAF5 TNF receptor-associated factor 5 0.352
AXL AXL receptor tyrosine kinase 0.350
CCL8 chemokine (C-C motif) ligand 8 0.331
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.320
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.304
TGFB1 transforming growth factor, beta 1 0.270
CXCL9 chemokine (C-X-C motif) ligand 9 0.262
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.260
VEGFA vascular endothelial growth factor A 0.220
IL4R interleukin 4 receptor 0.218
TICAM2 toll-like receptor adaptor molecule 2 0.207
PILRA paired immunoglobin-like type 2 receptor alpha 0.206
IL22RA1 interleukin 22 receptor, alpha 1 0.190
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.176
IRAK2 interleukin-1 receptor-associated kinase 2 0.170
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.164
A2M alpha-2-macroglobulin 0.157
IL2RG interleukin 2 receptor, gamma 0.155
CD86 CD86 molecule 0.155
ENG endoglin 0.152
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.151
APOC1 apolipoprotein C-I 0.148
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.143
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.139
HP haptoglobin 0.136
CCR7 chemokine (C-C motif) receptor 7 0.134
TRAF3 TNF receptor-associated factor 3 0.133
CALCOCO2 calcium binding and coiled-coil domain 2 0.130
HLA-DRA major histocompatibility complex, class II, DR alpha 0.128
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.126
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.119
HK3 hexokinase 3 (white cell) 0.109
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.109
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.106
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.102
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.094
NCOR2 nuclear receptor corepressor 2 0.093
BIRC2 baculoviral IAP repeat containing 2 0.090
LAT linker for activation of T cells 0.088
ANGPT1 angiopoietin 1 0.085
CCL13 chemokine (C-C motif) ligand 13 0.085
EMR1 egf-like module containing, mucin-like, hormone receptor-like 1 0.085
CCL7 chemokine (C-C motif) ligand 7 0.084
PTPRB protein tyrosine phosphatase, receptor type, B 0.084
TNF tumor necrosis factor 0.081
IFNG interferon, gamma 0.079
TRADD TNFRSF1A-associated via death domain 0.079
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.076
NLRP3 NLR family, pyrin domain containing 3 0.069
TYMP thymidine phosphorylase 0.069
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.067
SYK spleen tyrosine kinase 0.067
IDE insulin-degrading enzyme 0.064
ADAM17 ADAM metallopeptidase domain 17 0.064
CCL22 chemokine (C-C motif) ligand 22 0.062
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.062
CCR4 chemokine (C-C motif) receptor 4 0.061
CXCL10 chemokine (C-X-C motif) ligand 10 0.057
ZMYND11 zinc finger, MYND-type containing 11 0.056
HLA-F major histocompatibility complex, class I, F 0.056
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.055
LGALS9 lectin, galactoside-binding, soluble, 9 0.054
IL22RA2 interleukin 22 receptor, alpha 2 0.054
FSTL1 follistatin-like 1 0.053
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.050
CXCR4 chemokine (C-X-C motif) receptor 4 0.050
CDH5 cadherin 5, type 2 (vascular endothelium) 0.050
SLA Src-like-adaptor 0.048
CXCL13 chemokine (C-X-C motif) ligand 13 0.048
CCL11 chemokine (C-C motif) ligand 11 0.048
DPP4 dipeptidyl-peptidase 4 0.048
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.045
LCAT lecithin-cholesterol acyltransferase 0.045
CD80 CD80 molecule 0.044
HLA-C major histocompatibility complex, class I, C 0.043
IL1R1 interleukin 1 receptor, type I 0.043
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.042
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism