IMP

Process View

Homo sapiens

18 genes annotated in human

Multi-species View

regulation of osteoclast differentiation

GO:0045670

Any process that modulates the frequency, rate or extent of osteoclast differentiation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of osteoclast differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of osteoclast differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
ZNF43	zinc finger protein 43	0.999
IL4R	interleukin 4 receptor	0.991
ZNF273	zinc finger protein 273	0.990	Human
CCR5	chemokine (C-C motif) receptor 5	0.983	Human
ZNF253	zinc finger protein 253	0.973
TRAF1	TNF receptor-associated factor 1	0.951	Human
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.947
ZNF675	zinc finger protein 675	0.912
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.864
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.857
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.825
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.791
PILRA	paired immunoglobin-like type 2 receptor alpha	0.772	Mouse
CCL22	chemokine (C-C motif) ligand 22	0.755	Human
CD40	CD40 molecule, TNF receptor superfamily member 5	0.715
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.656
IFNG	interferon, gamma	0.644
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.623
CXCL9	chemokine (C-X-C motif) ligand 9	0.608
TRAF2	TNF receptor-associated factor 2	0.598	Human
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.564
ZNF117	zinc finger protein 117	0.479	Human
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.465
ZNF85	zinc finger protein 85	0.448	Human
ZNF91	zinc finger protein 91	0.433
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.429
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.417
CCL4	chemokine (C-C motif) ligand 4	0.409	Human
CCL5	chemokine (C-C motif) ligand 5	0.400	Human Rat
TRADD	TNFRSF1A-associated via death domain	0.393
TRAF3	TNF receptor-associated factor 3	0.388	Human
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.387	Human
ZNF93	zinc finger protein 93	0.368
CCR4	chemokine (C-C motif) receptor 4	0.347	Human
CCR7	chemokine (C-C motif) receptor 7	0.343	Human
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.342	Human
CD14	CD14 molecule	0.324
ZNF254	zinc finger protein 254	0.311	Human
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.311
FASLG	Fas ligand (TNF superfamily, member 6)	0.308	Human
CCR1	chemokine (C-C motif) receptor 1	0.298
IL2RB	interleukin 2 receptor, beta	0.268
IL10	interleukin 10	0.241
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.232
CCL8	chemokine (C-C motif) ligand 8	0.229	Human
PTAFR	platelet-activating factor receptor	0.224
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.211
SH2D1A	SH2 domain containing 1A	0.202
IL23A	interleukin 23, alpha subunit p19	0.199
IRF4	interferon regulatory factor 4	0.195
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.172
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.166
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.154
SIRPB1	signal-regulatory protein beta 1	0.145
SIGLEC7	sialic acid binding Ig-like lectin 7	0.143
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.140	Human Rat
CXCL13	chemokine (C-X-C motif) ligand 13	0.135
CCL7	chemokine (C-C motif) ligand 7	0.134	Human
CD40LG	CD40 ligand	0.134
HK3	hexokinase 3 (white cell)	0.114
ZNF708	zinc finger protein 708	0.107	Human
TGFB1	transforming growth factor, beta 1	0.106
CCR2	chemokine (C-C motif) receptor 2	0.104	Human
CCL13	chemokine (C-C motif) ligand 13	0.097	Human
IL1B	interleukin 1, beta	0.096
TNF	tumor necrosis factor	0.093
TRAF5	TNF receptor-associated factor 5	0.092	Human
ZNF430	zinc finger protein 430	0.089	Human
CD86	CD86 molecule	0.087
SLAMF7	SLAM family member 7	0.083
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.081
SH3BP2	SH3-domain binding protein 2	0.078
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.075
CCL2	chemokine (C-C motif) ligand 2	0.075	Human
CFLAR	CASP8 and FADD-like apoptosis regulator	0.067
FAS	Fas (TNF receptor superfamily, member 6)	0.066
ARRB1	arrestin, beta 1	0.065
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.062
SLAMF1	signaling lymphocytic activation molecule family member 1	0.061
ZNF680	zinc finger protein 680	0.059	Human
RIPK2	receptor-interacting serine-threonine kinase 2	0.057
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.055
CD80	CD80 molecule	0.053
ZMYND11	zinc finger, MYND-type containing 11	0.053
CXCR6	chemokine (C-X-C motif) receptor 6	0.053	Human
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.052
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.052
ZNF682	zinc finger protein 682	0.052	Human
BIRC3	baculoviral IAP repeat containing 3	0.052
PDPK1	3-phosphoinositide dependent protein kinase-1	0.048
DOCK7	dedicator of cytokinesis 7	0.048
IL10RA	interleukin 10 receptor, alpha	0.045
CCR3	chemokine (C-C motif) receptor 3	0.044	Human
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.044
SMAD1	SMAD family member 1	0.044
CD28	CD28 molecule	0.043
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.042
ZNF107	zinc finger protein 107	0.041
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	0.040
ZNF512B	zinc finger protein 512B	0.039
NLRP3	NLR family, pyrin domain containing 3	0.038
TREM1	triggering receptor expressed on myeloid cells 1	0.038
CCL3	chemokine (C-C motif) ligand 3	0.038
TYMP	thymidine phosphorylase	0.036
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.036
TRAF6	TNF receptor-associated factor 6	0.036
CCL19	chemokine (C-C motif) ligand 19	0.034	Human
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.034
AOAH	acyloxyacyl hydrolase (neutrophil)	0.034
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.033
IL1R2	interleukin 1 receptor, type II	0.033
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.031
CCR8	chemokine (C-C motif) receptor 8	0.030	Human
BMP2	bone morphogenetic protein 2	0.030
NUMBL	numb homolog (Drosophila)-like	0.030
CCL11	chemokine (C-C motif) ligand 11	0.029	Human
CXCR3	chemokine (C-X-C motif) receptor 3	0.029	Human
ZNF92	zinc finger protein 92	0.029	Human
TMSB4X	thymosin beta 4, X-linked	0.028
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.028
IDE	insulin-degrading enzyme	0.028
EBI3	Epstein-Barr virus induced 3	0.027
FADD	Fas (TNFRSF6)-associated via death domain	0.026
EPOR	erythropoietin receptor	0.026
ZNF506	zinc finger protein 506	0.026	Human
JUN	jun proto-oncogene	0.026
SH2D1B	SH2 domain containing 1B	0.026
JUND	jun D proto-oncogene	0.025
FPR2	formyl peptide receptor 2	0.025
SOCS3	suppressor of cytokine signaling 3	0.024
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.024
ATF2	activating transcription factor 2	0.023
JAG1	jagged 1	0.022
DPP4	dipeptidyl-peptidase 4	0.021
INHBA	inhibin, beta A	0.021
IL1A	interleukin 1, alpha	0.021
C1orf93	chromosome 1 open reading frame 93	0.020	Human
CD33	CD33 molecule	0.020
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.020
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.020
IGSF6	immunoglobulin superfamily, member 6	0.020
C2	complement component 2	0.019
EGR1	early growth response 1	0.019
FYN	FYN oncogene related to SRC, FGR, YES	0.019
CSK	c-src tyrosine kinase	0.019
CLEC10A	C-type lectin domain family 10, member A	0.018
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.018	Human
ZNF136	zinc finger protein 136	0.018
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.018	Human
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.018
CXCL11	chemokine (C-X-C motif) ligand 11	0.017
IL2RA	interleukin 2 receptor, alpha	0.017
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.017
IL1RN	interleukin 1 receptor antagonist	0.017
CCR9	chemokine (C-C motif) receptor 9	0.017	Human
MDFI	MyoD family inhibitor	0.016
CXCR2	chemokine (C-X-C motif) receptor 2	0.016	Human
MARCO	macrophage receptor with collagenous structure	0.016
LGALS2	lectin, galactoside-binding, soluble, 2	0.016
GRAP2	GRB2-related adaptor protein 2	0.016
FPR3	formyl peptide receptor 3	0.016
CD163	CD163 molecule	0.015
BMPR1A	bone morphogenetic protein receptor, type IA	0.015
FCAR	Fc fragment of IgA, receptor for	0.015	Human
IRAK2	interleukin-1 receptor-associated kinase 2	0.015
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.015
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.015	Mouse
CCL20	chemokine (C-C motif) ligand 20	0.015	Human
ZNF320	zinc finger protein 320	0.015
HCK	hemopoietic cell kinase	0.014
SLAMF8	SLAM family member 8	0.014
IER2	immediate early response 2	0.014
TRAF3IP2	TRAF3 interacting protein 2	0.014
TIFA	TRAF-interacting protein with forkhead-associated domain	0.014
ING2	inhibitor of growth family, member 2	0.014
ICAM1	intercellular adhesion molecule 1	0.014
NCOA2	nuclear receptor coactivator 2	0.014
CFP	complement factor properdin	0.014
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.014
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.014
CCL17	chemokine (C-C motif) ligand 17	0.013	Human
ADAMDEC1	ADAM-like, decysin 1	0.013
CD2	CD2 molecule	0.013
IL8	interleukin 8	0.013
CXCL10	chemokine (C-X-C motif) ligand 10	0.013
AR	androgen receptor	0.013
CMKLR1	chemokine-like receptor 1	0.013
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.013
NOD2	nucleotide-binding oligomerization domain containing 2	0.013
CCR6	chemokine (C-C motif) receptor 6	0.013	Human
WNT2	wingless-type MMTV integration site family member 2	0.013
RUNX2	runt-related transcription factor 2	0.013
AQP9	aquaporin 9	0.012
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.012
IL13	interleukin 13	0.012
SLC15A3	solute carrier family 15, member 3	0.012
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.012
C3AR1	complement component 3a receptor 1	0.012
LMO4	LIM domain only 4	0.012
C7orf64	chromosome 7 open reading frame 64	0.012
BATF	basic leucine zipper transcription factor, ATF-like	0.011
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.011
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.011
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.011
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.011
IL7R	interleukin 7 receptor	0.011
FST	follistatin	0.011	Human
PDCD1LG2	programmed cell death 1 ligand 2	0.011
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.011	Human
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.011
FSTL1	follistatin-like 1	0.011	Human
LAG3	lymphocyte-activation gene 3	0.011
IL12RB1	interleukin 12 receptor, beta 1	0.011
IL2RG	interleukin 2 receptor, gamma	0.011
GPR171	G protein-coupled receptor 171	0.010
IL6	interleukin 6 (interferon, beta 2)	0.010
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.010
CCL1	chemokine (C-C motif) ligand 1	0.010	Human
NOTCH2NL	notch 2 N-terminal like	0.010
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.010
CD83	CD83 molecule	0.010