IMP

Process View

Homo sapiens

24 genes annotated in human

Multi-species View

sister chromatid cohesion

GO:0007062

The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "sister chromatid cohesion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "sister chromatid cohesion" (in gray)

Name	Description	Probability	Func Analog Organism
SMC1A	structural maintenance of chromosomes 1A	0.999
RB1	retinoblastoma 1	0.997
SMC3	structural maintenance of chromosomes 3	0.995
STAG1	stromal antigen 1	0.979	Human Worm
STAG2	stromal antigen 2	0.975
RAD21	RAD21 homolog (S. pombe)	0.937
PDS5A	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.922
RBBP8	retinoblastoma binding protein 8	0.864
WAPAL	wings apart-like homolog (Drosophila)	0.861
RFC1	replication factor C (activator 1) 1, 145kDa	0.859
BRCA1	breast cancer 1, early onset	0.851
CBX5	chromobox homolog 5	0.785
RFC2	replication factor C (activator 1) 2, 40kDa	0.778	Yeast
PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.700
BRCA2	breast cancer 2, early onset	0.635
CHTF18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.617
CASC5	cancer susceptibility candidate 5	0.512
RFC3	replication factor C (activator 1) 3, 38kDa	0.486	Yeast
SMC6	structural maintenance of chromosomes 6	0.384
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.368
MDC1	mediator of DNA-damage checkpoint 1	0.361
RFC4	replication factor C (activator 1) 4, 37kDa	0.342	Yeast
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.290
RFC5	replication factor C (activator 1) 5, 36.5kDa	0.268	Yeast
CDK2	cyclin-dependent kinase 2	0.252	Yeast
PCGF2	polycomb group ring finger 2	0.245
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.245
RPA2	replication protein A2, 32kDa	0.227
NBN	nibrin	0.201
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.189
INCENP	inner centromere protein antigens 135/155kDa	0.173
CCNE1	cyclin E1	0.155
MCM8	minichromosome maintenance complex component 8	0.155
C19orf39	chromosome 19 open reading frame 39	0.150
RPA1	replication protein A1, 70kDa	0.138
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.123
MCM10	minichromosome maintenance complex component 10	0.118
NAA15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	0.116
CDCA5	cell division cycle associated 5	0.111
PLK1	polo-like kinase 1	0.099
SGOL1	shugoshin-like 1 (S. pombe)	0.096
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.095
CCNA2	cyclin A2	0.094
RBL1	retinoblastoma-like 1 (p107)	0.090	Human Fly
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.089
AURKB	aurora kinase B	0.086
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.080
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.079
PRIM1	primase, DNA, polypeptide 1 (49kDa)	0.076
PRIM2	primase, DNA, polypeptide 2 (58kDa)	0.072
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.070
SKP2	S-phase kinase-associated protein 2 (p45)	0.069
CTNNBIP1	catenin, beta interacting protein 1	0.066
ZNF207	zinc finger protein 207	0.063
WDYHV1	WDYHV motif containing 1	0.060
RYBP	RING1 and YY1 binding protein	0.057
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.056	Fly
CEP350	centrosomal protein 350kDa	0.055
MCM7	minichromosome maintenance complex component 7	0.051
APC	adenomatous polyposis coli	0.051
PCGF3	polycomb group ring finger 3	0.050
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.050
CENPE	centromere protein E, 312kDa	0.049
MCM6	minichromosome maintenance complex component 6	0.049
RPA3	replication protein A3, 14kDa	0.044
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.043
E2F5	E2F transcription factor 5, p130-binding	0.042
NIPBL	Nipped-B homolog (Drosophila)	0.041
CBX6	chromobox homolog 6	0.041
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.041
USP11	ubiquitin specific peptidase 11	0.040
RAD50	RAD50 homolog (S. cerevisiae)	0.040
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.039
SSU72	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0.038
TROAP	trophinin associated protein (tastin)	0.037
CCNF	cyclin F	0.035
HIST1H3B	histone cluster 1, H3b	0.034
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.034
KIAA1524	KIAA1524	0.032
MED13L	mediator complex subunit 13-like	0.032
PCGF1	polycomb group ring finger 1	0.032
ORC1	origin recognition complex, subunit 1	0.031
PCNA	proliferating cell nuclear antigen	0.030
RSRC1	arginine/serine-rich coiled-coil 1	0.030
CLSPN	claspin	0.030
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.030
BIN1	bridging integrator 1	0.030
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.030
AXIN1	axin 1	0.028	Human
SKP1	S-phase kinase-associated protein 1	0.028
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.027
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.026
PCGF5	polycomb group ring finger 5	0.026
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.026
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.025
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.024
FBXW7	F-box and WD repeat domain containing 7	0.023
TIPIN	TIMELESS interacting protein	0.023
CDT1	chromatin licensing and DNA replication factor 1	0.023
CBX1	chromobox homolog 1	0.022
SMC2	structural maintenance of chromosomes 2	0.022
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.022
TPR	translocated promoter region (to activated MET oncogene)	0.022
GSK3B	glycogen synthase kinase 3 beta	0.022
RBBP4	retinoblastoma binding protein 4	0.021
UBE2C	ubiquitin-conjugating enzyme E2C	0.021
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.021
RAD54L	RAD54-like (S. cerevisiae)	0.021
ADAM17	ADAM metallopeptidase domain 17	0.020
SCAF11	SR-related CTD-associated factor 11	0.020
PHF3	PHD finger protein 3	0.020
BMI1	BMI1 polycomb ring finger oncogene	0.019
ANLN	anillin, actin binding protein	0.019
SMC5	structural maintenance of chromosomes 5	0.018
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.018
CBX8	chromobox homolog 8	0.018
MAX	MYC associated factor X	0.017
MMS22L	MMS22-like, DNA repair protein	0.017
KPNA4	karyopherin alpha 4 (importin alpha 3)	0.017
TMPO	thymopoietin	0.016
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.016
PALB2	partner and localizer of BRCA2	0.016
GTSE1	G-2 and S-phase expressed 1	0.016
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.015
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.015
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	0.015
CDCA8	cell division cycle associated 8	0.015
CBX7	chromobox homolog 7	0.015
MIS18BP1	MIS18 binding protein 1	0.015
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.015
RPP30	ribonuclease P/MRP 30kDa subunit	0.015
CBX3	chromobox homolog 3	0.015
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.015
RAD52	RAD52 homolog (S. cerevisiae)	0.015
E2F1	E2F transcription factor 1	0.015
PLK4	polo-like kinase 4	0.015
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.014
BCOR	BCL6 corepressor	0.014
NSMCE2	non-SMC element 2, MMS21 homolog (S. cerevisiae)	0.014
RAD18	RAD18 homolog (S. cerevisiae)	0.014
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.014
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.014
ECT2	epithelial cell transforming sequence 2 oncogene	0.014
MCM4	minichromosome maintenance complex component 4	0.014
MCM3	minichromosome maintenance complex component 3	0.014
BTRC	beta-transducin repeat containing	0.014
ZNF148	zinc finger protein 148	0.013
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.013
CUL1	cullin 1	0.013
CCNB2	cyclin B2	0.013
LRIF1	ligand dependent nuclear receptor interacting factor 1	0.013
PRRC2C	proline-rich coiled-coil 2C	0.013
PPID	peptidylprolyl isomerase D	0.013
DSP	desmoplakin	0.013
PSEN1	presenilin 1	0.013
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.013
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.013
CTNND1	catenin (cadherin-associated protein), delta 1	0.013
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.013
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.013
CCDC6	coiled-coil domain containing 6	0.012
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.012
CCDC99	coiled-coil domain containing 99	0.012
FBXO5	F-box protein 5	0.012
CTCF	CCCTC-binding factor (zinc finger protein)	0.012
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.012
BBX	bobby sox homolog (Drosophila)	0.012
ZMYND8	zinc finger, MYND-type containing 8	0.012
LIN9	lin-9 homolog (C. elegans)	0.012
FOXM1	forkhead box M1	0.012
FBXW8	F-box and WD repeat domain containing 8	0.011
TMEM106C	transmembrane protein 106C	0.011
DSCC1	defective in sister chromatid cohesion 1 homolog (S. cerevisiae)	0.011
MLL5	myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)	0.011
DTL	denticleless homolog (Drosophila)	0.011
NKTR	natural killer-tumor recognition sequence	0.011
RBBP7	retinoblastoma binding protein 7	0.011
PRR14	proline rich 14	0.011
ATRIP	ATR interacting protein	0.011
KIF2C	kinesin family member 2C	0.010
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.010
PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	0.010
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.010
RIF1	RAP1 interacting factor homolog (yeast)	0.010
TNRC6B	trinucleotide repeat containing 6B	0.010
ATM	ataxia telangiectasia mutated	0.010
TRAIP	TRAF interacting protein	0.010