IMP

Process View

Homo sapiens

33 genes annotated in human

endothelium development

The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endothelium development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endothelium development" (in gray)

Name	Description	Probability	Func Analog Organism
BMPR1A	bone morphogenetic protein receptor, type IA	0.809	Human
SMAD7	SMAD family member 7	0.716
CAB39	calcium binding protein 39	0.586
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.505
NRP1	neuropilin 1	0.472
RARA	retinoic acid receptor, alpha	0.448
TGFB1	transforming growth factor, beta 1	0.438
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.437
FKBP1A	FK506 binding protein 1A, 12kDa	0.377
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.376	Human Mouse
SMAD2	SMAD family member 2	0.281
SMAD5	SMAD family member 5	0.276
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.254	Mouse
EGFR	epidermal growth factor receptor	0.227
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.219
VEGFA	vascular endothelial growth factor A	0.209	Mouse
CD44	CD44 molecule (Indian blood group)	0.204
CAV1	caveolin 1, caveolae protein, 22kDa	0.203
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.200
BMP2	bone morphogenetic protein 2	0.198	Human
DTNA	dystrobrevin, alpha	0.198
PAX3	paired box 3	0.179
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.174
JAG1	jagged 1	0.169
GAB1	GRB2-associated binding protein 1	0.169
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.161
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.144
PBX1	pre-B-cell leukemia homeobox 1	0.137
SCHIP1	schwannomin interacting protein 1	0.120
SMAD3	SMAD family member 3	0.118
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.115
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.107
POU3F2	POU class 3 homeobox 2	0.096
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.095
PTCH1	patched 1	0.092
TJP1	tight junction protein 1 (zona occludens 1)	0.090
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.089
VWF	von Willebrand factor	0.087
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.082
RANBP9	RAN binding protein 9	0.071
CNOT8	CCR4-NOT transcription complex, subunit 8	0.071
CDH5	cadherin 5, type 2 (vascular endothelium)	0.068
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.065
PROX1	prospero homeobox 1	0.065
SPOP	speckle-type POZ protein	0.064
ITSN1	intersectin 1 (SH3 domain protein)	0.062
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.060
NOTCH1	notch 1	0.058	Mouse Rat
NOTCH3	notch 3	0.057
ICAM2	intercellular adhesion molecule 2	0.054	Human
PECAM1	platelet/endothelial cell adhesion molecule	0.054
PTPRB	protein tyrosine phosphatase, receptor type, B	0.051
GATA2	GATA binding protein 2	0.050
HNF4A	hepatocyte nuclear factor 4, alpha	0.049	Human
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.048
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.047
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.046
GDF5	growth differentiation factor 5	0.046
ENG	endoglin	0.046
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.045
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.045
GAS6	growth arrest-specific 6	0.045
TECPR1	tectonin beta-propeller repeat containing 1	0.044
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.043
MED28	mediator complex subunit 28	0.043
RUNX1	runt-related transcription factor 1	0.043
RAP1A	RAP1A, member of RAS oncogene family	0.041
EPS8	epidermal growth factor receptor pathway substrate 8	0.041
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.039
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.039
BZW1	basic leucine zipper and W2 domains 1	0.038
MED25	mediator complex subunit 25	0.037
QKI	quaking homolog, KH domain RNA binding (mouse)	0.037
SMAD1	SMAD family member 1	0.036
PLEC	plectin	0.036
MEIS2	Meis homeobox 2	0.035
BCR	breakpoint cluster region	0.034
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.034	Mouse
TGFB3	transforming growth factor, beta 3	0.034
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.033
TCF12	transcription factor 12	0.032
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.032
ABI1	abl-interactor 1	0.032
GJA1	gap junction protein, alpha 1, 43kDa	0.031
MAML1	mastermind-like 1 (Drosophila)	0.031
FLNA	filamin A, alpha	0.031
TSC22D1	TSC22 domain family, member 1	0.031
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.030
MAPK8	mitogen-activated protein kinase 8	0.029
FSTL1	follistatin-like 1	0.029
GRB2	growth factor receptor-bound protein 2	0.029
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.029
ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40	0.029
CLDN5	claudin 5	0.029
CD34	CD34 molecule	0.029
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.028
SKIL	SKI-like oncogene	0.028
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.028
ZFYVE9	zinc finger, FYVE domain containing 9	0.027
GAB2	GRB2-associated binding protein 2	0.027
FAM46A	family with sequence similarity 46, member A	0.027
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.026
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.026
RAMP3	receptor (G protein-coupled) activity modifying protein 3	0.025
ITGB4	integrin, beta 4	0.025
TBC1D10A	TBC1 domain family, member 10A	0.025
PCDH12	protocadherin 12	0.024
PRKG1	protein kinase, cGMP-dependent, type I	0.024
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.024
PCDH17	protocadherin 17	0.024
ZC3H12A	zinc finger CCCH-type containing 12A	0.024
RALGDS	ral guanine nucleotide dissociation stimulator	0.024
ACVRL1	activin A receptor type II-like 1	0.024
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.024
CXCR5	chemokine (C-X-C motif) receptor 5	0.023
CTNNBIP1	catenin, beta interacting protein 1	0.023
MCAM	melanoma cell adhesion molecule	0.023
FERMT2	fermitin family member 2	0.023
INHBB	inhibin, beta B	0.022
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.022
PGF	placental growth factor	0.022
SPRY4	sprouty homolog 4 (Drosophila)	0.022
TAL1	T-cell acute lymphocytic leukemia 1	0.022	Zebrafish
RBPMS	RNA binding protein with multiple splicing	0.022
BMP4	bone morphogenetic protein 4	0.021
VEGFC	vascular endothelial growth factor C	0.021
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.021
PNRC1	proline-rich nuclear receptor coactivator 1	0.021
LAPTM5	lysosomal protein transmembrane 5	0.020
SMAD4	SMAD family member 4	0.020	Mouse
SREBF2	sterol regulatory element binding transcription factor 2	0.020
COL4A2	collagen, type IV, alpha 2	0.020
ZEB2	zinc finger E-box binding homeobox 2	0.020
EGFL7	EGF-like-domain, multiple 7	0.020
RHOA	ras homolog gene family, member A	0.020
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.020
GJA4	gap junction protein, alpha 4, 37kDa	0.019	Rat
HOXB7	homeobox B7	0.019
ERBB2IP	erbb2 interacting protein	0.019
MEOX2	mesenchyme homeobox 2	0.019
LYL1	lymphoblastic leukemia derived sequence 1	0.019
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.019	Human
CAV2	caveolin 2	0.018
BPTF	bromodomain PHD finger transcription factor	0.018
WNK4	WNK lysine deficient protein kinase 4	0.018
KANK3	KN motif and ankyrin repeat domains 3	0.018
ANGPT2	angiopoietin 2	0.018
SOCS5	suppressor of cytokine signaling 5	0.018
ZMYND11	zinc finger, MYND-type containing 11	0.018
DLL1	delta-like 1 (Drosophila)	0.018
TJP2	tight junction protein 2 (zona occludens 2)	0.017
IRAK2	interleukin-1 receptor-associated kinase 2	0.017
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.017
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.017
SPRED1	sprouty-related, EVH1 domain containing 1	0.017
FLT4	fms-related tyrosine kinase 4	0.017
CD93	CD93 molecule	0.017
DSP	desmoplakin	0.017
FOXF1	forkhead box F1	0.017
DTNB	dystrobrevin, beta	0.017
BTRC	beta-transducin repeat containing	0.017
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.017
ITM2A	integral membrane protein 2A	0.017
TBX2	T-box 2	0.017
TEK	TEK tyrosine kinase, endothelial	0.016
RHOG	ras homolog gene family, member G (rho G)	0.016
JUNB	jun B proto-oncogene	0.016
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.016
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.016
APC	adenomatous polyposis coli	0.016
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.016
PLXNB1	plexin B1	0.016
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.016
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.016
RUNDC3A	RUN domain containing 3A	0.015
MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5	0.015
GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.015	Fly
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.015
IER2	immediate early response 2	0.015
SALL2	sal-like 2 (Drosophila)	0.015
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.015
DDIT4	DNA-damage-inducible transcript 4	0.015
MDFI	MyoD family inhibitor	0.015
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.015
GPR116	G protein-coupled receptor 116	0.015
PICALM	phosphatidylinositol binding clathrin assembly protein	0.015
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.015
NOTCH2	notch 2	0.014
JUND	jun D proto-oncogene	0.014
ARHGEF15	Rho guanine nucleotide exchange factor (GEF) 15	0.014
PALM2-AKAP2	PALM2-AKAP2 readthrough	0.014
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.014
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.014
HOXB6	homeobox B6	0.014
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.014	Mouse
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.014
F2R	coagulation factor II (thrombin) receptor	0.014	Human
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.014
APLNR	apelin receptor	0.014
LRRC32	leucine rich repeat containing 32	0.014
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.014
RGS16	regulator of G-protein signaling 16	0.014
PLXND1	plexin D1	0.014
NCOR2	nuclear receptor corepressor 2	0.014
RET	ret proto-oncogene	0.014
SLCO2A1	solute carrier organic anion transporter family, member 2A1	0.014
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.014
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.014	Mouse
CTNND1	catenin (cadherin-associated protein), delta 1	0.014
ADAM11	ADAM metallopeptidase domain 11	0.014
GNA13	guanine nucleotide binding protein (G protein), alpha 13	0.014
MECOM	MDS1 and EVI1 complex locus	0.014
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.014
MED13	mediator complex subunit 13	0.014
AQP1	aquaporin 1 (Colton blood group)	0.013
HOXA9	homeobox A9	0.013
PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	0.013
USP15	ubiquitin specific peptidase 15	0.013
KRT5	keratin 5	0.013
ACVR1	activin A receptor, type I	0.013
HES1	hairy and enhancer of split 1, (Drosophila)	0.013
HR	hairless homolog (mouse)	0.013
BTG2	BTG family, member 2	0.013	Human
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.013
RRAS2	related RAS viral (r-ras) oncogene homolog 2	0.013
HOXB9	homeobox B9	0.013
CD2AP	CD2-associated protein	0.013
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.013
FZD4	frizzled homolog 4 (Drosophila)	0.013
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.013
COL6A1	collagen, type VI, alpha 1	0.013
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.013
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.013
JAG2	jagged 2	0.013
CLEC3B	C-type lectin domain family 3, member B	0.013
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.013
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.012
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.012
EZR	ezrin	0.012
ESAM	endothelial cell adhesion molecule	0.012
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.012
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.012
ATXN1	ataxin 1	0.012
ACTN4	actinin, alpha 4	0.012
SDPR	serum deprivation response	0.012
DAZAP2	DAZ associated protein 2	0.012
NOTCH4	notch 4	0.012	Mouse Rat
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.012
HOXA10	homeobox A10	0.012
ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.012
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.012
LMO4	LIM domain only 4	0.012
MMRN2	multimerin 2	0.012
BMP7	bone morphogenetic protein 7	0.012
SWAP70	SWAP switching B-cell complex 70kDa subunit	0.012
VCAM1	vascular cell adhesion molecule 1	0.012
S1PR1	sphingosine-1-phosphate receptor 1	0.012	Human Rat
ACTN1	actinin, alpha 1	0.012
FNDC3B	fibronectin type III domain containing 3B	0.012
EMCN	endomucin	0.012
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.011
IRAK3	interleukin-1 receptor-associated kinase 3	0.011
GOLM1	golgi membrane protein 1	0.011
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.011
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	0.011
CTBP2	C-terminal binding protein 2	0.011
RAP1B	RAP1B, member of RAS oncogene family	0.011
FGFR1	fibroblast growth factor receptor 1	0.011
SEPT10	septin 10	0.011
CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)	0.011
RHOC	ras homolog gene family, member C	0.011
GPR4	G protein-coupled receptor 4	0.011
ARRDC3	arrestin domain containing 3	0.011
MSN	moesin	0.011
ADRBK1	adrenergic, beta, receptor kinase 1	0.011
JUN	jun proto-oncogene	0.011
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.011
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.011
PTPRA	protein tyrosine phosphatase, receptor type, A	0.011
HNF1A	HNF1 homeobox A	0.011
TRIM33	tripartite motif containing 33	0.011
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.011
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.011
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.011
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.011
ADAMTS9	ADAM metallopeptidase with thrombospondin type 1 motif, 9	0.011
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.011
SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	0.011
LAT	linker for activation of T cells	0.011
PLVAP	plasmalemma vesicle associated protein	0.011
NOG	noggin	0.010
BCL6B	B-cell CLL/lymphoma 6, member B	0.010
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.010
ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	0.010
TRAM1	translocation associated membrane protein 1	0.010
CORO1C	coronin, actin binding protein, 1C	0.010
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.010
ATXN1L	ataxin 1-like	0.010
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.010
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.010
ADRB2	adrenergic, beta-2-, receptor, surface	0.010
SMAD9	SMAD family member 9	0.010
CSF1	colony stimulating factor 1 (macrophage)	0.010
BMP6	bone morphogenetic protein 6	0.010	Mouse
IRAK4	interleukin-1 receptor-associated kinase 4	0.010
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.010
SMAD6	SMAD family member 6	0.010
OLIG2	oligodendrocyte lineage transcription factor 2	0.010
SLIT2	slit homolog 2 (Drosophila)	0.010
IRAK1	interleukin-1 receptor-associated kinase 1	0.010