IMP

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Homo sapiens

26 genes annotated in human

lipopolysaccharide mediated signaling pathway

A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.999
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.992
IL1B	interleukin 1, beta	0.980
IRAK2	interleukin-1 receptor-associated kinase 2	0.978	Human Mouse
MYD88	myeloid differentiation primary response gene (88)	0.977	Mouse
TRAF6	TNF receptor-associated factor 6	0.968	Mouse
CCL4	chemokine (C-C motif) ligand 4	0.967	Human
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.956
IL1R1	interleukin 1 receptor, type I	0.909
BIRC3	baculoviral IAP repeat containing 3	0.904
TLR4	toll-like receptor 4	0.878
IRAK1	interleukin-1 receptor-associated kinase 1	0.869
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.825
TRAF1	TNF receptor-associated factor 1	0.778
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.766
NCF1	neutrophil cytosolic factor 1	0.757
IL8	interleukin 8	0.709
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.706
ICAM1	intercellular adhesion molecule 1	0.648
TLR2	toll-like receptor 2	0.625
CCR5	chemokine (C-C motif) receptor 5	0.607
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.588
CXCL9	chemokine (C-X-C motif) ligand 9	0.569
MAPK1	mitogen-activated protein kinase 1	0.564	Mouse
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.526
TRAF2	TNF receptor-associated factor 2	0.426
ZC3H12A	zinc finger CCCH-type containing 12A	0.387
MAPK14	mitogen-activated protein kinase 14	0.364	Mouse
CCL8	chemokine (C-C motif) ligand 8	0.357	Human
CCR1	chemokine (C-C motif) receptor 1	0.330
TICAM2	toll-like receptor adaptor molecule 2	0.318
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.296
IFNGR1	interferon gamma receptor 1	0.269
TNIP2	TNFAIP3 interacting protein 2	0.262
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.247	Human
DUSP1	dual specificity phosphatase 1	0.245
TRAF3	TNF receptor-associated factor 3	0.238
NCF2	neutrophil cytosolic factor 2	0.237
PRKCA	protein kinase C, alpha	0.236
CXCL2	chemokine (C-X-C motif) ligand 2	0.224
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.216
MAPK3	mitogen-activated protein kinase 3	0.202	Mouse
MED15	mediator complex subunit 15	0.197
IRF1	interferon regulatory factor 1	0.180
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.170
IRF7	interferon regulatory factor 7	0.169
SQSTM1	sequestosome 1	0.160
IRAK3	interleukin-1 receptor-associated kinase 3	0.149	Human
CCL2	chemokine (C-C motif) ligand 2	0.148
CXCL10	chemokine (C-X-C motif) ligand 10	0.147
TRIM21	tripartite motif containing 21	0.141	Human
CCL5	chemokine (C-C motif) ligand 5	0.141
CD14	CD14 molecule	0.133
IL6	interleukin 6 (interferon, beta 2)	0.125
ZNF263	zinc finger protein 263	0.125
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.106
CCL20	chemokine (C-C motif) ligand 20	0.102	Human
PELI3	pellino homolog 3 (Drosophila)	0.100
IL1R2	interleukin 1 receptor, type II	0.099
CXCL3	chemokine (C-X-C motif) ligand 3	0.098
RNASE6	ribonuclease, RNase A family, k6	0.098
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.096
IL7R	interleukin 7 receptor	0.095
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.094
DPP4	dipeptidyl-peptidase 4	0.094
CCL22	chemokine (C-C motif) ligand 22	0.093	Human
TNF	tumor necrosis factor	0.092
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.088
TNIP1	TNFAIP3 interacting protein 1	0.085
CTSS	cathepsin S	0.085
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.082
CD40	CD40 molecule, TNF receptor superfamily member 5	0.080
TRIM5	tripartite motif containing 5	0.079
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.075
CCR7	chemokine (C-C motif) receptor 7	0.075
SP100	SP100 nuclear antigen	0.073
IDE	insulin-degrading enzyme	0.072
XIAP	X-linked inhibitor of apoptosis	0.071
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.070
RNF31	ring finger protein 31	0.070
ARRB1	arrestin, beta 1	0.069
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.066
CCL13	chemokine (C-C motif) ligand 13	0.064	Human
RICTOR	RPTOR independent companion of MTOR, complex 2	0.063
ENG	endoglin	0.061
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.060
CD86	CD86 molecule	0.058
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.056
CXCL13	chemokine (C-X-C motif) ligand 13	0.054
ATF5	activating transcription factor 5	0.053
CCL19	chemokine (C-C motif) ligand 19	0.052	Human
CD163	CD163 molecule	0.051
SLAMF7	SLAM family member 7	0.050
UBD	ubiquitin D	0.050
NCF4	neutrophil cytosolic factor 4, 40kDa	0.048
IFNG	interferon, gamma	0.048
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.047
CXCL5	chemokine (C-X-C motif) ligand 5	0.046
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.045
IL2RB	interleukin 2 receptor, beta	0.045
CD48	CD48 molecule	0.043
RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	0.042
CYBB	cytochrome b-245, beta polypeptide	0.042
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.042
CXCL11	chemokine (C-X-C motif) ligand 11	0.041
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.041
PRKCD	protein kinase C, delta	0.041
FAS	Fas (TNF receptor superfamily, member 6)	0.041
JUN	jun proto-oncogene	0.040
CCL3	chemokine (C-C motif) ligand 3	0.040
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.040
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.039
FPR3	formyl peptide receptor 3	0.039
PLEK	pleckstrin	0.038
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.038
LY96	lymphocyte antigen 96	0.038
NLRC4	NLR family, CARD domain containing 4	0.038
TRIM26	tripartite motif containing 26	0.038
CCR4	chemokine (C-C motif) receptor 4	0.037
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.037
CYBA	cytochrome b-245, alpha polypeptide	0.036
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.036
CD83	CD83 molecule	0.036
TLR1	toll-like receptor 1	0.034	Human
TRIM34	tripartite motif containing 34	0.034
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.032
TRADD	TNFRSF1A-associated via death domain	0.032
FSTL1	follistatin-like 1	0.032
PI3	peptidase inhibitor 3, skin-derived	0.032
IL2RG	interleukin 2 receptor, gamma	0.031
NOD2	nucleotide-binding oligomerization domain containing 2	0.030
FASLG	Fas ligand (TNF superfamily, member 6)	0.030
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.030
IFI16	interferon, gamma-inducible protein 16	0.030
CLEC18C	C-type lectin domain family 18, member C	0.030
BIRC2	baculoviral IAP repeat containing 2	0.029
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.029
MBD1	methyl-CpG binding domain protein 1	0.028
MAP2K1	mitogen-activated protein kinase kinase 1	0.028
BIN2	bridging integrator 2	0.027
CFLAR	CASP8 and FADD-like apoptosis regulator	0.027
SOD2	superoxide dismutase 2, mitochondrial	0.027
IRAK4	interleukin-1 receptor-associated kinase 4	0.027
IL18RAP	interleukin 18 receptor accessory protein	0.026
CCL11	chemokine (C-C motif) ligand 11	0.026	Human
TRIM9	tripartite motif containing 9	0.025
TANK	TRAF family member-associated NFKB activator	0.025
BAD	BCL2-associated agonist of cell death	0.024
CCL7	chemokine (C-C motif) ligand 7	0.024	Human
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.024
SMAD3	SMAD family member 3	0.024
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.024
MR1	major histocompatibility complex, class I-related	0.023
DUSP3	dual specificity phosphatase 3	0.023
ADAMDEC1	ADAM-like, decysin 1	0.023
TRIM41	tripartite motif containing 41	0.023	Human
NLRP3	NLR family, pyrin domain containing 3	0.023
SIGLEC7	sialic acid binding Ig-like lectin 7	0.023
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.022
AQP9	aquaporin 9	0.022
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.022
CH25H	cholesterol 25-hydroxylase	0.022
CCR2	chemokine (C-C motif) receptor 2	0.022
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.021
CD80	CD80 molecule	0.021
TRIM32	tripartite motif containing 32	0.021
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.021
BCL2A1	BCL2-related protein A1	0.021
IL10RA	interleukin 10 receptor, alpha	0.021
LBP	lipopolysaccharide binding protein	0.020
APOE	apolipoprotein E	0.020
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.020
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.020
PIAS4	protein inhibitor of activated STAT, 4	0.019
IDO1	indoleamine 2,3-dioxygenase 1	0.019
TFEC	transcription factor EC	0.019
SLAMF8	SLAM family member 8	0.019
SELE	selectin E	0.019
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.019
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.017
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.017
CARD11	caspase recruitment domain family, member 11	0.017
RGS1	regulator of G-protein signaling 1	0.017
MSR1	macrophage scavenger receptor 1	0.017
CCL1	chemokine (C-C motif) ligand 1	0.016	Human
ZC3H12C	zinc finger CCCH-type containing 12C	0.016
IRF4	interferon regulatory factor 4	0.016
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.016
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.016
PELI1	pellino homolog 1 (Drosophila)	0.016
STAT4	signal transducer and activator of transcription 4	0.016
CARD16	caspase recruitment domain family, member 16	0.016
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.016
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.016
TGFBR1	transforming growth factor, beta receptor 1	0.016
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.015
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.015
TICAM1	toll-like receptor adaptor molecule 1	0.015	Mouse
GPR65	G protein-coupled receptor 65	0.015
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.015
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.015
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.015
PRKCB	protein kinase C, beta	0.015	Human
FADD	Fas (TNFRSF6)-associated via death domain	0.015
PLAUR	plasminogen activator, urokinase receptor	0.015
IL1A	interleukin 1, alpha	0.015	Human
TREM1	triggering receptor expressed on myeloid cells 1	0.015
BTK	Bruton agammaglobulinemia tyrosine kinase	0.015
IL32	interleukin 32	0.014
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.014
IL18BP	interleukin 18 binding protein	0.014
SREBF1	sterol regulatory element binding transcription factor 1	0.014
SELL	selectin L	0.014
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.014
C3AR1	complement component 3a receptor 1	0.014
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.014
CCR3	chemokine (C-C motif) receptor 3	0.014
DAXX	death-domain associated protein	0.014
SRGN	serglycin	0.014
IRF8	interferon regulatory factor 8	0.014
RNF126	ring finger protein 126	0.014
TMEM173	transmembrane protein 173	0.014
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.014
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.014
GBP1	guanylate binding protein 1, interferon-inducible	0.014
IER3	immediate early response 3	0.013
VCAM1	vascular cell adhesion molecule 1	0.013
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.013
KYNU	kynureninase	0.013
HECTD1	HECT domain containing 1	0.013
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.013
S100A12	S100 calcium binding protein A12	0.013
LAPTM5	lysosomal protein transmembrane 5	0.013
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.013
CCL21	chemokine (C-C motif) ligand 21	0.013
TRIM38	tripartite motif containing 38	0.013	Human
IL15	interleukin 15	0.013
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.013
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.012
CREBBP	CREB binding protein	0.012
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.012
CYTIP	cytohesin 1 interacting protein	0.012
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.012
JUNB	jun B proto-oncogene	0.012
TRIM43	tripartite motif containing 43	0.012
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.012
MAVS	mitochondrial antiviral signaling protein	0.012
GIMAP2	GTPase, IMAP family member 2	0.012
MARCO	macrophage receptor with collagenous structure	0.012
TGFB3	transforming growth factor, beta 3	0.012
SLMAP	sarcolemma associated protein	0.012
CCRL2	chemokine (C-C motif) receptor-like 2	0.012
NCOA1	nuclear receptor coactivator 1	0.012
C4BPA	complement component 4 binding protein, alpha	0.012	Human
IL1F5	interleukin 1 family, member 5 (delta)	0.012
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.012
MS4A7	membrane-spanning 4-domains, subfamily A, member 7	0.011
NOD1	nucleotide-binding oligomerization domain containing 1	0.011
PIAS1	protein inhibitor of activated STAT, 1	0.011
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.011
SP110	SP110 nuclear body protein	0.011
SAT1	spermidine/spermine N1-acetyltransferase 1	0.011
MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	0.011
TRIM6-TRIM34	TRIM6-TRIM34 readthrough	0.011
DUSP7	dual specificity phosphatase 7	0.011
NCOA3	nuclear receptor coactivator 3	0.011
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.011
CTSO	cathepsin O	0.011
CD68	CD68 molecule	0.011
LST1	leukocyte specific transcript 1	0.011
DARC	Duffy blood group, chemokine receptor	0.011
CMKLR1	chemokine-like receptor 1	0.011
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.011
GPR109B	G protein-coupled receptor 109B	0.011
NMI	N-myc (and STAT) interactor	0.011
INHBA	inhibin, beta A	0.011
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.011
TXN	thioredoxin	0.011
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.011
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.010
SPATA24	spermatogenesis associated 24	0.010
SOCS3	suppressor of cytokine signaling 3	0.010
S100A9	S100 calcium binding protein A9	0.010
CP	ceruloplasmin (ferroxidase)	0.010
HDAC6	histone deacetylase 6	0.010
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.010
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.010
CCL17	chemokine (C-C motif) ligand 17	0.010	Human
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.010
C5AR1	complement component 5a receptor 1	0.010
DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	0.010
CCDC50	coiled-coil domain containing 50	0.010
DHRS9	dehydrogenase/reductase (SDR family) member 9	0.010
MCOLN1	mucolipin 1	0.010