IMP
Process View
negative regulation of transforming growth factor beta receptor signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of transforming growth factor beta receptor signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 1.000 | Human | |
| SMAD4 | SMAD family member 4 | 0.998 | Human | |
| SMAD5 | SMAD family member 5 | 0.994 | Human | |
| SMAD1 | SMAD family member 1 | 0.993 | Human | |
| SMAD2 | SMAD family member 2 | 0.991 | Human | |
| SMAD7 | SMAD family member 7 | 0.982 | ||
| SNX6 | sorting nexin 6 | 0.980 | ||
| SMAD3 | SMAD family member 3 | 0.965 | Human | |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.952 | ||
| TBX5 | T-box 5 | 0.907 | ||
| ABI2 | abl-interactor 2 | 0.670 | ||
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.656 | ||
| TGFB1 | transforming growth factor, beta 1 | 0.630 | ||
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.627 | ||
| SNX1 | sorting nexin 1 | 0.599 | Human | |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.544 | ||
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.511 | ||
| ZFYVE9 | zinc finger, FYVE domain containing 9 | 0.480 | ||
| LOX | lysyl oxidase | 0.448 | ||
| MAGEF1 | melanoma antigen family F, 1 | 0.441 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.430 | ||
| SNX2 | sorting nexin 2 | 0.423 | Human | |
| FHL2 | four and a half LIM domains 2 | 0.338 | ||
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.334 | ||
| SKIL | SKI-like oncogene | 0.284 | ||
| MAD2L2 | MAD2 mitotic arrest deficient-like 2 (yeast) | 0.283 | ||
| AR | androgen receptor | 0.231 | ||
| DLG1 | discs, large homolog 1 (Drosophila) | 0.206 | ||
| ENG | endoglin | 0.196 | ||
| CXXC5 | CXXC finger protein 5 | 0.181 | ||
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.172 | Human | |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.170 | ||
| NCK2 | NCK adaptor protein 2 | 0.168 | ||
| DAB2 | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 0.162 | ||
| ELN | elastin | 0.158 | ||
| APOE | apolipoprotein E | 0.156 | ||
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.154 | ||
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.151 | ||
| AQP1 | aquaporin 1 (Colton blood group) | 0.150 | ||
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 0.147 | ||
| FBXL15 | F-box and leucine-rich repeat protein 15 | 0.143 | ||
| ERBB2IP | erbb2 interacting protein | 0.142 | ||
| COL6A1 | collagen, type VI, alpha 1 | 0.139 | ||
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.139 | ||
| SKI | v-ski sarcoma viral oncogene homolog (avian) | 0.128 | ||
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.121 | ||
| WWP1 | WW domain containing E3 ubiquitin protein ligase 1 | 0.118 | Human | |
| SCNN1B | sodium channel, nonvoltage-gated 1, beta | 0.115 | ||
| ITGAV | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 0.115 | ||
| COL8A1 | collagen, type VIII, alpha 1 | 0.100 | ||
| VCL | vinculin | 0.096 | ||
| SH3D19 | SH3 domain containing 19 | 0.094 | ||
| DNAJB11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | 0.093 | ||
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.090 | Human | |
| DCN | decorin | 0.089 | Human | |
| PTEN | phosphatase and tensin homolog | 0.082 | ||
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.081 | ||
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.080 | ||
| YAP1 | Yes-associated protein 1 | 0.078 | ||
| FN1 | fibronectin 1 | 0.075 | ||
| PARVA | parvin, alpha | 0.075 | ||
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.071 | ||
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.069 | ||
| PRKCDBP | protein kinase C, delta binding protein | 0.068 | ||
| KAT2B | K(lysine) acetyltransferase 2B | 0.068 | ||
| SMAD6 | SMAD family member 6 | 0.067 | ||
| SH3PXD2A | SH3 and PX domains 2A | 0.066 | ||
| COL1A1 | collagen, type I, alpha 1 | 0.064 | ||
| SOX7 | SRY (sex determining region Y)-box 7 | 0.064 | ||
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.063 | ||
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.059 | ||
| COL3A1 | collagen, type III, alpha 1 | 0.058 | ||
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.058 | ||
| FBLN2 | fibulin 2 | 0.055 | ||
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.054 | ||
| ANKRD13A | ankyrin repeat domain 13A | 0.054 | ||
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.049 | ||
| PXN | paxillin | 0.049 | Human | |
| SPG20 | spastic paraplegia 20 (Troyer syndrome) | 0.049 | ||
| FSTL1 | follistatin-like 1 | 0.049 | ||
| FBLN1 | fibulin 1 | 0.048 | ||
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.048 | ||
| LUM | lumican | 0.047 | Human | |
| MESDC2 | mesoderm development candidate 2 | 0.045 | ||
| APP | amyloid beta (A4) precursor protein | 0.044 | ||
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.044 | ||
| COL14A1 | collagen, type XIV, alpha 1 | 0.043 | ||
| MIB1 | mindbomb homolog 1 (Drosophila) | 0.041 | ||
| PTPN23 | protein tyrosine phosphatase, non-receptor type 23 | 0.041 | ||
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.041 | ||
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.040 | ||
| CDC42EP1 | CDC42 effector protein (Rho GTPase binding) 1 | 0.040 | ||
| MFAP2 | microfibrillar-associated protein 2 | 0.039 | ||
| DCUN1D1 | DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) | 0.039 | ||
| CTSK | cathepsin K | 0.039 | ||
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.037 | ||
| THBS2 | thrombospondin 2 | 0.036 | ||
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.035 | ||
| DPT | dermatopontin | 0.035 | ||
| AEBP1 | AE binding protein 1 | 0.034 | ||
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.034 | ||
| ISLR | immunoglobulin superfamily containing leucine-rich repeat | 0.033 | ||
| ZMYND11 | zinc finger, MYND-type containing 11 | 0.033 | ||
| RAP1B | RAP1B, member of RAS oncogene family | 0.032 | ||
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.032 | ||
| YY1 | YY1 transcription factor | 0.032 | ||
| SGCE | sarcoglycan, epsilon | 0.031 | ||
| ANTXR2 | anthrax toxin receptor 2 | 0.031 | ||
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.031 | ||
| NRP1 | neuropilin 1 | 0.031 | ||
| SORBS3 | sorbin and SH3 domain containing 3 | 0.031 | ||
| INHBA | inhibin, beta A | 0.030 | ||
| DOCK8 | dedicator of cytokinesis 8 | 0.029 | ||
| PAX8 | paired box 8 | 0.029 | ||
| MMP2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 0.029 | ||
| MFAP4 | microfibrillar-associated protein 4 | 0.028 | ||
| TSC22D1 | TSC22 domain family, member 1 | 0.028 | ||
| APBA1 | amyloid beta (A4) precursor protein-binding, family A, member 1 | 0.028 | ||
| HOXA1 | homeobox A1 | 0.028 | ||
| C1orf93 | chromosome 1 open reading frame 93 | 0.027 | ||
| MKL2 | MKL/myocardin-like 2 | 0.027 | ||
| ITGA7 | integrin, alpha 7 | 0.027 | ||
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.026 | ||
| AXIN1 | axin 1 | 0.026 | ||
| ITGB5 | integrin, beta 5 | 0.025 | ||
| SBF1 | SET binding factor 1 | 0.025 | ||
| FNDC3B | fibronectin type III domain containing 3B | 0.025 | ||
| DCP1B | DCP1 decapping enzyme homolog B (S. cerevisiae) | 0.025 | ||
| TGFB2 | transforming growth factor, beta 2 | 0.025 | ||
| TRIP6 | thyroid hormone receptor interactor 6 | 0.025 | ||
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 0.024 | ||
| FBN2 | fibrillin 2 | 0.024 | Mouse | |
| LHFP | lipoma HMGIC fusion partner | 0.024 | ||
| SIN3A | SIN3 homolog A, transcription regulator (yeast) | 0.023 | ||
| FOXO3 | forkhead box O3 | 0.022 | ||
| OGN | osteoglycin | 0.022 | ||
| TRIM33 | tripartite motif containing 33 | 0.022 | ||
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 | 0.022 | ||
| COL1A2 | collagen, type I, alpha 2 | 0.022 | ||
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.021 | ||
| USP15 | ubiquitin specific peptidase 15 | 0.021 | ||
| ICK | intestinal cell (MAK-like) kinase | 0.021 | ||
| GLT8D2 | glycosyltransferase 8 domain containing 2 | 0.021 | ||
| SIRT1 | sirtuin 1 | 0.021 | Mouse | |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.021 | ||
| VCAN | versican | 0.021 | ||
| ADAM10 | ADAM metallopeptidase domain 10 | 0.021 | ||
| ARRDC3 | arrestin domain containing 3 | 0.021 | ||
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.021 | ||
| NDN | necdin homolog (mouse) | 0.021 | ||
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.021 | ||
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.021 | ||
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like | 0.020 | Human | |
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.020 | ||
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.020 | ||
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific | 0.020 | ||
| BBS10 | Bardet-Biedl syndrome 10 | 0.020 | ||
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.020 | ||
| COL6A3 | collagen, type VI, alpha 3 | 0.019 | ||
| SPARCL1 | SPARC-like 1 (hevin) | 0.019 | ||
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.019 | ||
| F2R | coagulation factor II (thrombin) receptor | 0.019 | ||
| BGN | biglycan | 0.019 | Human | |
| FOXA2 | forkhead box A2 | 0.019 | ||
| SPOPL | speckle-type POZ protein-like | 0.019 | ||
| FOXD3 | forkhead box D3 | 0.019 | ||
| MTMR4 | myotubularin related protein 4 | 0.018 | ||
| SNAI2 | snail homolog 2 (Drosophila) | 0.018 | ||
| DCP1A | DCP1 decapping enzyme homolog A (S. cerevisiae) | 0.018 | ||
| RNF168 | ring finger protein 168 | 0.018 | ||
| ADAM9 | ADAM metallopeptidase domain 9 | 0.018 | Human | |
| DDX4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | 0.017 | ||
| MTOR | mechanistic target of rapamycin (serine/threonine kinase) | 0.017 | ||
| MED15 | mediator complex subunit 15 | 0.017 | ||
| FNBP1 | formin binding protein 1 | 0.017 | ||
| EID2 | EP300 interacting inhibitor of differentiation 2 | 0.017 | ||
| WDYHV1 | WDYHV motif containing 1 | 0.017 | ||
| PDCD6IP | programmed cell death 6 interacting protein | 0.017 | ||
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.017 | ||
| RANBP9 | RAN binding protein 9 | 0.017 | ||
| WNK1 | WNK lysine deficient protein kinase 1 | 0.016 | ||
| RARA | retinoic acid receptor, alpha | 0.016 | ||
| SFRP4 | secreted frizzled-related protein 4 | 0.016 | ||
| CREBBP | CREB binding protein | 0.016 | ||
| OLFML2B | olfactomedin-like 2B | 0.016 | ||
| GIT2 | G protein-coupled receptor kinase interacting ArfGAP 2 | 0.016 | ||
| SOX5 | SRY (sex determining region Y)-box 5 | 0.016 | ||
| SH2D2A | SH2 domain containing 2A | 0.016 | ||
| HIPK3 | homeodomain interacting protein kinase 3 | 0.016 | ||
| TGFB3 | transforming growth factor, beta 3 | 0.016 | Rat | |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.016 | ||
| FOXO1 | forkhead box O1 | 0.016 | ||
| COL5A2 | collagen, type V, alpha 2 | 0.015 | ||
| SOX30 | SRY (sex determining region Y)-box 30 | 0.015 | ||
| PHF21A | PHD finger protein 21A | 0.015 | ||
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.015 | ||
| PPIL4 | peptidylprolyl isomerase (cyclophilin)-like 4 | 0.015 | ||
| ZNF426 | zinc finger protein 426 | 0.015 | ||
| OMD | osteomodulin | 0.015 | ||
| LAMB1 | laminin, beta 1 | 0.015 | ||
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | 0.015 | ||
| COL18A1 | collagen, type XVIII, alpha 1 | 0.015 | ||
| MXRA5 | matrix-remodelling associated 5 | 0.014 | ||
| LAMA2 | laminin, alpha 2 | 0.014 | ||
| GATAD2B | GATA zinc finger domain containing 2B | 0.014 | ||
| EMCN | endomucin | 0.014 | ||
| MFAP5 | microfibrillar associated protein 5 | 0.014 | ||
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.014 | ||
| TGIF1 | TGFB-induced factor homeobox 1 | 0.014 | ||
| GEMIN6 | gem (nuclear organelle) associated protein 6 | 0.014 | ||
| NPHP1 | nephronophthisis 1 (juvenile) | 0.014 | ||
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.014 | ||
| TBC1D15 | TBC1 domain family, member 15 | 0.014 | ||
| REV3L | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 0.014 | ||
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.013 | ||
| RNF11 | ring finger protein 11 | 0.013 | ||
| CD59 | CD59 molecule, complement regulatory protein | 0.013 | ||
| CARD11 | caspase recruitment domain family, member 11 | 0.013 | ||
| MYH11 | myosin, heavy chain 11, smooth muscle | 0.013 | ||
| GPNMB | glycoprotein (transmembrane) nmb | 0.013 | ||
| RNF17 | ring finger protein 17 | 0.013 | ||
| ZNF331 | zinc finger protein 331 | 0.013 | ||
| GLIS2 | GLIS family zinc finger 2 | 0.013 | ||
| ACVR1 | activin A receptor, type I | 0.013 | Fly | |
| SEPT8 | septin 8 | 0.012 | ||
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 0.012 | ||
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.012 | ||
| DOCK9 | dedicator of cytokinesis 9 | 0.012 | ||
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.012 | ||
| COLEC12 | collectin sub-family member 12 | 0.012 | ||
| C1S | complement component 1, s subcomponent | 0.012 | ||
| ASPN | asporin | 0.012 | ||
| NID2 | nidogen 2 (osteonidogen) | 0.012 | ||
| LRRC15 | leucine rich repeat containing 15 | 0.012 | ||
| SRI | sorcin | 0.012 | ||
| COL5A3 | collagen, type V, alpha 3 | 0.012 | ||
| SDC2 | syndecan 2 | 0.012 | ||
| CTGF | connective tissue growth factor | 0.012 | ||
| HDLBP | high density lipoprotein binding protein | 0.012 | ||
| COL5A1 | collagen, type V, alpha 1 | 0.012 | ||
| KDM2A | lysine (K)-specific demethylase 2A | 0.012 | ||
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.012 | ||
| HES1 | hairy and enhancer of split 1, (Drosophila) | 0.012 | ||
| CENPB | centromere protein B, 80kDa | 0.012 | ||
| PAPOLA | poly(A) polymerase alpha | 0.012 | ||
| NDFIP2 | Nedd4 family interacting protein 2 | 0.012 | ||
| CD34 | CD34 molecule | 0.012 | ||
| DACT1 | dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) | 0.012 | ||
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 0.012 | ||
| EID3 | EP300 interacting inhibitor of differentiation 3 | 0.012 | ||
| IGF1 | insulin-like growth factor 1 (somatomedin C) | 0.012 | ||
| MAPK8 | mitogen-activated protein kinase 8 | 0.011 | ||
| PTF1A | pancreas specific transcription factor, 1a | 0.011 | ||
| EDNRB | endothelin receptor type B | 0.011 | ||
| WISP1 | WNT1 inducible signaling pathway protein 1 | 0.011 | ||
| CHUK | conserved helix-loop-helix ubiquitous kinase | 0.011 | ||
| STC2 | stanniocalcin 2 | 0.011 | ||
| LCAT | lecithin-cholesterol acyltransferase | 0.011 | ||
| SOCS5 | suppressor of cytokine signaling 5 | 0.011 | ||
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.011 | ||
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.011 | ||
| TRAF4 | TNF receptor-associated factor 4 | 0.011 | ||
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.011 | ||
| PXDN | peroxidasin homolog (Drosophila) | 0.011 | ||
| SNAPIN | SNAP-associated protein | 0.011 | ||
| ZBED5 | zinc finger, BED-type containing 5 | 0.011 | ||
| EID2B | EP300 interacting inhibitor of differentiation 2B | 0.011 | Human | |
| COL10A1 | collagen, type X, alpha 1 | 0.011 | ||
| RNPC3 | RNA-binding region (RNP1, RRM) containing 3 | 0.011 | ||
| PDGFC | platelet derived growth factor C | 0.011 | ||
| DACH1 | dachshund homolog 1 (Drosophila) | 0.011 | ||
| ITIH5 | inter-alpha (globulin) inhibitor H5 | 0.011 | ||
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.011 | ||
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.011 | ||
| SOD3 | superoxide dismutase 3, extracellular | 0.011 | ||
| ITGA6 | integrin, alpha 6 | 0.011 | ||
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.011 | ||
| SMAD9 | SMAD family member 9 | 0.010 | ||
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.010 | ||
| GPR124 | G protein-coupled receptor 124 | 0.010 | ||
| ERG | v-ets erythroblastosis virus E26 oncogene homolog (avian) | 0.010 | ||
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.010 | ||
| PRNP | prion protein | 0.010 | ||
| FAP | fibroblast activation protein, alpha | 0.010 | ||
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.010 | ||
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.010 | ||
| COL6A2 | collagen, type VI, alpha 2 | 0.010 | ||
| SNX5 | sorting nexin 5 | 0.010 | Human | |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | 0.010 | ||
| MAPT | microtubule-associated protein tau | 0.010 | ||
| TLN1 | talin 1 | 0.010 | ||
| PMP22 | peripheral myelin protein 22 | 0.010 | ||
| PRRX1 | paired related homeobox 1 | 0.010 | ||
| NRP2 | neuropilin 2 | 0.010 | ||
| PTRF | polymerase I and transcript release factor | 0.010 | ||
| PRKRA | protein kinase, interferon-inducible double stranded RNA dependent activator | 0.010 | ||
| C7 | complement component 7 | 0.010 | ||
| GATA4 | GATA binding protein 4 | 0.010 |